T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes

Nature Communications

Volumn 8, Issue 1, 2017, Pages

  Gomez Tourino, Iria ^a,b,c   Kamra, Yogesh ^a   Baptista, Roman ^a,b   Lorenc, Anna ^a   Peakman, Mark ^a,b  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b GUY'S AND ST THOMAS' NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF VIGO   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; GLUTAMATE DECARBOXYLASE 65; T LYMPHOCYTE RECEPTOR BETA CHAIN; AUTOANTIGEN; LYMPHOCYTE ANTIGEN RECEPTOR;

CELLS AND CELL COMPONENTS; DIABETES; GENE EXPRESSION; HEALTH RISK; IMMUNE RESPONSE;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN EXPRESSION; ARTICLE; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; COMPLEMENTARITY DETERMINING REGION; CONTROLLED STUDY; DISEASE PREDISPOSITION; GENE REARRANGEMENT; HIGH THROUGHPUT SEQUENCING; HUMAN; HYDROPHOBICITY; INSULIN DEPENDENT DIABETES MELLITUS; MOUSE; NEXT GENERATION SEQUENCING; NONHUMAN; NUCLEOTIDE SEQUENCE; RISK FACTOR; T LYMPHOCYTE SUBPOPULATION; ADULT; CELL DIFFERENTIATION; CELL SEPARATION; CYTOLOGY; FEMALE; FLOW CYTOMETRY; GENETICS; IMMUNOLOGY; MALE; METABOLISM; MIDDLE AGED; PROCEDURES; THYMUS; VDJ RECOMBINATION; YOUNG ADULT;

ADULT; AUTOANTIGENS; CELL DIFFERENTIATION; CELL SEPARATION; COMPLEMENTARITY DETERMINING REGIONS; DIABETES MELLITUS, TYPE 1; FEMALE; FLOW CYTOMETRY; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HUMANS; MALE; MIDDLE AGED; RECEPTORS, ANTIGEN, T-CELL, ALPHA-BETA; T-LYMPHOCYTE SUBSETS; THYMUS GLAND; V(D)J RECOMBINATION; YOUNG ADULT;

EID: 85035317900     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/s41467-017-01925-2     Document Type: Article

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