-
1
-
-
0036709969
-
A universal role for MyD88 in TLR/IL-1R-mediated signaling
-
Janssens, S., and R. Beyaert. 2002. A universal role for MyD88 in TLR/IL-1R-mediated signaling. Trends Biochem. Sci. 27: 474-482.
-
(2002)
Trends Biochem. Sci.
, vol.27
, pp. 474-482
-
-
Janssens, S.1
Beyaert, R.2
-
2
-
-
41149179018
-
The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammation
-
Ringwood, L., and L. Li. 2008. The involvement of the interleukin-1 receptor-associated kinases (IRAKs) in cellular signaling networks controlling inflammation. Cytokine 42: 1-7.
-
(2008)
Cytokine
, vol.42
, pp. 1-7
-
-
Ringwood, L.1
Li, L.2
-
3
-
-
70350129230
-
IRAK-4 inhibitors for inflammation
-
Wang, Z., H. Wesche, T. Stevens, N. Walker, and W.-C. Yeh. 2009. IRAK-4 inhibitors for inflammation. Curr. Top. Med. Chem. 9: 724-737.
-
(2009)
Curr. Top. Med. Chem.
, vol.9
, pp. 724-737
-
-
Wang, Z.1
Wesche, H.2
Stevens, T.3
Walker, N.4
Yeh, W.-C.5
-
4
-
-
34247566510
-
The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling
-
O'Neill, L. A. J., and A. G. Bowie. 2007. The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat. Rev. Immunol. 7: 353-364.
-
(2007)
Nat. Rev. Immunol.
, vol.7
, pp. 353-364
-
-
O'Neill, L.A.J.1
Bowie, A.G.2
-
5
-
-
33947722603
-
TLR pathways and IFN-regulatory factors: To each its own
-
Colonna, M. 2007. TLR pathways and IFN-regulatory factors: to each its own. Eur. J. Immunol. 37: 306-309.
-
(2007)
Eur. J. Immunol.
, vol.37
, pp. 306-309
-
-
Colonna, M.1
-
6
-
-
0037471003
-
Pyogenic bacterial infections in humans with IRAK-4 deficiency
-
Picard, C., A. Puel, M. Bonnet, C. L. Ku, J. Bustamante, K. Yang, C. Soudais, S. Dupuis, J. Feinberg, C. Fieschi, et al. 2003. Pyogenic bacterial infections in humans with IRAK-4 deficiency. Science 299: 2076-2079.
-
(2003)
Science
, vol.299
, pp. 2076-2079
-
-
Picard, C.1
Puel, A.2
Bonnet, M.3
Ku, C.L.4
Bustamante, J.5
Yang, K.6
Soudais, C.7
Dupuis, S.8
Feinberg, J.9
Fieschi, C.10
-
7
-
-
34948904198
-
Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity
-
Ku, C. L., H. von Bernuth, C. Picard, S. Y. Zhang, H. H. Chang, K. Yang, M. Chrabieh, A. C. Issekutz, C. K. Cunningham, J. I. Gallin, et al. 2007. Selective predisposition to bacterial infections in IRAK-4-deficient children: IRAK-4-dependent TLRs are otherwise redundant in protective immunity. J. Exp. Med. 204: 2407-2422.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 2407-2422
-
-
Ku, C.L.1
Von Bernuth, H.2
Picard, C.3
Zhang, S.Y.4
Chang, H.H.5
Yang, K.6
Chrabieh, M.7
Issekutz, A.C.8
Cunningham, C.K.9
Gallin, J.I.10
-
8
-
-
55349142293
-
IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans
-
Isnardi, I., Y.-S. Ng, I. Srdanovic, R. Motaghedi, S. Rudchenko, H. von Bernuth, S.-Y. Zhang, A. Puel, E. Jouanguy, C. Picard, et al. 2008. IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans. Immunity 29: 746-757.
