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Volumn 387, Issue 10035, 2016, Pages 2331-2339

Genetic risk factors for type 1 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

AUTOIMMUNE DISEASE; DIABETOGENESIS; GENETIC PREDISPOSITION; GENETIC RISK; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; REVIEW; THEORY; ADOLESCENT; ADULT; AGED; CHILD; DIABETES MELLITUS; GENETICS; GENOTYPE ENVIRONMENT INTERACTION; HAPLOTYPE; HUMAN GENOME; IMMUNOLOGY; INFANT; MIDDLE AGED; NEWBORN; PANCREAS ISLET BETA CELL; PRESCHOOL CHILD; RISK FACTOR; YOUNG ADULT;

EID: 84975920751     PISSN: 01406736     EISSN: 1474547X     Source Type: Journal    
DOI: 10.1016/S0140-6736(16)30582-7     Document Type: Review
Times cited : (402)

References (56)
  • 1
    • 84870765997 scopus 로고    scopus 로고
    • Year in diabetes 2012: The diabetes tsunami
    • 1 Sherwin, R, Jastreboff, AM, Year in diabetes 2012: The diabetes tsunami. J Clin Endocrinol Metab 97 (2012), 4293–4301.
    • (2012) J Clin Endocrinol Metab , vol.97 , pp. 4293-4301
    • Sherwin, R.1    Jastreboff, A.M.2
  • 2
    • 0018749607 scopus 로고
    • The value of islet cell antibody in predicting secondary failure of oral hypoglycaemic agent therapy in diabetes mellitus
    • 2 Irvine, WJ, Sawers, JS, Feek, CM, Prescott, RJ, Duncan, LJ, The value of islet cell antibody in predicting secondary failure of oral hypoglycaemic agent therapy in diabetes mellitus. J Clin Lab Immunol 2 (1979), 23–26.
    • (1979) J Clin Lab Immunol , vol.2 , pp. 23-26
    • Irvine, W.J.1    Sawers, J.S.2    Feek, C.M.3    Prescott, R.J.4    Duncan, L.J.5
  • 3
    • 0027500697 scopus 로고
    • Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease
    • 3 Tuomi, T, Groop, LC, Zimmet, PZ, Rowley, MJ, Knowles, W, Mackay, IR, Antibodies to glutamic acid decarboxylase reveal latent autoimmune diabetes mellitus in adults with a non-insulin-dependent onset of disease. Diabetes 42 (1993), 359–362.
    • (1993) Diabetes , vol.42 , pp. 359-362
    • Tuomi, T.1    Groop, L.C.2    Zimmet, P.Z.3    Rowley, M.J.4    Knowles, W.5    Mackay, I.R.6
  • 4
    • 33644761984 scopus 로고    scopus 로고
    • Is latent autoimmune diabetes in adults distinct from type 1 diabetes or just type 1 diabetes at an older age?
    • 4 Palmer, JP, Hampe, CS, Chiu, H, Goel, A, Brooks-Worrell, BM, Is latent autoimmune diabetes in adults distinct from type 1 diabetes or just type 1 diabetes at an older age?. Diabetes 54:suppl 2 (2005), S62–S67.
    • (2005) Diabetes , vol.54 , Issue.suppl 2 , pp. S62-S67
    • Palmer, J.P.1    Hampe, C.S.2    Chiu, H.3    Goel, A.4    Brooks-Worrell, B.M.5
  • 5
    • 84949319141 scopus 로고    scopus 로고
    • Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment
    • 5 Leslie, RD, Palmer, J, Schloot, NC, Lernmark, A, Diabetes at the crossroads: relevance of disease classification to pathophysiology and treatment. Diabetologia 59 (2016), 13–20.
    • (2016) Diabetologia , vol.59 , pp. 13-20
    • Leslie, R.D.1    Palmer, J.2    Schloot, N.C.3    Lernmark, A.4
  • 6
    • 84879114358 scopus 로고    scopus 로고
    • Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children
    • 6 Ziegler, AG, Rewers, M, Simell, O, et al. Seroconversion to multiple islet autoantibodies and risk of progression to diabetes in children. JAMA 309 (2013), 2473–2479.
