Carbon dioxide-mediated generation of hybrid nanoparticles for improved bioavailability of protein kinase inhibitors

Pharmaceutical Research

Volumn 31, Issue 3, 2014, Pages 694-705

  Jesson, Gérald ^a   Brisander, Magnus ^a   Andersson, Per ^a   Demirbüker, Mustafa ^a   Derand, Helene ^a   Lennernäs, Hans ^b   Malmsten, Martin ^b  

^a XSpray Microparticles   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

bioavailability; carbon dioxide; hybrid; nanoparticle; protein kinase inhibitor

Indexed keywords

CARBON DIOXIDE; EXCIPIENT; NANOCARRIER; NILOTINIB; SURFACTANT;

ANIMAL EXPERIMENT; ARTICLE; BEAGLE; DRUG BIOAVAILABILITY; DRUG RELEASE; DRUG SOLUBILITY; GASTROINTESTINAL ABSORPTION; HYBRID; INTESTINE FLUID; LASER DIFFRACTION; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STOMACH JUICE; SUPERCRITICAL FLUID EXTRACTION; ZETA POTENTIAL;

ADMINISTRATION, ORAL; ANIMALS; CARBON DIOXIDE; DOGS; DRUG CARRIERS; INTESTINAL ABSORPTION; MALE; NANOPARTICLES; POLYMERS; PROTEIN KINASE INHIBITORS; SOLUBILITY; SURFACE-ACTIVE AGENTS;

EID: 84895468887     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-013-1191-4     Document Type: Article

References (36)