-
(2008)
Immunity
, vol.29
, pp. 746-757
-
-
Isnardi, I.1
Ng, Y.-S.2
Srdanovic, I.3
Motaghedi, R.4
Rudchenko, S.5
Von Bernuth, H.6
Zhang, S.-Y.7
Puel, A.8
Jouanguy, E.9
Picard, C.10
-
9
-
-
65549124475
-
Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus
-
Jacob, C. O., J. Zhu, D. L. Armstrong, M. Yan, J. Han, X. J. Zhou, J. A. Thomas, A. Reiff, B. L. Myones, J. O. Ojwang, et al. 2009. Identification of IRAK1 as a risk gene with critical role in the pathogenesis of systemic lupus erythematosus. Proc. Natl. Acad. Sci. USA 106: 6256-6261.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 6256-6261
-
-
Jacob, C.O.1
Zhu, J.2
Armstrong, D.L.3
Yan, M.4
Han, J.5
Zhou, X.J.6
Thomas, J.A.7
Reiff, A.8
Myones, B.L.9
Ojwang, J.O.10
-
10
-
-
66149083275
-
Review of recent genome-wide association scans in lupus
-
Graham, R. R., G. Hom, W. Ortmann, and T.W. Behrens. 2009. Review of recent genome-wide association scans in lupus. J. Intern. Med. 265: 680-688.
-
(2009)
J. Intern. Med.
, vol.265
, pp. 680-688
-
-
Graham, R.R.1
Hom, G.2
Ortmann, W.3
Behrens, T.W.4
-
11
-
-
34249707811
-
TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity
-
Baccala, R., K. Hoebe, D. H. Kono, B. Beutler, and A. N. Theofilopoulos. 2007. TLR-dependent and TLR-independent pathways of type I interferon induction in systemic autoimmunity. Nat. Med. 13: 543-551.
-
(2007)
Nat. Med.
, vol.13
, pp. 543-551
-
-
Baccala, R.1
Hoebe, K.2
Kono, D.H.3
Beutler, B.4
Theofilopoulos, A.N.5
-
12
-
-
33750369226
-
Toll-like receptors in systemic autoimmune disease
-
Marshak-Rothstein, A. 2006. Toll-like receptors in systemic autoimmune disease. Nat. Rev. Immunol. 6: 823-835.
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 823-835
-
-
Marshak-Rothstein, A.1
-
13
-
-
85047693371
-
Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9
-
Means, T. K., E. Latz, F. Hayashi, M. R. Murali, D. T. Golenbock, and A. D. Luster. 2005. Human lupus autoantibody-DNA complexes activate DCs through cooperation of CD32 and TLR9. J. Clin. Invest. 115: 407-417.
-
(2005)
J. Clin. Invest.
, vol.115
, pp. 407-417
-
-
Means, T.K.1
Latz, E.2
Hayashi, F.3
Murali, M.R.4
Golenbock, D.T.5
Luster, A.D.6
-
14
-
-
28544449709
-
Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
-
Vollmer, J., S. Tluk, C. Schmitz, S. Hamm, M. Jurk, A. Forsbach, S. Akira, K. M. Kelly, W. H. Reeves, S. Bauer, and A. M. Krieg. 2005. Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J. Exp. Med. 202: 1575-1585.
-
(2005)
J. Exp. Med.
, vol.202
, pp. 1575-1585
-
-
Vollmer, J.1
Tluk, S.2
Schmitz, C.3
Hamm, S.4
Jurk, M.5
Forsbach, A.6
Akira, S.7
Kelly, K.M.8
Reeves, W.H.9
Bauer, S.10
Krieg, A.M.11
-
15
-
-
17144404177
-
IRF-7 is the master regulator of type-I interferon-dependent immune responses
-
Honda, K., H. Yanai, H. Negishi, M. Asagiri, M. Sato, T. Mizutani, N. Shimada, Y. Ohba, A. Takaoka, N. Yoshida, and T. Taniguchi. 2005. IRF-7 is the master regulator of type-I interferon-dependent immune responses. Nature 434: 772-777.
