메뉴 건너뛰기




Volumn 17, Issue 2, 2016, Pages

Focus on extracellular vesicles: Introducing the next small big thing

Author keywords

Apoptotic body; Biogenesis; Ectosome; Exosome; Extracellular vesicle; Isolation; Microvesicle; Molecular composition; Signal transduction

Indexed keywords

ABC TRANSPORTER A1; CD63 ANTIGEN; CD9 ANTIGEN; CYTOSKELETON PROTEIN; DOUBLE STRANDED DNA; METALLOPROTEINASE; SINGLE STRANDED DNA; SNARE PROTEIN;

EID: 84957583645     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms17020170     Document Type: Review
Times cited : (598)

References (202)
  • 1
    • 84874377202 scopus 로고    scopus 로고
    • Extracellular vesicles: Exosomes, microvesicles, and friends
    • Raposo, G., Stoorvogel, W. Extracellular vesicles: Exosomes, microvesicles, and friends. J. Cell Biol. 2013, 200, 373-383.
    • (2013) J. Cell Biol , vol.200 , pp. 373-383
    • Raposo, G.1    Stoorvogel, W.2
  • 2
    • 67949097489 scopus 로고    scopus 로고
    • Exosomes-vesicular carriers for intercellular communication
    • Simons, M., Raposo, G. Exosomes-vesicular carriers for intercellular communication. Curr. Opin. Cell Biol. 2009, 21, 575-581.
    • (2009) Curr. Opin. Cell Biol , vol.21 , pp. 575-581
    • Simons, M.1    Raposo, G.2
  • 3
  • 5
    • 0036676445 scopus 로고    scopus 로고
    • Exosomes: Composition, biogenesis and function
    • Théry, C., Zitvogel, L., Amigorena, S. Exosomes: Composition, biogenesis and function. Nat. Rev. Immunol. 2002, 2, 569-579.
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 569-579
    • Théry, C.1    Zitvogel, L.2    Amigorena, S.3
  • 6
    • 84921424656 scopus 로고    scopus 로고
    • Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic?
    • Gangoda, L., Boukouris, S., Liem, M., Kalra, H., Mathivanan, S. Extracellular vesicles including exosomes are mediators of signal transduction: Are they protective or pathogenic? Proteomics 2015, 15, 260-271.
    • (2015) Proteomics , vol.15 , pp. 260-271
    • Gangoda, L.1    Boukouris, S.2    Liem, M.3    Kalra, H.4    Mathivanan, S.5
  • 7
    • 79958048581 scopus 로고    scopus 로고
    • Body fluid derived exosomes as a novel template for clinical diagnostics
    • Keller, S., Ridinger, J., Rupp, A.-K., Janssen, J., Altevogt, P. Body fluid derived exosomes as a novel template for clinical diagnostics. J. Transl. Med. 2011, 9, doi:10.1186/1479-5876-9-86.
    • (2011) J. Transl. Med , pp. 9
    • Keller, S.1    Ridinger, J.2    Rupp, A.-K.3    Janssen, J.4    Altevogt, P.5
  • 8
    • 43249109372 scopus 로고    scopus 로고
    • Clayton, A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids
    • Théry, C., Amigorena, S., Raposo, G., Clayton, A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr. Protoc. Cell Biol. 2006, 3.22.1-3.22.29, doi:10.1002/0471143030.cb0322s30.
    • (2006) Curr. Protoc. Cell Biol
    • Théry, C.1    Amigorena, S.2    Raposo, G.3
  • 10
    • 0020956787 scopus 로고
    • Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor
    • Pan, B.-T., Johnstone, R.M. Fate of the transferrin receptor during maturation of sheep reticulocytes in vitro: Selective externalization of the receptor. Cell 1983, 33, 967-978.
    • (1983) Cell , vol.33 , pp. 967-978
    • Pan, B.-T.1    Johnstone, R.M.2
  • 11
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • Valadi, H., Ekström, K., Bossios, A., Sjöstrand, M., Lee, J.J., Lötvall, J.O. Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 2007, 9, 654-659.
    • (2007) Nat. Cell Biol , vol.9 , pp. 654-659
    • Valadi, H.1    Ekström, K.2    Bossios, A.3    Sjöstrand, M.4    Lee, J.J.5    Lötvall, J.O.6
  • 12
    • 84942870119 scopus 로고    scopus 로고
    • Extracellular vesicles including exosomes in cross kingdom regulation: A viewpoint from plant-fungal interactions
    • Samuel, M., Bleackley, M., Anderson, M., Mathivanan, S. Extracellular vesicles including exosomes in cross kingdom regulation: A viewpoint from plant-fungal interactions. Front. Plant Sci. 2015, 6, doi:10.3389/fpls. 2015.00766.
    • (2015) Front. Plant Sci , vol.6
    • Samuel, M.1    Bleackley, M.2    Erson, M.3    Mathivanan, S.4
  • 13
    • 76949101800 scopus 로고    scopus 로고
    • Astrocytes and Glioblastoma cells release exosomes carrying mtDNA
    • Guescini, M., Genedani, S., Stocchi, V., Agnati, L.F. Astrocytes and Glioblastoma cells release exosomes carrying mtDNA. J. Neural Transm. 2010, 117, 1-4.
    • (2010) J. Neural Transm , vol.117 , pp. 1-4
    • Guescini, M.1    Genedani, S.2    Stocchi, V.3    Agnati, L.F.4
  • 14
    • 84894189683 scopus 로고    scopus 로고
    • Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer
    • Kahlert, C., Melo, S.A., Protopopov, A., Tang, J., Seth, S., Koch, M., Zhang, J., Weitz, J., Chin, L., Futreal, A. Identification of double-stranded genomic DNA spanning all chromosomes with mutated KRAS and p53 DNA in the serum exosomes of patients with pancreatic cancer. J. Biol. Chem. 2014, 289, 3869-3875.
    • (2014) J. Biol. Chem. , vol.289 , pp. 3869-3875
    • Kahlert, C.1    Melo, S.A.2    Protopopov, A.3    Tang, J.4    Seth, S.5    Koch, M.6    Zhang, J.7    Weitz, J.8    Chin, L.9    Futreal, A.10
  • 16
    • 84906934030 scopus 로고    scopus 로고
    • Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells
    • Lee, T. H., Chennakrishnaiah, S., Audemard, E., Montermini, L., Meehan, B., Rak, J. Oncogenic ras-driven cancer cell vesiculation leads to emission of double-stranded DNA capable of interacting with target cells. Biochem. Biophys. Res. Commun. 2014, 451, 295-301.
    • (2014) Biochem. Biophys. Res. Commun , vol.451 , pp. 295-301
    • Lee, T.H.1    Chennakrishnaiah, S.2    Audemard, E.3    Montermini, L.4    Meehan, B.5    Rak, J.6
  • 17
    • 67349280860 scopus 로고    scopus 로고
    • Intercellular exchange of proteins: The immune cell habit of sharing
    • Rechavi, O., Goldstein, I., Kloog, Y. Intercellular exchange of proteins: The immune cell habit of sharing. FEBS Lett. 2009, 583, 1792-1799.
    • (2009) FEBS Lett , vol.583 , pp. 1792-1799
    • Rechavi, O.1    Goldstein, I.2    Kloog, Y.3
  • 19
    • 0034626690 scopus 로고    scopus 로고
    • RNA silencing. Moving targets
    • Carrington, J.C. RNA silencing. Moving targets. Nature 2000, 408, 150-151.
    • (2000) Nature , vol.408 , pp. 150-151
    • Carrington, J.C.1
  • 20
    • 77956404647 scopus 로고    scopus 로고
    • Exosomes: Extracellular organelles important in intercellular communication
    • Mathivanan, S., Ji, H., Simpson, R.J. Exosomes: Extracellular organelles important in intercellular communication. J. Proteom. 2010, 73, 1907-1920.
    • (2010) J. Proteom , vol.73 , pp. 1907-1920
    • Mathivanan, S.1    Ji, H.2    Simpson, R.J.3
  • 21
    • 84888042782 scopus 로고    scopus 로고
    • Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma
    • Kalra, H., Adda, C.G., Liem, M., Ang, C.S., Mechler, A., Simpson, R.J., Hulett, M.D., Mathivanan, S. Comparative proteomics evaluation of plasma exosome isolation techniques and assessment of the stability of exosomes in normal human blood plasma. Proteomics 2013, 13, 3354-3364.
