Obesity in Pregnancy: Optimizing Outcomes for Mom and Baby

Medical Clinics of North America

Volumn 102, Issue 1, 2018, Pages 87-106

  Dutton, Heidi ^a   Borengasser, Sarah Jean ^b   Gaudet, Laura Marie ^a   Barbour, Linda A ^c   Keely, Erin Joanne ^a  

^a UNIVERSITY OF OTTAWA   (Canada)

^b UNIVERSITY OF COLORADO   (United States)

^c UNIVERSITY OF COLORADO SCHOOL OF MEDICINE   (United States)

Author keywords

Intergenerational obesity; Obesity; Preconception; Pregnancy

Indexed keywords

ANESTHESIA COMPLICATION; BODY MASS; CESAREAN SECTION; COMORBIDITY; CONGENITAL MALFORMATION; DRUG SAFETY; EARLY DIAGNOSIS; EPIGENETICS; EVIDENCE BASED PRACTICE; FEMALE FERTILITY; FETUS OUTCOME; GESTATION PERIOD; HUMAN; HYPERGLYCEMIA; INTESTINE FLORA; LABOR MANAGEMENT; MATERNAL HYPERTENSION; METABOLIC DISORDER; NEWBORN CARE; NEWBORN DISEASE; NEWBORN SCREENING; OBESITY; OBSTETRIC ANESTHESIA; OBSTETRIC DELIVERY; POSTOPERATIVE COMPLICATION; POSTPARTUM HEMORRHAGE; PREGNANCY DIABETES MELLITUS; PREGNANCY OUTCOME; PREMATURE LABOR; PRENATAL SCREENING; PREPREGNANCY CARE; PRIORITY JOURNAL; PROGENY; PROPHYLAXIS; PUERPERIUM; REVIEW; RISK FACTOR; SURGICAL RISK; TIME TO PREGNANCY; VENOUS THROMBOEMBOLISM; WEIGHT GAIN; WEIGHT REDUCTION; ADULT; BIRTH WEIGHT; FEMALE; HEALTH PROMOTION; ORGANIZATION AND MANAGEMENT; PATIENT EDUCATION; PREGNANCY; PREGNANCY COMPLICATION; YOUNG ADULT;

ADULT; BIRTH WEIGHT; FEMALE; HEALTH PROMOTION; HUMANS; OBESITY; PATIENT EDUCATION AS TOPIC; POSTPARTUM PERIOD; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY OUTCOME; WEIGHT GAIN; YOUNG ADULT;

EID: 85034237856     PISSN: 00257125     EISSN: 15579859     Source Type: Journal    
DOI: 10.1016/j.mcna.2017.08.008     Document Type: Review

References (152)

1. Flegal, K.M., Kruszon-Moran, D., Carroll, M.D., et al. Trends in obesity among adults in the United States, 2005 to 2014. JAMA 315:21 (2016), 2284–2291.
2. Kominiarek, M.A., Chauhan, S.P., Obesity before, during, and after pregnancy: a review and comparison of five national guidelines. Am J Perinatol 33:5 (2016), 433–441.
3. Grohmann, B., Brazeau-Gravelle, P., Momoli, F., et al. Obstetric healthcare providers' perceptions of communicating gestational weight gain recommendations to overweight/obese pregnant women. Obstet Med 5:4 (2012), 161–165.
4. Dinsdale, S., Branch, K., Cook, L., et al. “As soon as you've had the baby that's it…” a qualitative study of 24 postnatal women on their experience of maternal obesity care pathways. BMC Public Health, 16, 2016, 625.
5. Heslehurst, N., Lang, R., Rankin, J., et al. Obesity in pregnancy: a study of the impact of maternal obesity on NHS maternity services. BJOG 114:3 (2007), 334–342.
6. Mills, A., Schmied, V.A., Dahlen, H.G., ‘Get alongside us’, women's experiences of being overweight and pregnant in Sydney, Australia. Matern Child Nutr 9:3 (2013), 309–321.
7. Canadian Obesity Network. 5 A's of healthy pregnancy weight gain. Available at: http://www.obesitynetwork.ca/pregnancy. Accessed May 27, 2017.
