메뉴 건너뛰기




Volumn 60, Issue 3, 2017, Pages 518-530

Associations of maternal BMI and insulin resistance with the maternal metabolome and newborn outcomes

Author keywords

Fetal growth; Maternal BMI; Maternal insulin resistance; Maternal metabolism; Pregnancy

Indexed keywords

ACYLCARNITINE; AMINO ACID; BRANCHED CHAIN AMINO ACID; CARBOHYDRATE; CARBOXYLIC ACID; LIPID; GLUCOSE BLOOD LEVEL;

EID: 85006154152     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-016-4182-2     Document Type: Article
Times cited : (74)

References (49)
  • 1
    • 77949310040 scopus 로고    scopus 로고
    • Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) study: associations with maternal body mass index
    • HAPO Study Cooperative Research Group (2010) Hyperglycaemia and Adverse Pregnancy Outcome (HAPO) study: associations with maternal body mass index. BJOG 117:575–584
    • (2010) BJOG , vol.117 , pp. 575-584
  • 2
    • 84944277603 scopus 로고    scopus 로고
    • Impact of maternal obesity on the metabolic profiles of pregnant women and their offspring at birth
    • COI: 1:CAS:528:DC%2BC2MXhsVajsLfN
    • Desert R, Canlet C, Costet N, Cordier S, Baonvallot N (2015) Impact of maternal obesity on the metabolic profiles of pregnant women and their offspring at birth. Metabolomics 11:1896–1907
    • (2015) Metabolomics , vol.11 , pp. 1896-1907
    • Desert, R.1    Canlet, C.2    Costet, N.3    Cordier, S.4    Baonvallot, N.5
  • 3
    • 84973376090 scopus 로고    scopus 로고
    • Trends in obesity among adults in the United States, 2005 to 2014
    • COI: 1:CAS:528:DC%2BC28XhtlOlsbrF, PID: 27272580
    • Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD, Ogden CL (2016) Trends in obesity among adults in the United States, 2005 to 2014. JAMA 315:2284–2291
    • (2016) JAMA , vol.315 , pp. 2284-2291
    • Flegal, K.M.1    Kruszon-Moran, D.2    Carroll, M.D.3    Fryar, C.D.4    Ogden, C.L.5
  • 4
    • 84862091707 scopus 로고    scopus 로고
    • The hyperglycemia and adverse pregnancy outcome study: associations of GDM and obesity with pregnancy outcomes
    • COI: 1:CAS:528:DC%2BC38Xmt1ChsL4%3D, PID: 22357187
    • Catalano PM, McIntyre HD, Cruickshank JK et al (2012) The hyperglycemia and adverse pregnancy outcome study: associations of GDM and obesity with pregnancy outcomes. Diabetes Care 35:780–786
    • (2012) Diabetes Care , vol.35 , pp. 780-786
    • Catalano, P.M.1    McIntyre, H.D.2    Cruickshank, J.K.3
  • 5
    • 7444238608 scopus 로고    scopus 로고
    • Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study
    • Cnattingius S, Reilly M, Pawitan Y, Lichtenstein P (2004) Maternal and fetal genetic factors account for most of familial aggregation of preeclampsia: a population-based Swedish cohort study. Am J Med Genet A 130:365–371
    • (2004) Am J Med Genet A , vol.130 , pp. 365-371
    • Cnattingius, S.1    Reilly, M.2    Pawitan, Y.3    Lichtenstein, P.4
  • 6
    • 77953817127 scopus 로고    scopus 로고
    • Maternal metabolism and obesity: modifiable determinants of pregnancy outcome
    • PID: 19966268
    • Nelson SM, Matthews P, Poston L (2010) Maternal metabolism and obesity: modifiable determinants of pregnancy outcome. Hum Reprod Update 16:255–275
    • (2010) Hum Reprod Update , vol.16 , pp. 255-275
    • Nelson, S.M.1    Matthews, P.2    Poston, L.3
  • 7
    • 84867644472 scopus 로고    scopus 로고
    • Birthweight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally
    • COI: 1:CAS:528:DC%2BC38Xhs1ansbjL, PID: 23082214