    • (2013) Proteomics , vol.13 , pp. 3354-3364
    • Kalra, H.1    Adda, C.G.2    Liem, M.3    Ang, C.S.4    Mechler, A.5    Simpson, R.J.6    Hulett, M.D.7    Mathivanan, S.8
  • 23
    • 0022201056 scopus 로고
    • Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes
    • Pan, B.-T., Teng, K., Wu, C., Adam, M., Johnstone, R.M. Electron microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J. Cell Biol. 1985, 101, 942-948.
    • (1985) J. Cell Biol , vol.101 , pp. 942-948
    • Pan, B.-T.1    Teng, K.2    Wu, C.3    Adam, M.4    Johnstone, R.M.5
  • 27
    • 0026080905 scopus 로고
    • Ectocytosis caused by sublytic autologous complement attack on human neutrophils. The sorting of endogenous plasma-membrane proteins and lipids into shed vesicles
    • Stein, J.M., Luzio, J.P. Ectocytosis caused by sublytic autologous complement attack on human neutrophils. The sorting of endogenous plasma-membrane proteins and lipids into shed vesicles. Biochem. J. 1991, 274, 381-386.
    • (1991) Biochem. J. , vol.274 , pp. 381-386
    • Stein, J.M.1    Luzio, J.P.2
  • 28
    • 0037402527 scopus 로고    scopus 로고
    • Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils
    • Gasser, O., Hess, C., Miot, S., Deon, C., Sanchez, J.C., Schifferli, J.A. Characterisation and properties of ectosomes released by human polymorphonuclear neutrophils. Exp. Cell Res. 2003, 285, 243-257.
    • (2003) Exp. Cell Res , vol.285 , pp. 243-257
    • Gasser, O.1    Hess, C.2    Miot, S.3    Deon, C.4    Sanchez, J.C.5    Schifferli, J.A.6
  • 29
    • 34147105872 scopus 로고    scopus 로고
    • ADAMs in cancer cell proliferation and progression
    • Mochizuki, S., Okada, Y. ADAMs in cancer cell proliferation and progression. Cancer Sci. 2007, 98, 621-628.
    • (2007) Cancer Sci , vol.98 , pp. 621-628
    • Mochizuki, S.1    Okada, Y.2
  • 30
    • 84876518109 scopus 로고    scopus 로고
    • Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke
    • Li, C.J., Liu, Y., Chen, Y., Yu, D., Williams, K.J., Liu, M.L. Novel proteolytic microvesicles released from human macrophages after exposure to tobacco smoke. Am. J. Pathol. 2013, 182, 1552-1562.
    • (2013) Am. J. Pathol , vol.182 , pp. 1552-1562
    • Li, C.J.1    Liu, Y.2    Chen, Y.3    Yu, D.4    Williams, K.J.5    Liu, M.L.6
  • 32
    • 23944509766 scopus 로고    scopus 로고
    • Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation
    • Del Conde, I., Shrimpton, C.N., Thiagarajan, P., Lopez, J.A. Tissue-factor-bearing microvesicles arise from lipid rafts and fuse with activated platelets to initiate coagulation. Blood 2005, 106, 1604-1611.
    • (2005) Blood , vol.106 , pp. 1604-1611
    • Del Conde, I.1    Shrimpton, C.N.2    Thiagarajan, P.3    Lopez, J.A.4
  • 33
    • 0033485648 scopus 로고    scopus 로고
    • Activated platelets release two types of membrane vesicles: Microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules
    • Heijnen, H.F., Schiel, A.E., Fijnheer, R., Geuze, H.J., Sixma, J.J. Activated platelets release two types of membrane vesicles: Microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and α-granules. Blood 1999, 94, 3791-3799.
    • (1999) Blood , vol.94 , pp. 3791-3799
    • Heijnen, H.F.1    Schiel, A.E.2    Fijnheer, R.3    Geuze, H.J.4    Sixma, J.J.5
  • 34
    • 12444303861 scopus 로고    scopus 로고
    • Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin
    • Falati, S., Liu, Q.D., Gross, P., Merrill-Skoloff, G., Chou, J., Vandendries, E., Celi, A., Croce, K., Furie, B.C., Furie, B. Accumulation of tissue factor into developing thrombi in vivo is dependent upon microparticle P-selectin glycoprotein ligand 1 and platelet P-selectin. J. Exp. Med. 2003, 197, 1585-1598.
    • (2003) J. Exp. Med. , vol.197 , pp. 1585-1598
    • Falati, S.1    Liu, Q.D.2    Gross, P.3    Merrill-Skoloff, G.4    Chou, J.5    Vandendries, E.6    Celi, A.7    Croce, K.8    Furie, B.C.9    Furie, B.10
  • 35
    • 84922323122 scopus 로고    scopus 로고
    • Inhibition of platelet activation prevents the P-selectin and integrin-dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasis in vivo
    • Mezouar, S., Darbousset, R., Dignat-George, F., Panicot-Dubois, L., Dubois, C. Inhibition of platelet activation prevents the P-selectin and integrin-dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasis in vivo. Int. J. Cancer 2015, 136, 462-475.
    • (2015) Int. J. Cancer , vol.136 , pp. 462-475
    • Mezouar, S.1    Darbousset, R.2    Dignat-George, F.3    Panicot-Dubois, L.4    Dubois, C.5
  • 36
    • 55249098470 scopus 로고    scopus 로고
    • Expression, activation, and function of integrin αMβ2 (Mac-1) on neutrophil-derived microparticles
    • Pluskota, E., Woody, N.M., Szpak, D., Ballantyne, C.M., Soloviev, D.A., Simon, D.I., Plow, E.F. Expression, activation, and function of integrin αMβ2 (Mac-1) on neutrophil-derived microparticles. Blood 2008, 112, 2327-2335.
    • (2008) Blood , vol.112 , pp. 2327-2335
    • Pluskota, E.1    Woody, N.M.2    Szpak, D.3    Ballantyne, C.M.4    Soloviev, D.A.5    Simon, D.I.6    Plow, E.F.7
  • 37
    • 77952365658 scopus 로고    scopus 로고
    • Microvesicles: Mediators of extracellular communication during cancer progression
    • Muralidharan-Chari, V., Clancy, J.W., Sedgwick, A., D’Souza-Schorey, C. Microvesicles: Mediators of extracellular communication during cancer progression. J. Cell Sci. 2010, 123, 1603-1611.
    • (2010) J. Cell Sci , vol.123 , pp. 1603-1611
    • Muralidharan-Chari, V.1    Clancy, J.W.2    Sedgwick, A.3    D’souza-Schorey, C.4
  • 40
    • 84858011488 scopus 로고    scopus 로고
    • Extracellular microvesicles: The need for internationally recognised nomenclature and stringent purification criteria
    • Simpson, R., Mathivanan, S. Extracellular microvesicles: The need for internationally recognised nomenclature and stringent purification criteria. J. Proteom. Bioinform. 2012, 5, 2.
    • (2012) J. Proteom. Bioinform , vol.5 , pp. 2
    • Simpson, R.1    Mathivanan, S.2
  • 42
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr, J.F., Wyllie, A.H., Currie, A.R. Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 1972, 26, 239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 44
    • 84957586685 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: Physiological role and signaling properties of extracellular membrane vesicles
    • Iraci, N., Leonardi, T., Gessler, F., Vega, B., Pluchino, S. Focus on extracellular vesicles: Physiological role and signaling properties of extracellular membrane vesicles. Int. J. Mol. Sci. 2016, 17, doi:10.3390/ijms17020171.
    • (2016) Int. J. Mol. Sci , pp. 17
    • Iraci, N.1    Leonardi, T.2    Gessler, F.3    Vega, B.4    Pluchino, S.5
  • 45
    • 84957552185 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: Development of exosome-based therapeutic systems
    • Ohno, S.I., Drummen, G.P.C., Kuroda, M. Focus on extracellular vesicles: Development of exosome-based therapeutic systems. Int. J. Mol. Sci. 2016, 17, doi:10.3390/ijms17020172.
    • (2016) Int. J. Mol. Sci , pp. 17
    • Ohno, S.I.1    Drummen, G.P.C.2    Kuroda, M.3
  • 46
    • 84957584941 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: Exosomes and their role in protein trafficking in Alzheimer’s and Parkinson’s disease
    • Vella, L.J., Hill, A.F., Cheng, L. Focus on extracellular vesicles: Exosomes and their role in protein trafficking in Alzheimer’s and Parkinson’s disease. Int. J. Mol. Sci. 2016, 17, doi:10.3390/ijms17020173.