8. Gesink Law, D.C., Maclehose, R.F., Longnecker, M.P., Obesity and time to pregnancy. Hum Reprod 22:2 (2007), 414–420.
9. Nohr, E.A., Timpson, N.J., Andersen, C.S., et al. Severe obesity in young women and reproductive health: the Danish National Birth Cohort. PLoS One, 4(12), 2009, e8444.
10. van der Steeg, J.W., Steures, P., Eijkemans, M.J., et al. Obesity affects spontaneous pregnancy chances in subfertile, ovulatory women. Hum Reprod 23:2 (2008), 324–328.
11. Alvarez-Blasco, F., Botella-Carretero, J.I., San Millan, J.L., et al. Prevalence and characteristics of the polycystic ovary syndrome in overweight and obese women. Arch Intern Med 166:19 (2006), 2081–2086.
12. Rotterdam ESHRE/ASRM-sponsored PCOS consensus working group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81:1 (2004), 19–25.
13. Metwally, M., Ong, K.J., Ledger, W.L., et al. Does high body mass index increase the risk of miscarriage after spontaneous and assisted conception? A meta-analysis of the evidence. Fertil Steril 90:3 (2008), 714–726.
14. Rittenberg, V., Seshadri, S., Sunkara, S.K., et al. Effect of body mass index on IVF treatment outcome: an updated systematic review and meta-analysis. Reprod Biomed Online 23:4 (2011), 421–439.
15. Sim, K.A., Partridge, S.R., Sainsbury, A., Does weight loss in overweight or obese women improve fertility treatment outcomes? A systematic review. Obes Rev 15:10 (2014), 839–850.
16. Mutsaerts, M.A., van Oers, A.M., Groen, H., et al. Randomized trial of a lifestyle program in obese infertile women. N Engl J Med 374:20 (2016), 1942–1953.
17. Legro, R.S., Dodson, W.C., Kunselman, A.R., et al. Benefit of delayed fertility therapy with preconception weight loss over immediate therapy in obese women with PCOS. J Clin Endocrinol Metab 101:7 (2016), 2658–2666.
18. Milone, M., De Placido, G., Musella, M., et al. Incidence of successful pregnancy after weight loss interventions in infertile women: a systematic review and meta-analysis of the literature. Obes Surg 26:2 (2016), 443–451.
19. Mechanick, J.I., Youdim, A., Jones, D.B., et al. Clinical practice guidelines for the perioperative nutritional, metabolic, and nonsurgical support of the bariatric surgery patient–2013 update: cosponsored by American Association of Clinical Endocrinologists, The Obesity Society, and American Society for Metabolic & Bariatric Surgery. Obesity (Silver Spring) 21:Suppl 1 (2013), S1–S27.
20. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 105: bariatric surgery and pregnancy. Obstet Gynecol 113:6 (2009), 1405–1413.
21. American College of Obstetricians and Gynecologists. ACOG practice bulletin no. 156: obesity in pregnancy. Obstet Gynecol 126:6 (2015), e112–126.
22. Practice Committee of the American Society for Reproductive Medicine. Obesity and reproduction: a committee opinion. Fertil Steril 104:5 (2015), 1116–1126.
23. Yi, X.Y., Li, Q.F., Zhang, J., et al. A meta-analysis of maternal and fetal outcomes of pregnancy after bariatric surgery. Int J Gynaecol Obstet 130:1 (2015), 3–9.
24. Kjaer, M.M., Lauenborg, J., Breum, B.M., et al. The risk of adverse pregnancy outcome after bariatric surgery: a nationwide register-based matched cohort study. Am J Obstet Gynecol, 208(6), 2013, 464.e1-5.
25. Roos, N., Neovius, M., Cnattingius, S., et al. Perinatal outcomes after bariatric surgery: nationwide population based matched cohort study. BMJ, 347, 2013, f6460.
26. Simmons, D., Prevention of gestational diabetes mellitus: where are we now?. Diabetes Obes Metab 17:9 (2015), 824–834.
27. Lifestyle intervention in preparation for pregnancy. Available at: https://clinicaltrials.gov/ct2/show/NCT03146156?term=catalano&rank=4. Accessed May 29, 2017.
28. Royal College of Obstetricians and Gynaecologists. Scientific impact paper #17: the role of reproductive surgery in improving reproductive health. 2015. Available at: https://www.rcog.org.uk/globalassets/documents/guidelines/scientific-impact-papers/sip_17.pdf. Accessed April 27, 2017.