    • (2013) JAMA , vol.309 , pp. 2473-2479
    • Ziegler, A.G.1    Rewers, M.2    Simell, O.3
  • 7
    • 84939961476 scopus 로고    scopus 로고
    • The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study
    • 7 Krischer, JP, Lynch, KF, Schatz, DA, et al. The 6 year incidence of diabetes-associated autoantibodies in genetically at-risk children: the TEDDY study. Diabetologia 58 (2015), 980–987.
    • (2015) Diabetologia , vol.58 , pp. 980-987
    • Krischer, J.P.1    Lynch, K.F.2    Schatz, D.A.3
  • 8
    • 84891542721 scopus 로고    scopus 로고
    • Patterns of beta-cell autoantibody appearance and genetic associations during the first years of life
    • 8 Ilonen, J, Hammais, A, Laine, AP, et al. Patterns of beta-cell autoantibody appearance and genetic associations during the first years of life. Diabetes 62 (2013), 3636–3640.
    • (2013) Diabetes , vol.62 , pp. 3636-3640
    • Ilonen, J.1    Hammais, A.2    Laine, A.P.3
  • 9
    • 0034931291 scopus 로고    scopus 로고
    • Environmental triggers of type 1 diabetes
    • 9 Couper, JJ, Environmental triggers of type 1 diabetes. J Paediatr Child Health 37 (2001), 218–220.
    • (2001) J Paediatr Child Health , vol.37 , pp. 218-220
    • Couper, J.J.1
  • 10
    • 0027308817 scopus 로고
    • On the appearance of islet associated autoimmunity in offspring of diabetic mothers: a prospective study from birth
    • 10 Ziegler, AG, Hillebrand, B, Rabl, W, et al. On the appearance of islet associated autoimmunity in offspring of diabetic mothers: a prospective study from birth. Diabetologia 36 (1993), 402–408.
    • (1993) Diabetologia , vol.36 , pp. 402-408
    • Ziegler, A.G.1    Hillebrand, B.2    Rabl, W.3
  • 11
    • 0028890395 scopus 로고
    • Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of IDDM. Members of the Swedish Childhood Diabetes Study
    • 11 Sanjeevi, CB, Lybrand, TP, DeWeese, C, et al. Polymorphic amino acid variations in HLA-DQ are associated with systematic physical property changes and occurrence of IDDM. Members of the Swedish Childhood Diabetes Study. Diabetes 44 (1995), 125–131.
    • (1995) Diabetes , vol.44 , pp. 125-131
    • Sanjeevi, C.B.1    Lybrand, T.P.2    DeWeese, C.3
  • 12
    • 0036319041 scopus 로고    scopus 로고
    • Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes
    • 12 Graham, J, Hagopian, WA, Kockum, I, et al. Genetic effects on age-dependent onset and islet cell autoantibody markers in type 1 diabetes. Diabetes 51 (2002), 1346–1355.
    • (2002) Diabetes , vol.51 , pp. 1346-1355
    • Graham, J.1    Hagopian, W.A.2    Kockum, I.3
  • 13
    • 8944258928 scopus 로고    scopus 로고
    • Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY)
    • 13 Rewers, M, Bugawan, TL, Norris, JM, et al. Newborn screening for HLA markers associated with IDDM: diabetes autoimmunity study in the young (DAISY). Diabetologia 39 (1996), 807–812.
    • (1996) Diabetologia , vol.39 , pp. 807-812
    • Rewers, M.1    Bugawan, T.L.2    Norris, J.M.3
  • 14
    • 49249134526 scopus 로고    scopus 로고
    • Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes
    • 14 Larsson, HE, Hansson, G, Carlsson, A, et al. Children developing type 1 diabetes before 6 years of age have increased linear growth independent of HLA genotypes. Diabetologia 51 (2008), 1623–1630.