    • Schellong K, Schulz S, Harder T, Plagemann A (2012) Birthweight and long-term overweight risk: systematic review and a meta-analysis including 643,902 persons from 66 studies and 26 countries globally. PLoS One 7, e47776
    • (2012) PLoS One , vol.7
    • Schellong, K.1    Schulz, S.2    Harder, T.3    Plagemann, A.4
  • 8
    • 84867682452 scopus 로고    scopus 로고
    • The relative contribution of prepregnancy overweight and obesity, gestational weight gain, and IADPSG-defined gestational diabetes mellitus to fetal overgrowth
    • PID: 22891256
    • Black MH, Sacks DA, Xiang AH, Lawrence JM (2013) The relative contribution of prepregnancy overweight and obesity, gestational weight gain, and IADPSG-defined gestational diabetes mellitus to fetal overgrowth. Diabetes Care 36:56–62
    • (2013) Diabetes Care , vol.36 , pp. 56-62
    • Black, M.H.1    Sacks, D.A.2    Xiang, A.H.3    Lawrence, J.M.4
  • 9
    • 84862645832 scopus 로고    scopus 로고
    • Maternal BMI, glucose tolerance, and adverse pregnancy outcomes
    • Stuebe AM, Landon MB, Lai Y et al (2012) Maternal BMI, glucose tolerance, and adverse pregnancy outcomes. Am J Obstet Gynecol 207:62.e1–62.e7
    • (2012) Am J Obstet Gynecol , vol.207 , pp. 62.e1-62.e7
    • Stuebe, A.M.1    Landon, M.B.2    Lai, Y.3
  • 10
    • 84962534148 scopus 로고    scopus 로고
    • Genetic evidence for causal relationships between maternal obesity-related traits and birthweight
    • COI: 1:CAS:528:DC%2BC28XhtlGrtrnF, PID: 26978208
    • Tyrrell J, Richmond RC, Palmer TM et al (2016) Genetic evidence for causal relationships between maternal obesity-related traits and birthweight. JAMA 315:1129–1140
    • (2016) JAMA , vol.315 , pp. 1129-1140
    • Tyrrell, J.1    Richmond, R.C.2    Palmer, T.M.3
  • 11
    • 43249096940 scopus 로고    scopus 로고
    • Hyperglycemia and adverse pregnancy outcomes
    • PID: 18463375
    • Metzger BE, Lowe LP, Dyer AR et al (2008) Hyperglycemia and adverse pregnancy outcomes. N Engl J Med 358:1991–2002
    • (2008) N Engl J Med , vol.358 , pp. 1991-2002
    • Metzger, B.E.1    Lowe, L.P.2    Dyer, A.R.3
  • 12
    • 84887369859 scopus 로고    scopus 로고
    • Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies
    • COI: 1:CAS:528:DC%2BC3sXhtl2jtLjO, PID: 23903356
    • Hayes MG, Urbanek M, Hivert MF et al (2013) Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies. Diabetes 62:3282–3291
    • (2013) Diabetes , vol.62 , pp. 3282-3291
    • Hayes, M.G.1    Urbanek, M.2    Hivert, M.F.3
  • 13
    • 84975840947 scopus 로고    scopus 로고
    • Metabolic networks and metabolites underlie associations between maternal glucose during pregnancy and newborn size at birth
    • COI: 1:CAS:528:DC%2BC28XhslWgt7fL, PID: 27207545
    • Scholtens DM, Bain JR, Reisetter AC et al (2016) Metabolic networks and metabolites underlie associations between maternal glucose during pregnancy and newborn size at birth. Diabetes 65:2039–2050
    • (2016) Diabetes , vol.65 , pp. 2039-2050
    • Scholtens, D.M.1    Bain, J.R.2    Reisetter, A.C.3
  • 14
    • 84881576359 scopus 로고    scopus 로고
    • The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study
    • COI: 1:CAS:528:DC%2BC3sXht1CktLjM, PID: 23575227
    • Urbanek M, Hayes MG, Armstrong LL et al (2013) The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study. Hum Mol Genet 22:3583–3596
    • (2013) Hum Mol Genet , vol.22 , pp. 3583-3596
    • Urbanek, M.1    Hayes, M.G.2    Armstrong, L.L.3
  • 15
    • 0036314111 scopus 로고    scopus 로고
    • The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study
    • HAPO Study Cooperative Research Group (2002) The Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study. Int J Gynaecol Obstet 78:69–77
