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Volumn 521, Issue 1-2, 2017, Pages 167-175

Exosomes as novel bio-carriers for gene and drug delivery

Author keywords

Cell free therapies; Drug delivery system; Exosomes; Nucleic acids

Indexed keywords

NANOCARRIER; BIOLOGICAL PRODUCT; NANOPARTICLE;

EID: 85013841167     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2017.02.038     Document Type: Review
Times cited : (275)

References (98)
  • 1
    • 79551625424 scopus 로고    scopus 로고
    • Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages
    • Akao, Y., Iio, A., Itoh, T., Noguchi, S., Itoh, Y., Ohtsuki, Y., Naoe, T., Microvesicle-mediated RNA molecule delivery system using monocytes/macrophages. Mol. Ther. 19 (2011), 395–399.
    • (2011) Mol. Ther. , vol.19 , pp. 395-399
    • Akao, Y.1    Iio, A.2    Itoh, T.3    Noguchi, S.4    Itoh, Y.5    Ohtsuki, Y.6    Naoe, T.7
  • 2
    • 0345701525 scopus 로고    scopus 로고
    • Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59
    • Aled, C., Claire L, H., Jacquelyn, C., Mason, M.D., Paul, M.B., Antigen-presenting cell exosomes are protected from complement-mediated lysis by expression of CD55 and CD59. Eur. J. Immunol. 33 (2003), 522–531.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 522-531
    • Aled, C.1    Claire L, H.2    Jacquelyn, C.3    Mason, M.D.4    Paul, M.B.5
  • 3
    • 84891858192 scopus 로고    scopus 로고
    • Exosome encased spherical nucleic acid gold nanoparticle conjugates as potent microRNA regulation agents
    • Alhasan, A.H., Patel, P.C., Choi, C.H., Mirkin, C.A., Exosome encased spherical nucleic acid gold nanoparticle conjugates as potent microRNA regulation agents. Small 10 (2014), 186–192.
    • (2014) Small , vol.10 , pp. 186-192
    • Alhasan, A.H.1    Patel, P.C.2    Choi, C.H.3    Mirkin, C.A.4
  • 4
    • 79953858598 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes
    • Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., Wood, M.J., Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes. Nat. Biotechnol. 29 (2011), 341–345.
    • (2011) Nat. Biotechnol. , vol.29 , pp. 341-345
    • Alvarez-Erviti, L.1    Seow, Y.2    Yin, H.3    Betts, C.4    Lakhal, S.5    Wood, M.J.6
  • 5
  • 9
    • 81055157988 scopus 로고    scopus 로고
    • Exosome secretion: molecular mechanisms and roles in immune responses
    • Bobrie, A., Colombo, M., Raposo, G., Théry, C., Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 12 (2011), 1659–1668.
    • (2011) Traffic , vol.12 , pp. 1659-1668
    • Bobrie, A.1    Colombo, M.2    Raposo, G.3    Théry, C.4
  • 10
    • 84894373371 scopus 로고    scopus 로고
    • Exosomes: a new weapon to treat the central nervous system
    • Braccioli, L., van Velthoven, C., Heijnen, C.J., Exosomes: a new weapon to treat the central nervous system. Mol. Neurobiol. 49 (2014), 113–119.
    • (2014) Mol. Neurobiol. , vol.49 , pp. 113-119
    • Braccioli, L.1    van Velthoven, C.2    Heijnen, C.J.3
  • 15
    • 85024946724 scopus 로고    scopus 로고
    • The influence of rotor type and centrifugation time on the yield and purity of extracellular vesicles
    • Cvjetkovic, A., Lötvall, J., Lässer, C., The influence of rotor type and centrifugation time on the yield and purity of extracellular vesicles. J. Extracell Vesicles 3 (2014), 1–11.
    • (2014) J. Extracell Vesicles , vol.3 , pp. 1-11
    • Cvjetkovic, A.1    Lötvall, J.2    Lässer, C.3
  • 16
    • 51049090204 scopus 로고    scopus 로고
    • Nanoparticle therapeutics: an emerging treatment modality for cancer
    • Davis, M.E., Zhuo, C., Dong, M.S., Nanoparticle therapeutics: an emerging treatment modality for cancer. Nat. Rev. Drug Discov. 7 (2008), 771–782.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 771-782
    • Davis, M.E.1    Zhuo, C.2    Dong, M.S.3
  • 17
    • 0033767690 scopus 로고    scopus 로고
    • Exosome: from internal vesicle of the multivesicular body to intercellular signaling device
    • Denzer, K., Kleijmeer, M.J., Heijnen, H.F., Stoorvogel, W., Geuze, H.J., Exosome: from internal vesicle of the multivesicular body to intercellular signaling device. J. Cell Sci. 19:113 Pt (2000), 3365–3374.
