Hypoxic exosomes promote angiogenesis

Blood

Volumn 124, Issue 25, 2014, Pages 3669-3670

  Fan, Guo Chang ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MICRORNA; MICRORNA 135B; MICRORNA 210; UNCLASSIFIED DRUG; HIF1AN PROTEIN, HUMAN; MIRN135 MICRORNA, HUMAN; MIXED FUNCTION OXIDASE; REPRESSOR PROTEIN;

ANGIOGENESIS; CELL COMMUNICATION; CELL HYPOXIA; EXOSOME; HUMAN; MULTIPLE MYELOMA; NOTE; UMBILICAL VEIN ENDOTHELIAL CELL; UPREGULATION; GENETICS; NEOVASCULARIZATION (PATHOLOGY);

EXOSOMES; HUMANS; MICRORNAS; MIXED FUNCTION OXYGENASES; NEOVASCULARIZATION, PATHOLOGIC; REPRESSOR PROTEINS;

EID: 84919680929     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2014-10-607846     Document Type: Note

References (10)

1. Umezu T, Tadokoro H, Azuma K, Yoshizawa S, Ohyashiki K, Ohyashiki JH. Exosomal miR-135b shed from hypoxic multiple myeloma cells enhances angiogenesis by targeting factor-inhibiting HIF-1. Blood. 2014;124(25):3748-3757.
2. Landgren O, Kyle RA, Pfeiffer RM, et al. Monoclonal gammopathy of undetermined significance (MGUS) consistently precedes multiple myeloma: a prospective study. Blood. 2009;113(22):5412-5417.
3. Palumbo A, Cavallo F. Have drug combinations supplanted stem cell transplantation in myeloma? Blood. 2012;120(24):4692-4698.
4. Ghobrial IM. Myeloma as a model for the process of metastasis: implications for therapy. Blood. 2012;120(1):20-30.
5. Ribeiro MF, Zhu H, Millard RW, Fan GC. Exosomes function in pro- and anti-angiogenesis. Current Angiogenesis. 2013;2:54-59.
6. Inal JM, Kosgodage U, Azam S, et al. Blood/plasma secretome and microvesicles. Biochim Biophys Acta. 2013;1834:2317-2325.
7. Wang X, Huang W, Liu G, et al. Cardiomyocytes mediate anti-angiogenesis in type 2 diabetic rats through the exosomal transfer of miR-320 into endothelial cells. J Mol Cell Cardiol. 2014;74:139-150.
8. Kucharzewska P, Christianson HC, Welch JE, et al. Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development. Proc Natl Acad Sci USA. 2013;110(18):7312-7317.
9. Ismail N, Wang Y, Dakhlallah D, et al. Macrophage microvesicles induce macrophage differentiation and miR-223 transfer. Blood. 2013;121(6):984-995.
10. Montecalvo A, Larregina AT, Shufesky WJ, et al. Mechanism of transfer of functional microRNAs between mouse dendritic cells via exosomes. Blood. 2012;119(3):756-766.