    • (2008) Diabetologia , vol.51 , pp. 1623-1630
    • Larsson, H.E.1    Hansson, G.2    Carlsson, A.3
  • 15
    • 0043062874 scopus 로고    scopus 로고
    • Prospective assessment in newborns of diabetes autoimmunity (PANDA): maternal understanding of infant diabetes risk
    • 15 Carmichael, SK, Johnson, SB, Baughcum, A, et al. Prospective assessment in newborns of diabetes autoimmunity (PANDA): maternal understanding of infant diabetes risk. Genet Med 5 (2003), 77–83.
    • (2003) Genet Med , vol.5 , pp. 77-83
    • Carmichael, S.K.1    Johnson, S.B.2    Baughcum, A.3
  • 16
    • 1942538579 scopus 로고    scopus 로고
    • Population-wide infant screening for HLA-based type 1 diabetes risk via dried blood spots from the public health infrastructure
    • 16 Wion, E, Brantley, M, Stevens, J, et al. Population-wide infant screening for HLA-based type 1 diabetes risk via dried blood spots from the public health infrastructure. Ann N Y Acad Sci 1005 (2003), 400–403.
    • (2003) Ann N Y Acad Sci , vol.1005 , pp. 400-403
    • Wion, E.1    Brantley, M.2    Stevens, J.3
  • 17
    • 0031847856 scopus 로고    scopus 로고
    • Screening for genetic IDDM risk and prevention trials in infancy
    • 17 Ilonen, J, Simell, O, Knip, M, Akerblom, HK, Screening for genetic IDDM risk and prevention trials in infancy. Diabetes Metab Rev, 14, 1998, 188.
    • (1998) Diabetes Metab Rev , vol.14 , pp. 188
    • Ilonen, J.1    Simell, O.2    Knip, M.3    Akerblom, H.K.4
  • 18
    • 0030061296 scopus 로고    scopus 로고
    • Population-based genetic screening for IDDM susceptibility as a source of HLA-genotyped control subjects
    • 18 Ilonen, J, Reijonen, H, Knip, M, Simell, O, Population-based genetic screening for IDDM susceptibility as a source of HLA-genotyped control subjects. Diabetologia, 39, 1996, 123.
    • (1996) Diabetologia , vol.39 , pp. 123
    • Ilonen, J.1    Reijonen, H.2    Knip, M.3    Simell, O.4
  • 19
    • 84962430639 scopus 로고    scopus 로고
    • Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association
    • 19 Insel, RA, Dunne, JL, Atkinson, MA, et al. Staging presymptomatic type 1 diabetes: a scientific statement of JDRF, the Endocrine Society, and the American Diabetes Association. Diabetes Care 38 (2015), 1964–1974.
    • (2015) Diabetes Care , vol.38 , pp. 1964-1974
    • Insel, R.A.1    Dunne, J.L.2    Atkinson, M.A.3
  • 20
    • 0036078122 scopus 로고    scopus 로고
    • Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes
    • 20 Knip, M, Kukko, M, Kulmala, P, et al. Humoral beta-cell autoimmunity in relation to HLA-defined disease susceptibility in preclinical and clinical type 1 diabetes. Am J Med Genet 115 (2002), 48–54.
    • (2002) Am J Med Genet , vol.115 , pp. 48-54
    • Knip, M.1    Kukko, M.2    Kulmala, P.3
  • 21
    • 0025896881 scopus 로고
    • Specific association of HLA-DR4 with increased prevalence and level of insulin autoantibodies in first-degree relatives of patients with type I diabetes
    • 21 Ziegler, R, Alper, CA, Awdeh, ZL, et al. Specific association of HLA-DR4 with increased prevalence and level of insulin autoantibodies in first-degree relatives of patients with type I diabetes. Diabetes 40 (1991), 709–714.
    • (1991) Diabetes , vol.40 , pp. 709-714
    • Ziegler, R.1    Alper, C.A.2    Awdeh, Z.L.3
  • 22
    • 84962440475 scopus 로고    scopus 로고
    • Next generation sequencing reveals that HLA-DRB3, -DRB4 and -DRB5 may be associated with islet autoantibodies and risk for childhood type 1 diabetes
    • 22 Zhao, LP, Alshiekh, S, Carlsson, A, et al. Next generation sequencing reveals that HLA-DRB3, -DRB4 and -DRB5 may be associated with islet autoantibodies and risk for childhood type 1 diabetes. Diabetes 65 (2016), 710–718.
