Low and High Birth Weights Are Risk Factors for Nonalcoholic Fatty Liver Disease in Children

Journal of Pediatrics

Volumn 187, Issue , 2017, Pages 141-146.e1

  Newton, Kimberly P ^u,v   Feldman, Haruna S ^m   Chambers, Christina D ^m   Wilson, Laura ^t,w   Behling, Cynthia ^m,x   Clark, Jeanne M ^t,w   Molleston, Jean P ^g,y   Chalasani, Naga ^g   Sanyal, Arun J ^p,z   Fishbein, Mark H ^i,aa   Lavine, Joel E ^d   Schwimmer, Jeffrey B ^m,u,v   Abrams, Stephanie H ^a   Barlow, Sarah ^a,j   Himes, Ryan ^a   Krisnamurthy, Rajesh ^a   Maldonado, Leanel ^a   Mahabir, Rory ^a   Carr, April ^b   Bernstein, Kimberlee ^b   Bramlage, Kristin ^b   Cecil, Kim ^b   DeVore, Stephanie ^b   Kohli, Rohit ^b   Lake, Kathleen ^b   Podberesky, Daniel ^b   Towbin, Alex ^b   Xanthakos, Stavra ^b   Allende, Daniela ^c   Dasarathy, Srinivasan ^c   McCullough, Arthur J ^c   Pagadala, Mangesh ^c   Pai, Rish ^c   Winston, Cha'Ron ^c   Behr, Gerald ^d   Lefkowitch, Jay H ^d   Mencin, Ali ^d   Reynoso, Elena ^d   Abdelmalek, Manal F ^e   Bashir, Mustafa ^e   Buie, Stephanie ^e   Diehl, Anna Mae ^e   Guy, Cynthia ^e   Kigongo, Christopher ^e   Malik, David ^e   Pan, Yi Ping ^e   Piercy, Dawn ^e   Kopping, Mariko ^e   Thrasher, Tyler ^e   Alazraki, Adina ^f   Cleeton, Rebecca ^f   Cordero, Maria ^f   Hernandez, Albert ^f   Karpen, Saul ^f   Munos, Jessica Cruz ^f   Raviele, Nicholas ^f   Vos, Miriam ^f   Bozic, Molly ^g   Cummings, Oscar W ^g   Gawrieh, Samer ^g   Klipsch, Ann ^g   Ragozzino, Emily ^g   Ragozzino, Linda ^g   Sandrasegaran, Kumar ^g   Subbarao, Girish ^g   Vuppalanchi, Raj ^g   Walker, Laura ^g   Kafka, Kimberly ^h   Scheimann, Ann ^h   Ito, Joy ⁱ   Mohammad, Saeed ⁱ   Rigsby, Cynthia ⁱ   Sharda, Lisa ⁱ   Whitington, Peter F ⁱ   Cattoor, Theresa ^j   Derdoy, Jose ^j   Freebersyser, Janet ^j   Jain, Ajay ^j   King, Debra ^j   Lai, Jinping ^j   Osmack, Pat ^j   Siegner, Joan ^j   Stewart, Susan ^j   Neuschwander Tetri, Brent A ^j   Torretta, Susan ^j   Wriston, Kristina ^j   Assadian, Fereshteh ^k   Barone, Vanessa ^k   Gonzalez, Maria Cardona ^k   Davila, Jodie ^k   Fix, Oren ^k   Hennessey, Kelly Anne ^k   Kowdley, Kris V ^k   Lopez, Kacie ^k   Ness, Erik ^k   Poitevin, Michelle ^k   Procaccini, Nicholas ^k   Quist, Brook ^k   Saddic, Alana ^k   Wiseman, Cara ^k   Yeh, Matthew ^k,o   Baker, Susan S ^l   Lopez Graham, Diana ^l   Williams, Sonja ^l   Zhu, Lixin ^l   Africa, Jonathan ^m   Ang, Brandon ^m   Awai, Hannah ^m   Bhatt, Archana ^m   Bross, Craig ^m   Collins, Jennifer ^m   Durelle, Janis ^m   Harlow, Kathryn ^m   Loomba, Rohit ^m   Middleton, Michael ^m   Newton, Kimberly ^m   Paiz, Melissa ^m   Sirlin, Claude ^m   Ugalde Nicalo, Patricia ^m   Villarreal, Mariana Dominguez ^m   Aouizerat, Bradley ⁿ   Bass, Nathan M ⁿ   Brandman, Danielle ⁿ   Courtier, Jesse ⁿ   Ferrell, Linda D ⁿ   Feier, Natasha ⁿ   Gill, Ryan ⁿ   Hameed, Bilal ⁿ   Langlois, Camille ⁿ   Maher, Jacqueline ⁿ   Perito, Emily Rothbaum ⁿ   Ramos, Claudia ⁿ   Rosenthal, Philip ⁿ   Terrault, Norah ⁿ   Tsai, Patrika ⁿ   Ungermann, Ashley ⁿ   Atla, Pradeep ⁿ   Croft, Brandon ⁿ   Garcia, Rebekah ⁿ   Garcia, Sonia ⁿ   Sheikh, Muhammad ⁿ   Singh, Mandeep ⁿ   Cooper, Kara ^o   Horslen, Simon ^o   Hsu, Evelyn ^o   Murray, Karen ^o   Otto, Randolph ^o   Young, Melissa ^o   Boyett, Sherry ^p   Carucci, Laura ^p   Contos, Melissa J ^p   Kirwin, Sherri ^p   Kraft, Kenneth ^p   Luketic, Velimir A C ^p   Puri, Puneet ^p   Schlosser, Jolene ^p   Siddiqui, Mohammad S ^p   Brunt, Elizabeth M ^q   Fowler, Kathryn ^q   Kleiner, David E ^r   Brown, Sherry ^s   Doo, Edward C ^s   Hoofnagle, Jay H ^s   Robuck, Patricia R ^s   Sherker, Averell ^s   Torrance, Rebecca ^s   Belt, Patricia ^t   Donithan, Michele ^t   Hallinan, Erin ^t   Isaacson, Milana ^t   May, Kevin P ^t   Miriel, Laura ^t   Sternberg, Alice ^t   Tonascia, James ^t   Van Natta, Mark ^t   Yates, Katherine ^t   more..

