Mx1 reveals innate pathways to antiviral resistance and lethal influenza disease

Science

Volumn 352, Issue 6284, 2016, Pages 463-466

  Pillai, Padmini S ^a   Molony, Ryan D ^a   Martinod, Kimberly ^b   Dong, Huiping ^a   Pang, Iris K ^a   Tal, Michal C ^a   Solis, Angel G ^a   Bielecki, Piotr ^a   Mohanty, Subhasis ^c   Trentalange, Mark ^c   Homer, Robert J ^c   Flavell, Richard A ^a,e   Wagner, Denisa D ^b   Montgomery, Ruth R ^c   Shaw, Albert C ^c   Staeheli, Peter ^d   Iwasaki, Akiko ^a,e  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF FREIBURG   (Germany)

^e HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 11; GUANOSINE TRIPHOSPHATASE; INFLAMMASOME; INTERFERON; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MYELOID DIFFERENTIATION FACTOR 88; MYXOVIRUS RESISTANCE PROTEIN 1; STAT1 PROTEIN; TOLL LIKE RECEPTOR 7; UNCLASSIFIED DRUG; BETA INTERFERON; CASP11 PROTEIN, MOUSE; CASPASE; IPS-1 PROTEIN, MOUSE; MEMBRANE PROTEIN; MX1 PROTEIN, MOUSE; MYXOVIRUS RESISTANCE PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TLR7 PROTEIN, MOUSE;

CELLS AND CELL COMPONENTS; DISEASE INCIDENCE; GENE EXPRESSION; INFLUENZA; MORTALITY; PATHOLOGY; RODENT; VIRUS; VULNERABILITY;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL RESISTANCE; ARTICLE; BACTERIAL LOAD; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; IN VIVO STUDY; INFLUENZA; INFLUENZA A VIRUS; INNATE IMMUNITY; INTERFERON PRODUCTION; MACROPHAGE; MONOCYTE; MOUSE; NEUTROPHIL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; TISSUE INJURY; VIRUS LOAD; ANIMAL; BACTERIAL INFECTIONS; COMPLICATION; FEMALE; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MICROBIOLOGY; ORTHOMYXOVIRUS INFECTION; PHYSIOLOGY; RESPIRATORY TRACT INFECTION; VERY ELDERLY; YOUNG ADULT;

BACTERIA (MICROORGANISMS); INFLUENZA A VIRUS; MUS;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ADULT; AGED; AGED, 80 AND OVER; ANIMALS; BACTERIAL INFECTIONS; CASPASE 1; CASPASES; FEMALE; HUMANS; IMMUNITY, INNATE; INFLUENZA A VIRUS; INFLUENZA, HUMAN; INTERFERON-BETA; MALE; MEMBRANE GLYCOPROTEINS; MICE; MONOCYTES; MYXOVIRUS RESISTANCE PROTEINS; NEUTROPHILS; ORTHOMYXOVIRIDAE INFECTIONS; RESPIRATORY TRACT INFECTIONS; TOLL-LIKE RECEPTOR 7; VIRAL LOAD; YOUNG ADULT;

EID: 84964798222     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aaf3926     Document Type: Article

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