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Volumn 3, Issue 4, 2014, Pages

Secretory pathways generating immunosuppressive NKG2D ligands: New targets for therapeutic intervention

Author keywords

Exosomes; NKG2D; NKs; Shedding; Soluble NKG2D ligands

Indexed keywords

ANTINEOPLASTIC AGENT; BATIMASTAT; BINDING PROTEIN; DOXORUBICIN; EPIRUBICIN; ERP5 PROTEIN; GI 254023X; GLUCOSE REGULATED PROTEIN 78; GW 280264X; HLA A ANTIGEN; HLA B ANTIGEN; ISOMERASE; LYMPHOCYTE RECEPTOR; MATRIX METALLOPROTEINASE INHIBITOR; METALLOPROTEINASE; NATURAL KILLER CELL RECEPTOR NKG2D; NATURAL KILLER GROUP 2 MEMBER D LIGAND; SORAFENIB; UL 16 BINDING PROTEIN 2; UNCLASSIFIED DRUG; VALPROIC ACID;

EID: 84902579112     PISSN: 21624011     EISSN: 2162402X     Source Type: Journal    
DOI: 10.4161/onci.28497     Document Type: Review
Times cited : (72)

References (80)
  • 1
    • 20844458666 scopus 로고    scopus 로고
    • Immunobiology of human NKG2D and its ligands
    • PMID:16329186
    • González S, Groh V, Spies T. Immunobiology of human NKG2D and its ligands. Curr Top Microbiol Immunol 2006; 298:121-38; PMID:16329186; http://dx.doi.org/10.1007/3-540-27743-9_6
    • (2006) Curr Top Microbiol Immunol , vol.298 , pp. 121-138
    • González, S.1    Groh, V.2    Spies, T.3
  • 3
    • 70449368140 scopus 로고    scopus 로고
    • ULBP6/RAET1L is an additional human NKG2D ligand
    • PMID:19658097
    • Eagle RA, Traherne JA, Hair JR, Jafferji I, Trowsdale J. ULBP6/RAET1L is an additional human NKG2D ligand. Eur J Immunol 2009; 39:3207-16; http://dx.doi.org/10.1002/eji.200939502; PMID:19658097
    • (2009) Eur J Immunol , vol.39 , pp. 3207-3216
    • Eagle, R.A.1    Traherne, J.A.2    Hair, J.R.3    Jafferji, I.4    Trowsdale, J.5
  • 4
    • 84900346239 scopus 로고    scopus 로고
    • New prospects on the NKG2D/NKG2DL system for oncology
    • PMID:24353908
    • Ullrich E, Koch J, Cerwenka A, Steinle A. New prospects on the NKG2D/NKG2DL system for oncology. Oncoimmunology 2013; 2:e26097; PMID:24353908; http://dx.doi.org/10.4161/onci.26097
    • (2013) Oncoimmunology , vol.2
    • Ullrich, E.1    Koch, J.2    Cerwenka, A.3    Steinle, A.4
  • 5
    • 84875509728 scopus 로고    scopus 로고
    • Regulation of ligands for the NKG2D activating receptor
    • PMID:23298206
    • Raulet DH, Gasser S, Gowen BG, Deng W, Jung H. Regulation of ligands for the NKG2D activating receptor. Annu Rev Immunol 2013; 31:413-41; http://dx.doi.org/10.1146/annurevimmunol-032712-095951; PMID:23298206
    • (2013) Annu Rev Immunol , vol.31 , pp. 413-441
    • Raulet, D.H.1    Gasser, S.2    Gowen, B.G.3    Deng, W.4    Jung, H.5
  • 6
    • 84855906694 scopus 로고    scopus 로고
    • Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D
    • PMID:22102694
    • Heinemann A, Zhao F, Pechlivanis S, Eberle J, Steinle A, Diederichs S, Schadendorf D, Paschen A. Tumor suppressive microRNAs miR-34a/c control cancer cell expression of ULBP2, a stress-induced ligand of the natural killer cell receptor NKG2D. Cancer Res 2012; 72:460-71; http://dx.doi.org/10.1158/0008-5472.CAN-11-1977; PMID:22102694
    • (2012) Cancer Res , vol.72 , pp. 460-471
    • Heinemann, A.1    Zhao, F.2    Pechlivanis, S.3    Eberle, J.4    Steinle, A.5    Diederichs, S.6    Schadendorf, D.7    Paschen, A.8
  • 8
    • 40349108462 scopus 로고    scopus 로고
    • Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance
    • PMID:18223157
    • Unni AM, Bondar T, Medzhitov R. Intrinsic sensor of oncogenic transformation induces a signal for innate immunosurveillance. Proc Natl Acad Sci U S A 2008; 105:1686-91; http://dx.doi.org/10.1073/pnas.0701675105; PMID:18223157
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 1686-1691
    • Unni, A.M.1    Bondar, T.2    Medzhitov, R.3
  • 9
    • 84871915611 scopus 로고    scopus 로고
    • RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry
    • PMID:23166357
    • Jung H, Hsiung B, Pestal K, Procyk E, Raulet DH. RAE-1 ligands for the NKG2D receptor are regulated by E2F transcription factors, which control cell cycle entry. J Exp Med 2012; 209:2409-22; http://dx.doi.org/10.1084/jem.20120565; PMID:23166357
    • (2012) J Exp Med , vol.209 , pp. 2409-2422
    • Jung, H.1    Hsiung, B.2    Pestal, K.3    Procyk, E.4    Raulet, D.H.5
  • 11
    • 0036829733 scopus 로고    scopus 로고
    • Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2Ddependent natural killer cell cytotoxicity
    • PMID:12414645
    • Pende D, Rivera P, Marcenaro S, Chang CC, Biassoni R, Conte R, Kubin M, Cosman D, Ferrone S, Moretta L, et al. Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2Ddependent natural killer cell cytotoxicity. Cancer Res 2002; 62:6178-86; PMID:12414645
    • (2002) Cancer Res , vol.62 , pp. 6178-6186
    • Pende, D.1    Rivera, P.2    Marcenaro, S.3    Chang, C.C.4    Biassoni, R.5    Conte, R.6    Kubin, M.7    Cosman, D.8    Ferrone, S.9    Moretta, L.10
  • 13
  • 14
    • 33749234357 scopus 로고    scopus 로고
    • TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells
    • PMID:16891318
    • Eisele G, Wischhusen J, Mittelbronn M, Meyermann R, Waldhauer I, Steinle A, Weller M, Friese MA. TGF-beta and metalloproteinases differentially suppress NKG2D ligand surface expression on malignant glioma cells. Brain 2006; 129:2416-25; PMID:16891318; http://dx.doi.org/10.1093/brain/awl205
    • (2006) Brain , vol.129 , pp. 2416-2425
    • Eisele, G.1    Wischhusen, J.2    Mittelbronn, M.3    Meyermann, R.4    Waldhauer, I.5    Steinle, A.6    Weller, M.7    Friese, M.A.8
  • 15
    • 61449083795 scopus 로고    scopus 로고
    • Interferon-gamma downregulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells
    • PMID:19089914
    • Schwinn N, Vokhminova D, Sucker A, Textor S, Striegel S, Moll I, Nausch N, Tuettenberg J, Steinle A, Cerwenka A, et al. Interferon-gamma downregulates NKG2D ligand expression and impairs the NKG2D-mediated cytolysis of MHC class I-deficient melanoma by natural killer cells. Int J Cancer 2009; 124:1594-604; http://dx.doi.org/10.1002/ijc.24098; PMID:19089914
    • (2009) Int J Cancer , vol.124 , pp. 1594-1604
    • Schwinn, N.1    Vokhminova, D.2    Sucker, A.3    Textor, S.4    Striegel, S.5    Moll, I.6    Nausch, N.7    Tuettenberg, J.8    Steinle, A.9    Cerwenka, A.10
  • 16
    • 79955761733 scopus 로고    scopus 로고
    • Post-transcriptional regulation of ULBP1 ligand for the activating immunoreceptor NKG2D involves 3′ untranslated region
    • PMID:21406206
    • Himmelreich H, Mathys A, Wodnar-Filipowicz A, Kalberer CP. Post-transcriptional regulation of ULBP1 ligand for the activating immunoreceptor NKG2D involves 3′ untranslated region. Hum Immunol 2011; 72:470-8; http://dx.doi.org/10.1016/j.humimm.2011.03.005; PMID:21406206
    • (2011) Hum Immunol , vol.72 , pp. 470-478
    • Himmelreich, H.1    Mathys, A.2    Wodnar-Filipowicz, A.3    Kalberer, C.P.4
  • 17
    • 77955928100 scopus 로고    scopus 로고
    • The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination
    • PMID:20694010
    • Nachmani D, Lankry D, Wolf DG, Mandelboim O. The human cytomegalovirus microRNA miR-UL112 acts synergistically with a cellular microRNA to escape immune elimination. Nat Immunol 2010; 11:806-13; http://dx.doi.org/10.1038/ni.1916; PMID:20694010
    • (2010) Nat Immunol , vol.11 , pp. 806-813
    • Nachmani, D.1    Lankry, D.2    Wolf, D.G.3    Mandelboim, O.4
  • 19
    • 59849122968 scopus 로고    scopus 로고
    • Cutting edge: down-regulation of MHC class I-related chain A on tumor cells by IFN-gammainduced microRNA
    • PMID:19109132
    • Yadav D, Ngolab J, Lim RS, Krishnamurthy S, Bui JD. Cutting edge: down-regulation of MHC class I-related chain A on tumor cells by IFN-gammainduced microRNA. J Immunol 2009; 182:39-43; PMID:19109132; http://dx.doi.org/10.4049/jimmunol.182.1.39
    • (2009) J Immunol , vol.182 , pp. 39-43
    • Yadav, D.1    Ngolab, J.2    Lim, R.S.3    Krishnamurthy, S.4    Bui, J.D.5
  • 20
    • 84868246872 scopus 로고    scopus 로고
    • MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells
    • PMID:22915757
    • Tsukerman P, Stern-Ginossar N, Gur C, Glasner A, Nachmani D, Bauman Y, Yamin R, Vitenshtein A, Stanietsky N, Bar-Mag T, et al. MiR-10b downregulates the stress-induced cell surface molecule MICB, a critical ligand for cancer cell recognition by natural killer cells. Cancer Res 2012; 72:5463-72; http://dx.doi.org/10.1158/0008-5472.CAN-11-2671; PMID:22915757
    • (2012) Cancer Res , vol.72 , pp. 5463-5472
    • Tsukerman, P.1    Stern-Ginossar, N.2    Gur, C.3    Glasner, A.4    Nachmani, D.5    Bauman, Y.6    Yamin, R.7    Vitenshtein, A.8    Stanietsky, N.9    Bar-Mag, T.10