    • (2000) J. Cell Sci. , vol.19 , Issue.113 Pt , pp. 3365-3374
    • Denzer, K.1    Kleijmeer, M.J.2    Heijnen, H.F.3    Stoorvogel, W.4    Geuze, H.J.5
  • 18
    • 84899968840 scopus 로고    scopus 로고
    • Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease
    • Dinkins, M.B., Dasgupta, S., Wang, G., Zhu, G., Bieberich, E., Exosome reduction in vivo is associated with lower amyloid plaque load in the 5XFAD mouse model of Alzheimer's disease. Neurobiol. Aging 35 (2014), 1792–1800.
    • (2014) Neurobiol. Aging , vol.35 , pp. 1792-1800
    • Dinkins, M.B.1    Dasgupta, S.2    Wang, G.3    Zhu, G.4    Bieberich, E.5
  • 20
    • 84874980515 scopus 로고    scopus 로고
    • Exosomes for targeted siRNA delivery across biological barriers
    • El, A.S., Lakhal, S., Mäger, I., Wood, M.J., Exosomes for targeted siRNA delivery across biological barriers. Adv. Drug Deliver. Rev. 65 (2013), 391–397.
    • (2013) Adv. Drug Deliver. Rev. , vol.65 , pp. 391-397
    • El, A.S.1    Lakhal, S.2    Mäger, I.3    Wood, M.J.4
  • 21
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S.M., Harborth, J., Lendeckel, W., Yalcin, A., Weber, K., Tuschl, T., Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411 (2015), 494–498.
    • (2015) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 22
  • 23
    • 40449092935 scopus 로고    scopus 로고
    • Nanogeometry: beyond drug delivery
    • Ferrari, M., Nanogeometry: beyond drug delivery. Nat. Nanotechnol. 3 (2008), 131–132.
    • (2008) Nat. Nanotechnol. , vol.3 , pp. 131-132
    • Ferrari, M.1
  • 25
    • 50149101511 scopus 로고    scopus 로고
    • Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates
    • Frank-Kamenetsky, M., Fitzgerald, K., Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. Proc. Natl. Acad. Sci. 105 (2008), 11915–11920.
    • (2008) Proc. Natl. Acad. Sci. , vol.105 , pp. 11915-11920
    • Frank-Kamenetsky, M.1    Fitzgerald, K.2
  • 27
    • 0037383050 scopus 로고    scopus 로고
    • Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research
    • Gehl, J., Electroporation: theory and methods, perspectives for drug delivery, gene therapy and research. Acta Physiol. Scand. 177 (2003), 437–447.
    • (2003) Acta Physiol. Scand. , vol.177 , pp. 437-447
    • Gehl, J.1
  • 28
    • 84929376742 scopus 로고    scopus 로고
    • Self-assembled polymer/inorganic hybrid nanovesicles for multiple drug delivery to overcome drug resistance in cancer chemotherapy
    • Gong, M.Q., Wu, J.L., Chen, B., Zhuo, R.X., Cheng, S.X., Self-assembled polymer/inorganic hybrid nanovesicles for multiple drug delivery to overcome drug resistance in cancer chemotherapy. Langmuir Acs J. Surf. Colloids 31 (2015), 5115–5122.
    • (2015) Langmuir Acs J. Surf. Colloids , vol.31 , pp. 5115-5122
    • Gong, M.Q.1    Wu, J.L.2    Chen, B.3    Zhuo, R.X.4    Cheng, S.X.5
  • 29
    • 84949934993 scopus 로고    scopus 로고
    • As we wait: coping with an imperfect nomenclature for extracellular vesicles
    • Gould, S.J., Raposo, G., As we wait: coping with an imperfect nomenclature for extracellular vesicles. J. Extracell Vesicles, 2, 2013.
    • (2013) J. Extracell Vesicles , vol.2
    • Gould, S.J.1    Raposo, G.2
  • 32
    • 84880169292 scopus 로고    scopus 로고
    • Intercellular communication by exosome-derived microRNAs in cancer
    • Hannafon, B.N., Ding, W.Q., Intercellular communication by exosome-derived microRNAs in cancer. Int. J. Mol. Sci. 14 (2013), 14240–14269.