29. Madsen, N.L., Schwartz, S.M., Lewin, M.B., et al. Prepregnancy body mass index and congenital heart defects among offspring: a population-based study. Congenit Heart Dis 8:2 (2013), 131–141.
30. Stothard, K.J., Tennant, P.W., Bell, R., et al. Maternal overweight and obesity and the risk of congenital anomalies: a systematic review and meta-analysis. JAMA 301:6 (2009), 636–650.
31. Mills, J.L., Troendle, J., Conley, M.R., et al. Maternal obesity and congenital heart defects: a population-based study. Am J Clin Nutr 91:6 (2010), 1543–1549.
32. Brite, J., Laughon, S.K., Troendle, J., et al. Maternal overweight and obesity and risk of congenital heart defects in offspring. Int J Obes (Lond) 38:6 (2014), 878–882.
33. Masho, S.W., Bassyouni, A., Cha, S., Pre-pregnancy obesity and non-adherence to multivitamin use: findings from the National Pregnancy Risk Assessment Monitoring System (2009-2011). BMC Pregnancy Childbirth, 16(1), 2016, 210.
34. Tinker, S.C., Hamner, H.C., Berry, R.J., et al. Does obesity modify the association of supplemental folic acid with folate status among nonpregnant women of childbearing age in the United States?. Birth Defects Res A Clin Mol Teratol 94:10 (2012), 749–755.
35. Royal College of Obstetricians and Gynaecologists. Management of women with obesity in pregnancy. Joint Guideline. 2010. Available at: https://www.rcog.org.uk/globalassets/documents/guidelines/cmacercogjointguidelinemanagementwomenobesitypregnancya.pdf. Accessed 27 May 2017.
36. Mojtabai, R., Body mass index and serum folate in childbearing age women. Eur J Epidemiol 19:11 (2004), 1029–1036.
37. Ferraro, Z.M., Contador, F., Tawfiq, A., et al. Gestational weight gain and medical outcomes of pregnancy. Obstet Med 8:3 (2015), 133–137.
38. Adamo, K.B., Ferraro, Z.M., Brett, K.E., Pregnancy is a critical period for prevention of obesity and cardiometabolic risk. Can J Diabetes 36 (2012), 133–141.
39. Weisman, C.S., Hillemeier, M.M., Downs, D.S., et al. Preconception predictors of weight gain during pregnancy: prospective findings from the Central Pennsylvania Women's Health Study. Womens Health Issues 20:2 (2010), 126–132.
40. Ferraro, Z.M., Barrowman, N., Prud'homme, D., et al. Excessive gestational weight gain predicts large for gestational age neonates independent of maternal body mass index. J Matern Fetal Neonatal Med 25:5 (2012), 538–542.
41. Institute of Medicine and National Research Council Committee to Reexamine IOM Pregnancy Weight Guidelines, Rasmussen KM, Yaktine AL, editors. Weight gain during pregnancy: reexamining the guidelines. Washington, DC: 2009.
42. Kapadia, M.Z., Park, C.K., Beyene, J., et al. Can we safely recommend gestational weight gain below the 2009 guidelines in obese women? A systematic review and meta-analysis. Obes Rev 16:3 (2015), 189–206.
43. Bogaerts, A., Ameye, L., Martens, E., et al. Weight loss in obese pregnant women and risk for adverse perinatal outcomes. Obstet Gynecol 125:3 (2015), 566–575.
44. Blomberg, M., Maternal and neonatal outcomes among obese women with weight gain below the new Institute of Medicine recommendations. Obstet Gynecol 117:5 (2011), 1065–1070.
45. American College of Obstetricians and Gynecologists. ACOG Committee opinion no. 548: weight gain during pregnancy. Obstet Gynecol 121:1 (2013), 210–212.
46. Davies, G.A., Maxwell, C., McLeod, L., et al. SOGC clinical practice guidelines: obesity in pregnancy. No. 239, February 2010. Int J Gynaecol Obstet 110:2 (2010), 167–173.
47. Muktabhant, B., Lawrie, T.A., Lumbiganon, P., et al. Diet or exercise, or both, for preventing excessive weight gain in pregnancy. Cochrane Database Syst Rev(6), 2015 CD007145.