  • 21
    • 84856841046 scopus 로고    scopus 로고
    • 2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation
    • PMID:22227571
    • Andresen L, Skovbakke SL, Persson G, Hagemann-Jensen M, Hansen KA, Jensen H, Skov S. 2-deoxy D-glucose prevents cell surface expression of NKG2D ligands through inhibition of N-linked glycosylation. J Immunol 2012; 188:1847-55; http://dx.doi.org/10.4049/jimmunol.1004085; PMID:22227571
    • (2012) J Immunol , vol.188 , pp. 1847-1855
    • Andresen, L.1    Skovbakke, S.L.2    Persson, G.3    Hagemann-Jensen, M.4    Hansen, K.A.5    Jensen, H.6    Skov, S.7
  • 23
    • 33746585232 scopus 로고    scopus 로고
    • Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function
    • PMID:16849432
    • Roda-Navarro P, Vales-Gomez M, Chisholm SE, Reyburn HT. Transfer of NKG2D and MICB at the cytotoxic NK cell immune synapse correlates with a reduction in NK cell cytotoxic function. Proc Natl Acad Sci U S A 2006; 103:11258-63; PMID:16849432; http://dx.doi.org/10.1073/pnas.0600721103
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 11258-11263
    • Roda-Navarro, P.1    Vales-Gomez, M.2    Chisholm, S.E.3    Reyburn, H.T.4
  • 24
    • 68249104197 scopus 로고    scopus 로고
    • Tumourexperienced T cells promote NK cell activity through trogocytosis of NKG2D and NKp46 ligands
    • PMID:19498463
    • Domaica CI, Fuertes MB, Rossi LE, Girart MV, Avila DE, Rabinovich GA, Zwirner NW. Tumourexperienced T cells promote NK cell activity through trogocytosis of NKG2D and NKp46 ligands. EMBO Rep 2009; 10:908-15; http://dx.doi.org/10.1038/embor.2009.92; PMID:19498463
    • (2009) EMBO Rep , vol.10 , pp. 908-915
    • Domaica, C.I.1    Fuertes, M.B.2    Rossi, L.E.3    Girart, M.V.4    Avila, D.E.5    Rabinovich, G.A.6    Zwirner, N.W.7
  • 25
    • 0037108517 scopus 로고    scopus 로고
    • Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding
    • PMID:12370336
    • Salih HR, Rammensee HG, Steinle A. Cutting edge: down-regulation of MICA on human tumors by proteolytic shedding. J Immunol 2002; 169:4098-102; PMID:12370336; http://dx.doi.org/10.4049/jimmunol.169.8.4098
    • (2002) J Immunol , vol.169 , pp. 4098-4102
    • Salih, H.R.1    Rammensee, H.G.2    Steinle, A.3
  • 26
    • 0041737499 scopus 로고    scopus 로고
    • Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia
    • PMID:12714493
    • Salih HR, Antropius H, Gieseke F, Lutz SZ, Kanz L, Rammensee HG, Steinle A. Functional expression and release of ligands for the activating immunoreceptor NKG2D in leukemia. Blood 2003; 102:1389-96; PMID:12714493; http://dx.doi.org/10.1182/blood-2003-01-0019
    • (2003) Blood , vol.102 , pp. 1389-1396
    • Salih, H.R.1    Antropius, H.2    Gieseke, F.3    Lutz, S.Z.4    Kanz, L.5    Rammensee, H.G.6    Steinle, A.7
  • 27
    • 84864131272 scopus 로고    scopus 로고
    • Comprehensive analysis of NKG2D ligand expression and release in leukemia: implications for NKG2D-mediated NK cell responses
    • PMID:22730533
    • Hilpert J, Grosse-Hovest L, Grünebach F, Buechele C, Nuebling T, Raum T, Steinle A, Salih HR. Comprehensive analysis of NKG2D ligand expression and release in leukemia: implications for NKG2D-mediated NK cell responses. J Immunol 2012; 189:1360-71; http://dx.doi.org/10.4049/jimmunol.1200796; PMID:22730533
    • (2012) J Immunol , vol.189 , pp. 1360-1371
    • Hilpert, J.1    Grosse-Hovest, L.2    Grünebach, F.3    Buechele, C.4    Nuebling, T.5    Raum, T.6    Steinle, A.7    Salih, H.R.8
  • 31
    • 84866385963 scopus 로고    scopus 로고
    • Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma
    • PMID:23024757
    • Kumar V, Yi Lo PH, Sawai H, Kato N, Takahashi A, Deng Z, Urabe Y, Mbarek H, Tokunaga K, Tanaka Y, et al. Soluble MICA and a MICA variation as possible prognostic biomarkers for HBV-induced hepatocellular carcinoma. PLoS One 2012; 7:e44743; PMID:23024757; http://dx.doi.org/10.1371/journal.pone.0044743
    • (2012) PLoS One , vol.7
    • Kumar, V.1    Yi Lo, P.H.2    Sawai, H.3    Kato, N.4    Takahashi, A.5    Deng, Z.6    Urabe, Y.7    Mbarek, H.8    Tokunaga, K.9    Tanaka, Y.10
  • 32
    • 79960333930 scopus 로고    scopus 로고
    • Clinical significance of the immunostimulatory MHC class I chain-related molecule A and NKG2D receptor on NK cells in pancreatic cancer
