Hydrophobic CDR3 residues promote the development of self-reactive T cells

Nature Immunology

Volumn 17, Issue 8, 2016, Pages 946-955

  Stadinski, Brian D ^a   Shekhar, Karthik ^b   Gómez Touriño, Iria ^c   Jung, Jonathan ^a   Sasaki, Katsuhiro ^a   Sewell, Andrew K ^d   Peakman, Mark ^c   Chakraborty, Arup K ^e,f   Huseby, Eric S ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d CARDIFF UNIVERSITY   (United Kingdom)

^e MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^f Massachusetts Institute of Technology   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; T LYMPHOCYTE RECEPTOR BETA CHAIN; AUTOANTIGEN; COMPLEMENTARITY DETERMINING REGION; HLA ANTIGEN CLASS 2; I-A G7 ANTIGEN; I-A(B) ANTIGEN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY COMBINING SITE; ARTICLE; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CELL MATURATION; COMPLEMENTARITY DETERMINING REGION; COMPLEMENTARITY DETERMINING REGION 3 BETA; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; HUMAN; HYDROPHOBICITY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; MOLECULAR RECOGNITION; MOUSE; NEXT GENERATION SEQUENCING; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; SELF REACTIVITY; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; THYMOCYTE; ANIMAL; AUTOIMMUNITY; C57BL MOUSE; CELL DIFFERENTIATION; CHEMICAL PHENOMENA; GENETICS; HIGH THROUGHPUT SEQUENCING; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; INSULIN DEPENDENT DIABETES MELLITUS; KNOCKOUT MOUSE; METABOLISM; NONOBESE DIABETIC MOUSE; PHYSIOLOGY;

ANIMALS; AUTOANTIGENS; AUTOIMMUNITY; CELL DIFFERENTIATION; CENTRAL TOLERANCE; COMPLEMENTARITY DETERMINING REGIONS; DIABETES MELLITUS, TYPE 1; FEMALE; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; HISTOCOMPATIBILITY ANTIGENS CLASS II; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MALE; MICE; MICE, INBRED C57BL; MICE, INBRED NOD; MICE, KNOCKOUT; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES, REGULATORY;

EID: 84976292366     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3491     Document Type: Article

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