    • (2002) Int J Gynaecol Obstet , vol.78 , pp. 69-77
  • 16
    • 77649252159 scopus 로고    scopus 로고
    • Estimates of insulin sensitivity using glucose and C-peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance test
    • COI: 1:CAS:528:DC%2BC3cXkvValsLc%3D, PID: 20032280
    • Radaelli T, Farrell KA, Huston-Presley L et al (2010) Estimates of insulin sensitivity using glucose and C-peptide from the hyperglycemia and adverse pregnancy outcome glucose tolerance test. Diabetes Care 33:490–494
    • (2010) Diabetes Care , vol.33 , pp. 490-494
    • Radaelli, T.1    Farrell, K.A.2    Huston-Presley, L.3
  • 17
    • 84892374966 scopus 로고    scopus 로고
    • Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy
    • COI: 1:CAS:528:DC%2BC2cXjt1yruro%3D, PID: 23990511
    • Scholtens DM, Muehlbauer MJ, Daya NR et al (2014) Metabolomics reveals broad-scale metabolic perturbations in hyperglycemic mothers during pregnancy. Diabetes Care 37:158–166
    • (2014) Diabetes Care , vol.37 , pp. 158-166
    • Scholtens, D.M.1    Muehlbauer, M.J.2    Daya, N.R.3
  • 18
    • 72449186517 scopus 로고    scopus 로고
    • FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry
    • COI: 1:CAS:528:DC%2BD1MXhsVGntrjP
    • Kind T, Wohlgemuth G, Lee do Y (2009) FiehnLib: mass spectral and retention index libraries for metabolomics based on quadrupole and time-of-flight gas chromatography/mass spectrometry. Anal Chem 81:10,038–10,048
    • (2009) Anal Chem , vol.81 , pp. 10,038-10,048
    • Kind, T.1    Wohlgemuth, G.2    Lee do, Y.3
  • 19
    • 0032991929 scopus 로고    scopus 로고
    • Deconvolution gas chromatography/mass spectrometry of urinary organic acids – potential for pattern recognition and automated identification of metabolic disorders
    • COI: 1:CAS:528:DyaK1MXhtlKntrw%3D, PID: 10097403
    • Halket JM, Przyborowska A, Stein SE, Mallard WG, Down S, Chalmers RA (1999) Deconvolution gas chromatography/mass spectrometry of urinary organic acids – potential for pattern recognition and automated identification of metabolic disorders. Rapid Commun Mass Spectrom 13:279–284
    • (1999) Rapid Commun Mass Spectrom , vol.13 , pp. 279-284
    • Halket, J.M.1    Przyborowska, A.2    Stein, S.E.3    Mallard, W.G.4    Down, S.5    Chalmers, R.A.6
  • 20
    • 84911380992 scopus 로고    scopus 로고
    • Metabomxtr: an R package for mixture-model analysis of non-targeted metabolomics data
    • COI: 1:CAS:528:DC%2BC28XhtlKqurfP, PID: 25075114
    • Nodzenski M, Muehlbauer MJ, Bain JR, Reisetter AC, Lowe WL Jr, Scholtens DM (2014) Metabomxtr: an R package for mixture-model analysis of non-targeted metabolomics data. Bioinformatics 30:3287–3288
    • (2014) Bioinformatics , vol.30 , pp. 3287-3288
    • Nodzenski, M.1    Muehlbauer, M.J.2    Bain, J.R.3    Reisetter, A.C.4    Lowe, W.L.5    Scholtens, D.M.6
  • 21
    • 0034370950 scopus 로고    scopus 로고
    • On the adaptive control of the false discovery rate in multiple testing with independent statistics
    • Benjamini Y, Hochberg Y (2000) On the adaptive control of the false discovery rate in multiple testing with independent statistics. J Educ Behav Stat 25:60–83
    • (2000) J Educ Behav Stat , vol.25 , pp. 60-83
    • Benjamini, Y.1    Hochberg, Y.2
  • 23
    • 0345832338 scopus 로고    scopus 로고
    • A global test for groups of genes: testing association with a clinical outcome
    • COI: 1:CAS:528:DC%2BD2cXns12i, PID: 14693814
    • Goeman JJ, van de Geer SA, de Kort F, van Houwelingen HC (2004) A global test for groups of genes: testing association with a clinical outcome. Bioinformatics 20:93–99