    • PMID:20354827
    • Duan X, Deng L, Chen X, Lu Y, Zhang Q, Zhang K, Hu Y, Zeng J, Sun W. Clinical significance of the immunostimulatory MHC class I chain-related molecule A and NKG2D receptor on NK cells in pancreatic cancer. Med Oncol 2011; 28:466-74; http://dx.doi.org/10.1007/s12032-010-9480-9; PMID:20354827
    • (2011) Med Oncol , vol.28 , pp. 466-474
    • Duan, X.1    Deng, L.2    Chen, X.3    Lu, Y.4    Zhang, Q.5    Zhang, K.6    Hu, Y.7    Zeng, J.8    Sun, W.9
  • 33
    • 80051803606 scopus 로고    scopus 로고
    • Clinical significance of serum levels of immune-associated molecules, uric acid and soluble MHC class I chain-related molecules A and B, as diagnostic tumor markers for pancreatic ductal adenocarcinoma
    • PMID:21615621
    • Chung HW, Lim JB. Clinical significance of serum levels of immune-associated molecules, uric acid and soluble MHC class I chain-related molecules A and B, as diagnostic tumor markers for pancreatic ductal adenocarcinoma. Cancer Sci 2011; 102:1673-9; http://dx.doi.org/10.1111/j.1349-7006.2011.01989.x; PMID:21615621
    • (2011) Cancer Sci , vol.102 , pp. 1673-1679
    • Chung, H.W.1    Lim, J.B.2
  • 35
    • 69349104067 scopus 로고    scopus 로고
    • Differential clinical significance of individual NKG2D ligands in melanoma: soluble ULBP2 as an indicator of poor prognosis superior to S100B
    • PMID:19671853
    • Paschen A, Sucker A, Hill B, Moll I, Zapatka M, Nguyen XD, Sim GC, Gutmann I, Hassel J, Becker JC, et al. Differential clinical significance of individual NKG2D ligands in melanoma: soluble ULBP2 as an indicator of poor prognosis superior to S100B. Clin Cancer Res 2009; 15:5208-15; http://dx.doi.org/10.1158/1078-0432.CCR-09-0886; PMID:19671853
    • (2009) Clin Cancer Res , vol.15 , pp. 5208-5215
    • Paschen, A.1    Sucker, A.2    Hill, B.3    Moll, I.4    Zapatka, M.5    Nguyen, X.D.6    Sim, G.C.7    Gutmann, I.8    Hassel, J.9    Becker, J.C.10
  • 39
    • 84872785819 scopus 로고    scopus 로고
    • Serum soluble MICB (sMICB) correlates with disease progression and survival in melanoma patients
    • PMID:23150178
    • Wu BJ, Li WP, Qian C, Ding W, Zhou ZW, Jiang H. Serum soluble MICB (sMICB) correlates with disease progression and survival in melanoma patients. Tumour Biol 2013; 34:565-9; http://dx.doi.org/10.1007/s13277-012-0582-1; PMID:23150178
    • (2013) Tumour Biol , vol.34 , pp. 565-569
    • Wu, B.J.1    Li, W.P.2    Qian, C.3    Ding, W.4    Zhou, Z.W.5    Jiang, H.6
  • 40
    • 27744566433 scopus 로고    scopus 로고
    • Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas
    • PMID:16168521
    • Jinushi M, Takehara T, Tatsumi T, Hiramatsu N, Sakamori R, Yamaguchi S, Hayashi N. Impairment of natural killer cell and dendritic cell functions by the soluble form of MHC class I-related chain A in advanced human hepatocellular carcinomas. J Hepatol 2005; 43:1013-20; PMID:16168521; http://dx.doi.org/10.1016/j.jhep.2005.05.026
    • (2005) J Hepatol , vol.43 , pp. 1013-1020
    • Jinushi, M.1    Takehara, T.2    Tatsumi, T.3    Hiramatsu, N.4    Sakamori, R.5    Yamaguchi, S.6    Hayashi, N.7
  • 41
    • 33947180394 scopus 로고    scopus 로고
    • Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients
    • PMID:17218152
    • Rebmann V, Schütt P, Brandhorst D, Opalka B, Moritz T, Nowrousian MR, Grosse-Wilde H. Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients. Clin Immunol 2007; 123:114-20; PMID:17218152; http://dx.doi.org/10.1016/j.clim.2006.11.007
    • (2007) Clin Immunol , vol.123 , pp. 114-120
    • Rebmann, V.1    Schütt, P.2    Brandhorst, D.3    Opalka, B.4    Moritz, T.5    Nowrousian, M.R.6    Grosse-Wilde, H.7
  • 42
    • 34547132338 scopus 로고    scopus 로고
    • RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity
    • PMID:17470428
    • Cao W, Xi X, Hao Z, Li W, Kong Y, Cui L, Ma C, Ba D, He W. RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity. J Biol Chem 2007; 282:18922-8; PMID:17470428; http://dx.doi.org/10.1074/jbc.M702504200
    • (2007) J Biol Chem , vol.282 , pp. 18922-18928
    • Cao, W.1    Xi, X.2    Hao, Z.3    Li, W.4    Kong, Y.5    Cui, L.6    Ma, C.7    Ba, D.8    He, W.9
  • 45
    • 84860641102 scopus 로고    scopus 로고
    • The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?