48. American College of Obstetricians and Gynecologists. ACOG committee opinion no. 650: physical activity and exercise during pregnancy and the postpartum period. Obstet Gynecol 126:6 (2015), e135–142.
49. McIntyre, H.D., Sacks, D.A., Barbour, L.A., et al. Issues with the diagnosis and classification of hyperglycemia in early pregnancy. Diabetes Care 39:1 (2016), 53–54.
50. Hughes, R.C., Moore, M.P., Gullam, J.E., et al. An early pregnancy HbA1c >/=5.9% (41 mmol/mol) is optimal for detecting diabetes and identifies women at increased risk of adverse pregnancy outcomes. Diabetes Care 37:11 (2014), 2953–2959.
51. Barbour, L.A., Unresolved controversies in gestational diabetes: implications on maternal and infant health. Curr Opin Endocrinol Diabetes Obes 21:4 (2014), 264–270.
52. American College of Obstetricians and Gynecologists. Practice bulletin No. 137: gestational diabetes mellitus. Obstet Gynecol 122:2 Pt 1 (2013), 406–416.
53. Wong, T., Ross, G.P., Jalaludin, B.B., et al. The clinical significance of overt diabetes in pregnancy. Diabet Med 30:4 (2013), 468–474.
54. Robinson, H.E., O'Connell, C.M., Joseph, K.S., et al. Maternal outcomes in pregnancies complicated by obesity. Obstet Gynecol 106:6 (2005), 1357–1364.
55. O'Brien, T.E., Ray, J.G., Chan, W.S., Maternal body mass index and the risk of preeclampsia: a systematic overview. Epidemiology 14:3 (2003), 368–374.
56. Sorensen, T.K., Williams, M.A., Lee, I.M., et al. Recreational physical activity during pregnancy and risk of preeclampsia. Hypertension 41:6 (2003), 1273–1280.
57. Saftlas, A.F., Logsden-Sackett, N., Wang, W., et al. Work, leisure-time physical activity, and risk of preeclampsia and gestational hypertension. Am J Epidemiol 160:8 (2004), 758–765.
58. American College of Obstetricians and Gynecologists. Task force on hypertension in pregnancy. Hypertension in pregnancy. Obstet Gynecol 122:5 (2013), 1122–1131.
59. Magee, L.A., Pels, A., Helewa, M., et al. Diagnosis, evaluation, and management of the hypertensive disorders of pregnancy: executive summary. J Obstet Gynaecol Can 36:7 (2014), 575–576.
60. Cantu, J.A., Jauk, V.R., Owen, J., et al. Is low-dose aspirin therapy to prevent preeclampsia more efficacious in non-obese women or when initiated early in pregnancy?. J Matern Fetal Neonatal Med 28:10 (2015), 1128–1132.
61. Hildebrand, E., Kallen, B., Josefsson, A., et al. Maternal obesity and risk of Down syndrome in the offspring. Prenat Diagn 34:4 (2014), 310–315.
62. Wang, E., Batey, A., Struble, C., et al. Gestational age and maternal weight effects on fetal cell-free DNA in maternal plasma. Prenat Diagn 33:7 (2013), 662–666.
63. Aagaard-Tillery, K.M., Flint Porter, T., Malone, F.D., et al. Influence of maternal BMI on genetic sonography in the FaSTER trial. Prenat Diagn 30:1 (2010), 14–22.
64. Dashe, J.S., McIntire, D.D., Twickler, D.M., Effect of maternal obesity on the ultrasound detection of anomalous fetuses. Obstet Gynecol 113:5 (2009), 1001–1007.
65. Dashe, J.S., McIntire, D.D., Twickler, D.M., Maternal obesity limits the ultrasound evaluation of fetal anatomy. J Ultrasound Med 28:8 (2009), 1025–1030.
66. Cnattingius, S., Villamor, E., Johansson, S., et al. Maternal obesity and risk of preterm delivery. JAMA 309:22 (2013), 2362–2370.
67. Carmichael, S.L., Blumenfeld, Y.J., Mayo, J., et al. Prepregnancy obesity and risks of stillbirth. PLoS One, 10(10), 2015, e0138549.
68. Jacob, L., Kostev, K., Kalder, M., Risk of stillbirth in pregnant women with obesity in the United Kingdom. Obes Res Clin Pract 10:5 (2016), 574–579.