    • (2004) Bioinformatics , vol.20 , pp. 93-99
    • Goeman, J.J.1    van de Geer, S.A.2    de Kort, F.3    van Houwelingen, H.C.4
  • 24
    • 77951972600 scopus 로고    scopus 로고
    • BioNet: an R-package for the functional analysis of biological networks
    • COI: 1:CAS:528:DC%2BC3cXkvVOqs7s%3D, PID: 20189939
    • Beisser D, Klau GW, Dandekar T, Muller T, Dittrich MT (2010) BioNet: an R-package for the functional analysis of biological networks. Bioinformatics 26:1129–1130
    • (2010) Bioinformatics , vol.26 , pp. 1129-1130
    • Beisser, D.1    Klau, G.W.2    Dandekar, T.3    Muller, T.4    Dittrich, M.T.5
  • 25
    • 46249128543 scopus 로고    scopus 로고
    • Identifying functional modules in protein–protein interaction networks: an integrated exact approach
    • COI: 1:CAS:528:DC%2BD1cXnvV2rtrk%3D, PID: 18586718
    • Dittrich MT, Klau GW, Rosenwald A, Dandekar T, Muller T (2008) Identifying functional modules in protein–protein interaction networks: an integrated exact approach. Bioinformatics 24:i223–i231
    • (2008) Bioinformatics , vol.24 , pp. i223-i231
    • Dittrich, M.T.1    Klau, G.W.2    Rosenwald, A.3    Dandekar, T.4    Muller, T.5
  • 26
    • 43349094507 scopus 로고    scopus 로고
    • The igraph software package for complex network research
    • Csardi G, Nepusz T (2006) The igraph software package for complex network research. Interjournal - Complex Systems: 1695
    • (2006) Interjournal - Complex Systems , pp. 1695
    • Csardi, G.1    Nepusz, T.2
  • 27
    • 33746227724 scopus 로고    scopus 로고
    • Statistical mechanics of community detection
    • Reichardt J, Bornholdt S (2006) Statistical mechanics of community detection. Phys Rev E 74:016110
    • (2006) Phys Rev E , vol.74 , pp. 016110
    • Reichardt, J.1    Bornholdt, S.2
  • 28
    • 0035478854 scopus 로고    scopus 로고
    • Random forests
    • Breiman L (2001) Random forests. Mach Learn 45:5–32
    • (2001) Mach Learn , vol.45 , pp. 5-32
    • Breiman, L.1
  • 30
    • 63449111894 scopus 로고    scopus 로고
    • A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance
    • COI: 1:CAS:528:DC%2BD1MXlsFyru78%3D, PID: 19356713
    • Newgard CB, An J, Bain JR et al (2009) A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab 9:311–326
    • (2009) Cell Metab , vol.9 , pp. 311-326
    • Newgard, C.B.1    An, J.2    Bain, J.R.3
  • 31
    • 84872051718 scopus 로고    scopus 로고
    • Acylcarnitines: reflecting or inflicting insulin resistance?
    • COI: 1:CAS:528:DC%2BC3sXlt1Gntw%3D%3D, PID: 23258903
    • Schooneman MG, Vaz FM, Houten SM, Soeters MR (2013) Acylcarnitines: reflecting or inflicting insulin resistance? Diabetes 62:1–8
    • (2013) Diabetes , vol.62 , pp. 1-8
    • Schooneman, M.G.1    Vaz, F.M.2    Houten, S.M.3    Soeters, M.R.4
  • 32
    • 84926667894 scopus 로고    scopus 로고
    • A systematic review of metabolite profiling in gestational diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2cXhsFelu7%2FK, PID: 25193282
    • Huynh J, Xiong G, Bentley-Lewis R (2014) A systematic review of metabolite profiling in gestational diabetes mellitus. Diabetologia 57:2453–2464
    • (2014) Diabetologia , vol.57 , pp. 2453-2464
    • Huynh, J.1    Xiong, G.2    Bentley-Lewis, R.3
  • 33
    • 84898781706 scopus 로고    scopus 로고
    • Metabolic fingerprint of gestational diabetes mellitus
    • COI: 1:CAS:528:DC%2BC2cXovFChsrg%3D, PID: 24698665
    • Dudzik D, Zorawski M, Skotnicki M et al (2014) Metabolic fingerprint of gestational diabetes mellitus. J Proteomics 103:57–71
    • (2014) J Proteomics , vol.103 , pp. 57-71