    • PMID:21906355
    • Duffy MJ, Mullooly M, O'Donovan N, Sukor S, Crown J, Pierce A, McGowan PM. The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer? Clin Proteomics 2011; 8:9; http://dx.doi.org/10.1186/1559-0275-8-9; PMID:21906355
    • (2011) Clin Proteomics , vol.8 , Issue.9
    • Duffy, M.J.1    Mullooly, M.2    O'Donovan, N.3    Sukor, S.4    Crown, J.5    Pierce, A.6    McGowan, P.M.7
  • 47
    • 79955745583 scopus 로고    scopus 로고
    • MMP9 mediates MICA shedding in human osteosarcomas
    • PMID:21143201
    • Sun D, Wang X, Zhang H, Deng L, Zhang Y. MMP9 mediates MICA shedding in human osteosarcomas. Cell Biol Int 2011; 35:569-74; http://dx.doi.org/10.1042/CBI20100431; PMID:21143201
    • (2011) Cell Biol Int , vol.35 , pp. 569-574
    • Sun, D.1    Wang, X.2    Zhang, H.3    Deng, L.4    Zhang, Y.5
  • 48
    • 84866443923 scopus 로고    scopus 로고
    • Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells
    • PMID:22923031
    • Yamanegi K, Yamane J, Kobayashi K, Ohyama H, Nakasho K, Yamada N, Hata M, Fukunaga S, Futani H, Okamura H, et al. Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells. Oncol Rep 2012; 28:1585-90; http://dx.doi.org/10.3892/or.2012.1981; PMID:22923031
    • (2012) Oncol Rep , vol.28 , pp. 1585-1590
    • Yamanegi, K.1    Yamane, J.2    Kobayashi, K.3    Ohyama, H.4    Nakasho, K.5    Yamada, N.6    Hata, M.7    Fukunaga, S.8    Futani, H.9    Okamura, H.10
  • 49
    • 10344255835 scopus 로고    scopus 로고
    • TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells
    • PMID:15492828
    • Kim ES, Kim MS, Moon A. TGF-beta-induced upregulation of MMP-2 and MMP-9 depends on p38 MAPK, but not ERK signaling in MCF10A human breast epithelial cells. Int J Oncol 2004; 25:1375-82; PMID:15492828
    • (2004) Int J Oncol , vol.25 , pp. 1375-1382
    • Kim, E.S.1    Kim, M.S.2    Moon, A.3
  • 50
    • 77951629654 scopus 로고    scopus 로고
    • The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases
    • PMID:20208009
    • Liu G, Atteridge CL, Wang X, Lundgren AD, Wu JD. The membrane type matrix metalloproteinase MMP14 mediates constitutive shedding of MHC class I chain-related molecule A independent of A disintegrin and metalloproteinases. J Immunol 2010; 184:3346-50; http://dx.doi.org/10.4049/jimmunol.0903789; PMID:20208009
    • (2010) J Immunol , vol.184 , pp. 3346-3350
    • Liu, G.1    Atteridge, C.L.2    Wang, X.3    Lundgren, A.D.4    Wu, J.D.5
  • 51
    • 84880273084 scopus 로고    scopus 로고
    • Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17
    • PMID:23526433
    • Chitadze G, Lettau M, Bhat J, Wesch D, Steinle A, Fürst D, Mytilineos J, Kalthoff H, Janssen O, Oberg HH, et al. Shedding of endogenous MHC class I-related chain molecules A and B from different human tumor entities: heterogeneous involvement of the "a disintegrin and metalloproteases" 10 and 17. Int J Cancer 2013; 133:1557-66; http://dx.doi.org/10.1002/ijc.28174; PMID:23526433
    • (2013) Int J Cancer , vol.133 , pp. 1557-1566
    • Chitadze, G.1    Lettau, M.2    Bhat, J.3    Wesch, D.4    Steinle, A.5    Fürst, D.6    Mytilineos, J.7    Kalthoff, H.8    Janssen, O.9    Oberg, H.H.10
  • 52
    • 84255170452 scopus 로고    scopus 로고
    • Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide
    • PMID:22006996
    • Barsoum IB, Hamilton TK, Li X, Cotechini T, Miles EA, Siemens DR, Graham CH. Hypoxia induces escape from innate immunity in cancer cells via increased expression of ADAM10: role of nitric oxide. Cancer Res 2011; 71:7433-41; http://dx.doi.org/10.1158/0008-5472.CAN-11-2104; PMID:22006996
    • (2011) Cancer Res , vol.71 , pp. 7433-7441
    • Barsoum, I.B.1    Hamilton, T.K.2    Li, X.3    Cotechini, T.4    Miles, E.A.5    Siemens, D.R.6    Graham, C.H.7
  • 53
    • 84855822415 scopus 로고    scopus 로고
    • Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE
    • PMID:22246777
    • Adrain C, Zettl M, Christova Y, Taylor N, Freeman M. Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE. Science 2012; 335:225-8; http://dx.doi.org/10.1126/science.1214400; PMID:22246777
    • (2012) Science , vol.335 , pp. 225-228
    • Adrain, C.1    Zettl, M.2    Christova, Y.3    Taylor, N.4    Freeman, M.5
  • 54
    • 84862909285 scopus 로고    scopus 로고
    • iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS
    • PMID:22246778