    • (2016) Int. J. Mol. Sci , pp. 17
    • Vella, L.J.1    Hill, A.F.2    Cheng, L.3
  • 47
    • 84957603483 scopus 로고    scopus 로고
    • Focus on extracellular vesicles: Therapeutic efficacy of stem cell-derived extracellular vesicles
    • Zhang, B., Tan, K.H., Lim, S.K. Focus on extracellular vesicles: Therapeutic efficacy of stem cell-derived extracellular vesicles. Int. J. Mol. Sci. 2016, 17, doi:10.3390/ijms17020174.
    • (2016) Int. J. Mol. Sci , pp. 17
    • Zhang, B.1    Tan, K.H.2    Lim, S.K.3
  • 48
    • 84890458696 scopus 로고    scopus 로고
    • Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles
    • Colombo, M., Moita, C., van Niel, G., Kowal, J., Vigneron, J., Benaroch, P., Manel, N., Moita, L.F., Thery, C., Raposo, G. Analysis of ESCRT functions in exosome biogenesis, composition and secretion highlights the heterogeneity of extracellular vesicles. J. Cell Sci. 2013, 126, 5553-5565.
    • (2013) J. Cell Sci , vol.126 , pp. 5553-5565
    • Colombo, M.1    Moita, C.2    Van Niel, G.3    Kowal, J.4    Vigneron, J.5    Benaroch, P.6    Manel, N.7    Moita, L.F.8    Thery, C.9    Raposo, G.10
  • 49
    • 67349263394 scopus 로고    scopus 로고
    • Trafficking and function of the tetraspanin CD63
    • Pols, M.S., Klumperman, J. Trafficking and function of the tetraspanin CD63. Exp. Cell Res. 2009, 315, 1584-1592.
    • (2009) Exp. Cell Res , vol.315 , pp. 1584-1592
    • Pols, M.S.1    Klumperman, J.2
  • 52
    • 63649086486 scopus 로고    scopus 로고
    • The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins
    • Raiborg, C., Stenmark, H. The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins. Nature 2009, 458, 445-452.
    • (2009) Nature , vol.458 , pp. 445-452
    • Raiborg, C.1    Stenmark, H.2
  • 55
    • 84858230240 scopus 로고    scopus 로고
    • Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein
    • Nabhan, J.F., Hu, R., Oh, R.S., Cohen, S.N., Lu, Q. Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein. Proc. Natl. Acad. Sci. USA 2012, 109, 4146-4151.
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 4146-4151
    • Nabhan, J.F.1    Hu, R.2    Oh, R.S.3    Cohen, S.N.4    Lu, Q.5
  • 56
    • 84890875112 scopus 로고    scopus 로고
    • ALIX and the multivesicular endosome: ALIX in Wonderland
    • Bissig, C., Gruenberg, J. ALIX and the multivesicular endosome: ALIX in Wonderland. Trends Cell Biol. 2014, 24, 19-25.
    • (2014) Trends Cell Biol , vol.24 , pp. 19-25
    • Bissig, C.1    Gruenberg, J.2
  • 57
    • 84863199863 scopus 로고    scopus 로고
    • Get on the exosome bus with ALIX
    • Hurley, J.H., Odorizzi, G. Get on the exosome bus with ALIX. Nat. Cell Biol. 2012, 14, 654-655.
    • (2012) Nat. Cell Biol , vol.14 , pp. 654-655
    • Hurley, J.H.1    Odorizzi, G.2
  • 58
    • 67249110996 scopus 로고    scopus 로고
    • Multivesicular endosome biogenesis in the absence of ESCRTs
    • Stuffers, S., Sem Wegner, C., Stenmark, H., Brech, A. Multivesicular endosome biogenesis in the absence of ESCRTs. Traffic 2009, 10, 925-937.
    • (2009) Traffic , vol.10 , pp. 925-937
    • Stuffers, S.1    Sem Wegner, C.2    Stenmark, H.3    Brech, A.4
  • 60
    • 77950863406 scopus 로고    scopus 로고
    • Molecular mechanism of multivesicular body biogenesis by ESCRT complexes
    • Wollert, T., Hurley, J.H. Molecular mechanism of multivesicular body biogenesis by ESCRT complexes. Nature 2010, 464, 864-869.
    • (2010) Nature , vol.464 , pp. 864-869
    • Wollert, T.1    Hurley, J.H.2
  • 62
    • 0037096162 scopus 로고    scopus 로고
    • The exosome pathway in K562 cells is regulated by Rab11
    • Savina, A., Vidal, M., Colombo, M.I. The exosome pathway in K562 cells is regulated by Rab11. J. Cell Sci. 2002, 115, 2505-2515.
    • (2002) J. Cell Sci , vol.115 , pp. 2505-2515
    • Savina, A.1    Vidal, M.2    Colombo, M.I.3
  • 64
    • 0022602283 scopus 로고
    • Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells
    • Miller, K., Beardmore, J., Kanety, H., Schlessinger, J., Hopkins, C.R. Localization of the epidermal growth factor (EGF) receptor within the endosome of EGF-stimulated epidermoid carcinoma (A431) cells. J. Cell Biol. 1986, 102, 500-509.
    • (1986) J. Cell Biol , vol.102 , pp. 500-509
    • Miller, K.1    Beardmore, J.2    Kanety, H.3    Schlessinger, J.4    Hopkins, C.R.5
  • 65
    • 62649159446 scopus 로고    scopus 로고
    • Endocytosis and intracellular trafficking of ErbBs
    • Sorkin, A., Goh, L.K. Endocytosis and intracellular trafficking of ErbBs. Exp. Cell Res. 2009, 315, 683-696.
    • (2009) Exp. Cell Res , vol.315 , pp. 683-696
    • Sorkin, A.1    Goh, L.K.2
  • 70
    • 77953720612 scopus 로고    scopus 로고
    • Phospholipid scramblase: An update
    • Bevers, E.M., Williamson, P.L. Phospholipid scramblase: An update. FEBS Lett. 2010, 584, 2724-2730.
    • (2010) FEBS Lett. , vol.584 , pp. 2724-2730
    • Bevers, E.M.1    Williamson, P.L.2
  • 71
    • 0142218366 scopus 로고    scopus 로고
    • Regulation of transbilayer plasma membrane phospholipid asymmetry
    • Daleke, D.L. Regulation of transbilayer plasma membrane phospholipid asymmetry. J. Lipid Res. 2003, 44, 233-242.
    • (2003) J. Lipid Res , vol.44 , pp. 233-242
    • Daleke, D.L.1
  • 72
    • 0034115889 scopus 로고    scopus 로고
    • ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins
    • Oram, J.F., Vaughan, A.M. ABCA1-mediated transport of cellular cholesterol and phospholipids to HDL apolipoproteins. Curr. Opin. Lipidol. 2000, 11, 253-260.
    • (2000) Curr. Opin. Lipidol , vol.11 , pp. 253-260
    • Oram, J.F.1    Vaughan, A.M.2
  • 74
    • 0032520262 scopus 로고    scopus 로고
    • Impaired Ca2+-induced tyrosine phosphorylation and defective lipid scrambling in erythrocytes from a patient with Scott syndrome: A study using an inhibitor for scramblase that mimics the defect in Scott syndrome
    • Dekkers, D.W., Comfurius, P., Vuist, W.M., Billheimer, J.T., Dicker, I., Weiss, H.J., Zwaal, R.F., Bevers, E.M. Impaired Ca2+-induced tyrosine phosphorylation and defective lipid scrambling in erythrocytes from a patient with Scott syndrome: A study using an inhibitor for scramblase that mimics the defect in Scott syndrome. Blood 1998, 91, 2133-2138.
    • (1998) Blood , vol.91 , pp. 2133-2138
    • Dekkers, D.W.1    Comfurius, P.2    Vuist, W.M.3    Billheimer, J.T.4    Dicker, I.5    Weiss, H.J.6    Zwaal, R.F.7    Bevers, E.M.8
  • 75
    • 78650172970 scopus 로고    scopus 로고
    • Calcium-dependent phospholipid scrambling by TMEM16F
    • Suzuki, J., Umeda, M., Sims, P.J., Nagata, S. Calcium-dependent phospholipid scrambling by TMEM16F. Nature 2010, 468, 834-838.