-
(2005)
Nature
, vol.434
, pp. 772-777
-
-
Honda, K.1
Yanai, H.2
Negishi, H.3
Asagiri, M.4
Sato, M.5
Mizutani, T.6
Shimada, N.7
Ohba, Y.8
Takaoka, A.9
Yoshida, N.10
Taniguchi, T.11
-
16
-
-
34249712937
-
Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: Assignment of a type I interferon signature in a subpopulation of patients
-
van der Pouw Kraan, T. C., C. A. Wijbrandts, L. G. van Baarsen, A. E. Voskuyl, F. Rustenburg, J. M. Baggen, S. M. Ibrahim, M. Fero, B. A. Dijkmans, P. P. Tak, and C. L. Verweij. 2007. Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients. Ann. Rheum. Dis. 66: 1008-1014.
-
(2007)
Ann. Rheum. Dis.
, vol.66
, pp. 1008-1014
-
-
Van Der Pouw Kraan, T.C.1
Wijbrandts, C.A.2
Van Baarsen, L.G.3
Voskuyl, A.E.4
Rustenburg, F.5
Baggen, J.M.6
Ibrahim, S.M.7
Fero, M.8
Dijkmans, B.A.9
Tak, P.P.10
Verweij, C.L.11
-
17
-
-
16244376480
-
Toll-like receptors, endogenous ligands, and systemic autoimmune disease
-
Rifkin, I. R., E. A. Leadbetter, L. Busconi, G. Viglianti, and A. Marshak-Rothstein. 2005. Toll-like receptors, endogenous ligands, and systemic autoimmune disease. Immunol. Rev. 204: 27-42.
-
(2005)
Immunol. Rev.
, vol.204
, pp. 27-42
-
-
Rifkin, I.R.1
Leadbetter, E.A.2
Busconi, L.3
Viglianti, G.4
Marshak-Rothstein, A.5
-
18
-
-
48749085127
-
Plasmacytoid dendritic cells: Sensing nucleic acids in viral infection and autoimmune diseases
-
Gilliet, M., W. Cao, and Y. J. Liu. 2008. Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases. Nat. Rev. Immunol. 8: 594-606.
-
(2008)
Nat. Rev. Immunol.
, vol.8
, pp. 594-606
-
-
Gilliet, M.1
Cao, W.2
Liu, Y.J.3
-
19
-
-
34249078495
-
A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity
-
Kim, T. W., K. A. Staschke, K. Bulek, J. Yao, K. Peters, K. H. Oh, Y. Vandenburg, H. Xiao, W. Qian, T. Hamilton, et al. 2007. A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J. Exp. Med. 204: 1025-1036.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1025-1036
-
-
Kim, T.W.1
Staschke, K.A.2
Bulek, K.3
Yao, J.4
Peters, K.5
Oh, K.H.6
Vandenburg, Y.7
Xiao, H.8
Qian, W.9
Hamilton, T.10
-
20
-
-
34249095729
-
Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling
-
Kawagoe, T., S. Sato, A. Jung, M. Yamamoto, K. Matsui, H. Kato, S. Uematsu, O. Takeuchi, and S. Akira. 2007. Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling. J. Exp. Med. 204: 1013-1024.
-
(2007)
J. Exp. Med.
, vol.204
, pp. 1013-1024
-
-
Kawagoe, T.1
Sato, S.2
Jung, A.3
Yamamoto, M.4
Matsui, K.5
Kato, H.6
Uematsu, S.7
Takeuchi, O.8
Akira, S.9
-
21
-
-
68949094003
-
IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease
-
Staschke, K. A., S. Dong, J. Saha, J. Zhao, N. A. Brooks, D. L. Hepburn, J. Xia, M. F. Gulen, Z. Kang, C. Z. Altuntas, et al. 2009. IRAK4 kinase activity is required for Th17 differentiation and Th17-mediated disease. J. Immunol. 183: 568-577.
-
(2009)
J. Immunol.
, vol.183
, pp. 568-577
-
-
Staschke, K.A.1
Dong, S.2
Saha, J.3
Zhao, J.4
Brooks, N.A.5
Hepburn, D.L.6
Xia, J.7
Gulen, M.F.8
Kang, Z.9
Altuntas, C.Z.10
-
22
-
-
35348926002
-
The PI3K inhibitor arsenal: Choose your weapon!
-
Crabbe, T., M. J. Welham, and S. G. Ward. 2007. The PI3K inhibitor arsenal: choose your weapon! Trends Biochem. Sci. 32: 450-456.