69. Lee, V.R., Liu, B., Anjali, K., et al. Optimal timing of delivery in obese women: a decision analysis. Obstet Gynecol 123:S1 (2014), 152S–153S.
70. Lee, V.R., Darney, B.G., Snowden, J.M., et al. Term elective induction of labour and perinatal outcomes in obese women: retrospective cohort study. BJOG 123:2 (2016), 271–278.
71. Alanis, M.C., Villers, M.S., Law, T.L., et al. Complications of cesarean delivery in the massively obese parturient. Am J Obstet Gynecol, 203(3), 2010, 271.e1-7.
72. Alexander, C.I., Liston, W.A., Operating on the obese woman–a review. BJOG 113:10 (2006), 1167–1172.
73. Wall, P.D., Deucy, E.E., Glantz, J.C., et al. Vertical skin incisions and wound complications in the obese parturient. Obstet Gynecol 102:5 Pt 1 (2003), 952–956.
74. Tan, T., Sia, A.T., Anesthesia considerations in the obese gravida. Semin Perinatol 35:6 (2011), 350–355.
75. Fyfe, E.M., Thompson, J.M., Anderson, N.H., et al. Maternal obesity and postpartum haemorrhage after vaginal and caesarean delivery among nulliparous women at term: a retrospective cohort study. BMC Pregnancy Childbirth, 12, 2012, 112.
76. Bates, S.M., Greer, I.A., Middeldorp, S., et al. VTE, thrombophilia, antithrombotic therapy, and pregnancy: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines. Chest 141:2 Suppl (2012), e691S–736S.
77. Chan, W.S., Rey, E., Kent, N.E., et al. Venous thromboembolism and antithrombotic therapy in pregnancy. J Obstet Gynaecol Can 36:6 (2014), 527–553.
78. World Health Organization. Breastfeeding. health topics. Available at: http://www.who.int/topics/breastfeeding/en/. Accessed December 6, 2016.
79. American Academy of Pediatrics. Breastfeeding and the use of human milk. Pediatrics 129 (2012), e827–e841.
80. Schwarz, E.B., Ray, R.M., Stuebe, A.M., et al. Duration of lactation and risk factors for maternal cardiovascular disease. Obstet Gynecol 113:5 (2009), 974–982.
81. Stuebe, A.M., Rich-Edwards, J.W., Willett, W.C., et al. Duration of lactation and incidence of type 2 diabetes. JAMA 294:20 (2005), 2601–2610.
82. Liu, B., Jorm, L., Banks, E., Parity, breastfeeding, and the subsequent risk of maternal type 2 diabetes. Diabetes Care 33:6 (2010), 1239–1241.
83. Natland, S.T., Nilsen, T.I., Midthjell, K., et al. Lactation and cardiovascular risk factors in mothers in a population-based study: the HUNT-study. Int Breastfeed J, 7(1), 2012, 8.
84. McClure, C.K., Schwarz, E.B., Conroy, M.B., et al. Breastfeeding and subsequent maternal visceral adiposity. Obesity (Silver Spring) 19:11 (2011), 2205–2213.
85. Baker, J.L., Gamborg, M., Heitmann, B.L., et al. Breastfeeding reduces postpartum weight retention. Am J Clin Nutr 88:6 (2008), 1543–1551.
86. Coitinho, D.C., Sichieri, R., D'Aquino Benicio, M.H., Obesity and weight change related to parity and breast-feeding among parous women in Brazil. Public Health Nutr 4:4 (2001), 865–870.
87. Palmer, J.R., Kipping-Ruane, K., Wise, L.A., et al. Lactation in relation to long-term maternal weight gain in African-American women. Am J Epidemiol 181:12 (2015), 932–939.
88. Thompson, L.A., Zhang, S., Black, E., et al. The association of maternal pre-pregnancy body mass index with breastfeeding initiation. Matern Child Health J 17:10 (2013), 1842–1851.
89. Amir, L.H., Donath, S., A systematic review of maternal obesity and breastfeeding intention, initiation and duration. BMC Pregnancy Childbirth, 7, 2007, 9.
90. Bever Babendure, J., Reifsnider, E., Mendias, E., et al. Reduced breastfeeding rates among obese mothers: a review of contributing factors, clinical considerations and future directions. Int Breastfeed J, 10, 2015, 21.