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

^c LERNER RESEARCH INSTITUTE   (United States)

^d Howard Hughes Medical Institute   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f EMORY UNIVERSITY   (United States)

^g INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^h JOHNS HOPKINS HOSPITAL   (United States)

ⁱ NORTHWESTERN UNIVERSITY   (United States)

^j SAINT LOUIS UNIVERSITY   (United States)

^k SWEDISH MEDICAL CENTER   (United States)

^l UNIVERSITY AT BUFFALO   (United States)

^m UNIVERSITY OF CALIFORNIA   (United States)

ⁿ UNIVERSITY OF CALIFORNIA   (United States)

^o UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^p VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^q WASHINGTON UNIVERSITY   (United States)

^r NATIONAL CANCER INSTITUTE   (United States)

^s NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^t JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

^u UNIVERSITY OF CALIFORNIA   (United States)

^v RADY CHILDREN'S HOSPITAL   (United States)

^w JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^x Sharp Fertility Center   (United States)

^y RILEY CHILDREN S HOSPITAL   (United States)

^z VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

^aa CHILDREN'S MEMORIAL HOSPITAL   (United States)

more..

Author keywords

birth weight; children; epidemiology; nonalcoholic fatty liver disease; nonalcoholic steatohepatitis; obesity

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; TRIACYLGLYCEROL;

ADOLESCENT; ARTICLE; CHILDHOOD DISEASE; CLINICAL ASSESSMENT; CLINICAL FEATURE; COHORT ANALYSIS; COMPARATIVE STUDY; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE SEVERITY; FATTY LIVER; FEMALE; HIGH BIRTH WEIGHT; HIGH RISK POPULATION; HUMAN; HUMAN TISSUE; LIVER BIOPSY; LIVER FIBROSIS; LIVER HISTOLOGY; LOW BIRTH WEIGHT; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; NONALCOHOLIC FATTY LIVER; POPULATION; POPULATION DISTRIBUTION; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; BIOPSY; BIRTH WEIGHT; CHILD; CLINICAL TRIAL; FACTUAL DATABASE; LIVER; NON-ALCOHOLIC FATTY LIVER DISEASE; PATHOLOGY; POSTMATURITY; UNITED STATES;

ADOLESCENT; BIOPSY; BIRTH WEIGHT; CHILD; CROSS-SECTIONAL STUDIES; DATABASES, FACTUAL; FEMALE; HUMANS; INFANT, LOW BIRTH WEIGHT; INFANT, POSTMATURE; LIVER; MALE; NON-ALCOHOLIC FATTY LIVER DISEASE; RISK FACTORS; UNITED STATES;