-
(2007)
Trends Biochem. Sci.
, vol.32
, pp. 450-456
-
-
Crabbe, T.1
Welham, M.J.2
Ward, S.G.3
-
23
-
-
67650444732
-
Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune disease
-
Chiang, E. Y., G. A. Kolumam, X. Yu, M. Francesco, S. Ivelja, I. Peng, P. Gribling, J. Shu, W. P. Lee, C. J. Refino, et al. 2009. Targeted depletion of lymphotoxin-alpha-expressing TH1 and TH17 cells inhibits autoimmune disease. Nat. Med. 15: 766-773.
-
(2009)
Nat. Med.
, vol.15
, pp. 766-773
-
-
Chiang, E.Y.1
Kolumam, G.A.2
Yu, X.3
Francesco, M.4
Ivelja, S.5
Peng, I.6
Gribling, P.7
Shu, J.8
Lee, W.P.9
Refino, C.J.10
-
24
-
-
17844380477
-
Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction
-
Honda, K., Y. Ohba, H. Yanai, H. Negishi, T. Mizutani, A. Takaoka, C. Taya, and T. Taniguchi. 2005. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434: 1035-1040.
-
(2005)
Nature
, vol.434
, pp. 1035-1040
-
-
Honda, K.1
Ohba, Y.2
Yanai, H.3
Negishi, H.4
Mizutani, T.5
Takaoka, A.6
Taya, C.7
Taniguchi, T.8
-
25
-
-
67349280350
-
Role of phosphoinositide 3-kinase p110 delta in TLR4- and TLR9-mediated B cell cytokine production and differentiation
-
Dil, N., and A. J. Marshall. 2009. Role of phosphoinositide 3-kinase p110 delta in TLR4- and TLR9-mediated B cell cytokine production and differentiation. Mol. Immunol. 46: 1970-1978.
-
(2009)
Mol. Immunol.
, vol.46
, pp. 1970-1978
-
-
Dil, N.1
Marshall, A.J.2
-
26
-
-
0038236749
-
Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells
-
Hartmann, G., J. Battiany, H. Poeck, M. Wagner, M. Kerkmann, N. Lubenow, S. Rothenfusser, and S. Endres. 2003. Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells. Eur. J. Immunol. 33: 1633-1641.
-
(2003)
Eur. J. Immunol.
, vol.33
, pp. 1633-1641
-
-
Hartmann, G.1
Battiany, J.2
Poeck, H.3
Wagner, M.4
Kerkmann, M.5
Lubenow, N.6
Rothenfusser, S.7
Endres, S.8
-
27
-
-
0037407691
-
Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells
-
Kerkmann, M., S. Rothenfusser, V. Hornung, A. Towarowski, M. Wagner, A. Sarris, T. Giese, S. Endres, and G. Hartmann. 2003. Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J. Immunol. 170: 4465-4474.
-
(2003)
J. Immunol.
, vol.170
, pp. 4465-4474
-
-
Kerkmann, M.1
Rothenfusser, S.2
Hornung, V.3
Towarowski, A.4
Wagner, M.5
Sarris, A.6
Giese, T.7
Endres, S.8
Hartmann, G.9
-
28
-
-
33746884630
-
Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation
-
Guiducci, C., G. Ott, J. H. Chan, E. Damon, C. Calacsan, T. Matray, K. D. Lee, R. L. Coffman, and F. J. Barrat. 2006. Properties regulating the nature of the plasmacytoid dendritic cell response to Toll-like receptor 9 activation. J. Exp. Med. 203: 1999-2008.
-
(2006)
J. Exp. Med.
, vol.203
, pp. 1999-2008
-
-
Guiducci, C.1
Ott, G.2
Chan, J.H.3
Damon, E.4
Calacsan, C.5
Matray, T.6
Lee, K.D.7
Coffman, R.L.8
Barrat, F.J.9
-
29
-
-
47249089097
-
IL-1, IL-18, and IL-33 families of cytokines
-
Arend, W. P., G. Palmer, and C. Gabay. 2008. IL-1, IL-18, and IL-33 families of cytokines. Immunol. Rev. 223: 20-38.