    • (2016) Diabetes , vol.65 , pp. 710-718
    • Zhao, L.P.1    Alshiekh, S.2    Carlsson, A.3
  • 23
    • 84879551555 scopus 로고    scopus 로고
    • Next generation sequencing reveals the association of DRB3*02:02 with type 1 diabetes
    • 23 Erlich, HA, Valdes, AM, McDevitt, SL, et al. Next generation sequencing reveals the association of DRB3*02:02 with type 1 diabetes. Diabetes 62 (2013), 2618–2622.
    • (2013) Diabetes , vol.62 , pp. 2618-2622
    • Erlich, H.A.1    Valdes, A.M.2    McDevitt, S.L.3
  • 24
    • 84981556018 scopus 로고    scopus 로고
    • Role of type 1 diabetes-associated SNPs on risk of autoantibody positivity in the TEDDY study
    • 24 Torn, C, Hadley, D, Lee, HS, et al. Role of type 1 diabetes-associated SNPs on risk of autoantibody positivity in the TEDDY study. Diabetes 64 (2015), 1818–1829.
    • (2015) Diabetes , vol.64 , pp. 1818-1829
    • Torn, C.1    Hadley, D.2    Lee, H.S.3
  • 25
    • 80053036722 scopus 로고    scopus 로고
    • The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants
    • 25 Hagopian, WA, Erlich, H, Lernmark, A, et al. The Environmental Determinants of Diabetes in the Young (TEDDY): genetic criteria and international diabetes risk screening of 421 000 infants. Pediatr Diabetes 12 (2011), 733–743.
    • (2011) Pediatr Diabetes , vol.12 , pp. 733-743
    • Hagopian, W.A.1    Erlich, H.2    Lernmark, A.3
  • 26
    • 0033016840 scopus 로고    scopus 로고
    • Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study
    • 26 Ziegler, AG, Hummel, M, Schenker, M, Bonifacio, E, Autoantibody appearance and risk for development of childhood diabetes in offspring of parents with type 1 diabetes: the 2-year analysis of the German BABYDIAB Study. Diabetes 48 (1999), 460–468.
    • (1999) Diabetes , vol.48 , pp. 460-468
    • Ziegler, A.G.1    Hummel, M.2    Schenker, M.3    Bonifacio, E.4
  • 27
    • 0033401173 scopus 로고    scopus 로고
    • Population-based genetic screening for the estimation of Type 1 diabetes mellitus risk in Finland: selective genotyping of markers in the HLA-DQB1, HLA-DQA1 and HLA-DRB1 loci
    • 27 Nejentsev, S, Sjoroos, M, Soukka, T, et al. Population-based genetic screening for the estimation of Type 1 diabetes mellitus risk in Finland: selective genotyping of markers in the HLA-DQB1, HLA-DQA1 and HLA-DRB1 loci. Diabet Med 16 (1999), 985–992.
    • (1999) Diabet Med , vol.16 , pp. 985-992
    • Nejentsev, S.1    Sjoroos, M.2    Soukka, T.3
  • 28
    • 84928406046 scopus 로고    scopus 로고
    • Effects of high-dose oral insulin on immune responses in children at high risk for type 1 diabetes: the Pre-POINT randomized clinical trial
    • 28 Bonifacio, E, Ziegler, AG, Klingensmith, G, et al. Effects of high-dose oral insulin on immune responses in children at high risk for type 1 diabetes: the Pre-POINT randomized clinical trial. JAMA 313 (2015), 1541–1549.
    • (2015) JAMA , vol.313 , pp. 1541-1549
    • Bonifacio, E.1    Ziegler, A.G.2    Klingensmith, G.3
  • 29
    • 67349199566 scopus 로고    scopus 로고
    • Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes
    • 29 Barrett, JC, Clayton, DG, Concannon, P, et al. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. Nat Genet 41 (2009), 703–707.