    • (2010) Nature , vol.468 , pp. 834-838
    • Suzuki, J.1    Umeda, M.2    Sims, P.J.3    Nagata, S.4
  • 78
    • 0037709857 scopus 로고    scopus 로고
    • Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis
    • Jimenez, J.J., Jy, W., Mauro, L.M., Soderland, C., Horstman, L.L., Ahn, Y.S. Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis. Thromb. Res. 2003, 109, 175-180.
    • (2003) Thromb. Res , vol.109 , pp. 175-180
    • Jimenez, J.J.1    Jy, W.2    Mauro, L.M.3    Soderland, C.4    Horstman, L.L.5    Ahn, Y.S.6
  • 79
    • 77952074366 scopus 로고    scopus 로고
    • The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib
    • Connor, D.E., Exner, T., Ma, D.D., Joseph, J.E. The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib. Thromb. Haemost. 2010, 103, 1044-1052.
    • (2010) Thromb. Haemost , vol.103 , pp. 1044-1052
    • Connor, D.E.1    Exner, T.2    Ma, D.D.3    Joseph, J.E.4
  • 80
    • 79952588626 scopus 로고    scopus 로고
    • Multiple interactions between the ESCRT machinery and arrestin-related proteins: Implications for PPXY-dependent budding
    • Rauch, S., Martin-Serrano, J. Multiple interactions between the ESCRT machinery and arrestin-related proteins: Implications for PPXY-dependent budding. J. Virol. 2011, 85, 3546-3556.
    • (2011) J. Virol. , vol.85 , pp. 3546-3556
    • Rauch, S.1    Martin-Serrano, J.2
  • 82
    • 63049118579 scopus 로고    scopus 로고
    • P38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles
    • Curtis, A.M., Wilkinson, P.F., Gui, M., Gales, T.L., Hu, E., Edelberg, J.M. p38 mitogen-activated protein kinase targets the production of proinflammatory endothelial microparticles. J. Thromb. Haemost. 2009, 7, 701-709.
    • (2009) J. Thromb. Haemost , vol.7 , pp. 701-709
    • Curtis, A.M.1    Wilkinson, P.F.2    Gui, M.3    Gales, T.L.4    Hu, E.5    Edelberg, J.M.6
  • 83
    • 34249035506 scopus 로고    scopus 로고
    • Enlargeosome traffic: Exocytosis triggered by various signals is followed by endocytosis, membrane shedding or both
    • Cocucci, E., Racchetti, G., Podini, P., Meldolesi, J. Enlargeosome traffic: Exocytosis triggered by various signals is followed by endocytosis, membrane shedding or both. Traffic 2007, 8, 742-757.
    • (2007) Traffic , vol.8 , pp. 742-757
    • Cocucci, E.1    Racchetti, G.2    Podini, P.3    Meldolesi, J.4
  • 85
    • 1342343923 scopus 로고    scopus 로고
    • The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions
    • Sidhu, S.S., Mengistab, A.T., Tauscher, A.N., LaVail, J., Basbaum, C. The microvesicle as a vehicle for EMMPRIN in tumor-stromal interactions. Oncogene 2004, 23, 956-963.
    • (2004) Oncogene , vol.23 , pp. 956-963
    • Sidhu, S.S.1    Mengistab, A.T.2    Tauscher, A.N.3    Lavail, J.4    Basbaum, C.5
  • 88
    • 42149097315 scopus 로고    scopus 로고
    • Role of microparticles in atherothrombosis
    • Leroyer, A.S., Tedgui, A., Boulanger, C.M. Role of microparticles in atherothrombosis. J. Intern. Med. 2008, 263, 528-537.
    • (2008) J. Intern. Med , vol.263 , pp. 528-537
    • Leroyer, A.S.1    Tedgui, A.2    Boulanger, C.M.3
  • 90
    • 77949900365 scopus 로고    scopus 로고
    • T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells
    • DeKruyff, R.H., Bu, X., Ballesteros, A., Santiago, C., Chim, Y.L., Lee, H.H., Karisola, P., Pichavant, M., Kaplan, G.G., Umetsu, D.T., et al. T cell/transmembrane, Ig, and mucin-3 allelic variants differentially recognize phosphatidylserine and mediate phagocytosis of apoptotic cells. J. Immunol. 2010, 184, 1918-1930.
    • (2010) J. Immunol , vol.184 , pp. 1918-1930
    • Dekruyff, R.H.1    Bu, X.2    Ballesteros, A.3    Santiago, C.4    Chim, Y.L.5    Lee, H.H.6    Karisola, P.7    Pichavant, M.8    Kaplan, G.G.9    Umetsu, D.T.10
  • 91
    • 0037046580 scopus 로고    scopus 로고
    • Identification of a factor that links apoptotic cells to phagocytes
    • Hanayama, R., Tanaka, M., Miwa, K., Shinohara, A., Iwamatsu, A., Nagata, S. Identification of a factor that links apoptotic cells to phagocytes. Nature 2002, 417, 182-187.
    • (2002) Nature , vol.417 , pp. 182-187
    • Hanayama, R.1    Tanaka, M.2    Miwa, K.3    Shinohara, A.4    Iwamatsu, A.5    Nagata, S.6
  • 92
    • 28444436585 scopus 로고    scopus 로고
    • Coated-platelets: An emerging component of the procoagulant response
    • Dale, G.L. Coated-platelets: An emerging component of the procoagulant response. J. Thromb. Haemost. 2005, 3, 2185-2192.
    • (2005) J. Thromb. Haemost , vol.3 , pp. 2185-2192
    • Dale, G.L.1
  • 94
    • 42649140235 scopus 로고    scopus 로고
    • Immunobiology of the TAM receptors
    • Lemke, G., Rothlin, C.V. Immunobiology of the TAM receptors. Nat. Rev. Immunol 2008, 8, 327-336.
    • (2008) Nat. Rev. Immunol , vol.8 , pp. 327-336
    • Lemke, G.1    Rothlin, C.V.2
  • 95
    • 0842328856 scopus 로고    scopus 로고
    • Coagulation, inflammation, and apoptosis: Different roles for protein S and the protein S-C4b binding protein complex
    • Rezende, S.M., Simmonds, R.E., Lane, D.A. Coagulation, inflammation, and apoptosis: Different roles for protein S and the protein S-C4b binding protein complex. Blood 2004, 103, 1192-1201.
    • (2004) Blood , vol.103 , pp. 1192-1201
    • Rezende, S.M.1    Simmonds, R.E.2    Lane, D.A.3
  • 96
    • 0037404152 scopus 로고    scopus 로고
    • Macrophage recognition of externalized phosphatidylserine and phagocytosis of apoptotic Jurkat cells—Existence of a threshold
    • Borisenko, G.G., Matsura, T., Liu, S.X., Tyurin, V.A., Jianfei, J., Serinkan, F.B., Kagan, V.E. Macrophage recognition of externalized phosphatidylserine and phagocytosis of apoptotic Jurkat cells—Existence of a threshold. Arch. Biochem. Biophys. 2003, 413, 41-52.
    • (2003) Arch. Biochem. Biophys. , vol.413 , pp. 41-52
    • Borisenko, G.G.1    Matsura, T.2    Liu, S.X.3    Tyurin, V.A.4    Jianfei, J.5    Serinkan, F.B.6    Kagan, V.E.7
  • 97
    • 0032695108 scopus 로고    scopus 로고
    • Natural adjuvants: Endogenous activators of dendritic cells
    • Gallucci, S., Lolkema, M., Matzinger, P. Natural adjuvants: Endogenous activators of dendritic cells. Nat. Med. 1999, 5, 1249-1255.
    • (1999) Nat. Med , vol.5 , pp. 1249-1255
    • Gallucci, S.1    Lolkema, M.2    Matzinger, P.3
  • 99
    • 79958050089 scopus 로고    scopus 로고
    • Microparticles (Ectosomes) shed by stored human platelets downregulate macrophages and modify the development of dendritic cells
    • Sadallah, S., Eken, C., Martin, P.J., Schifferli, J.A. Microparticles (ectosomes) shed by stored human platelets downregulate macrophages and modify the development of dendritic cells. J. Immunol. 2011, 186, 6543-6552.
    • (2011) J. Immunol , vol.186 , pp. 6543-6552
    • Sadallah, S.1    Eken, C.2    Martin, P.J.3    Schifferli, J.A.4
  • 100
    • 83255162004 scopus 로고    scopus 로고
    • Decreases in CD31 and CD47 levels on the cell surface during etoposide-induced Jurkat cell apoptosis
    • Azuma, Y., Nakagawa, H., Dote, K., Higai, K., Matsumoto, K. Decreases in CD31 and CD47 levels on the cell surface during etoposide-induced Jurkat cell apoptosis. Biol. Pharm. Bull. 2011, 34, 1828-1834.