    • (2013) Int. J. Mol. Sci. , vol.14 , pp. 14240-14269
    • Hannafon, B.N.1    Ding, W.Q.2
  • 33
    • 71549122588 scopus 로고    scopus 로고
    • Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells
    • Hong, B.S., Cho, J.H., Kim, H., Choi, E.J., Rho, S., Kim, J., Ji, H.K., Choi, D.S., Kim, Y.K., Hwang, D., Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells. Bmc Genomics 10 (2009), 4212–4224.
    • (2009) Bmc Genomics , vol.10 , pp. 4212-4224
    • Hong, B.S.1    Cho, J.H.2    Kim, H.3    Choi, E.J.4    Rho, S.5    Kim, J.6    Ji, H.K.7    Choi, D.S.8    Kim, Y.K.9    Hwang, D.10
  • 34
    • 84891542333 scopus 로고    scopus 로고
    • Maximizing exosome colloidal stability following electroporation
    • Hood, J.L., Scott, M.J., Wickline, S.A., Maximizing exosome colloidal stability following electroporation. Anal. Biochem. 448 (2014), 41–49.
    • (2014) Anal. Biochem. , vol.448 , pp. 41-49
    • Hood, J.L.1    Scott, M.J.2    Wickline, S.A.3
  • 35
    • 77957016314 scopus 로고    scopus 로고
    • Mesenchymal stem cells: a promising targeted-delivery vehicle in cancer gene therapy
    • Hu, Y.L., Fu, Y.H., Tabata, Y., Gao, J.Q., Mesenchymal stem cells: a promising targeted-delivery vehicle in cancer gene therapy. J. Controlled Release 147 (2010), 154–162.
    • (2010) J. Controlled Release , vol.147 , pp. 154-162
    • Hu, Y.L.1    Fu, Y.H.2    Tabata, Y.3    Gao, J.Q.4
  • 36
    • 84865960775 scopus 로고    scopus 로고
    • Mesenchymal stem cells as a novel carrier for targeted delivery of gene in cancer therapy based on nonviral transfection
    • Hu, Y.L., Huang, B., Zhang, T.Y., Miao, P.H., Tang, G.P., Tabata, Y., Gao, J.Q., Mesenchymal stem cells as a novel carrier for targeted delivery of gene in cancer therapy based on nonviral transfection. Mol. Pharm. 9 (2012), 2698–2709.
    • (2012) Mol. Pharm. , vol.9 , pp. 2698-2709
    • Hu, Y.L.1    Huang, B.2    Zhang, T.Y.3    Miao, P.H.4    Tang, G.P.5    Tabata, Y.6    Gao, J.Q.7
  • 37
    • 84893204121 scopus 로고    scopus 로고
    • Reversal of tumor growth by gene modification of mesenchymal stem cells using spermine-pullulan/DNA nanoparticles
    • Hu, Y.L., Miao, P.H., Huang, B., Zhang, T.Y., Hu, Z.J., Tabata, Y., Gao, J.Q., Reversal of tumor growth by gene modification of mesenchymal stem cells using spermine-pullulan/DNA nanoparticles. J. Biomed. Nanotechnol. 10 (2013), 299–308.
    • (2013) J. Biomed. Nanotechnol. , vol.10 , pp. 299-308
    • Hu, Y.L.1    Miao, P.H.2    Huang, B.3    Zhang, T.Y.4    Hu, Z.J.5    Tabata, Y.6    Gao, J.Q.7
  • 38
    • 84899825335 scopus 로고    scopus 로고
    • A comprehensive overview of exosomes as drug delivery vehicles – endogenous nanocarriers for targeted cancer therapy
    • Johnsen, K.B., Gudbergsson, J.M., Skov, M.N., Pilgaard, L., Moos, T., Duroux, M., A comprehensive overview of exosomes as drug delivery vehicles – endogenous nanocarriers for targeted cancer therapy. Biochim. Biophys. Acta 1846 (2014), 75–87.