    • (2009) Nat Genet , vol.41 , pp. 703-707
    • Barrett, J.C.1    Clayton, D.G.2    Concannon, P.3
  • 30
    • 84930408328 scopus 로고    scopus 로고
    • Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers
    • 30 Onengut-Gumuscu, S, Chen, WM, Burren, O, et al. Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers. Nat Genet 47 (2015), 381–386.
    • (2015) Nat Genet , vol.47 , pp. 381-386
    • Onengut-Gumuscu, S.1    Chen, W.M.2    Burren, O.3
  • 31
    • 68249108329 scopus 로고    scopus 로고
    • Prediction and interaction in complex disease genetics: experience in type 1 diabetes
    • 31 Clayton, DG, Prediction and interaction in complex disease genetics: experience in type 1 diabetes. PLoS Genet, 5, 2009, e1000540.
    • (2009) PLoS Genet , vol.5 , pp. e1000540
    • Clayton, D.G.1
  • 32
    • 84888321284 scopus 로고    scopus 로고
    • Genetics of diabetes—are we missing the genes or the disease?
    • 32 Groop, L, Pociot, F, Genetics of diabetes—are we missing the genes or the disease?. Mol Cell Endocinol 382 (2014), 726–739.
    • (2014) Mol Cell Endocinol , vol.382 , pp. 726-739
    • Groop, L.1    Pociot, F.2
  • 33
    • 84865712382 scopus 로고    scopus 로고
    • Annotation of functional variation in personal genomes using RegulomeDB
    • 33 Boyle, AP, Hong, EL, Hariharan, M, et al. Annotation of functional variation in personal genomes using RegulomeDB. Genome Res 22 (2012), 1790–1797.
    • (2012) Genome Res , vol.22 , pp. 1790-1797
    • Boyle, A.P.1    Hong, E.L.2    Hariharan, M.3
  • 34
    • 84937502692 scopus 로고    scopus 로고
    • Effects of GWAS-associated genetic variants on lncRNAs within IBD and T1D candidate loci
    • 34 Mirza, AH, Kaur, S, Brorsson, CA, Pociot, F, Effects of GWAS-associated genetic variants on lncRNAs within IBD and T1D candidate loci. PLoS One, 9, 2014, e105723.
    • (2014) PLoS One , vol.9 , pp. e105723
    • Mirza, A.H.1    Kaur, S.2    Brorsson, C.A.3    Pociot, F.4
  • 35
    • 21844444831 scopus 로고    scopus 로고
    • New IL-12 family members: IL-23 and IL-27, cytokines with divergent functions
    • 35 Hunter, CA, New IL-12 family members: IL-23 and IL-27, cytokines with divergent functions. Nat Rev Genet 7 (2005), 521–531.
    • (2005) Nat Rev Genet , vol.7 , pp. 521-531
    • Hunter, C.A.1
  • 36
    • 84945444431 scopus 로고    scopus 로고
    • IL-27-induced modulation of autoimmunity and its therapeutic potential
    • 36 Meka, RR, Venkatesha, SH, Dudics, S, Acharya, B, Moudgil, KD, IL-27-induced modulation of autoimmunity and its therapeutic potential. Autoimmun Rev 14 (2015), 1131–1141.
    • (2015) Autoimmun Rev , vol.14 , pp. 1131-1141
    • Meka, R.R.1    Venkatesha, S.H.2    Dudics, S.3    Acharya, B.4    Moudgil, K.D.5
  • 37
    • 80055003184 scopus 로고    scopus 로고
    • IL-27 inhibits hyperglycaemia and pancreatic islet inflammation induced by streptozotocin in mice
    • 37 Fujimoto, H, Hirase, T, Miyazaki, Y, et al. IL-27 inhibits hyperglycaemia and pancreatic islet inflammation induced by streptozotocin in mice. Am J Pathol 179 (2011), 2327–2336.