-
(2008)
Immunol. Rev.
, vol.223
, pp. 20-38
-
-
Arend, W.P.1
Palmer, G.2
Gabay, C.3
-
30
-
-
0033971259
-
IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells
-
Tominaga, K., T. Yoshimoto, K. Torigoe, M. Kurimoto, K. Matsui, T. Hada, H. Okamura, and K. Nakanishi. 2000. IL-12 synergizes with IL-18 or IL-1beta for IFN-gamma production from human T cells. Int. Immunol. 12: 151-160.
-
(2000)
Int. Immunol.
, vol.12
, pp. 151-160
-
-
Tominaga, K.1
Yoshimoto, T.2
Torigoe, K.3
Kurimoto, M.4
Matsui, K.5
Hada, T.6
Okamura, H.7
Nakanishi, K.8
-
31
-
-
64049089798
-
Critical regulation of early Th17 cell differentiation by interleukin-1 signaling
-
Chung, Y., S. H. Chang, G. J. Martinez, X. O. Yang, R. Nurieva, H. S. Kang, L. Ma, S. S. Watowich, A. M. Jetten, Q. Tian, and C. Dong. 2009. Critical regulation of early Th17 cell differentiation by interleukin-1 signaling. Immunity 30: 576-587.
-
(2009)
Immunity
, vol.30
, pp. 576-587
-
-
Chung, Y.1
Chang, S.H.2
Martinez, G.J.3
Yang, X.O.4
Nurieva, R.5
Kang, H.S.6
Ma, L.7
Watowich, S.S.8
Jetten, A.M.9
Tian, Q.10
Dong, C.11
-
32
-
-
20244388983
-
Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-a induction
-
Uematsu, S., S. Sato, M. Yamamoto, T. Hirotani, H. Kato, F. Takeshita, M. Matsuda, C. Coban, K. J. Ishii, T. Kawai, et al. 2005. Interleukin-1 receptor-associated kinase-1 plays an essential role for Toll-like receptor (TLR)7- and TLR9-mediated interferon-a induction. J. Exp. Med. 201: 915-923.
-
(2005)
J. Exp. Med.
, vol.201
, pp. 915-923
-
-
Uematsu, S.1
Sato, S.2
Yamamoto, M.3
Hirotani, T.4
Kato, H.5
Takeshita, F.6
Matsuda, M.7
Coban, C.8
Ishii, K.J.9
Kawai, T.10
-
33
-
-
0033565779
-
Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase
-
Thomas, J. A., J. L. Allen, M. Tsen, T. Dubnicoff, J. Danao, X. C. Liao, Z. Cao, and S. A. Wasserman. 1999. Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J. Immunol. 163: 978-984.
-
(1999)
J. Immunol.
, vol.163
, pp. 978-984
-
-
Thomas, J.A.1
Allen, J.L.2
Tsen, M.3
Dubnicoff, T.4
Danao, J.5
Liao, X.C.6
Cao, Z.7
Wasserman, S.A.8
-
34
-
-
0347297142
-
IL-1 receptor-associated kinase 1 regulates susceptibility to organ-specific autoimmunity
-
Deng, C., C. Radu, A. Diab, M. F. Tsen, R. Hussain, J. S. Cowdery, M. K. Racke, and J. A. Thomas. 2003. IL-1 receptor-associated kinase 1 regulates susceptibility to organ-specific autoimmunity. J. Immunol. 170: 2833-2842.
-
(2003)
J. Immunol.
, vol.170
, pp. 2833-2842
-
-
Deng, C.1
Radu, C.2
Diab, A.3
Tsen, M.F.4
Hussain, R.5
Cowdery, J.S.6
Racke, M.K.7
Thomas, J.A.8
-
35
-
-
0032526555
-
Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production
-
Kanakaraj, P., P. H. Schafer, D. E. Cavender, Y. Wu, K. Ngo, P. F. Grealish, S. A. Wadsworth, P. A. Peterson, J. J. Siekierka, C. A. Harris, and W. P. Fung- Leung. 1998. Interleukin (IL)-1 receptor-associated kinase (IRAK) requirement for optimal induction of multiple IL-1 signaling pathways and IL-6 production. J. Exp. Med. 187: 2073-2079.