    • (2014) Biochim. Biophys. Acta , vol.1846 , pp. 75-87
    • Johnsen, K.B.1    Gudbergsson, J.M.2    Skov, M.N.3    Pilgaard, L.4    Moos, T.5    Duroux, M.6
  • 39
    • 0023645106 scopus 로고
    • Vesicle formation during reticulocyte maturation: association of plasma membrane activities with released vesicles (exosomes)
    • Johnstone, R.M., Adam, M., Hammond, J.R., Orr, L., Turbide, C., Vesicle formation during reticulocyte maturation: association of plasma membrane activities with released vesicles (exosomes). J. Biol. Chem. 262 (1987), 9412–9420.
    • (1987) J. Biol. Chem. , vol.262 , pp. 9412-9420
    • Johnstone, R.M.1    Adam, M.2    Hammond, J.R.3    Orr, L.4    Turbide, C.5
  • 40
    • 84879603171 scopus 로고    scopus 로고
    • Exosomes in tumor microenvironment influence cancer progression and metastasis
    • Kahlert, C., Kalluri, R., Exosomes in tumor microenvironment influence cancer progression and metastasis. J. Mol. Med. 91 (2013), 431–437.
    • (2013) J. Mol. Med. , vol.91 , pp. 431-437
    • Kahlert, C.1    Kalluri, R.2
  • 41
    • 84902539393 scopus 로고    scopus 로고
    • Curcumin-primed exosomes mitigate endothelial cell dysfunction during hyperhomocysteinemia
    • Kalani, A., Kamat, P.K., Chaturvedi, P., Tyagi, S.C., Tyagi, N., Curcumin-primed exosomes mitigate endothelial cell dysfunction during hyperhomocysteinemia. Life Sci. 107 (2014), 1–7.
    • (2014) Life Sci. , vol.107 , pp. 1-7
    • Kalani, A.1    Kamat, P.K.2    Chaturvedi, P.3    Tyagi, S.C.4    Tyagi, N.5
  • 42
    • 84894294740 scopus 로고    scopus 로고
    • Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics
    • Kalani, A., Tyagi, A., Tyagi, N., Exosomes: mediators of neurodegeneration, neuroprotection and therapeutics. Mol. Neurobiol. 49 (2014), 590–600.
    • (2014) Mol. Neurobiol. , vol.49 , pp. 590-600
    • Kalani, A.1    Tyagi, A.2    Tyagi, N.3
  • 43
    • 84888042782 scopus 로고    scopus 로고
    • Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma
    • Kalra, H., Adda, C.G., Liem, M., Ang, C.S., Mechler, A., Simpson, R.J., Hulett, M.D., Mathivanan, S., Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma. Proteomics 13 (2013), 3354–3364.
    • (2013) Proteomics , vol.13 , pp. 3354-3364
    • Kalra, H.1    Adda, C.G.2    Liem, M.3    Ang, C.S.4    Mechler, A.5    Simpson, R.J.6    Hulett, M.D.7    Mathivanan, S.8
  • 44
    • 60049097220 scopus 로고    scopus 로고
    • Efficient siRNA delivery with non-viral polymeric vehicles
    • Kim, W.J., Kim, S.W., Efficient siRNA delivery with non-viral polymeric vehicles. Pharmaceut. Res. 26 (2009), 657–666.
    • (2009) Pharmaceut. Res. , vol.26 , pp. 657-666
    • Kim, W.J.1    Kim, S.W.2
  • 49
    • 84929353279 scopus 로고    scopus 로고
    • Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters
    • Lai, C.P., Kim, E.Y., Badr, C.E., Weissleder, R., Mempel, T.R., Tannous, B.A., Breakefield, X.O., Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters. Nat. Commun., 6, 2015, 7029.
    • (2015) Nat. Commun. , vol.6 , pp. 7029
    • Lai, C.P.1    Kim, E.Y.2    Badr, C.E.3    Weissleder, R.4    Mempel, T.R.5    Tannous, B.A.6    Breakefield, X.O.7
  • 50
    • 80052831943 scopus 로고    scopus 로고
    • Exosome nanotechnology: an emerging paradigm shift in drug delivery
    • Lakhal, S., Wood, M.J.A., Exosome nanotechnology: an emerging paradigm shift in drug delivery. Bioessays 33 (2011), 737–741.
    • (2011) Bioessays , vol.33 , pp. 737-741
    • Lakhal, S.1    Wood, M.J.A.2
  • 51
    • 84857011554 scopus 로고    scopus 로고
    • Isolation and characterization of RNA-containing exosomes
    • Lasser, C., Eldh, M., Lotvall, J., Isolation and characterization of RNA-containing exosomes. J. Vis Exp., 2012, e3037.