    • (2011) Am J Pathol , vol.179 , pp. 2327-2336
    • Fujimoto, H.1    Hirase, T.2    Miyazaki, Y.3
  • 38
    • 57349116921 scopus 로고    scopus 로고
    • The pathogenic role of interleukin-27 in autoimmune diabetes. Cellular and molecular life sciences
    • 38 Wang, R, Han, G, Wang, J, et al. The pathogenic role of interleukin-27 in autoimmune diabetes. Cellular and molecular life sciences. Cell Mol Life Sci 65 (2008), 3851–3860.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 3851-3860
    • Wang, R.1    Han, G.2    Wang, J.3
  • 39
    • 84925582722 scopus 로고    scopus 로고
    • BH3-only proteins: a 20-year stock-take
    • 39 Doerflinger, M, Glab, JA, Puthalakath, H, BH3-only proteins: a 20-year stock-take. FEBS J 282 (2015), 1006–1016.
    • (2015) FEBS J , vol.282 , pp. 1006-1016
    • Doerflinger, M.1    Glab, J.A.2    Puthalakath, H.3
  • 40
    • 79959618962 scopus 로고    scopus 로고
    • Bcl-2 proteins in diabetes: mitochondrial pathways of beta-cell death and dysfunction
    • 40 Gurzov, EN, Eizirik, DL, Bcl-2 proteins in diabetes: mitochondrial pathways of beta-cell death and dysfunction. Trends Cell Biol 21 (2011), 424–431.
    • (2011) Trends Cell Biol , vol.21 , pp. 424-431
    • Gurzov, E.N.1    Eizirik, D.L.2
  • 41
    • 38949140180 scopus 로고    scopus 로고
    • Dual role of proapoptotic BAD in insulin secretion and beta cell survival
    • 41 Danial, NN, Walensky, LD, Zhang, CY, et al. Dual role of proapoptotic BAD in insulin secretion and beta cell survival. Nat Med 14 (2008), 144–153.
    • (2008) Nat Med , vol.14 , pp. 144-153
    • Danial, N.N.1    Walensky, L.D.2    Zhang, C.Y.3
  • 42
    • 69949123393 scopus 로고    scopus 로고
    • Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells
    • 42 Wei, P, Shi, M, Barnum, S, Cho, H, Carlson, T, Fraser, JD, Effects of glucokinase activators GKA50 and LY2121260 on proliferation and apoptosis in pancreatic INS-1 beta cells. Diabetologia 52 (2009), 2142–2150.
    • (2009) Diabetologia , vol.52 , pp. 2142-2150
    • Wei, P.1    Shi, M.2    Barnum, S.3    Cho, H.4    Carlson, T.5    Fraser, J.D.6
  • 44
    • 84904353328 scopus 로고    scopus 로고
    • CTSH regulates beta-cell function and disease progression in newly diagnosed type 1 diabetes patients
    • 44 Fløyel, T, Brorsson, C, Nielsen, LB, et al. CTSH regulates beta-cell function and disease progression in newly diagnosed type 1 diabetes patients. Proc Natl Acad Sci USA 111 (2014), 10305–10310.
    • (2014) Proc Natl Acad Sci USA , vol.111 , pp. 10305-10310
    • Fløyel, T.1    Brorsson, C.2    Nielsen, L.B.3
  • 45
    • 84949729662 scopus 로고    scopus 로고
    • The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus
    • 45 Kaur, S, Mirza, AH, Brorsson, CA, et al. The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus. Mol Cell Endocrinol 419 (2016), 83–91.
    • (2016) Mol Cell Endocrinol , vol.419 , pp. 83-91
    • Kaur, S.1    Mirza, A.H.2    Brorsson, C.A.3
  • 46
    • 84903196141 scopus 로고    scopus 로고
    • The diabetes susceptibility gene Clec16a regulates mitophagy
    • 46 Soleimanpour, SA, Gupta, A, Bakay, M, et al. The diabetes susceptibility gene Clec16a regulates mitophagy. Cell 157 (2014), 1577–1590.
    • (2014) Cell , vol.157 , pp. 1577-1590
    • Soleimanpour, S.A.1    Gupta, A.2    Bakay, M.3
  • 48
    • 84855363144 scopus 로고    scopus 로고
    • Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene
    • 48 Davison, LJ, Wallace, C, Cooper, JD, et al. Long-range DNA looping and gene expression analyses identify DEXI as an autoimmune disease candidate gene. Hum Mol Genet 21 (2012), 322–333.