    • Dudzik, D.1    Zorawski, M.2    Skotnicki, M.3
  • 34
    • 84894081964 scopus 로고    scopus 로고
    • Genetics, genomics and metabolomics: new insights into maternal metabolism during pregnancy
    • COI: 1:CAS:528:DC%2BC2cXivFWlsLc%3D, PID: 24528228
    • Lowe WL Jr, Karban J (2014) Genetics, genomics and metabolomics: new insights into maternal metabolism during pregnancy. Diabet Med 31:254–262
    • (2014) Diabet Med , vol.31 , pp. 254-262
    • Lowe, W.L.1    Karban, J.2
  • 35
    • 84949955729 scopus 로고    scopus 로고
    • A combined metabolomic and proteomic analysis of gestational diabetes mellitus
    • COI: 1:CAS:528:DC%2BC28XhsVyrs7rK
    • Hajduk J, Klupczynska A, Derezinski P et al (2015) A combined metabolomic and proteomic analysis of gestational diabetes mellitus. Int J Mol Sci 16:30,034–30,045
    • (2015) Int J Mol Sci , vol.16 , pp. 30,034-30,045
    • Hajduk, J.1    Klupczynska, A.2    Derezinski, P.3
  • 36
    • 84956951007 scopus 로고    scopus 로고
    • Longitudinal metabolomic profiling of amino acids and lipids across healthy pregnancy
    • PID: 26716698
    • Lindsay KL, Hellmuth C, Uhl O et al (2015) Longitudinal metabolomic profiling of amino acids and lipids across healthy pregnancy. PLoS One 10, e0145794
    • (2015) PLoS One , vol.10
    • Lindsay, K.L.1    Hellmuth, C.2    Uhl, O.3
  • 37
    • 84896772976 scopus 로고    scopus 로고
    • Pregnancy-induced metabolic phenotype variations in maternal plasma
    • COI: 1:CAS:528:DC%2BC2cXhtVKks7s%3D, PID: 24450375
    • Luan H, Meng N, Liu P et al (2014) Pregnancy-induced metabolic phenotype variations in maternal plasma. J Proteome Res 13:1527–1536
    • (2014) J Proteome Res , vol.13 , pp. 1527-1536
    • Luan, H.1    Meng, N.2    Liu, P.3
  • 38
    • 84922607627 scopus 로고    scopus 로고
    • Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine
    • COI: 1:CAS:528:DC%2BC2cXitFCrs7nP, PID: 25529102
    • Pinto J, Barros AS, Domingues MR et al (2015) Following healthy pregnancy by NMR metabolomics of plasma and correlation to urine. J Proteome Res 14:1263–1274
    • (2015) J Proteome Res , vol.14 , pp. 1263-1274
    • Pinto, J.1    Barros, A.S.2    Domingues, M.R.3
  • 39
    • 77956299196 scopus 로고    scopus 로고
    • Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS)
    • COI: 1:CAS:528:DC%2BC3cXpvVyltrk%3D, PID: 20560578
    • Kim JY, Park JY, Kim OY et al (2010) Metabolic profiling of plasma in overweight/obese and lean men using ultra performance liquid chromatography and Q-TOF mass spectrometry (UPLC-Q-TOF MS). J Proteome Res 9:4368–4375
    • (2010) J Proteome Res , vol.9 , pp. 4368-4375
    • Kim, J.Y.1    Park, J.Y.2    Kim, O.Y.3
  • 40
    • 84896939208 scopus 로고    scopus 로고
    • Genome metabolome integrated network analysis to uncover connections between genetic variants and complex traits: an application to obesity
    • PID: 24573330
    • Valcarcel B, Ebbels TM, Kangas AJ et al (2014) Genome metabolome integrated network analysis to uncover connections between genetic variants and complex traits: an application to obesity. J R Soc Interface 11:20130908
    • (2014) J R Soc Interface , vol.11 , pp. 20130908
    • Valcarcel, B.1    Ebbels, T.M.2    Kangas, A.J.3
  • 41
    • 84860756406 scopus 로고    scopus 로고
    • Metabolite profiling identifies pathways associated with metabolic risk in humans
    • COI: 1:CAS:528:DC%2BC38Xms12jurc%3D, PID: 22496159
    • Cheng S, Rhee EP, Larson MG et al (2012) Metabolite profiling identifies pathways associated with metabolic risk in humans. Circulation 125:2222–2231