    • McIlwain DR, Lang PA, Maretzky T, Hamada K, Ohishi K, Maney SK, Berger T, Murthy A, Duncan G, Xu HC, et al. iRhom2 regulation of TACE controls TNF-mediated protection against Listeria and responses to LPS. Science 2012; 335:229-32; http://dx.doi.org/10.1126/science.1214448; PMID:22246778
    • (2012) Science , vol.335 , pp. 229-232
    • McIlwain, D.R.1    Lang, P.A.2    Maretzky, T.3    Hamada, K.4    Ohishi, K.5    Maney, S.K.6    Berger, T.7    Murthy, A.8    Duncan, G.9    Xu, H.C.10
  • 55
    • 84862491782 scopus 로고    scopus 로고
    • iRhom2 is required for the secretion of mouse TNFα
    • PMID:22550345
    • Siggs OM, Xiao N, Wang Y, Shi H, Tomisato W, Li X, Xia Y, Beutler B. iRhom2 is required for the secretion of mouse TNFα. Blood 2012; 119:5769-71; http://dx.doi.org/10.1182/blood-2012-03-417949; PMID:22550345
    • (2012) Blood , vol.119 , pp. 5769-5771
    • Siggs, O.M.1    Xiao, N.2    Wang, Y.3    Shi, H.4    Tomisato, W.5    Li, X.6    Xia, Y.7    Beutler, B.8
  • 56
    • 77950613332 scopus 로고    scopus 로고
    • Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9
    • PMID:20099300
    • Kohga K, Takehara T, Tatsumi T, Ishida H, Miyagi T, Hosui A, Hayashi N. Sorafenib inhibits the shedding of major histocompatibility complex class I-related chain A on hepatocellular carcinoma cells by down-regulating a disintegrin and metalloproteinase 9. Hepatology 2010; 51:1264-73; http://dx.doi.org/10.1002/hep.23456; PMID:20099300
    • (2010) Hepatology , vol.51 , pp. 1264-1273
    • Kohga, K.1    Takehara, T.2    Tatsumi, T.3    Ishida, H.4    Miyagi, T.5    Hosui, A.6    Hayashi, N.7
  • 58
    • 59449091648 scopus 로고    scopus 로고
    • Obstructing shedding of the immunostimulatory MHC class I chain-related gene B prevents tumor formation
    • PMID:19147769
    • Wu JD, Atteridge CL, Wang X, Seya T, Plymate SR. Obstructing shedding of the immunostimulatory MHC class I chain-related gene B prevents tumor formation. Clin Cancer Res 2009; 15:632-40; http://dx.doi.org/10.1158/1078-0432.CCR-08-1305; PMID:19147769
    • (2009) Clin Cancer Res , vol.15 , pp. 632-640
    • Wu, J.D.1    Atteridge, C.L.2    Wang, X.3    Seya, T.4    Plymate, S.R.5
  • 59
    • 84862840809 scopus 로고    scopus 로고
    • Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fasand NK cell-mediated cell death
    • PMID:22576685
    • Yamanegi K, Yamane J, Kobayashi K, Kato-Kogoe N, Ohyama H, Nakasho K, Yamada N, Hata M, Fukunaga S, Futani H, et al. Valproic acid cooperates with hydralazine to augment the susceptibility of human osteosarcoma cells to Fasand NK cell-mediated cell death. Int J Oncol 2012; 41:83-91; http://dx.doi.org/10.3892/ijo.2012.1438; PMID:22576685
    • (2012) Int J Oncol , vol.41 , pp. 83-91
    • Yamanegi, K.1    Yamane, J.2    Kobayashi, K.3    Kato-Kogoe, N.4    Ohyama, H.5    Nakasho, K.6    Yamada, N.7    Hata, M.8    Fukunaga, S.9    Futani, H.10
  • 60
    • 84873198111 scopus 로고    scopus 로고
    • ADAM15 is involved in MICB shedding and mediates the effects of gemcitabine on MICB shedding in PANC-1 pancreatic cancer cells
    • PMID:23314034
    • Duan X, Mao X, Sun W. ADAM15 is involved in MICB shedding and mediates the effects of gemcitabine on MICB shedding in PANC-1 pancreatic cancer cells. Mol Med Rep 2013; 7:991-7; http://dx.doi.org/10.3892/mmr.2013.1272; PMID:23314034
    • (2013) Mol Med Rep , vol.7 , pp. 991-997
    • Duan, X.1    Mao, X.2    Sun, W.3
  • 61
    • 59849101423 scopus 로고    scopus 로고
    • Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein
    • PMID:19109134
    • Boutet P, Agüera-González S, Atkinson S, Pennington CJ, Edwards DR, Murphy G, Reyburn HT, Valés-Gómez M. Cutting edge: the metalloproteinase ADAM17/TNF-alpha-converting enzyme regulates proteolytic shedding of the MHC class I-related chain B protein. J Immunol 2009; 182:49-53; PMID:19109134; http://dx.doi.org/10.4049/jimmunol.182.1.49
    • (2009) J Immunol , vol.182 , pp. 49-53
    • Boutet, P.1    Agüera-González, S.2    Atkinson, S.3    Pennington, C.J.4    Edwards, D.R.5    Murphy, G.6    Reyburn, H.T.7    Valés-Gómez, M.8
  • 63
    • 33645049837 scopus 로고    scopus 로고
    • Proteolytic release of soluble UL16-binding protein 2 from tumor cells
    • PMID:16510567
    • Waldhauer I, Steinle A. Proteolytic release of soluble UL16-binding protein 2 from tumor cells. Cancer Res 2006; 66:2520-6; PMID:16510567; http://dx.doi.org/10.1158/0008-5472.CAN-05-2520