    • (2012) Hum Mol Genet , vol.21 , pp. 322-333
    • Davison, L.J.1    Wallace, C.2    Cooper, J.D.3
  • 49
    • 77955611528 scopus 로고    scopus 로고
    • Genetically dependent ERBB3 expression modulates antigen presenting cell function and type 1 diabetes risk
    • 49 Wang, H, Jin, Y, Reddy, MV, et al. Genetically dependent ERBB3 expression modulates antigen presenting cell function and type 1 diabetes risk. PLoS One, 5, 2010, e11789.
    • (2010) PLoS One , vol.5 , pp. e11789
    • Wang, H.1    Jin, Y.2    Reddy, M.V.3
  • 50
    • 84965186550 scopus 로고    scopus 로고
    • Shared genetic basis for type 1 diabetes, islet autoantibodies, and autoantibodies associated with other immune-mediated diseases in families with type 1 diabetes
    • 50 Brorsson, CA, Pociot, F, Type 1 Diabetes Genetics Consortium. Shared genetic basis for type 1 diabetes, islet autoantibodies, and autoantibodies associated with other immune-mediated diseases in families with type 1 diabetes. Diabetes Care 38:suppl 3 (2015), S8–13.
    • (2015) Diabetes Care , vol.38 , Issue.suppl 3 , pp. S8-13
    • Brorsson, C.A.1    Pociot, F.2
  • 51
    • 84981556018 scopus 로고    scopus 로고
    • Role of type 1 diabetes-associated SNPs on risk of autoantibody positivity in the TEDDY study
    • 51 Torn, C, Hadley, D, Lee, HS, et al. Role of type 1 diabetes-associated SNPs on risk of autoantibody positivity in the TEDDY study. Diabetes 64 (2015), 1818–1829.
    • (2015) Diabetes , vol.64 , pp. 1818-1829
    • Torn, C.1    Hadley, D.2    Lee, H.S.3
  • 52
    • 84920496635 scopus 로고    scopus 로고
    • Systems biology of asthma and allergic diseases: a multiscale approach
    • 52 Bunyavanich, S, Schadt, EE, Systems biology of asthma and allergic diseases: a multiscale approach. J Allergy Clin Immunol 135 (2015), 31–42.
    • (2015) J Allergy Clin Immunol , vol.135 , pp. 31-42
    • Bunyavanich, S.1    Schadt, E.E.2
  • 53
    • 78650070483 scopus 로고    scopus 로고
    • Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY)
    • 53 Stene, LC, Oikarinen, S, Hyoty, H, et al. Enterovirus infection and progression from islet autoimmunity to type 1 diabetes: the Diabetes and Autoimmunity Study in the Young (DAISY). Diabetes 59 (2010), 3174–3180.
    • (2010) Diabetes , vol.59 , pp. 3174-3180
    • Stene, L.C.1    Oikarinen, S.2    Hyoty, H.3
  • 54
    • 78449281681 scopus 로고    scopus 로고
    • Influence of intensive versus conventional glucose control on microvascular and macrovascular complications in type 1 and 2 diabetes mellitus
    • 54 Mattila, TK, de Boer, A, Influence of intensive versus conventional glucose control on microvascular and macrovascular complications in type 1 and 2 diabetes mellitus. Drugs 70 (2010), 2229–2245.
    • (2010) Drugs , vol.70 , pp. 2229-2245
    • Mattila, T.K.1    de Boer, A.2
  • 56
    • 84882449068 scopus 로고    scopus 로고
    • Genetic insights into common pathways and complex relationships among immune-mediated diseases
    • 56 Parkes, M, Cortes, A, van Heel, DA, Brown, MA, Genetic insights into common pathways and complex relationships among immune-mediated diseases. Nat Rev Genet 14 (2013), 661–673.
    • (2013) Nat Rev Genet , vol.14 , pp. 661-673
    • Parkes, M.1    Cortes, A.2    van Heel, D.A.3    Brown, M.A.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.