    • (2011) Biol. Pharm. Bull. , vol.34 , pp. 1828-1834
    • Azuma, Y.1    Nakagawa, H.2    Dote, K.3    Higai, K.4    Matsumoto, K.5
  • 101
    • 34250308322 scopus 로고    scopus 로고
    • Apoptosis: A review of programmed cell death
    • Elmore, S. Apoptosis: A review of programmed cell death. Toxicol. Pathol. 2007, 35, 495-516.
    • (2007) Toxicol. Pathol , vol.35 , pp. 495-516
    • Elmore, S.1
  • 102
    • 84896690342 scopus 로고    scopus 로고
    • Apoptotic cell clearance: Basic biology and therapeutic potential
    • Poon, I.K., Lucas, C.D., Rossi, A.G., Ravichandran, K.S. Apoptotic cell clearance: Basic biology and therapeutic potential. Nat. Rev. Immunol. 2014, 14, 166-180.
    • (2014) Nat. Rev. Immunol , vol.14 , pp. 166-180
    • Poon, I.K.1    Lucas, C.D.2    Rossi, A.G.3    Ravichandran, K.S.4
  • 105
    • 69249100500 scopus 로고    scopus 로고
    • Human caspases: Activation, specificity, and regulation
    • Pop, C., Salvesen, G.S. Human caspases: Activation, specificity, and regulation. J. Biol. Chem. 2009, 284, 21777-217781.
    • (2009) J. Biol. Chem , vol.284 , pp. 21777-217781
    • Pop, C.1    Salvesen, G.S.2
  • 106
    • 26244439708 scopus 로고    scopus 로고
    • Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells
    • Lane, J.D., Allan, V.J., Woodman, P.G. Active relocation of chromatin and endoplasmic reticulum into blebs in late apoptotic cells. J. Cell Sci. 2005, 118, 4059-4071.
    • (2005) J. Cell Sci , vol.118 , pp. 4059-4071
    • Lane, J.D.1    Allan, V.J.2    Woodman, P.G.3
  • 107
    • 0035072953 scopus 로고    scopus 로고
    • Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I
    • Coleman, M.L., Sahai, E.A., Yeo, M., Bosch, M., Dewar, A., Olson, M.F. Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I. Nat. Cell Biol. 2001, 3, 339-345.
    • (2001) Nat. Cell Biol , vol.3 , pp. 339-345
    • Coleman, M.L.1    Sahai, E.A.2    Yeo, M.3    Bosch, M.4    Dewar, A.5    Olson, M.F.6
  • 108
    • 0035075597 scopus 로고    scopus 로고
    • Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing
    • Sebbagh, M., Renvoize, C., Hamelin, J., Riche, N., Bertoglio, J., Breard, J. Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing. Nat. Cell Biol. 2001, 3, 346-352.
    • (2001) Nat. Cell Biol , vol.3 , pp. 346-352
    • Sebbagh, M.1    Renvoize, C.2    Hamelin, J.3    Riche, N.4    Bertoglio, J.5    Breard, J.6
  • 109
    • 33749233824 scopus 로고    scopus 로고
    • Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis
    • Chang, J., Xie, M., Shah, V.R., Schneider, M.D., Entman, M.L., Wei, L., Schwartz, R.J. Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. Proc. Natl. Acad. Sci. USA 2006, 103, 14495-14500.
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 14495-14500
    • Chang, J.1    Xie, M.2    Shah, V.R.3    Schneider, M.D.4    Entman, M.L.5    Wei, L.6    Schwartz, R.J.7
  • 111
    • 77950460749 scopus 로고    scopus 로고
    • Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells
    • Kinchen, J.M., Ravichandran, K.S. Identification of two evolutionarily conserved genes regulating processing of engulfed apoptotic cells. Nature 2010, 464, 778-782.
    • (2010) Nature , vol.464 , pp. 778-782
    • Kinchen, J.M.1    Ravichandran, K.S.2
  • 112
    • 84880758440 scopus 로고    scopus 로고
    • Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells
    • Suzuki, J., Denning, D.P., Imanishi, E., Horvitz, H.R., Nagata, S. Xk-related protein 8 and CED-8 promote phosphatidylserine exposure in apoptotic cells. Science 2013, 341, 403-406.
    • (2013) Science , vol.341 , pp. 403-406
    • Suzuki, J.1    Denning, D.P.2    Imanishi, E.3    Horvitz, H.R.4    Nagata, S.5
  • 113
    • 84901849205 scopus 로고    scopus 로고
    • Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure
    • Segawa, K., Kurata, S., Yanagihashi, Y., Brummelkamp, T.R., Matsuda, F., Nagata, S. Caspase-mediated cleavage of phospholipid flippase for apoptotic phosphatidylserine exposure. Science 2014, 344, 1164-1168.
    • (2014) Science , vol.344 , pp. 1164-1168
    • Segawa, K.1    Kurata, S.2    Yanagihashi, Y.3    Brummelkamp, T.R.4    Matsuda, F.5    Nagata, S.6
  • 114
    • 0033564620 scopus 로고    scopus 로고
    • Regulation of plasma membrane blebbing by the cytoskeleton
    • Hagmann, J., Burger, M.M., Dagan, D. Regulation of plasma membrane blebbing by the cytoskeleton. J. Cell. Biochem. 1999, 73, 488-499.
    • (1999) J. Cell. Biochem , vol.73 , pp. 488-499
    • Hagmann, J.1    Burger, M.M.2    Dagan, D.3
  • 117
    • 34247401712 scopus 로고    scopus 로고
    • Bridge over troubled water: Milk fat globule epidermal growth factor 8 promotes human monocyte-derived macrophage clearance of non-blebbing phosphatidylserine-positive target cells
    • Witasp, E., Uthaisang, W., Elenstrom-Magnusson, C., Hanayama, R., Tanaka, M., Nagata, S., Orrenius, S., Fadeel, B. Bridge over troubled water: Milk fat globule epidermal growth factor 8 promotes human monocyte-derived macrophage clearance of non-blebbing phosphatidylserine-positive target cells. Cell Death Differ. 2007, 14, 1063-1065.
    • (2007) Cell Death Differ , vol.14 , pp. 1063-1065
    • Witasp, E.1    Uthaisang, W.2    Elenstrom-Magnusson, C.3    Hanayama, R.4    Tanaka, M.5    Nagata, S.6    Orrenius, S.7    Fadeel, B.8
  • 118
    • 84928265432 scopus 로고    scopus 로고
    • Open source software for quantification of cell migration, protrusions, and fluorescence intensities
    • Barry, D.J., Durkin, C.H., Abella, J.V., Way, M. Open source software for quantification of cell migration, protrusions, and fluorescence intensities. J. Cell Biol. 2015, 209, 163-180.
    • (2015) J. Cell Biol , vol.209 , pp. 163-180
    • Barry, D.J.1    Durkin, C.H.2    Abella, J.V.3    Way, M.4
  • 119
    • 33750701767 scopus 로고    scopus 로고
    • Reassembly of contractile actin cortex in cell blebs
    • Charras, G.T., Hu, C.K., Coughlin, M., Mitchison, T.J. Reassembly of contractile actin cortex in cell blebs. J. Cell Biol. 2006, 175, 477-490.
    • (2006) J. Cell Biol , vol.175 , pp. 477-490
    • Charras, G.T.1    Hu, C.K.2    Coughlin, M.3    Mitchison, T.J.4
  • 120
    • 33745505525 scopus 로고    scopus 로고
    • A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation
    • Moss, D.K., Betin, V.M., Malesinski, S.D., Lane, J.D. A novel role for microtubules in apoptotic chromatin dynamics and cellular fragmentation. J. Cell Sci. 2006, 119, 2362-2374.
    • (2006) J. Cell Sci , vol.119 , pp. 2362-2374
    • Moss, D.K.1    Betin, V.M.2    Malesinski, S.D.3    Lane, J.D.4
  • 124
    • 68849129712 scopus 로고    scopus 로고
    • Membrane vesicles as conveyors of immune responses
    • Théry, C., Ostrowski, M., Segura, E. Membrane vesicles as conveyors of immune responses. Nat. Rev. Immunol. 2009, 9, 581-593.