    • (2006) Cancer Res , vol.66 , pp. 2520-2526
    • Waldhauer, I.1    Steinle, A.2
  • 64
    • 79952159254 scopus 로고    scopus 로고
    • Thermal- and oxidative stress causes enhanced release of NKG2D ligandbearing immunosuppressive exosomes in leukemia/lymphoma T and B cells
    • PMID:21364924
    • Hedlund M, Nagaeva O, Kargl D, Baranov V, Mincheva-Nilsson L. Thermal- and oxidative stress causes enhanced release of NKG2D ligandbearing immunosuppressive exosomes in leukemia/lymphoma T and B cells. PLoS One 2011; 6:e16899; http://dx.doi.org/10.1371/journal.pone.0016899; PMID:21364924
    • (2011) PLoS One , vol.6
    • Hedlund, M.1    Nagaeva, O.2    Kargl, D.3    Baranov, V.4    Mincheva-Nilsson, L.5
  • 65
    • 0036800192 scopus 로고    scopus 로고
    • Metalloproteinase inhibitors: biological actions and therapeutic opportunities
    • PMID:12235282
    • Baker AH, Edwards DR, Murphy G. Metalloproteinase inhibitors: biological actions and therapeutic opportunities. J Cell Sci 2002; 115:3719-27; PMID:12235282; http://dx.doi.org/10.1242/jcs.00063
    • (2002) J Cell Sci , vol.115 , pp. 3719-3727
    • Baker, A.H.1    Edwards, D.R.2    Murphy, G.3
  • 66
    • 77956301181 scopus 로고    scopus 로고
    • Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion
    • PMID:20470890
    • Bourboulia D, Stetler-Stevenson WG. Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs): Positive and negative regulators in tumor cell adhesion. Semin Cancer Biol 2010; 20:161-8; http://dx.doi.org/10.1016/j.semcancer.2010.05.002; PMID:20470890
    • (2010) Semin Cancer Biol , vol.20 , pp. 161-168
    • Bourboulia, D.1    Stetler-Stevenson, W.G.2
  • 67
    • 77049113770 scopus 로고    scopus 로고
    • The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity
    • PMID:20080133
    • Brew K, Nagase H. The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. Biochim Biophys Acta 2010; 1803:55-71; http://dx.doi.org/10.1016/j.bbamcr.2010.01.003; PMID:20080133
    • (2010) Biochim Biophys Acta , vol.1803 , pp. 55-71
    • Brew, K.1    Nagase, H.2
  • 68
    • 77955474897 scopus 로고    scopus 로고
    • Roles of GRP78 in physiology and cancer
    • PMID:20506407
    • Zhang LH, Zhang X. Roles of GRP78 in physiology and cancer. J Cell Biochem 2010; 110:1299-305; http://dx.doi.org/10.1002/jcb.22679; PMID:20506407
    • (2010) J Cell Biochem , vol.110 , pp. 1299-1305
    • Zhang, L.H.1    Zhang, X.2
  • 69
    • 34249295619 scopus 로고    scopus 로고
    • Disulphide-isomerase-enabled shedding of tumourassociated NKG2D ligands
    • PMID:17495932
    • Kaiser BK, Yim D, Chow IT, Gonzalez S, Dai Z, Mann HH, Strong RK, Groh V, Spies T. Disulphide-isomerase-enabled shedding of tumourassociated NKG2D ligands. Nature 2007; 447:482-6; PMID:17495932; http://dx.doi.org/10.1038/nature05768
    • (2007) Nature , vol.447 , pp. 482-486
    • Kaiser, B.K.1    Yim, D.2    Chow, I.T.3    Gonzalez, S.4    Dai, Z.5    Mann, H.H.6    Strong, R.K.7    Groh, V.8    Spies, T.9
  • 70
    • 84856836302 scopus 로고    scopus 로고
    • High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas
    • PMID:22167753
    • Zocchi MR, Catellani S, Canevali P, Tavella S, Garuti A, Villaggio B, Zunino A, Gobbi M, Fraternali-Orcioni G, Kunkl A, et al. High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas. Blood 2012; 119:1479-89; http://dx.doi.org/10.1182/blood-2011-07-370841; PMID:22167753
    • (2012) Blood , vol.119 , pp. 1479-1489
    • Zocchi, M.R.1    Catellani, S.2    Canevali, P.3    Tavella, S.4    Garuti, A.5    Villaggio, B.6    Zunino, A.7    Gobbi, M.8    Fraternali-Orcioni, G.9    Kunkl, A.10
  • 71
    • 79952261021 scopus 로고    scopus 로고
    • Exosomes and cancer: a newly described pathway of immune suppression
    • PMID:21224375
    • Zhang HG, Grizzle WE. Exosomes and cancer: a newly described pathway of immune suppression. Clin Cancer Res 2011; 17:959-64; http://dx.doi.org/10.1158/1078-0432.CCR-10-1489; PMID:21224375
    • (2011) Clin Cancer Res , vol.17 , pp. 959-964
    • Zhang, H.G.1    Grizzle, W.E.2
  • 72
    • 47249144117 scopus 로고    scopus 로고
    • Human tumor-derived exosomes downmodulate NKG2D expression
    • PMID:18490724
    • Clayton A, Mitchell JP, Court J, Linnane S, Mason MD, Tabi Z. Human tumor-derived exosomes downmodulate NKG2D expression. J Immunol 2008; 180:7249-58; PMID:18490724; http://dx.doi.org/10.4049/jimmunol.180.11.7249