-
(1998)
J. Exp. Med.
, vol.187
, pp. 2073-2079
-
-
Kanakaraj, P.1
Schafer, P.H.2
Cavender, D.E.3
Wu, Y.4
Ngo, K.5
Grealish, P.F.6
Wadsworth, S.A.7
Peterson, P.A.8
Siekierka, J.J.9
Harris, C.A.10
Fung-Leung, W.P.11
-
36
-
-
0033526110
-
Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice
-
Kanakaraj, P., K. Ngo, Y. Wu, A. Angulo, P. Ghazal, C. A. Harris, J. J. Siekierka, P. A. Peterson, and W. P. Fung-Leung. 1999. Defective interleukin (IL)-18-mediated natural killer and T helper cell type 1 responses in IL-1 receptor-associated kinase (IRAK)-deficient mice. J. Exp. Med. 189: 1129-1138.
-
(1999)
J. Exp. Med.
, vol.189
, pp. 1129-1138
-
-
Kanakaraj, P.1
Ngo, K.2
Wu, Y.3
Angulo, A.4
Ghazal, P.5
Harris, C.A.6
Siekierka, J.J.7
Peterson, P.A.8
Fung-Leung, W.P.9
-
37
-
-
34250370957
-
IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression
-
Koziczak-Holbro, M., C. Joyce, A. Glück, B. Kinzel, M. Müller, C. Tschopp, J. C. Mathison, C. N. Davis, and H. Gram. 2007. IRAK-4 kinase activity is required for interleukin-1 (IL-1) receptor- and toll-like receptor 7-mediated signaling and gene expression. J. Biol. Chem. 282: 13552-13560.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 13552-13560
-
-
Koziczak-Holbro, M.1
Joyce, C.2
Glück, A.3
Kinzel, B.4
Müller, M.5
Tschopp, C.6
Mathison, J.C.7
Davis, C.N.8
Gram, H.9
-
38
-
-
33645470115
-
A critical role for the innate immune signaling molecule IRAK-4 in T cell activation
-
Suzuki, N., S. Suzuki, D. G. Millar, M. Unno, H. Hara, T. Calzascia, S. Yamasaki, T. Yokosuka, N. J. Chen, A. R. Elford, et al. 2006. A critical role for the innate immune signaling molecule IRAK-4 in T cell activation. Science 311: 1927-1932.
-
(2006)
Science
, vol.311
, pp. 1927-1932
-
-
Suzuki, N.1
Suzuki, S.2
Millar, D.G.3
Unno, M.4
Hara, H.5
Calzascia, T.6
Yamasaki, S.7
Yokosuka, T.8
Chen, N.J.9
Elford, A.R.10
-
39
-
-
43649107807
-
IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses
-
Lye, E., S. Dhanji, T. Calzascia, A. R. Elford, and P. S. Ohashi. 2008. IRAK-4 kinase activity is required for IRAK-4-dependent innate and adaptive immune responses. Eur. J. Immunol. 38: 870-876.
-
(2008)
Eur. J. Immunol.
, vol.38
, pp. 870-876
-
-
Lye, E.1
Dhanji, S.2
Calzascia, T.3
Elford, A.R.4
Ohashi, P.S.5
-
40
-
-
66449130625
-
The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation
-
Koziczak-Holbro, M., A. Littlewood-Evans, B. Pöllinger, J. Kovarik, J. Dawson, G. Zenke, C. Burkhart, M. Müller, and H. Gram. 2009. The critical role of kinase activity of interleukin-1 receptor-associated kinase 4 in animal models of joint inflammation. Arthritis Rheum. 60: 1661-1671.
-
(2009)
Arthritis Rheum.
, vol.60
, pp. 1661-1671
-
-
Koziczak-Holbro, M.1
Littlewood-Evans, A.2
Pöllinger, B.3
Kovarik, J.4
Dawson, J.5
Zenke, G.6
Burkhart, C.7
Müller, M.8
Gram, H.9
-
41
-
-
0033560731
-
Overexpression of an enzymically inactive interleukin-1-receptor- associated kinase activates nuclear factor-kappaB
-
Maschera, B., K. Ray, K. Burns, and F. Volpe. 1999. Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB. Biochem. J. 339: 227-231.