    • (2009) Nat. Rev. Immunol , vol.9 , pp. 581-593
    • Théry, C.1    Ostrowski, M.2    Segura, E.3
  • 126
    • 84945429803 scopus 로고    scopus 로고
    • Rapid and comprehensive “shotgun” lipidome profiling of colorectal cancer cell derived exosomes
    • Lydic, T.A., Townsend, S., Adda, C.G., Collins, C., Mathivanan, S., Reid, G.E. Rapid and comprehensive “shotgun” lipidome profiling of colorectal cancer cell derived exosomes. Methods 2015, 87, 83-95.
    • (2015) Methods , vol.87 , pp. 83-95
    • Lydic, T.A.1    Townsend, S.2    Adda, C.G.3    Collins, C.4    Mathivanan, S.5    Reid, G.E.6
  • 129
    • 70350449455 scopus 로고    scopus 로고
    • ExoCarta: A compendium of exosomal proteins and RNA
    • Mathivanan, S., Simpson, R.J. ExoCarta: A compendium of exosomal proteins and RNA. Proteomics 2009, 9, 4997-5000.
    • (2009) Proteomics , vol.9 , pp. 4997-5000
    • Mathivanan, S.1    Simpson, R.J.2
  • 133
    • 76649094917 scopus 로고    scopus 로고
    • Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature
    • Mathivanan, S., Lim, J.W., Tauro, B.J., Ji, H., Moritz, R.L., Simpson, R.J. Proteomics analysis of A33 immunoaffinity-purified exosomes released from the human colon tumor cell line LIM1215 reveals a tissue-specific protein signature. Mol. Cell. Proteom. 2010, 9, 197-208.
    • (2010) Mol. Cell. Proteom , vol.9 , pp. 197-208
    • Mathivanan, S.1    Lim, J.W.2    Tauro, B.J.3    Ji, H.4    Moritz, R.L.5    Simpson, R.J.6
  • 134
    • 33846502114 scopus 로고    scopus 로고
    • Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies
    • Subra, C., Laulagnier, K., Perret, B., Record, M. Exosome lipidomics unravels lipid sorting at the level of multivesicular bodies. Biochimie 2007, 89, 205-212.
    • (2007) Biochimie , vol.89 , pp. 205-212
    • Subra, C.1    Laulagnier, K.2    Perret, B.3    Record, M.4
  • 140
    • 84892653021 scopus 로고    scopus 로고
    • CD169 mediates the capture of exosomes in spleen and lymph node
    • Saunderson, S.C., Dunn, A.C., Crocker, P.R., McLellan, A.D. CD169 mediates the capture of exosomes in spleen and lymph node. Blood 2014, 123, 208-216.
    • (2014) Blood , vol.123 , pp. 208-216
    • Saunderson, S.C.1    Dunn, A.C.2    Crocker, P.R.3    McLellan, A.D.4
  • 141
    • 43049139913 scopus 로고    scopus 로고
    • Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells
    • Al-Nedawi, K., Meehan, B., Micallef, J., Lhotak, V., May, L., Guha, A., Rak, J. Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat. Cell Biol. 2008, 10, 619-624.
    • (2008) Nat. Cell Biol , vol.10 , pp. 619-624
    • Al-Nedawi, K.1    Meehan, B.2    Micallef, J.3    Lhotak, V.4    May, L.5    Guha, A.6    Rak, J.7
  • 143
    • 84944445453 scopus 로고    scopus 로고
    • Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells—Evidence of unique microRNA cargos
    • Lunavat, T.R., Cheng, L., Kim, D.K., Bhadury, J., Jang, S.C., Lasser, C., Sharples, R.A., Lopez, M.D., Nilsson, J., Gho, Y.S., et al. Small RNA deep sequencing discriminates subsets of extracellular vesicles released by melanoma cells—Evidence of unique microRNA cargos. RNA Biol. 2015, 12, 810-823.
    • (2015) RNA Biol , vol.12 , pp. 810-823
    • Lunavat, T.R.1    Cheng, L.2    Kim, D.K.3    Bhadury, J.4    Jang, S.C.5    Lasser, C.6    Sharples, R.A.7    Lopez, M.D.8    Nilsson, J.9    Gho, Y.S.10
  • 144
    • 0037086034 scopus 로고    scopus 로고
    • Phospholipid composition of cell-derived microparticles determined by one-dimensional high-performance thin-layer chromatography
    • Weerheim, A.M., Kolb, A.M., Sturk, A., Nieuwland, R. Phospholipid composition of cell-derived microparticles determined by one-dimensional high-performance thin-layer chromatography. Anal. Biochem. 2002, 302, 191-198.
    • (2002) Anal. Biochem , vol.302 , pp. 191-198
    • Weerheim, A.M.1    Kolb, A.M.2    Sturk, A.3    Nieuwland, R.4
  • 146
    • 0032891440 scopus 로고    scopus 로고
    • Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: A role for apoptosis in plaque thrombogenicity
    • Mallat, Z., Hugel, B., Ohan, J., Leseche, G., Freyssinet, J.M., Tedgui, A. Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: A role for apoptosis in plaque thrombogenicity. Circulation 1999, 99, 348-353.
    • (1999) Circulation , vol.99 , pp. 348-353
    • Mallat, Z.1    Hugel, B.2    Ohan, J.3    Leseche, G.4    Freyssinet, J.M.5    Tedgui, A.6
  • 149
    • 84878629272 scopus 로고    scopus 로고
    • Proteomics, transcriptomics and lipidomics of exosomes and ectosomes
    • Choi, D.S., Kim, D.K., Kim, Y.K., Gho, Y.S. Proteomics, transcriptomics and lipidomics of exosomes and ectosomes. Proteomics 2013, 13, 1554-1571.
    • (2013) Proteomics , vol.13 , pp. 1554-1571
    • Choi, D.S.1    Kim, D.K.2    Kim, Y.K.3    Gho, Y.S.4
  • 150
    • 34249726598 scopus 로고    scopus 로고
    • Miniaturized asymmetrical flow field-flow fractionation: Application to biological vesicles
    • Oh, S., Kang, D., Ahn, S.M., Simpson, R.J., Lee, B.H., Moon, M.H. Miniaturized asymmetrical flow field-flow fractionation: Application to biological vesicles. J. Sep. Sci. 2007, 30, 1082-1087.
    • (2007) J. Sep. Sci , vol.30 , pp. 1082-1087
    • Oh, S.1    Kang, D.2    Ahn, S.M.3    Simpson, R.J.4    Lee, B.H.5    Moon, M.H.6
  • 151
    • 84937248650 scopus 로고    scopus 로고
    • Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes
    • Taylor, D.D., Shah, S. Methods of isolating extracellular vesicles impact down-stream analyses of their cargoes. Methods 2015, 87, 3-10.
    • (2015) Methods , vol.87 , pp. 3-10
    • Taylor, D.D.1    Shah, S.2
  • 154
    • 84858037808 scopus 로고    scopus 로고
    • Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes
    • Tauro, B.J., Greening, D.W., Mathias, R.A., Ji, H., Mathivanan, S., Scott, A.M., Simpson, R.J. Comparison of ultracentrifugation, density gradient separation, and immunoaffinity capture methods for isolating human colon cancer cell line LIM1863-derived exosomes. Methods 2012, 56, 293-304.
    • (2012) Methods , vol.56 , pp. 293-304
    • Tauro, B.J.1    Greening, D.W.2    Mathias, R.A.3    Ji, H.4    Mathivanan, S.5    Scott, A.M.6    Simpson, R.J.7
  • 157
    • 84928057135 scopus 로고    scopus 로고
    • Exosomes in bodily fluids are a highly stable resource of disease biomarkers
    • Boukouris, S., Mathivanan, S. Exosomes in bodily fluids are a highly stable resource of disease biomarkers. Proteom. Clin. Appl. 2015, 9, 358-367.
    • (2015) Proteom. Clin. Appl , vol.9 , pp. 358-367
    • Boukouris, S.1    Mathivanan, S.2
  • 158
    • 84906334565 scopus 로고    scopus 로고
    • Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: Apoptotic bodies, microvesicles, and exosomes
    • Lázaro-Ibáñez, E., Sanz-Garcia, A., Visakorpi, T., Escobedo-Lucea, C., Siljander, P., Ayuso-Sacido, A., Yliperttula, M. Different gDNA content in the subpopulations of prostate cancer extracellular vesicles: Apoptotic bodies, microvesicles, and exosomes. Prostate 2014, 74, 1379-1390.