    • (2008) J Immunol , vol.180 , pp. 7249-7258
    • Clayton, A.1    Mitchell, J.P.2    Court, J.3    Linnane, S.4    Mason, M.D.5    Tabi, Z.6
  • 73
    • 63449129623 scopus 로고    scopus 로고
    • Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha
    • PMID:19319200
    • Viaud S, Terme M, Flament C, Taieb J, André F, Novault S, Escudier B, Robert C, Caillat-Zucman S, Tursz T, et al. Dendritic cell-derived exosomes promote natural killer cell activation and proliferation: a role for NKG2D ligands and IL-15Ralpha. PLoS One 2009; 4:e4942; http://dx.doi.org/10.1371/journal.pone.0004942; PMID:19319200
    • (2009) PLoS One , vol.4
    • Viaud, S.1    Terme, M.2    Flament, C.3    Taieb, J.4    André, F.5    Novault, S.6    Escudier, B.7    Robert, C.8    Caillat-Zucman, S.9    Tursz, T.10
  • 74
    • 76549099879 scopus 로고    scopus 로고
    • Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes
    • PMID:20068167
    • Ashiru O, Boutet P, Fernández-Messina L, Agüera-González S, Skepper JN, Valés-Gómez M, Reyburn HT. Natural killer cell cytotoxicity is suppressed by exposure to the human NKG2D ligand MICA*008 that is shed by tumor cells in exosomes. Cancer Res 2010; 70:481-9; http://dx.doi.org/10.1158/0008-5472.CAN-09-1688; PMID:20068167
    • (2010) Cancer Res , vol.70 , pp. 481-489
    • Ashiru, O.1    Boutet, P.2    Fernández-Messina, L.3    Agüera-González, S.4    Skepper, J.N.5    Valés-Gómez, M.6    Reyburn, H.T.7
  • 76
    • 79956204623 scopus 로고    scopus 로고
    • Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: role of uric acid accumulation in gemcitabineinduced MICA/B expression
    • PMID:21605422
    • Xu X, Rao GS, Groh V, Spies T, Gattuso P, Kaufman HL, Plate J, Prinz RA. Major histocompatibility complex class I-related chain A/B (MICA/B) expression in tumor tissue and serum of pancreatic cancer: role of uric acid accumulation in gemcitabineinduced MICA/B expression. BMC Cancer 2011; 11:194; http://dx.doi.org/10.1186/1471-2407-11-194; PMID:21605422
    • (2011) BMC Cancer , vol.11 , pp. 194
    • Xu, X.1    Rao, G.S.2    Groh, V.3    Spies, T.4    Gattuso, P.5    Kaufman, H.L.6    Plate, J.7    Prinz, R.A.8
  • 77
    • 79961185621 scopus 로고    scopus 로고
    • Combinatorial cytotoxicity of gemcitabine and cytokine-activated killer cells in hepatocellular carcinoma via the NKG2D-MICA/B system
    • PMID:21873167
    • Morisaki T, Onishi H, Koya N, Kiyota A, Tanaka H, Umebayashi M, Ogino T, Nagamatsu I, Katano M. Combinatorial cytotoxicity of gemcitabine and cytokine-activated killer cells in hepatocellular carcinoma via the NKG2D-MICA/B system. Anticancer Res 2011; 31:2505-10; PMID:21873167
    • (2011) Anticancer Res , vol.31 , pp. 2505-2510
    • Morisaki, T.1    Onishi, H.2    Koya, N.3    Kiyota, A.4    Tanaka, H.5    Umebayashi, M.6    Ogino, T.7    Nagamatsu, I.8    Katano, M.9
  • 78
    • 70350230209 scopus 로고    scopus 로고
    • Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma
    • PMID:19826051
    • Kohga K, Takehara T, Tatsumi T, Miyagi T, Ishida H, Ohkawa K, Kanto T, Hiramatsu N, Hayashi N. Anticancer chemotherapy inhibits MHC class I-related chain a ectodomain shedding by downregulating ADAM10 expression in hepatocellular carcinoma. Cancer Res 2009; 69:8050-7; http://dx.doi.org/10.1158/0008-5472.CAN-09-0789; PMID:19826051
    • (2009) Cancer Res , vol.69 , pp. 8050-8057
    • Kohga, K.1    Takehara, T.2    Tatsumi, T.3    Miyagi, T.4    Ishida, H.5    Ohkawa, K.6    Kanto, T.7    Hiramatsu, N.8    Hayashi, N.9
  • 79
    • 84866443923 scopus 로고    scopus 로고
    • Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells
    • PMID:22923031
    • Yamanegi K, Yamane J, Kobayashi K, Ohyama H, Nakasho K, Yamada N, Hata M, Fukunaga S, Futani H, Okamura H, et al. Downregulation of matrix metalloproteinase-9 mRNA by valproic acid plays a role in inhibiting the shedding of MHC class I-related molecules A and B on the surface of human osteosarcoma cells. Oncol Rep 2012; 28:1585-90; http://dx.doi.org/10.3892/or.2012.1981; PMID:22923031
    • (2012) Oncol Rep , vol.28 , pp. 1585-1590
    • Yamanegi, K.1    Yamane, J.2    Kobayashi, K.3    Ohyama, H.4    Nakasho, K.5    Yamada, N.6    Hata, M.7    Fukunaga, S.8    Futani, H.9    Okamura, H.10


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