    • (2012) J. Vis Exp. , pp. e3037
    • Lasser, C.1    Eldh, M.2    Lotvall, J.3
  • 52
    • 67349233077 scopus 로고    scopus 로고
    • Targeted delivery of doxorubicin using stealth liposomes modified with transferrin
    • Li, X.M., Ding, L.Y., Xu, Y., Wang, Y., Ping, Q.N., Targeted delivery of doxorubicin using stealth liposomes modified with transferrin. Int. J. Pharm. 373 (2009), 116–123.
    • (2009) Int. J. Pharm. , vol.373 , pp. 116-123
    • Li, X.M.1    Ding, L.Y.2    Xu, Y.3    Wang, Y.4    Ping, Q.N.5
  • 53
    • 84887249207 scopus 로고    scopus 로고
    • Synthetic nucleic acids delivered by exosomes: a potential therapeutic for generelated metabolic brain diseases
    • Liu, R., Liu, J., Ji, X., Liu, Y., Synthetic nucleic acids delivered by exosomes: a potential therapeutic for generelated metabolic brain diseases. Metab. Brain Dis. 28 (2013), 551–562.
    • (2013) Metab. Brain Dis. , vol.28 , pp. 551-562
    • Liu, R.1    Liu, J.2    Ji, X.3    Liu, Y.4
  • 60
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor
    • Pan, B.T., Johnstone, R.M., Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: selective externalization of the receptor. Cell 33 (1983), 967–978.
    • (1983) Cell , vol.33 , pp. 967-978
    • Pan, B.T.1    Johnstone, R.M.2
  • 62
    • 77950889558 scopus 로고    scopus 로고
    • Functional delivery of viral miRNAs via exosomes
    • Pegtel, D.M., Kieff, E., Functional delivery of viral miRNAs via exosomes. Proc. Natl. Acad. Sci. U. S. A. 107 (2010), 6328–6333.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , pp. 6328-6333
    • Pegtel, D.M.1    Kieff, E.2
  • 65
    • 84904298291 scopus 로고    scopus 로고
    • Functions and application of exosomes
    • Qin, J., Xu, Q., Functions and application of exosomes. Acta Pol. Pharm. 71 (2014), 537–543.
    • (2014) Acta Pol. Pharm. , vol.71 , pp. 537-543
    • Qin, J.1    Xu, Q.2
  • 66
    • 84979030811 scopus 로고    scopus 로고
    • Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humans in vitro
    • Rao, Q., Zuo, B., Lu, Z., Gao, X., You, A., Wu, C., Du, Z., Yin, H., Tumor-derived exosomes elicit tumor suppression in murine hepatocellular carcinoma models and humans in vitro. Hepatology, 64, 2016, 456.
    • (2016) Hepatology , vol.64 , pp. 456
    • Rao, Q.1    Zuo, B.2    Lu, Z.3    Gao, X.4    You, A.5    Wu, C.6    Du, Z.7    Yin, H.8
  • 67
    • 79955481749 scopus 로고    scopus 로고
    • Exosomes as intercellular signalosomes and pharmacological effectors
    • Record, M., Subra, C., Silvente-Poirot, S., Poirot, M., Exosomes as intercellular signalosomes and pharmacological effectors. Biochem. Pharmacol. 81 (2011), 1171–1182.
    • (2011) Biochem. Pharmacol. , vol.81 , pp. 1171-1182
    • Record, M.1    Subra, C.2    Silvente-Poirot, S.3    Poirot, M.4
  • 73
    • 77951762023 scopus 로고    scopus 로고
    • Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy
    • Sharma, S., Rasool, H.I., Palanisamy, V., Mathisen, C., Schmidt, M., Wong, D.T., Gimzewski, J.K., Structural-mechanical characterization of nanoparticle exosomes in human saliva, using correlative AFM, FESEM, and force spectroscopy. ACS Nano 4 (2010), 1921–1926.
    • (2010) ACS Nano , vol.4 , pp. 1921-1926
    • Sharma, S.1    Rasool, H.I.2    Palanisamy, V.3    Mathisen, C.4    Schmidt, M.5    Wong, D.T.6    Gimzewski, J.K.7
  • 75
  • 76
    • 55749112807 scopus 로고    scopus 로고
    • Proteomic profiling of exosomes: current perspectives
    • Simpson, R.J., Jensen, S.S., Lim, J.W.E., Proteomic profiling of exosomes: current perspectives. Proteomics 8 (2008), 4083–4099.