1. Di Gion P, Kanefendt F, Lindauer A, Doroshyenko O, Fuhr U, Wolf J, et al. Clinical pharmacokinetics of tyrosin kinase inhibitors: focus on pyrimidines, pyridines, and pyrroles. Clin Pharmacokin. 2011;50:551-603.
2. Lowery A, Han ZZ. Assessment of tumor response to tyrosine kinase inhibitors. Front Biosci Landmark. 2011;16:1996-2007.
3. Lindfors L, Forssen S, Westergren J, Olsson U. Nucleation and crystal growth in supersaturated solutions of a model drug. J Colloid Interface Sci. 2008;325:404-13.
4. Douroumis D, Fahr A. Stable carbamazepine colloidal systems using the cosolvent technique. Eur J Pharm Sci. 2007;30:367-74.
5. Puri V, Dantuluri AK, Bansal AK. Investigation of atypical dissolution behaviour of an encapsulated solid dispersion. J Pharm Sci. 2011;100:2460-8.
6. Pasquali I, Bettini R. Are pharmaceutics going supercritical? Int J Pharm. 2008;364:176-87.
7. Moribe K, Tozuka Y, Yamamoto K. Supercritical carbon dioxide processing of active pharmaceutical ingredients for polymorphic control and for complex formation. Adv Drug Delivery Rev. 2008;60:328-38.
8. Reverchon E, Adami R, Cardea S, Della Porta G. Supercritical fluids processing of polymers for pharmaceutical and medical applications. J Supercrit Fluids. 2009;47:484-92.
9. Byrappa K, Ohara S, Adschiri T. Nanoparticle synthesis using supercritical fluid technology - towards biomedical applications. Adv Drug Delivery Rev. 2008;60:299-327.
10. Martin A, Cocero MJ. Micronization processes with supercritical fluids: fundamentals and mechanisms. Adv Drug Delivery Rev. 2008;60:339-50.
11. Pasquali I, Bettini R, Giordano F. Supercritical fluid technologies: an innovative approach for manipulating the solid state in pharmaceuticals. Adv Drug Delivery Rev. 2008;60:399-410.
12. Okamoto H, Danjo K. Application of supercritical fluid to preparation of powders of high-molecular weight drugs for inhalation. Adv Drug Delivery Rev. 2008;60:433-46.
13. Tom JW, Debenedetti PG. Particle formation with supercritical fluids - a review. J Aerosol Sci. 1991;22:555-84.
14. Cocero MJ, Martin A, Mattea F, Varona S. Encapsulation and co-precipitation processes with supercritical fluids: fundamentals and applications. J Supercrit Fluids. 2009;47:546-55.
15. 2 using a lattice fluid hydrogen-bonding model. Ind Eng Chem Res. 1997;36:2821-33.
16. O'Neill ML, Cao Q, Fang M, Johnston KP, Wilkinson SP, Smith CD, et al. Solubility of homopolymers and copolymers in carbon dioxide. Ind Eng Chem Res. 1998;37:3067-79.
17. Duarte ARC, Costa MS, Simplicio AL, Cardoso MM, Duarte CMM. Preparation of controlled release microspheres using supercritical fluid technology for delivery of anti-inflammatory drugs. Int J Pharm. 2006;308:168-74.
18. Breitenbach A, Mohr D, Kissel T. Biodegradable semi-crystalline comb polyesters influence the microsphere production by means of a supercritical extraction technique (ASES). J Control Release. 2000;63:53-60.
19. Bodmeier R, Wang H, Dixon DJ, Mawson S, Johnston KP. Polymeric microspheres prepared by spraying into compressed carbon dioxide. Pharm Res. 1995;12:1211-7.
20. Tian F, Sandler N, Aaltonen J, Lang C, Saville DJ, Gordon KC, et al. Influence of polymorphic form, morphology, and excipient interactions on the dissolution of carbamazepine compacts. J Pharm Sci. 2007;96:584-94.
21. 2-based microencapsulation. Langmuir. 2005;21:379-85.
22. Jantratid E, Dressman J. Biorelevant dissolution media simulating the proximal human gastrointestinal tract: an update. Dissolut Technol. 2009;8:21-5.
23. Couchman PR. Glass-transition temperatures of compatible polymer mixtures. Phys Lett. 1979;70A:155-7.
24. Kim D, Srivastava S, Narayanan S, Archer LA. Polymer nanocomposites: polymer and particle dynamics. Soft Matter. 2012;8:10813-8.
25. Malmsten M. Soft drug delivery systems. Soft Matter. 2006;2:760-9.
26. Malmsten M. Phase transformations in self-assembly systems for drug delivery applications. J Disp Sci Technol. 2007;28:63-72.
27. Lim RTY, Ng WK, Tan RBH. Amorphization of pharmaceutical compounds by co-precipitation using supercritical anti-solvent (SAS) process (Part I). J Supercrit Fluids. 2010;53:179-84.
28. Matsuda Y, Kawaguchi S, Kobayashi H, Nishijo H. Physicochemical characterization of spray-dried phenylbutasone polymorphs. J Pharm Sci. 1984;73:173-8.
29. 2 anti-solvent precipitation. J Supercrit Fluids. 2009;48:176-82.
30. Evans DE, Wennerström H. The colloidal domain - where physics, chemistry, biology, and technology meet. New York: Wiley-VHC; 1999.
31. Van Eerdenbrugh B, Vermant J, Martens JA, Froyen L, Van Humbeeck J, Augustijns P, et al. A screening study of surface stabilization during the production of drug nanocrystals. J Pharm Sci. 2009;98:2091-103.
32. Raseneck N, Hartenhauer H, Müller BW. Microcrystals for dissolution rate enhancement of poorly water-soluble drugs. Int J Pharm. 2003;254:137-45.
33. Malmsten M, Claesson PM. Temperature-dependent adsorption and surface forces in aqueous ethyl(hydroxyethyl)cellulose solutions. Langmuir. 1991;7:988-94.
34. Malmsten M, Tiberg F. Adsorption of ethyl(hydroxyethyl)cellulose at polystyrene. Langmuir. 1993;9:1098-103.
35. Van Eerdenbrugh B, Froyen L, Van Humbeeck J, Martens JA, Augustijns P, Van den Mooter G. Drying of crystalline drug nanosuspensions - the importance of surface hydrophobicity on dissolution behavior upon redispersion. Eur J Pharm Sci. 2008;35:127-35.
36. Lee J, Choi JY, Park CH. Characteristics of polymers enabling nano-comminution of water-insoluble drugs. Int J Pharm. 2008;355:328-36.