Microparticles harboring Sonic Hedgehog promote angiogenesis through the upregulation of adhesion proteins and proangiogenic factors

Carcinogenesis

Volumn 30, Issue 4, 2009, Pages 580-588

  Soleti, Raffaella ^a   Benameur, Tarek ^a   Porro, Chiara ^a   Panaro, Maria Antonietta ^b   Andriantsitohaina, Ramaroson ^a   Martínez, Maria Carmen ^a  

^a UNIVERSITÉ D'ANGERS   (France)

^b UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA5 INTEGRIN; ANGIOGENIN; ANGIOTENSIN I; ANGIOTENSIN II; BETA3 INTEGRIN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CXCR2; CYCLOPAMINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EPHRIN B2; FIBROBLAST GROWTH FACTOR 1; FIBROBLAST GROWTH FACTOR 10; FIBROBLAST GROWTH FACTOR 2; FIBROBLAST GROWTH FACTOR 3; FIBROBLAST GROWTH FACTOR 5; FIBROBLAST GROWTH FACTOR 8; FIBROBLAST GROWTH FACTOR RECEPTOR 1; FIBROBLAST GROWTH FACTOR RECEPTOR 2; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 1BETA; INTERLEUKIN 6; KERATINOCYTE GROWTH FACTOR; MESSENGER RNA; RHO KINASE; SMALL INTERFERING RNA; SONIC HEDGEHOG PROTEIN; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1;

ANGIOGENESIS; ARTICLE; CARCINOGENESIS; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; GENETIC ANALYSIS; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE MICROPARTICLE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TUMOR GROWTH; UPREGULATION;

ANGIOGENESIS INDUCING AGENTS; CELL ADHESION; CELL ADHESION MOLECULES; CELL MOVEMENT; CELL PROLIFERATION; CELL-DERIVED MICROPARTICLES; CELLS, CULTURED; ENDOTHELIUM, VASCULAR; HEDGEHOG PROTEINS; HUMANS; NEOVASCULARIZATION, PATHOLOGIC; RHOA GTP-BINDING PROTEIN; RNA, MESSENGER; RNA, SMALL INTERFERING; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VERATRUM ALKALOIDS;

EID: 64349092619     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgp030     Document Type: Article

References (51)