91. Cnattingius, S., Villamor, E., Weight change between successive pregnancies and risks of stillbirth and infant mortality: a nationwide cohort study. Lancet 387:10018 (2016), 558–565.
92. Villamor, E., Cnattingius, S., Interpregnancy weight change and risk of adverse pregnancy outcomes: a population-based study. Lancet 368:9542 (2006), 1164–1170.
93. Glazer, N.L., Hendrickson, A.F., Schellenbaum, G.D., et al. Weight change and the risk of gestational diabetes in obese women. Epidemiology 15:6 (2004), 733–737.
94. Jain, A.P., Gavard, J.A., Rice, J.J., et al. The impact of interpregnancy weight change on birthweight in obese women. Am J Obstet Gynecol, 208(3), 2013, 205.e1-7.
95. Callegari, L.S., Sterling, L.A., Zelek, S.T., et al. Interpregnancy body mass index change and success of term vaginal birth after cesarean delivery. Am J Obstet Gynecol, 210(4), 2014, 330.e1-7.
96. Amorim, A.R., Linne, Y.M., Lourenco, P.M., Diet or exercise, or both, for weight reduction in women after childbirth. Cochrane Database Syst Rev(3), 2007 CD005627.
97. Cunningham, S.A., Kramer, M.R., Narayan, K.M., Incidence of childhood obesity in the United States. N Engl J Med 370:17 (2014), 1660–1661.
98. Ogden, C.L., Carroll, M.D., Kit, B.K., et al. Prevalence of childhood and adult obesity in the United States, 2011-2012. JAMA 311:8 (2014), 806–814.
99. Starling, A.P., Brinton, J.T., Glueck, D.H., et al. Associations of maternal BMI and gestational weight gain with neonatal adiposity in the Healthy Start study. Am J Clin Nutr 101:2 (2015), 302–309.
100. Nicklas, J.M., Barbour, L.A., Optimizing weight for maternal and infant health - tenable, or too late?. Expert Rev Endocrinol Metab 10:2 (2015), 227–242.
101. Olson, C.M., Strawderman, M.S., Dennison, B.A., Maternal weight gain during pregnancy and child weight at age 3 years. Matern Child Health J 13:6 (2009), 839–846.
102. Catalano, P.M., Farrell, K., Thomas, A., et al. Perinatal risk factors for childhood obesity and metabolic dysregulation. Am J Clin Nutr 90:5 (2009), 1303–1313.
103. Reynolds, R.M., Osmond, C., Phillips, D.I., et al. Maternal BMI, parity, and pregnancy weight gain: influences on offspring adiposity in young adulthood. J Clin Endocrinol Metab 95:12 (2010), 5365–5369.
104. Catalano, P.M., Presley, L., Minium, J., et al. Fetuses of obese mothers develop insulin resistance in utero. Diabetes Care 32:6 (2009), 1076–1080.
105. Nicholas, L.M., Morrison, J.L., Rattanatray, L., et al. The early origins of obesity and insulin resistance: timing, programming and mechanisms. Int J Obes (Lond) 40:2 (2016), 229–238.
106. Barbour, L.A., Changing perspectives in pre-existing diabetes and obesity in pregnancy: maternal and infant short- and long-term outcomes. Curr Opin Endocrinol Diabetes Obes 21:4 (2014), 257–263.
107. Singhal, A., Lucas, A., Early origins of cardiovascular disease: is there a unifying hypothesis?. Lancet 363:9421 (2004), 1642–1645.
108. Reynolds, R.M., Allan, K.M., Raja, E.A., et al. Maternal obesity during pregnancy and premature mortality from cardiovascular event in adult offspring: follow-up of 1 323 275 person years. BMJ, 347, 2013, f4539.
109. McCurdy, C.E., Bishop, J.M., Williams, S.M., et al. Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest 119:2 (2009), 323–335.
110. Brumbaugh, D.E., Tearse, P., Cree-Green, M., et al. Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes. J Pediatr 162:5 (2013), 930–936.e1.
111. Wesolowski, S.R., Kasmi, K.C., Jonscher, K.R., et al. Developmental origins of NAFLD: a womb with a clue. Nat Rev Gastroenterol Hepatol 14:2 (2017), 81–96.
112. Newton, K.P., Feldman, H.S., Chambers, C.D., et al. Low and high birth weights are risk factors for nonalcoholic fatty liver disease in children. J Pediatr 187 (2017), 141–146.e1.