    • (2014) Prostate , vol.74 , pp. 1379-1390
    • Lázaro-Ibáñez, E.1    Sanz-Garcia, A.2    Visakorpi, T.3    Escobedo-Lucea, C.4    Siljander, P.5    Ayuso-Sacido, A.6    Yliperttula, M.7
  • 159
    • 7244221520 scopus 로고    scopus 로고
    • Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro
    • Hristov, M., Erl, W., Linder, S., Weber, P.C. Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro. Blood 2004, 104, 2761-2766.
    • (2004) Blood , vol.104 , pp. 2761-2766
    • Hristov, M.1    Erl, W.2    Linder, S.3    Weber, P.C.4
  • 160
    • 50949128891 scopus 로고    scopus 로고
    • Discrimination between exosomes and HIV-1: Purification of both vesicles from cell-free supernatants
    • Cantin, R., Diou, J., Bélanger, D., Tremblay, A.M., Gilbert, C. Discrimination between exosomes and HIV-1: Purification of both vesicles from cell-free supernatants. J. Immunol. Methods 2008, 338, 21-30.
    • (2008) J. Immunol. Methods , vol.338 , pp. 21-30
    • Cantin, R.1    Diou, J.2    Bélanger, D.3    Tremblay, A.M.4    Gilbert, C.5
  • 161
    • 79251591623 scopus 로고    scopus 로고
    • Detection and isolation of cell-derived microparticles are compromised by protein complexes due to shared biophysical parameters
    • Gyorgy, B., Modos, K., Pallinger, E., Paloczi, K., Pasztoi, M., Misjak, P., Deli, M., Sipos, A., Szalai, A., Voszka, I., et al. Detection and isolation of cell-derived microparticles are compromised by protein complexes due to shared biophysical parameters. Blood 2011, 117, e39-e48.
    • (2011) Blood , vol.117 , pp. e39-e48
    • Gyorgy, B.1    Modos, K.2    Pallinger, E.3    Paloczi, K.4    Pasztoi, M.5    Misjak, P.6    Deli, M.7    Sipos, A.8    Szalai, A.9    Voszka, I.10
  • 162
    • 77957557995 scopus 로고    scopus 로고
    • Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome
    • Rood, I.M., Deegens, J.K., Merchant, M.L., Tamboer, W.P., Wilkey, D.W., Wetzels, J.F., Klein, J.B. Comparison of three methods for isolation of urinary microvesicles to identify biomarkers of nephrotic syndrome. Kidney Int. 2010, 78, 810-816.
    • (2010) Kidney Int , vol.78 , pp. 810-816
    • Rood, I.M.1    Deegens, J.K.2    Merchant, M.L.3    Tamboer, W.P.4    Wilkey, D.W.5    Wetzels, J.F.6    Klein, J.B.7
  • 166
    • 70350771238 scopus 로고    scopus 로고
    • The role of cbl family of ubiquitin ligases in gastric cancer exosome-induced apoptosis of Jurkat T cells
    • Qu, J.L., Qu, X.J., Zhao, M.F., Teng, Y.E., Zhang, Y., Hou, K.Z., Jiang, Y.H., Yang, X.H., Liu, Y.P. The role of cbl family of ubiquitin ligases in gastric cancer exosome-induced apoptosis of Jurkat T cells. Acta Oncol. 2009, 48, 1173-1180.
    • (2009) Acta Oncol , vol.48 , pp. 1173-1180
    • Qu, J.L.1    Qu, X.J.2    Zhao, M.F.3    Teng, Y.E.4    Zhang, Y.5    Hou, K.Z.6    Jiang, Y.H.7    Yang, X.H.8    Liu, Y.P.9
  • 167
    • 67349092235 scopus 로고    scopus 로고
    • Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes
    • Ochieng, J., Pratap, S., Khatua, A.K., Sakwe, A.M. Anchorage-independent growth of breast carcinoma cells is mediated by serum exosomes. Exp. Cell Res. 2009, 315, 1875-1888.
    • (2009) Exp. Cell Res , vol.315 , pp. 1875-1888
    • Ochieng, J.1    Pratap, S.2    Khatua, A.K.3    Sakwe, A.M.4
  • 168
    • 77953481684 scopus 로고    scopus 로고
    • Secretion of extracellular hsp90α via exosomes increases cancer cell motility: A role for plasminogen activation
    • McCready, J., Sims, J.D., Chan, D., Jay, D.G. Secretion of extracellular hsp90α via exosomes increases cancer cell motility: A role for plasminogen activation. BMC Cancer 2010, 10, 294.
    • (2010) BMC Cancer , vol.10 , pp. 294
    • McCready, J.1    Sims, J.D.2    Chan, D.3    Jay, D.G.4
  • 172
    • 74549132676 scopus 로고    scopus 로고
    • Exosomes derived from IL-12-anchored renal cancer cells increase induction of specific antitumor response in vitro: A novel vaccine for renal cell carcinoma
    • Zhang, Y., Luo, C.L., He, B.C., Zhang, J.M., Cheng, G., Wu, X.H. Exosomes derived from IL-12-anchored renal cancer cells increase induction of specific antitumor response in vitro: A novel vaccine for renal cell carcinoma. Int. J. Oncol. 2010, 36, 133-140.
    • (2010) Int. J. Oncol , vol.36 , pp. 133-140
    • Zhang, Y.1    Luo, C.L.2    He, B.C.3    Zhang, J.M.4    Cheng, G.5    Wu, X.H.6
  • 173
    • 43249087541 scopus 로고    scopus 로고
    • Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes
    • Sharples, R.A., Vella, L.J., Nisbet, R.M., Naylor, R., Perez, K., Barnham, K.J., Masters, C.L., Hill, A.F. Inhibition of gamma-secretase causes increased secretion of amyloid precursor protein C-terminal fragments in association with exosomes. FASEB J. 2008, 22, 1469-1478.
    • (2008) FASEB J , vol.22 , pp. 1469-1478
    • Sharples, R.A.1    Vella, L.J.2    Nisbet, R.M.3    Naylor, R.4    Perez, K.5    Barnham, K.J.6    Masters, C.L.7    Hill, A.F.8
  • 174
    • 84871118236 scopus 로고    scopus 로고
    • The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space
    • Perez-Gonzalez, R., Gauthier, S.A., Kumar, A., Levy, E. The exosome secretory pathway transports amyloid precursor protein carboxyl-terminal fragments from the cell into the brain extracellular space. J. Biol. Chem. 2012, 287, 43108-43115.
    • (2012) J. Biol. Chem , vol.287 , pp. 43108-43115
    • Perez-Gonzalez, R.1    Gauthier, S.A.2    Kumar, A.3    Levy, E.4
  • 177
    • 84909952796 scopus 로고    scopus 로고
    • ATP13A2/PARK9 regulates secretion of exosomes and alpha-synuclein
    • Tsunemi, T., Hamada, K., Krainc, D. ATP13A2/PARK9 regulates secretion of exosomes and alpha-synuclein. J. Neurosci. 2014, 34, 15281-15287.
    • (2014) J. Neurosci , vol.34 , pp. 15281-15287
    • Tsunemi, T.1    Hamada, K.2    Krainc, D.3
  • 179
    • 33747616431 scopus 로고    scopus 로고
    • Membrane-derived microvesicles: Important and underappreciated mediators of cell-to-cell communication
    • Ratajczak, J., Wysoczynski, M., Hayek, F., Janowska-Wieczorek, A., Ratajczak, M.Z. Membrane-derived microvesicles: Important and underappreciated mediators of cell-to-cell communication. Leukemia 2006, 20, 1487-1495.
    • (2006) Leukemia , vol.20 , pp. 1487-1495
    • Ratajczak, J.1    Wysoczynski, M.2    Hayek, F.3    Janowska-Wieczorek, A.4    Ratajczak, M.Z.5
  • 180
    • 84894273114 scopus 로고    scopus 로고
    • Epc-derived microvesicles protect cardiomyocytes from Ang II-induced hypertrophy and apoptosis
    • Gu, S., Zhang, W., Chen, J., Ma, R., Xiao, X., Ma, X., Yao, Z., Chen, Y. Epc-derived microvesicles protect cardiomyocytes from Ang II-induced hypertrophy and apoptosis. PLoS ONE 2014, 9, e85396.
