Mesenchymal stem cells from infants born to obese mothers exhibit greater potential for adipogenesis: The healthy start babybump project

Diabetes

Volumn 65, Issue 3, 2016, Pages 647-659

  Boyle, Kristen E ^a   Patinkin, Zachary W ^a   Shapiro, Allison L B ^b   Baker, Peter R ^a   Dabelea, Dana ^b   Friedman, Jacob E ^a  

^a University of Colorado Denver and Children s Hospital Colorado   (United States)

^b Food Science and Human Nutrition   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5' NUCLEOTIDASE; BETA CATENIN; CD19 ANTIGEN; CD34 ANTIGEN; CD45 ANTIGEN; ENDOGLIN; GLYCOGEN SYNTHASE KINASE 3BETA; LIPID; LITHIUM CHLORIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SERINE; THREONINE; THY 1 ANTIGEN; GLYCOGEN SYNTHASE KINASE 3; GSK3B PROTEIN, HUMAN;

ADIPOCYTE; ADIPOGENESIS; ADOLESCENT; ADULT; ARTICLE; CELL DIFFERENTIATION; CHILDHOOD OBESITY; CLINICAL ARTICLE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATIONAL STUDY; EVIDENCE BASED PRACTICE; FAT MASS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INFANT; LIPID STORAGE; MALE; MATERNAL OBESITY; MESENCHYMAL STEM CELL; MOTHER; MUSCLE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; STEM CELL CULTURE; UMBILICAL CORD; CELL CULTURE; COHORT ANALYSIS; CYTOLOGY; LONGITUDINAL STUDY; MESENCHYMAL STROMA CELL; METABOLISM; OBESITY; PHYSIOLOGY; PREGNANCY; PREGNANCY COMPLICATION;

ADIPOGENESIS; ADULT; BETA CATENIN; CELL DIFFERENTIATION; CELLS, CULTURED; COHORT STUDIES; FEMALE; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; HUMANS; LONGITUDINAL STUDIES; MALE; MESENCHYMAL STROMAL CELLS; MUSCLE DEVELOPMENT; OBESITY; PEDIATRIC OBESITY; PPAR GAMMA; PREGNANCY; PREGNANCY COMPLICATIONS; UMBILICAL CORD;

EID: 84962425317     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db15-0849     Document Type: Article

References (39)