EID: 85016452208     PISSN: 00223476     EISSN: 10976833     Source Type: Journal    
DOI: 10.1016/j.jpeds.2017.03.007     Document Type: Article

References (34)

1. Schwimmer, J.B., Deutsch, R., Kahen, T., Lavine, J.E., Stanley, C., Behling, C., Prevalence of fatty liver in children and adolescents. Pediatrics 118 (2006), 1388–1393.
2. Lindbäck, S.M., Gabbert, C., Johnson, B.L., Smorodinsky, E., Sirlin, C.B., Garcia, N., et al. Pediatric nonalcoholic fatty liver disease: a comprehensive review. Adv Pediatr 57 (2010), 85–140.
3. Molleston, J.P., Schwimmer, J.B., Yates, K.P., Murray, K.F., Cummings, O.W., Lavine, J.E., et al. Histological abnormalities in children with nonalcoholic fatty liver disease and normal or mildly elevated alanine aminotransferase levels. J Pediatr 164 (2014), 707–713 e3.
4. Schwimmer, J.B., Zepeda, A., Newton, K.P., Xanthakos, S.A., Behling, C., Hallinan, E.K., et al. Longitudinal assessment of high blood pressure in children with nonalcoholic fatty liver disease. PLoS ONE, 9, 2014 e112569.
5. Newton, K.P., Hou, J., Crimmins, N.A., Lavine, J.E., Barlow, S.E., Xanthakos, S.A., et al. Prevalence of prediabetes and type 2 diabetes in children with nonalcoholic fatty liver disease. JAMA Pediatr, 170, 2016 e161971.
6. Erhuma, A., Salter, A.M., Sculley, D.V., Langley-Evans, S.C., Bennett, A.J., Prenatal exposure to a low-protein diet programs disordered regulation of lipid metabolism in the aging rat. Am J Physiol Endocrinol Metab 292 (2007), E1702–14.
7. Desai, M., Jellyman, J.K., Han, G., Beall, M., Lane, R.H., Ross, M.G., Maternal obesity and high-fat diet program offspring metabolic syndrome. Am J Obstet Gynecol, 211, 2014, 237 e1-13.
8. Whincup, P.H., Kaye, S.J., Owen, C.G., Huxley, R., Cook, D.G., Anazawa, S., et al. Birth weight and risk of type 2 diabetes: a systematic review. JAMA 300 (2008), 2886–2897.
9. Mu, M., Wang, S.F., Sheng, J., Zhao, Y., Li, H.Z., Hu, C.L., et al. Birth weight and subsequent blood pressure: a meta-analysis. Arch Cardiovasc Dis 105 (2012), 99–113.
10. Modi, N., Murgasova, D., Ruager-Martin, R., Thomas, E.L., Hyde, M.J., Gale, C., et al. The influence of maternal body mass index on infant adiposity and hepatic lipid content. Pediatr Res 70 (2011), 287–291.
11. Brumbaugh, D.E., Tearse, P., Cree-Green, M., Fenton, L.Z., Brown, M., Scherzinger, A., et al. Intrahepatic fat is increased in the neonatal offspring of obese women with gestational diabetes. J Pediatr 162 (2013), 930–936 e1.
12. Patel, K.R., White, F.V., Deutsch, G.H., Hepatic steatosis is prevalent in stillborns delivered to women with diabetes mellitus. J Pediatr Gastroenterol Nutr 60 (2015), 152–158.
13. Nobili, V., Marcellini, M., Marchesini, G., Vanni, E., Manco, M., Villani, A., et al. Intrauterine growth retardation, insulin resistance, and nonalcoholic fatty liver disease in children. Diabetes Care 30 (2007), 2638–2640.
14. Fraser, A., Ebrahim, S., Smith, G.D., Lawlor, D.A., The associations between birthweight and adult markers of liver damage and function. Paediatr Perinat Epidemiol 22 (2008), 12–21.
15. Patton, H.M., Lavine, J.E., Van Natta, M.L., Schwimmer, J.B., Kleiner, D., Molleston, J., et al. Clinical correlates of histopathology in pediatric nonalcoholic steatohepatitis. Gastroenterology 135 (2008), 1961–1971 e2.
16. Lavine, J.E., Schwimmer, J.B., Van Natta, M.L., Molleston, J.P., Murray, K.F., Rosenthal, P., et al. Effect of vitamin E or metformin for treatment of nonalcoholic fatty liver disease in children and adolescents: the TONIC randomized controlled trial. JAMA 305 (2011), 1659–1668.