113. Goyal, N.P., Schwimmer, J.B., The progression and natural history of pediatric nonalcoholic fatty liver disease. Clin Liver Dis 20:2 (2016), 325–338.
114. Kral, J.G., Biron, S., Simard, S., et al. Large maternal weight loss from obesity surgery prevents transmission of obesity to children who were followed for 2 to 18 years. Pediatrics 118:6 (2006), e1644–1649.
115. Smith, J., Cianflone, K., Biron, S., et al. Effects of maternal surgical weight loss in mothers on intergenerational transmission of obesity. J Clin Endocrinol Metab 94:11 (2009), 4275–4283.
116. Barker, D.J., Winter, P.D., Osmond, C., et al. Weight in infancy and death from ischaemic heart disease. Lancet 2:8663 (1989), 577–580.
117. Boyle, K.E., Patinkin, Z.W., Shapiro, A.L., et al. Mesenchymal stem cells from infants born to obese mothers exhibit greater potential for adipogenesis: the Healthy Start BabyBUMP Project. Diabetes 65:3 (2016), 647–659.
118. Heerwagen, M.J., Miller, M.R., Barbour, L.A., et al. Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol 299:3 (2010), R711–R722.
119. El Hajj, N., Schneider, E., Lehnen, H., et al. Epigenetics and life-long consequences of an adverse nutritional and diabetic intrauterine environment. Reproduction 148:6 (2014), R111–R120.
120. Ganu, R.S., Harris, R.A., Collins, K., et al. Maternal diet: a modulator for epigenomic regulation during development in nonhuman primates and humans. Int J Obes Suppl 2:Suppl 2 (2012), S14–S18.
121. Teh, A.L., Pan, H., Chen, L., et al. The effect of genotype and in utero environment on interindividual variation in neonate DNA methylomes. Genome Res 24:7 (2014), 1064–1074.
122. Ollikainen, M., Smith, K.R., Joo, E.J., et al. DNA methylation analysis of multiple tissues from newborn twins reveals both genetic and intrauterine components to variation in the human neonatal epigenome. Hum Mol Genet 19:21 (2010), 4176–4188.
123. Cooper, W.N., Khulan, B., Owens, S., et al. DNA methylation profiling at imprinted loci after periconceptional micronutrient supplementation in humans: results of a pilot randomized controlled trial. FASEB J 26:5 (2012), 1782–1790.
124. Khulan, B., Cooper, W.N., Skinner, B.M., et al. Periconceptional maternal micronutrient supplementation is associated with widespread gender related changes in the epigenome: a study of a unique resource in the Gambia. Hum Mol Genet 21:9 (2012), 2086–2101.
125. Lin, X., Lim, I.Y., Wu, Y., et al. Developmental pathways to adiposity begin before birth and are influenced by genotype, prenatal environment and epigenome. BMC Med, 15(1), 2017, 50.
126. Waterland, R.A., Kellermayer, R., Laritsky, E., et al. Season of conception in rural Gambia affects DNA methylation at putative human metastable epialleles. PLoS Genet, 6(12), 2010, e1001252.
127. Dominguez-Salas, P., Moore, S.E., Baker, M.S., et al. Maternal nutrition at conception modulates DNA methylation of human metastable epialleles. Nat Commun, 5, 2014, 3746.
128. Koren, O., Goodrich, J.K., Cullender, T.C., et al. Host remodeling of the gut microbiome and metabolic changes during pregnancy. Cell 150:3 (2012), 470–480.
129. Chu, D.M., Meyer, K.M., Prince, A.L., et al. Impact of maternal nutrition in pregnancy and lactation on offspring gut microbial composition and function. Gut Microbes 7:6 (2016), 459–470.
130. Brumbaugh, D.E., Arruda, J., Robbins, K., et al. Mode of delivery determines neonatal pharyngeal bacterial composition and early intestinal colonization. J Pediatr Gastroenterol Nutr 63:3 (2016), 320–328.
131. Prince, A.L., Antony, K.M., Ma, J., et al. The microbiome and development: a mother's perspective. Semin Reprod Med 32:1 (2014), 14–22.
132. Chu, D.M., Antony, K.M., Ma, J., et al. The early infant gut microbiome varies in association with a maternal high-fat diet. Genome Med, 8(1), 2016, 77.