-
(1999)
Biochem. J.
, vol.339
, pp. 227-231
-
-
Maschera, B.1
Ray, K.2
Burns, K.3
Volpe, F.4
-
42
-
-
0033036063
-
Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity
-
Knop, J., and M. U. Martin. 1999. Effects of IL-1 receptor-associated kinase (IRAK) expression on IL-1 signaling are independent of its kinase activity. FEBS Lett. 448: 81-85.
-
(1999)
FEBS Lett.
, vol.448
, pp. 81-85
-
-
Knop, J.1
Martin, M.U.2
-
43
-
-
2942748292
-
IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness
-
Qin, J., Z. Jiang, Y. Qian, J. L. Casanova, and X. Li. 2004. IRAK4 kinase activity is redundant for interleukin-1 (IL-1) receptor-associated kinase phosphorylation and IL-1 responsiveness. J. Biol. Chem. 279: 26748-26753.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 26748-26753
-
-
Qin, J.1
Jiang, Z.2
Qian, Y.3
Casanova, J.L.4
Li, X.5
-
44
-
-
33746365872
-
TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent
-
Qin, J., J. Yao, G. Cui, H. Xiao, T. W. Kim, J. Fraczek, P. Wightman, S. Sato, S. Akira, A. Puel, et al. 2006. TLR8-mediated NF-kappaB and JNK activation are TAK1-independent and MEKK3-dependent. J. Biol. Chem. 281: 21013-21021.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 21013-21021
-
-
Qin, J.1
Yao, J.2
Cui, G.3
Xiao, H.4
Kim, T.W.5
Fraczek, J.6
Wightman, P.7
Sato, S.8
Akira, S.9
Puel, A.10
-
45
-
-
62749099990
-
The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells
-
Song, K. W., F. X. Talamas, R. T. Suttmann, P. S. Olson, J. W. Barnett, S. W. Lee, K. D. Thompson, S. Jin, M. Hekmat-Nejad, T. Z. Cai, et al. 2009. The kinase activities of interleukin-1 receptor associated kinase (IRAK)-1 and 4 are redundant in the control of inflammatory cytokine expression in human cells. Mol. Immunol. 46: 1458-1466.
-
(2009)
Mol. Immunol.
, vol.46
, pp. 1458-1466
-
-
Song, K.W.1
Talamas, F.X.2
Suttmann, R.T.3
Olson, P.S.4
Barnett, J.W.5
Lee, S.W.6
Thompson, K.D.7
Jin, S.8
Hekmat-Nejad, M.9
Cai, T.Z.10
-
46
-
-
77953275701
-
Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides
-
Avalos, A. M., E. Latz, B. Mousseau, S. R. Christensen, M. J. Shlomchik, F. Lund, and A. Marshak-Rothstein. 2009. Differential cytokine production and bystander activation of autoreactive B cells in response to CpG-A and CpG-B oligonucleotides. J. Immunol. 183: 6262-6268.
-
(2009)
J. Immunol.
, vol.183
, pp. 6262-6268
-
-
Avalos, A.M.1
Latz, E.2
Mousseau, B.3
Christensen, S.R.4
Shlomchik, M.J.5
Lund, F.6
Marshak-Rothstein, A.7
-
47
-
-
44649161194
-
The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens
-
Chaturvedi, A., D. Dorward, and S. K. Pierce. 2008. The B cell receptor governs the subcellular location of Toll-like receptor 9 leading to hyperresponses to DNA-containing antigens. Immunity 28: 799-809.
-
(2008)
Immunity
, vol.28
, pp. 799-809
-
-
Chaturvedi, A.1
Dorward, D.2
Pierce, S.K.3
-
48
-
-
29144531808
-
Rheumatoid arthritis synovium contains plasmacytoid dendritic cells
-
Cavanagh, L. L., A. Boyce, L. Smith, J. Padmanabha, L. Filgueira, P. Pietschmann, and R. Thomas. 2005. Rheumatoid arthritis synovium contains plasmacytoid dendritic cells. Arthritis Res. Ther. 7: R230-R240.