    • (2014) Plos ONE , vol.9
    • Gu, S.1    Zhang, W.2    Chen, J.3    Ma, R.4    Xiao, X.5    Ma, X.6    Yao, Z.7    Chen, Y.8
  • 182
    • 44449087410 scopus 로고    scopus 로고
    • Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localized bone destruction
    • Kogianni, G., Mann, V., Noble, B.S. Apoptotic bodies convey activity capable of initiating osteoclastogenesis and localized bone destruction. J. Bone Miner. Res. 2008, 23, 915-927.
    • (2008) J. Bone Miner. Res. , vol.23 , pp. 915-927
    • Kogianni, G.1    Mann, V.2    Noble, B.S.3
  • 183
    • 67349172516 scopus 로고    scopus 로고
    • Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways
    • Jiang, J.X., Mikami, K., Venugopal, S., Li, Y., Torok, N.J. Apoptotic body engulfment by hepatic stellate cells promotes their survival by the JAK/STAT and Akt/NF-κB-dependent pathways. J. Hepatol. 2009, 51, 139-148.
    • (2009) J. Hepatol. , vol.51 , pp. 139-148
    • Jiang, J.X.1    Mikami, K.2    Venugopal, S.3    Li, Y.4    Torok, N.J.5
  • 187
    • 33746238574 scopus 로고    scopus 로고
    • Direct exosome stimulation of peripheral human T cells detected by ELISPOT
    • Admyre, C., Johansson, S.M., Paulie, S., Gabrielsson, S. Direct exosome stimulation of peripheral human T cells detected by ELISPOT. Eur. J. Immunol. 2006, 36, 1772-1781.
    • (2006) Eur. J. Immunol , vol.36 , pp. 1772-1781
    • Admyre, C.1    Johansson, S.M.2    Paulie, S.3    Gabrielsson, S.4
  • 190
    • 34548655590 scopus 로고    scopus 로고
    • CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo
    • Segura, E., Guerin, C., Hogg, N., Amigorena, S., Thery, C. CD8+ dendritic cells use LFA-1 to capture MHC-peptide complexes from exosomes in vivo. J. Immunol. 2007, 179, 1489-1496.
    • (2007) J. Immunol , vol.179 , pp. 1489-1496
    • Segura, E.1    Guerin, C.2    Hogg, N.3    Amigorena, S.4    Thery, C.5
  • 191
    • 0036906477 scopus 로고    scopus 로고
    • Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes
    • Théry, C., Duban, L., Segura, E., Veron, P., Lantz, O., Amigorena, S. Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Nat. Immunol. 2002, 3, 1156-1162.
    • (2002) Nat. Immunol , vol.3 , pp. 1156-1162
    • Théry, C.1    Duban, L.2    Segura, E.3    Veron, P.4    Lantz, O.5    Amigorena, S.6
  • 192
    • 63149192294 scopus 로고    scopus 로고
    • Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomes
    • Walker, J.D., Maier, C.L., Pober, J.S. Cytomegalovirus-infected human endothelial cells can stimulate allogeneic CD4+ memory T cells by releasing antigenic exosomes. J. Immunol. 2009, 182, 1548-1559.
    • (2009) J. Immunol , vol.182 , pp. 1548-1559
    • Walker, J.D.1    Maier, C.L.2    Pober, J.S.3
  • 193
    • 49249091823 scopus 로고    scopus 로고
    • Bovis BCG infected macrophages activate antigen-specific CD4+ and CD8+ T cells in vitro and in vivo
    • Giri, P.K., Schorey, J.S. Exosomes derived from M. Bovis BCG infected macrophages activate antigen-specific CD4+ and CD8+ T cells in vitro and in vivo. PLoS ONE 2008, 3, e2461.
    • (2008) Plos ONE , vol.3
    • Giri, P.K.1    Schorey, J.S.2    Exosomes Derived From, M.3
  • 194
    • 40149107541 scopus 로고    scopus 로고
    • B lymphocytes and macrophages release cell membrane deposited C3-fragments on exosomes with T cell response-enhancing capacity
    • Papp, K., Vegh, P., Prechl, J., Kerekes, K., Kovacs, J., Csikos, G., Bajtay, Z., Erdei, A. B lymphocytes and macrophages release cell membrane deposited C3-fragments on exosomes with T cell response-enhancing capacity. Mol. Immunol. 2008, 45, 2343-2351.
    • (2008) Mol. Immunol , vol.45 , pp. 2343-2351
    • Papp, K.1    Vegh, P.2    Prechl, J.3    Kerekes, K.4    Kovacs, J.5    Csikos, G.6    Bajtay, Z.7    Erdei, A.8
  • 195
    • 34948874323 scopus 로고    scopus 로고
    • T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes
    • Muntasell, A., Berger, A.C., Roche, P.A. T cell-induced secretion of MHC class II-peptide complexes on B cell exosomes. EMBO J. 2007, 26, 4263-4272.
    • (2007) EMBO J , vol.26 , pp. 4263-4272
    • Muntasell, A.1    Berger, A.C.2    Roche, P.A.3
  • 196
    • 28244488762 scopus 로고    scopus 로고
    • Tolerosome-induced oral tolerance is MHC dependent
    • Ostman, S., Taube, M., Telemo, E. Tolerosome-induced oral tolerance is MHC dependent. Immunology 2005, 116, 464-476.
    • (2005) Immunology , vol.116 , pp. 464-476
    • Ostman, S.1    Taube, M.2    Telemo, E.3
  • 197
    • 0037443410 scopus 로고    scopus 로고
    • Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo
    • Skokos, D., Botros, H.G., Demeure, C., Morin, J., Peronet, R., Birkenmeier, G., Boudaly, S., Mecheri, S. Mast cell-derived exosomes induce phenotypic and functional maturation of dendritic cells and elicit specific immune responses in vivo. J. Immunol. 2003, 170, 3037-3045.
    • (2003) J. Immunol , vol.170 , pp. 3037-3045
    • Skokos, D.1    Botros, H.G.2    Demeure, C.3    Morin, J.4    Peronet, R.5    Birkenmeier, G.6    Boudaly, S.7    Mecheri, S.8
  • 198
    • 84896818399 scopus 로고    scopus 로고
    • Regulation of immune responses by extracellular vesicles
    • Robbins, P.D., Morelli, A.E. Regulation of immune responses by extracellular vesicles. Nat. Rev. Immunol. 2014, 14, 195-208.
    • (2014) Nat. Rev. Immunol , vol.14 , pp. 195-208
    • Robbins, P.D.1    Morelli, A.E.2
  • 199
    • 0030702085 scopus 로고    scopus 로고
    • The exosome: A conserved eukaryotic RNA processing complex containing multiple 3′→5′ exoribonucleases
    • Mitchell, P., Petfalski, E., Shevchenko, A., Mann, M., Tollervey, D. The exosome: A conserved eukaryotic RNA processing complex containing multiple 3′→5′ exoribonucleases. Cell 1997, 91, 457-466.
    • (1997) Cell , vol.91 , pp. 457-466
    • Mitchell, P.1    Petfalski, E.2    Shevchenko, A.3    Mann, M.4    Tollervey, D.5
  • 200
    • 84876729225 scopus 로고    scopus 로고
    • Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection
    • Takahashi, Y., Nishikawa, M., Shinotsuka, H., Matsui, Y., Ohara, S., Imai, T., Takakura, Y. Visualization and in vivo tracking of the exosomes of murine melanoma B16-BL6 cells in mice after intravenous injection. J. Biotechnol. 2013, 165, 77-84.
    • (2013) J. Biotechnol , vol.165 , pp. 77-84
    • Takahashi, Y.1    Nishikawa, M.2    Shinotsuka, H.3    Matsui, Y.4    Ohara, S.5    Imai, T.6    Takakura, Y.7
  • 201
    • 84922895759 scopus 로고    scopus 로고
    • Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice
    • Morishita, M., Takahashi, Y., Nishikawa, M., Sano, K., Kato, K., Yamashita, T., Imai, T., Saji, H., Takakura, Y. Quantitative analysis of tissue distribution of the B16BL6-derived exosomes using a streptavidin-lactadherin fusion protein and iodine-125-labeled biotin derivative after intravenous injection in mice. J. Pharm. Sci. 2015, 104, 705-713.
    • (2015) J. Pharm. Sci. , vol.104 , pp. 705-713
    • Morishita, M.1    Takahashi, Y.2    Nishikawa, M.3    Sano, K.4    Kato, K.5    Yamashita, T.6    Imai, T.7    Saji, H.8    Takakura, Y.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.