    • (2012) Circulation , vol.125 , pp. 2222-2231
    • Cheng, S.1    Rhee, E.P.2    Larson, M.G.3
  • 42
    • 84959440715 scopus 로고    scopus 로고
    • Metabolomic profiles of body mass index in the Framingham Heart Study reveal distinct cardiometabolic phenotypes
    • PID: 26863521
    • Ho JE, Larson MG, Ghorbani A et al (2016) Metabolomic profiles of body mass index in the Framingham Heart Study reveal distinct cardiometabolic phenotypes. PLoS One 11, e0148361
    • (2016) PLoS One , vol.11
    • Ho, J.E.1    Larson, M.G.2    Ghorbani, A.3
  • 43
    • 84951567538 scopus 로고    scopus 로고
    • Body mass index, gestational weight gain and fatty acid concentrations during pregnancy: the Generation R Study
    • COI: 1:CAS:528:DC%2BC2MXitVenu7%2FP, PID: 26666541
    • Vidakovic AJ, Jaddoe VW, Gishti O et al (2015) Body mass index, gestational weight gain and fatty acid concentrations during pregnancy: the Generation R Study. Eur J Epidemiol 30:1175–1185
    • (2015) Eur J Epidemiol , vol.30 , pp. 1175-1185
    • Vidakovic, A.J.1    Jaddoe, V.W.2    Gishti, O.3
  • 44
    • 77955601911 scopus 로고    scopus 로고
    • Fatty acid supply to the human fetus
    • COI: 1:CAS:528:DC%2BC3cXhsVWgsbrI, PID: 20438366
    • Haggarty P (2010) Fatty acid supply to the human fetus. Annu Rev Nutr 30:237–255
    • (2010) Annu Rev Nutr , vol.30 , pp. 237-255
    • Haggarty, P.1
  • 45
    • 77949267650 scopus 로고    scopus 로고
    • Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men
    • COI: 1:CAS:528:DC%2BC3cXis1Cmu7Y%3D, PID: 20076942
    • Tai ES, Tan ML, Stevens RD et al (2010) Insulin resistance is associated with a metabolic profile of altered protein metabolism in Chinese and Asian-Indian men. Diabetologia 53:757–767
    • (2010) Diabetologia , vol.53 , pp. 757-767
    • Tai, E.S.1    Tan, M.L.2    Stevens, R.D.3
  • 46
    • 79958164780 scopus 로고    scopus 로고
    • Is it time to revisit the Pedersen hypothesis in the face of the obesity epidemic?
    • PID: 21288502
    • Catalano PM, Hauguel-De Mouzon S (2011) Is it time to revisit the Pedersen hypothesis in the face of the obesity epidemic? Am J Obstet Gynecol 204:479–487
    • (2011) Am J Obstet Gynecol , vol.204 , pp. 479-487
    • Catalano, P.M.1    Hauguel-De Mouzon, S.2
  • 47
    • 84960172990 scopus 로고    scopus 로고
    • A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance
    • COI: 1:CAS:528:DC%2BC28XjslGrtLc%3D, PID: 26950361
    • Jang C, Oh SF, Wada S et al (2016) A branched-chain amino acid metabolite drives vascular fatty acid transport and causes insulin resistance. Nat Med 22:421–426
    • (2016) Nat Med , vol.22 , pp. 421-426
    • Jang, C.1    Oh, S.F.2    Wada, S.3
  • 48
    • 24144446404 scopus 로고    scopus 로고
    • Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability
    • COI: 1:CAS:528:DC%2BD2MXhtVSjs7vP, PID: 16123357
    • Tremblay F, Krebs M, Dombrowski L et al (2005) Overactivation of S6 kinase 1 as a cause of human insulin resistance during increased amino acid availability. Diabetes 54:2674–2684
    • (2005) Diabetes , vol.54 , pp. 2674-2684
    • Tremblay, F.1    Krebs, M.2    Dombrowski, L.3
  • 49
    • 33745020255 scopus 로고    scopus 로고
    • Maternal lipid metabolism and placental lipid transfer
    • COI: 1:CAS:528:DC%2BD28XksV2isbo%3D, PID: 16612115
    • Herrera E, Amusquivar E, Lopez-Soldado I, Ortega H (2006) Maternal lipid metabolism and placental lipid transfer. Horm Res 65(Suppl 3):59–64
    • (2006) Horm Res , vol.65 , pp. 59-64
    • Herrera, E.1    Amusquivar, E.2    Lopez-Soldado, I.3    Ortega, H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.