1. Flegal KM, Carroll MD, Kit BK, Ogden CL. Prevalence of obesity and trends in the distribution of body mass index among US adults, 1999-2010. JAMA 2012; 307:491-497
2. Gluckman PD, Hanson MA. Developmental and epigenetic pathways to obesity: an evolutionary-developmental perspective. Int J Obes 2008;32(Suppl. 7):S62-S71
3. Heerwagen MJR, Miller MR, Barbour LA, Friedman JE. Maternal obesity and fetal metabolic programming: a fertile epigenetic soil. Am J Physiol Regul Integr Comp Physiol 2010;299:R711-R722
4. Sewell MF, Huston-Presley L, Super DM, Catalano P. Increased neonatal fat mass, not lean body mass, is associated with maternal obesity. Am J Obstet Gynecol 2006;195:1100-1103
5. Starling AP, Brinton JT, Glueck DH, et al. Associations of maternal BMI and gestational weight gain with neonatal adiposity in the Healthy Start study. Am J Clin Nutr. 2015;101:302-309
6. Shapiro ALB, Schmiege SJ, Brinton JT, et al. Testing the fuel-mediated hypothesis: maternal insulin resistance and glucose mediate the association between maternal and neonatal adiposity, the Healthy Start study. Diabetologia 2015;58:937-941
7. Pirkola J, Pouta A, Bloigu A, et al. Risks of overweight and abdominal obesity at age 16 years associated with prenatal exposures to maternal pre-pregnancy overweight and gestational diabetes mellitus. Diabetes Care 2010;33: 1115-1121
8. von Maltzahn J, Chang NC, Bentzinger CF, Rudnicki MA. Wnt signaling in myogenesis. Trends Cell Biol 2012;22:602-609
9. Shang Y-C, Wang S-H, Xiong F, et al. Wnt3a signaling promotes proliferation, myogenic differentiation, and migration of rat bone marrow mesenchymal stem cells. Acta Pharmacol Sin 2007;28:1761-1774
10. Armstrong DD, Esser KA. Wnt/beta-catenin signaling activates growth-control genes during overload-induced skeletal muscle hypertrophy. Am J Physiol Cell Physiol 2005;289:C853-C859
11. Sharma M, Chuang WW, Sun Z. Phosphatidylinositol 3-kinase/Akt stimulates androgen pathway through GSK3beta inhibition and nuclear beta-catenin accumulation. J Biol Chem 2002;277:30935-30941
12. Ross SE, Hemati N, Longo KA, et al. Inhibition of adipogenesis by Wnt signaling. Science 2000;289:950-953
13. Kang S, Bennett CN, Gerin I, Rapp LA, Hankenson KD, MacDougald OA. Wnt signaling stimulates osteoblastogenesis of mesenchymal precursors by suppressing CCAAT/enhancer-binding protein alpha and peroxisome proliferator-activated receptor gamma. J Biol Chem 2007;282:14515-14524
14. Yan X, Huang Y, Zhao J-X, et al. Maternal obesity-impaired insulin signaling in sheep and induced lipid accumulation and fibrosis in skeletal muscle of offspring. Biol Reprod 2011;85:172-178
15. Tong JF, Yan X, Zhu MJ, Ford SP, Nathanielsz PW, Du M. Maternal obesity downregulates myogenesis and beta-catenin signaling in fetal skeletal muscle. Am J Physiol Endocrinol Metab 2009;296:E917-E924
16. Zhu MJ, Han B, Tong J, et al. AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep. J Physiol 2008;586:2651-2664
17. Barbet JP, Thornell LE, Butler-Browne GS. Immunocytochemical characterisation of two generations of fibers during the development of the human quadriceps muscle. Mech Dev 1991;35:3-11
18. Poissonnet CM, Burdi AR, Garn SM. The chronology of adipose tissue appearance and distribution in the human fetus. Early Hum Dev 1984;10:1-11
19. Majore I, Moretti P, Stahl F, Hass R, Kasper C. Growth and differentiation properties of mesenchymal stromal cell populations derived from whole human umbilical cord. Stem Cell Rev 2011;7:17-31
20. Shapiro HM. Parameters and probes. In Practical Flow Cytometry. 3rd ed. Hoboken, NJ, John Wiley & Sons, Inc, 2005, p. 273-410
21. Janderová L, McNeil M, Murrell AN, Mynatt RL, Smith SR. Human mesenchymal stem cells as an in vitro model for human adipogenesis. Obes Res 2003;11:65-74
22. Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 2001;7:211-228
23. Tsai C-C, Su P-F, Huang Y-F, Yew T-L, Hung S-C. Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells. Mol Cell 2012;47:169-182
24. Boyle KE, Newsom SA, Janssen RC, Lappas M, Friedman JE. Skeletal muscle MnSOD, mitochondrial complex II, and SIRT3 enzyme activities are decreased in maternal obesity during human pregnancy and gestational diabetes mellitus. J Clin Endocrinol Metab 2013;98:E1601-E1609
25. Boyle KE, Hwang H, Janssen RC, et al. Gestational diabetes is characterized by reduced mitochondrial protein expression and altered calcium signaling proteins in skeletal muscle. PLoS One 2014;9:e106872
26. Iaffaldano L, Nardelli C, Raia M, et al. High aminopeptidase N/CD13 levels characterize human amniotic mesenchymal stem cells and drive their increased adipogenic potential in obese women. Stem Cells Dev 2013;22: 2287-2297
27. Zhao J, Yue W, Zhu MJ, Sreejayan N, Du M. AMP-activated protein kinase (AMPK) cross-talks with canonical Wnt signaling via phosphorylation of beta-catenin at Ser 552. Biochem Biophys Res Commun 2010;395:146-151
28. Metcalfe C, Bienz M. Inhibition of GSK3 by Wnt signalling-two contrasting models. J Cell Sci 2011;124:3537-3544
29. Bikkavilli RK, Feigin ME, Malbon CC. p38 mitogen-activated protein kinase regulates canonical Wnt-beta-catenin signaling by inactivation of GSK3beta. J Cell Sci 2008;121:3598-3607
30. Ohashi K, Nagata Y, Wada E, Zammit PS, Shiozuka M, Matsuda R. Zinc promotes proliferation and activation of myogenic cells via the PI3K/Akt and ERK signaling cascade. Exp Cell Res 2015;333:228-237
31. Ding Q, Xia W, Liu J-C, et al. Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell 2005;19: 159-170
32. Zhu MJ, Han B, Tong J, et al. AMP-activated protein kinase signalling pathways are down regulated and skeletal muscle development impaired in fetuses of obese, over-nourished sheep. J Physiol 2008;586:2651-2664
33. Vanella L, Sanford C Jr, Kim DH, Abraham NG, Ebraheim N. Oxidative stress and heme oxygenase-1 regulated human mesenchymal stem cells differentiation. Int J Hypertens 2012;2012:890671
34. Chuang CC, Yang RS, Tsai KS, Ho FM, Liu SH. Hyperglycemia enhances adipogenic induction of lipid accumulation: involvement of extracellular signalregulated protein kinase 1/2, phosphoinositide 3-kinase/Akt, and peroxisome proliferator-activated receptor gamma signaling. Endocrinology 2007;148: 4267-4275
35. Scarda A, Franzin C, Milan G, et al. Increased adipogenic conversion of muscle satellite cells in obese Zucker rats. Int J Obes 2010;34:1319-1327
36. Rutkowski JM, Stern JH, Scherer PE. The cell biology of fat expansion. J Cell Biol 2015;208:501-512
37. Lendeckel U, Kähne T, Arndt M, Frank K, Ansorge S. Inhibition of alanyl aminopeptidase induces MAP-kinase p42/ERK2 in the human T cell line KARPAS-299. Biochem Biophys Res Commun 1998;252:5-9
38. Rahman MM, Ghosh M, Subramani J, Fong G-H, Carlson ME, Shapiro LH. CD13 regulates anchorage and differentiation of the skeletal muscle satellite stem cell population in ischemic injury. Stem Cells 2014;32:1564-1577
39. Harmon KA, Gerard L, Jensen DR, et al. Continuous glucose profiles in obese and normal-weight pregnant women on a controlled diet: metabolic determinants of fetal growth. Diabetes Care 2011;34:2198-2204