17. Kleiner, D.E., Brunt, E.M., Van Natta, M., Behling, C., Contos, M.J., Cummings, O.W., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41 (2005), 1313–1321.
18. Sanyal, A.J., Brunt, E.M., Kleiner, D.E., Kowdley, K.V., Chalasani, N., Lavine, J.E., et al. Endpoints and clinical trial design for nonalcoholic steatohepatitis. Hepatology 54 (2011), 344–353.
19. Ventura, S.J., Martin J.A., Curtin, S.C., Mathews, T.J., Report of final natality statistics, 1995. Monthly Vital Stat Rep 45:Suppl 11 (1997), 1–22.
20. Barker, D.J., The origins of the developmental origins theory. J Intern Med 261 (2007), 412–417.
21. Barker, D.J., Winter, P.D., Osmond, C., Margetts, B., Simmonds, S.J., Weight in infancy and death from ischaemic heart disease. Lancet 2 (1989), 577–580.
22. Mzayek, F., Hassig, S., Sherwin, R., Hughes, J., Chen, W., Srinivasan, S., et al. The association of birth weight with developmental trends in blood pressure from childhood through mid-adulthood: the Bogalusa Heart Study. Am J Epidemiol 166 (2007), 413–420.
23. Nightingale, C.M., Rudnicka, A.R., Owen, C.G., Newton, S.L., Bales, J.L., Donin, A.S., et al. Birthweight and risk markers for type 2 diabetes and cardiovascular disease in childhood: the Child Heart and Health Study in England (CHASE). Diabetologia 58 (2015), 474–484.
24. Palatianou, M.E., Simos, Y.V., Andronikou, S.K., Kiortsis, D.N., Long-term metabolic effects of high birth weight: a critical review of the literature. Horm Metab Res 46 (2014), 911–920.
25. Ananth, C.V., Wen, S.W., Trends in fetal growth among singleton gestations in the United States and Canada, 1985 through 1998. Semin Perinatol 26 (2002), 260–267.
26. Andersen, A.M., Osler, M., Birth dimensions, parental mortality, and mortality in early adult age: a cohort study of Danish men born in 1953. Int J Epidemiol 33 (2004), 92–99.
27. Sarr, O., Blake, A., Thompson, J.A., Zhao, L., Rabicki, K., Walsh, J.C., et al. The differential effects of low birth weight and Western diet consumption upon early life hepatic fibrosis development in guinea pig. J Physiol 594 (2016), 1753–1772.
28. Skilton, M.R., Siitonen, N., Würtz, P., Viikari, J.S., Juonala, M., Seppälä, I., et al. High birth weight is associated with obesity and increased carotid wall thickness in young adults: the Cardiovascular Risk in Young Finns Study. Arterioscler Thromb Vasc Biol 34 (2014), 1064–1068.
29. Qiao, Y., Ma, J., Wang, Y., Li, W., Katzmarzyk, P.T., Chaput, J.P., et al. Birth weight and childhood obesity: a 12-country study. Int J Obes Suppl 5:Suppl 2 (2015), S74–9.
30. Johnsson, I.W., Haglund, B., Ahlsson, F., Gustafsson, J., A high birth weight is associated with increased risk of type 2 diabetes and obesity. Pediatr Obes 10 (2015), 77–83.
31. Oben, J.A., Mouralidarane, A., Samuelsson, A.M., Matthews, P.J., Morgan, M.L., McKee, C., et al. Maternal obesity during pregnancy and lactation programs the development of offspring non-alcoholic fatty liver disease in mice. J Hepatol 52 (2010), 913–920.
32. McCurdy, C.E., Bishop, J.M., Williams, S.M., Grayson, B.E., Smith, M.S., Friedman, J.E., et al. Maternal high-fat diet triggers lipotoxicity in the fetal livers of nonhuman primates. J Clin Invest 119 (2009), 323–335.
33. Bruce, K.D., Cagampang, F.R., Argenton, M., Zhang, J., Ethirajan, P.L., Burdge, G.C., et al. Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology 50 (2009), 1796–1808.
34. Seidman, D.S., Slater, P.E., Ever-Hadani, P., Gale, R., Accuracy of mothers' recall of birthweight and gestational age. Br J Obstet Gynaecol 94 (1987), 731–735.