133. Cotillard, A., Kennedy, S.P., Kong, L.C., et al. Dietary intervention impact on gut microbial gene richness. Nature 500:7464 (2013), 585–588.
134. Le Chatelier, E., Nielsen, T., Qin, J., et al. Richness of human gut microbiome correlates with metabolic markers. Nature 500:7464 (2013), 541–546.
135. Ma, J., Prince, A.L., Bader, D., et al. High-fat maternal diet during pregnancy persistently alters the offspring microbiome in a primate model. Nat Commun, 5, 2014, 3889.
136. Lemas, D.J., Young, B.E., Baker, P.R. 2nd, et al. Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome. Am J Clin Nutr 103:5 (2016), 1291–1300.
137. Soderborg, T.K., Borengasser, S.J., Barbour, L.A., et al. Microbial transmission from mothers with obesity or diabetes to infants: an innovative opportunity to interrupt a vicious cycle. Diabetologia 59:5 (2016), 895–906.
138. Luoto, R., Laitinen, K., Nermes, M., et al. Impact of maternal probiotic-supplemented dietary counselling on pregnancy outcome and prenatal and postnatal growth: a double-blind, placebo-controlled study. Br J Nutr 103:12 (2010), 1792–1799.
139. Wickens, K.L., Barthow, C.A., Murphy, R., et al. Early pregnancy probiotic supplementation with Lactobacillus rhamnosus HN001 may reduce the prevalence of gestational diabetes mellitus: a randomised controlled trial. Br J Nutr 117:6 (2017), 804–813.
140. Nitert, M.D., Barrett, H.L., Foxcroft, K., et al. SPRING: an RCT study of probiotics in the prevention of gestational diabetes mellitus in overweight and obese women. BMC Pregnancy Childbirth, 13, 2013, 50.
141. Sandler, V., Reisetter, A.C., Bain, J.R., et al. Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes. Diabetologia 60:3 (2017), 518–530.
142. Hellmuth, C., Lindsay, K.L., Uhl, O., et al. Association of maternal prepregnancy BMI with metabolomic profile across gestation. Int J Obes (Lond) 41:1 (2017), 159–169.
143. Ng, S.F., Lin, R.C., Laybutt, D.R., et al. Chronic high-fat diet in fathers programs beta-cell dysfunction in female rat offspring. Nature 467:7318 (2010), 963–966.
144. de Castro Barbosa, T., Ingerslev, L.R., Alm, P.S., et al. High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring. Mol Metab 5:3 (2016), 184–197.
145. Donkin, I., Versteyhe, S., Ingerslev, L.R., et al. Obesity and bariatric surgery drive epigenetic variation of spermatozoa in humans. Cell Metab 23:2 (2016), 369–378.
146. Balserak, B., Sleep disordered breathing in pregnancy. Breathe (Sheff) 11:4 (2015), 268–277.
147. Rice, J.R., Larrabure-Torrealva, G.T., Luque Fernandez, M.A., et al. High risk for obstructive sleep apnea and other sleep disorders among overweight and obese pregnant women. BMC Pregnancy Childbirth, 15, 2015, 198.
148. Louis, J., Auckley, D., Miladinovic, B., et al. Perinatal outcomes associated with obstructive sleep apnea in obese pregnant women. Obstet Gynecol 120:5 (2012), 1085–1092.
149. Dietrich, P., Hellerbrand, C., Non-alcoholic fatty liver disease, obesity and the metabolic syndrome. Best Pract Res Clin Gastroenterol 28:4 (2014), 637–653.
150. Hagstrom, H., Hoijer, J., Ludvigsson, J.F., et al. Adverse outcomes of pregnancy in women with non-alcoholic fatty liver disease. Liver Int 36:2 (2016), 268–274.
151. Chelmow, D., Rodriguez, E.J., Sabatini, M.M., Suture closure of subcutaneous fat and wound disruption after cesarean delivery: a meta-analysis. Obstet Gynecol 103:5 part 1 (2004), 974–980.
152. Tuuli, M.G., Rampersad, R.M., Carbone, J.F., et al. Staples compared with subcuticular suture for skin closure after cesarean delivery: a systematic review and meta-analysis. Obstet Gynecol 117:3 (2011), 682–690.