1. Bailey,J.M. et al. (2007) Cancer metastasis facilitated by developmental pathways: Sonic hedgehog, Notch, and bone morphogenic proteins. J. Cell. Biochem., 102, 829-839.
2. Olsen,C.L. et al. (2004) Hedgehog-interacting protein is highly expressed in endothelial cells but down-regulated during angiogenesis and in several human tumors. BMC Cancer, 4, 43.
3. Tenzen,T. et al. (2006) The cell surface membrane proteins Cdo and Boc are components and targets of the Hedgehog signaling pathway and feedback network in mice. Dev. Cell, 10, 647-656.
4. Kanda,S. et al. (2003) Sonic hedgehog induces capillary morphogenesis by endothelial cells through phosphoinositide 3-kinase. J. Biol. Chem., 278, 8244-8249.
5. Pola,R. et al. (2001) The morphogen Sonic hedgehog is an indirect angiogenic agent upregulating two families of angiogenic growth factors. Nat. Med., 7, 706-711.
6. Riobó,N.A. et al. (2006) Phosphoinositide 3-kinase and Akt are essential for Sonic Hedgehog signaling. Proc. Natl Acad. Sci. USA, 103, 4505-4510.
7. Fu,J.R. et al. (2006) Sonic hedgehog protein promotes bone marrow-derived endothelial progenitor cell proliferation, migration and VEGF production via PI 3-kinase/Akt signaling pathways. Acta Pharmacol. Sin., 27, 685-693.
8. Kusano,K.F. et al. (2005) Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling. Nat. Med., 11, 1197-1204.
9. Asai,J. et al. (2006) Topical sonic hedgehog gene therapy accelerates wound healing in diabetes by enhancing endothelial progenitor cell-mediated microvascular remodeling. Circulation, 113, 2413-2424.
10. Taipale,J. et al. (2001) The Hedgehog and Wnt signalling pathways in cancer. Nature, 411, 349-354.
11. Pasca di Magliano,M. et al. (2003) Hedgehog signalling in cancer formation and maintenance. Nat. Rev. Cancer, 3, 903-911.
12. Ruiz i Altaba,A. et al. (2002) Gli and hedgehog in cancer: tumours, embryos and stem cells. Nat. Rev. Cancer, 2, 361-372.
13. Xie,J. et al. (2001) A role of PDGFRa in basal cell carcinoma proliferation. Proc. Natl Acad. Sci. USA, 98, 9255-9259.
14. Zedan,W. et al. (2001) Expression of the Sonic Hedgehog receptor "PATCHED" in basal cell carcinomas and odontogenic keratocysts. J. Pathol., 194, 473-477.
15. Zwicker,J.I. et al. (2007) Cancer-associated thrombosis. Crit. Rev. Oncol. Hematol., 62, 126-136.
16. Kanazawa,S. et al. (2003) Monocyte-derived microparticles may be a sign of vascular complication in patients with lung cancer. Lung Cancer, 39, 145-149.
17. Kim,H.K. et al. (2003) Elevated levels of circulating platelet microparticles, VEGF, IL-6 and RANTES in patients with gastric cancer: possible role of a metastasis predictor. Eur. J. Cancer, 239 184-191.
18. Yu,J.L. et al. (2004) Shedding of tissue factor (TF)-containing microparticles rather than alternatively spliced TF is the main source of TF activity released from human cancer cells. J. Thromb. Haemost. 2, 2065-2067.
19. Angelucci,A. et al. (2000) Vesicle-associated urokinase plasminogen activator promotes invasion in prostate cancer cell lines. Clin. Exp. Metastasis, 18, 163-170.
20. Millimaggi,D. et al. (2007) Tumor vesicle-associated CD147 modulates the angiogenic capability of endothelial cells. Neoplasia 9, 349-357.
21. Janowska-Wieczorek,A. et al. (2006) Enhancing effect of platelet-derived microvesicles on the invasive potential of breast cancer cells. Transfusion, 46, 1199-1209.
22. Janowska-Wieczorek,A. et al. (2005) Microvesicles derived from activated platelets induce metastasis and angiogenesis in lung cancer. Int. J. Cancer, 113, 752-760.
23. Kalinkovich,A. et al. (2006) Functional CXCR4-expressing microparticles and SDF-1 correlate with circulating acute myelogenous leukemia cells. Cancer Res., 66, 11013-11020.
24. Martínez,M.C. et al. (2006) Transfer of differentiation signal by membrane microvesicles harbouring hedgehog morphogens. Blood, 108, 3012-3020.
25. Agouni,A. et al. (2007) Sonic hedgehog carried by microparticles corrects endothelial injury through nitric oxide release. FASEB J. 21, 2735-2741.
26. Favot,L. et al. (2003) Involvement of cyclin-dependent pathway in the inhibitory effect of delphinidin on angiogenesis. Cardiovasc. Res., 59, 479-487.
27. Gross,I. et al. (2008) The intestine-specific homobox gene Cdx2 decreases mobility and antagonizes dissemination of colon cancer cells. Oncogene, 27, 107-115.
28. Vandesompele,J. et al. (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol., 3, RESEARCH0034.
29. Qin,G. et al. (2006) Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J. Exp. Med., 203, 153-163.
30. Suzuki,K. et al. (1999) A novel glycosylphosphatidyl inositol-anchored protein on human leukocytes: A possible role for regulation of neutrophil adherence and migration. J. Immunol., 162, 4277-4284.
31. Griffioen,A.W. et al. (2000) Angiogenesis: Potentials for pharmacologic intervention in the treatment of cancer, cardiovascular diseases, and chronic inflammation. Pharmacol. Rev., 52, 237-268.
32. Ziche,M. et al. (1997) Nitric oxide lies downstream from vascular endothelial growth factor-induced but not basic fibroblast growth factor-induced angiogenesis. J. Clin. Invest., 99, 2625-2634.
33. Kim,I. et al. (2001) Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. J. Biol. Chem., 276, 7614-7620.
34. Krum,J.M. et al. (1998) VEGF mRNA and its receptor flt-1 are expressed in reactive astroycytes following neural grafting and tumor cell implantation in the adult CNS. Exp. Neurol., 154, 57-65.
35. Raffetto,J.D. et al. (2008) Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. Biochem. Pharmacol., 75, 346-359.
36. Solà-Villà,D. et al. (2006) IL-1beta induces VEGF, independently of PGE2 induction, mainly through the PI3-K/mTOR pathway in renal mesangial cells. Kidney Int., 70, 1935-1941.
37. Morishita,R. et al. (2004) Therapeutic angiogenesis using hepatocyte growth factor (HGF). Curr. Gene Ther., 4, 199-206.
38. Gordon,K.J. et al. (2008) Role of transforming growth factor-β superfamily signaling pathways in human disease. Biochim. Biophys. Acta, 1782, 197-228.
39. Dennler,S. et al. (2007) Induction of sonic hedgehog mediators by transforming growth-beta: Smad3-dependent activation of Gli2 and Gli1 expression in vitro and in vivo. Cancer Res., 67, 6981-6986.
40. Lee,S.W. et al. (2007) Sonic hedgehog inversely regulates the expression of angiopoietin-1 and angiopoietin-2 in fibroblasts. Int. J. Mol. Med., 19, 445-451.
41. van Tuyl,M. et al. (2007) Angiogenic factors stimulate tubular branching morphogenesis of sonic hedgehog-deficient lungs. Dev. Biol. 303, 514-526.
42. Kasai,K. et al. (2004) The G12 family of heterotrimeric G proteins and Rho GTPase mediate Sonic hedgehog signaling. Gene Cells, 9 49-58.
43. Nishimaki,H. et al. (2004) A role of activated Sonic hedgehog signaling for the cellular proliferation of oral squamous cell carcinoma cell line. Biochem. Biophys. Res. Commun., 314, 313-320.
44. Le Jan,S. et al. (2003) Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma. Am. J. Pathol., 162, 1521-1528.
45. Cazes,A. et al. (2006) Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton. Circ. Res., 99, 1207-1215.
46. Miguet,L. et al. (2006) Proteomic analysis of malignant lymphocyte membrane microparticles using double ionization coverage optimization. Proteomics, 6, 153-171.
47. Smalley,D.M. et al. (2007) Proteomic discovery of 21 proteins expressed in human plasma-derived but not platelet-derived microparticles. Thromb. Haemost., 97, 67-80.
48. Becher,O.J. et al. (2008) Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas. Cancer Res., 268, 2241-2249.
49. Marsh,D. et al. (2008) Alpha vbeta 6 integrin promotes the invasion of morphoiec basal cell carcinoma through stromal modulation. Cancer Res., 68, 3295-3303.
50. Mimeault,M. et al. (2007) Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetoxel on metastatic prostate cancer cells. Mol. Cancer Ther., 6, 967-978.
51. Nakashima,H. et al. (2006) Nuclear factor-kappaB contributes to hedgehog signaling pathway activation through sonic hedgehog induction in pancreatic cancer. Cancer Res., 66, 7041-7049.