-
(2005)
Arthritis Res. Ther.
, vol.7
-
-
Cavanagh, L.L.1
Boyce, A.2
Smith, L.3
Padmanabha, J.4
Filgueira, L.5
Pietschmann, P.6
Thomas, R.7
-
49
-
-
4043170537
-
Characterization and recruitment of plasmacytoid dendritic cells in synovial fluid and tissue of patients with chronic inflammatory arthritis
-
Lande, R., E. Giacomini, B. Serafini, B. Rosicarelli, G. D. Sebastiani, G. Minisola, U. Tarantino, V. Riccieri, G. Valesini, and E. M. Coccia. 2004. Characterization and recruitment of plasmacytoid dendritic cells in synovial fluid and tissue of patients with chronic inflammatory arthritis. J. Immunol. 173: 2815-2824.
-
(2004)
J. Immunol.
, vol.173
, pp. 2815-2824
-
-
Lande, R.1
Giacomini, E.2
Serafini, B.3
Rosicarelli, B.4
Sebastiani, G.D.5
Minisola, G.6
Tarantino, U.7
Riccieri, V.8
Valesini, G.9
Coccia, E.M.10
-
50
-
-
77953723966
-
TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus
-
Guiducci, C., M. Gong, Z. Xu, M. Gill, D. Chaussabel, T. Meeker, J. H. Chan, T. Wright, M. Punaro, S. Bolland, et al. 2010. TLR recognition of self nucleic acids hampers glucocorticoid activity in lupus. Nature 465: 937-941.
-
(2010)
Nature
, vol.465
, pp. 937-941
-
-
Guiducci, C.1
Gong, M.2
Xu, Z.3
Gill, M.4
Chaussabel, D.5
Meeker, T.6
Chan, J.H.7
Wright, T.8
Punaro, M.9
Bolland, S.10
-
51
-
-
34948862264
-
Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide
-
Lande, R., J. Gregorio, V. Facchinetti, B. Chatterjee, Y. H. Wang, B. Homey, W. Cao, Y. H. Wang, B. Su, F. O. Nestle, et al. 2007. Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide. Nature 449: 564-569.
-
(2007)
Nature
, vol.449
, pp. 564-569
-
-
Lande, R.1
Gregorio, J.2
Facchinetti, V.3
Chatterjee, B.4
Wang, Y.H.5
Homey, B.6
Cao, W.7
Wang, Y.H.8
Su, B.9
Nestle, F.O.10
-
52
-
-
0036841956
-
Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes
-
Paulsen, F., T. Pufe, L. Conradi, D. Varoga, M. Tsokos, J. Papendieck, and W. Petersen. 2002. Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes. J. Pathol. 198: 369-377.
-
(2002)
J. Pathol.
, vol.198
, pp. 369-377
-
-
Paulsen, F.1
Pufe, T.2
Conradi, L.3
Varoga, D.4
Tsokos, M.5
Papendieck, J.6
Petersen, W.7
-
53
-
-
34249827580
-
Proteomic analysis of secreted proteins in early rheumatoid arthritis: Anticitrulline autoreactivity is associated with up regulation of proinflammatory cytokines
-
Hueber, W., B. H. Tomooka, X. Zhao, B. A. Kidd, J. W. Drijfhout, J. F. Fries, W. J. van Venrooij, A. L. Metzger, M. C. Genovese, and W. H. Robinson. 2007. Proteomic analysis of secreted proteins in early rheumatoid arthritis: anticitrulline autoreactivity is associated with up regulation of proinflammatory cytokines. Ann. Rheum. Dis. 66: 712-719.
-
(2007)
Ann. Rheum. Dis.
, vol.66
, pp. 712-719
-
-
Hueber, W.1
Tomooka, B.H.2
Zhao, X.3
Kidd, B.A.4
Drijfhout, J.W.5
Fries, J.F.6
Van Venrooij, W.J.7
Metzger, A.L.8
Genovese, M.C.9
Robinson, W.H.10
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