    • (2008) Proteomics , vol.8 , pp. 4083-4099
    • Simpson, R.J.1    Jensen, S.S.2    Lim, J.W.E.3
  • 77
    • 0024253430 scopus 로고
    • Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity
    • Sims, P.J., Faioni, E.M., Wiedmer, T., Shattil, S.J., Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity. J. Biol. Chem. 263 (1988), 18205–18212.
    • (1988) J. Biol. Chem. , vol.263 , pp. 18205-18212
    • Sims, P.J.1    Faioni, E.M.2    Wiedmer, T.3    Shattil, S.J.4
  • 78
    • 84939887131 scopus 로고    scopus 로고
    • Extracellular vesicles and their synthetic analogues in aging and age-associated brain diseases
    • Smith, J.A., Leonardi, T., Huang, B., Iraci, N., Vega, B., Pluchino, S., Extracellular vesicles and their synthetic analogues in aging and age-associated brain diseases. Biogerontology 16 (2015), 147–185.
    • (2015) Biogerontology , vol.16 , pp. 147-185
    • Smith, J.A.1    Leonardi, T.2    Huang, B.3    Iraci, N.4    Vega, B.5    Pluchino, S.6
  • 80
    • 77956264919 scopus 로고    scopus 로고
    • A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes
    • Sun, D., Zhuang, X.X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W., Miller, D., Zhang, H.G., A novel nanoparticle drug delivery system: the anti-inflammatory activity of curcumin is enhanced when encapsulated in exosomes. Mol. Ther. J. Am. Soc. Gene Ther. 18 (2010), 1606–1614.
    • (2010) Mol. Ther. J. Am. Soc. Gene Ther. , vol.18 , pp. 1606-1614
    • Sun, D.1    Zhuang, X.X.2    Liu, Y.3    Zhang, S.4    Liu, C.5    Barnes, S.6    Grizzle, W.7    Miller, D.8    Zhang, H.G.9
  • 81
    • 84858037808 scopus 로고    scopus 로고
    • Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863 exosomes
    • Tauro, B.J., Greening, D.W., Mathias, R.A., Ji, H., Mathivanan, S., Scott, A.M., Simpson, R.J., Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863 exosomes. Methods 56 (2012), 293–304.
    • (2012) Methods , vol.56 , pp. 293-304
    • Tauro, B.J.1    Greening, D.W.2    Mathias, R.A.3    Ji, H.4    Mathivanan, S.5    Scott, A.M.6    Simpson, R.J.7
  • 82
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Théry, C., Ostrowski, M., Segura, E., Membrane vesicles as conveyors of immune responses. Nat. Rev. Immunol. 9 (2009), 581–593.
    • (2009) Nat. Rev. Immunol. , vol.9 , pp. 581-593
    • Théry, C.1    Ostrowski, M.2    Segura, E.3
  • 83
    • 84891372823 scopus 로고    scopus 로고
    • A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy
    • Tian, Y., Li, S., Song, J., Ji, T., Zhu, M., Anderson, G.J., Wei, J., Nie, G., A doxorubicin delivery platform using engineered natural membrane vesicle exosomes for targeted tumor therapy. Biomaterials 35 (2014), 2383–2390.
    • (2014) Biomaterials , vol.35 , pp. 2383-2390
    • Tian, Y.1    Li, S.2    Song, J.3    Ji, T.4    Zhu, M.5    Anderson, G.J.6    Wei, J.7    Nie, G.8
  • 84
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J.J., Lötvall, J.O., Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell. Biol. 9 (2007), 654–659.
    • (2007) Nat. Cell. Biol. , vol.9 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 85
  • 86
    • 84860858416 scopus 로고    scopus 로고
    • Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials
    • Vlassov, A.V., Magdaleno, S., Setterquist, R., Conrad, R., Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim. Biophys. Acta 1820 (2012), 940–948.
    • (2012) Biochim. Biophys. Acta , vol.1820 , pp. 940-948
    • Vlassov, A.V.1    Magdaleno, S.2    Setterquist, R.3    Conrad, R.4
  • 88
    • 84887117028 scopus 로고    scopus 로고
    • Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats
    • Xin, H., Li, Y., Cui, Y., Yang, J.J., Zhang, Z.G., Chopp, M., Systemic administration of exosomes released from mesenchymal stromal cells promote functional recovery and neurovascular plasticity after stroke in rats. J. Cereb. Blood Flow Metab.: Off. J. Int. Soc. Cereb. Blood Flow Metab. 33 (2013), 1711–1715.
    • (2013) J. Cereb. Blood Flow Metab.: Off. J. Int. Soc. Cereb. Blood Flow Metab. , vol.33 , pp. 1711-1715
    • Xin, H.1    Li, Y.2    Cui, Y.3    Yang, J.J.4    Zhang, Z.G.5    Chopp, M.6
  • 89
    • 84905010074 scopus 로고    scopus 로고
    • Co-opting biology to deliver drugs
    • Yousefpour, P., Chilkoti, A., Co-opting biology to deliver drugs. Biotechnol. Bioeng. 111 (2014), 1699–1716.
    • (2014) Biotechnol. Bioeng. , vol.111 , pp. 1699-1716
    • Yousefpour, P.1    Chilkoti, A.2
  • 90
    • 84964688291 scopus 로고    scopus 로고
    • Exosomes in stroke pathogenesis and therapy
    • Zhang, Z.G., Chopp, M., Exosomes in stroke pathogenesis and therapy. J. Clin. Invest. 126 (2016), 1190–1197.
    • (2016) J. Clin. Invest. , vol.126 , pp. 1190-1197
    • Zhang, Z.G.1    Chopp, M.2
  • 91
    • 84890969331 scopus 로고    scopus 로고
    • Gene recombinant bone marrow mesenchymal stem cells as a tumor-targeted suicide gene delivery vehicle in pulmonary metastasis therapy using non-viral transfection
    • Zhang, T.Y., Huang, B., Yuan, Z.Y., Hu, Y.L., Tabata, Y., Gao, J.Q., Gene recombinant bone marrow mesenchymal stem cells as a tumor-targeted suicide gene delivery vehicle in pulmonary metastasis therapy using non-viral transfection. Nanomed. Nanotechnol. Biol. Med. 10 (2014), 257–267.
    • (2014) Nanomed. Nanotechnol. Biol. Med. , vol.10 , pp. 257-267
    • Zhang, T.Y.1    Huang, B.2    Yuan, Z.Y.3    Hu, Y.L.4    Tabata, Y.5    Gao, J.Q.6
  • 92
    • 84929321834 scopus 로고    scopus 로고
    • Synergistic effects of co-administration of suicide gene expressing mesenchymal stem cells and prodrug-encapsulated liposome on aggressive lung melanoma metastases in mice
    • Zhang, T.Y., Huang, B., Wu, H.B., Wu, J.H., Li, L.M., Li, Y.X., Hu, Y.L., Han, M., Shen, Y.Q., Tabata, Y., Synergistic effects of co-administration of suicide gene expressing mesenchymal stem cells and prodrug-encapsulated liposome on aggressive lung melanoma metastases in mice. J. Controlled Release Off. J. Controlled Release Soc. 209 (2015), 260–271.
    • (2015) J. Controlled Release Off. J. Controlled Release Soc. , vol.209 , pp. 260-271
    • Zhang, T.Y.1    Huang, B.2    Wu, H.B.3    Wu, J.H.4    Li, L.M.5    Li, Y.X.6    Hu, Y.L.7    Han, M.8    Shen, Y.Q.9    Tabata, Y.10
  • 93
    • 84964329540 scopus 로고    scopus 로고
    • Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury
    • Zhang, Y., Chopp, M., Meng, Y., Katakowski, M., Xin, H., Mahmood, A., Xiong, Y., Effect of exosomes derived from multipluripotent mesenchymal stromal cells on functional recovery and neurovascular plasticity in rats after traumatic brain injury. J. Neurosurg. 122 (2015), 856–867.
    • (2015) J. Neurosurg. , vol.122 , pp. 856-867
    • Zhang, Y.1    Chopp, M.2    Meng, Y.3    Katakowski, M.4    Xin, H.5    Mahmood, A.6    Xiong, Y.7
  • 95
  • 96
    • 34347387938 scopus 로고    scopus 로고
    • Strategies to improve drug delivery across the blood-brain barrier
    • de Boer, A.G., Gaillard, P.J., Strategies to improve drug delivery across the blood-brain barrier. Clin. Pharmacokinet. 46 (2007), 553–576.
    • (2007) Clin. Pharmacokinet. , vol.46 , pp. 553-576
    • de Boer, A.G.1    Gaillard, P.J.2
  • 98


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