Depression and sterile inflammation: Essential role of danger associated molecular patterns

Brain, Behavior, and Immunity

Volumn 72, Issue , 2018, Pages 2-13

  Franklin, Tina C ^a   Xu, Chelsea ^a   Duman, Ronald S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

ATP; Cytokines; Depression; HMGB1; HSP70; Inflammation; NLRP3; Psychiatry; RAGE; S100b; Sterile inflammation; Stress; TLR4; Uric acid

Indexed keywords

ADENOSINE TRIPHOSPHATE; ADVANCED GLYCATION END PRODUCT RECEPTOR; C REACTIVE PROTEIN; CRYOPYRIN; HEAT SHOCK PROTEIN 70; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1; INTERLEUKIN 6; PATHOGEN ASSOCIATED MOLECULAR PATTERN; PATTERN RECOGNITION RECEPTOR; PROTEIN S100B; TOLL LIKE RECEPTOR 4; URIC ACID; ALARMIN; CYTOKINE; INFLAMMASOME;

ACUTE STRESS; ARTICLE; CHRONIC STRESS; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DISEASE SEVERITY; EXTRACELLULAR MATRIX; HIPPOCAMPUS; HUMAN; MAJOR DEPRESSION; MENTAL STRESS; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PATHOPHYSIOLOGY; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR BINDING; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; DEPRESSION; IMMUNOLOGY; INFLAMMATION; METABOLISM; MOOD DISORDER; PHYSIOLOGY;

ALARMINS; ANIMALS; CYTOKINES; DEPRESSION; DEPRESSIVE DISORDER, MAJOR; HUMANS; INFLAMMASOMES; INFLAMMATION; MOOD DISORDERS; RECEPTORS, PATTERN RECOGNITION; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL;

EID: 85033587806     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2017.10.025     Document Type: Article

References (149)

1. Alcocer-Gomez, E., Casas-Barquero, N., Williams, M.R., Romero-Guillena, S.L., Canadas-Lozano, D., Bullon, P., Sanchez-Alcazar, J.A., Navarro-Pando, J.M., Cordero, M.D., Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder. Pharmacol. Res. 121 (2017), 114–121.
2. Alcocer-Gomez, E., de Miguel, M., Casas-Barquero, N., Nunez-Vasco, J., Sanchez-Alcazar, J.A., Fernandez-Rodriguez, A., Cordero, M.D., NLRP3 inflammasome is activated in mononuclear blood cells from patients with major depressive disorder. Brain Behav. Immun. 36 (2014), 111–117.
3. Alo, R., Mele, M., Fazzari, G., Avolio, E., Canonaco, M., Exposure to sub-chronic unpredictable stress accounts for antidepressant-like effects in hamsters treated with BDNF and CNQX. Brain Res. Bull. 118 (2015), 65–77.
4. Ambree, O., Bergink, V., Grosse, L., Alferink, J., Drexhage, H.A., Rothermundt, M., Arolt, V., Birkenhager, T.K., 2015. S100B Serum Levels Predict Treatment Response in Patients with Melancholic Depression. Int. J. Neuropsychopharmacol. 19, pyv103.
5. Backlund, L., Nikamo, P., Hukic, D.S., Ek, I.R., Traskman-Bendz, L., Landen, M., Edman, G., Schalling, M., Frisen, L., Osby, U., Cognitive manic symptoms associated with the P2RX7 gene in bipolar disorder. Bipolar Disord. 13 (2011), 500–508.
6. Barden, N., Harvey, M., Gagne, B., Shink, E., Tremblay, M., Raymond, C., Labbe, M., Villeneuve, A., Rochette, D., Bordeleau, L., Stadler, H., Holsboer, F., Muller-Myhsok, B., Analysis of single nucleotide polymorphisms in genes in the chromosome 12Q24.31 region points to P2RX7 as a susceptibility gene to bipolar affective disorder. Am. J. Med. Genet. B Neuropsychiatr. Genet. 141B (2006), 374–382.
7. Bartoli, F., Crocamo, C., Dakanalis, A., Brosio, E., Miotto, A., Capuzzi, E., Clerici, M., Carra, G., Purinergic system dysfunctions in subjects with bipolar disorder: A comparative cross-sectional study. Compr. Psychiatry 73 (2017), 1–6.
8. Bartoli, F., Crocamo, C., Mazza, M.G., Clerici, M., Carra, G., Uric acid levels in subjects with bipolar disorder: A comparative meta-analysis. J. Psychiatr. Res. 81 (2016), 133–139.
9. Bhattacharya, A., Biber, K., The microglial ATP-gated ion channel P2X7 as a CNS drug target. Glia 64 (2016), 1772–1787.
10. Bluthe, R.M., Laye, S., Michaud, B., Combe, C., Dantzer, R., Parnet, P., Role of interleukin-1beta and tumour necrosis factor-alpha in lipopolysaccharide-induced sickness behaviour: a study with interleukin-1 type I receptor-deficient mice. Eur. J. Neurosci. 12 (2000), 4447–4456.
11. Bluthe, R.M., Michaud, B., Poli, V., Dantzer, R., Role of IL-6 in cytokine-induced sickness behavior: a study with IL-6 deficient mice. Physiol. Behav. 70 (2000), 367–373.
12. Bonaccorso, S., Marino, V., Biondi, M., Grimaldi, F., Ippoliti, F., Maes, M., Depression induced by treatment with interferon-alpha in patients affected by hepatits C virus. J. Affect. Disord., 2002.
13. Borges, T.J., Lang, B.J., Lopes, R.L., Bonorino, C., Modulation of alloimmunity by heat shock proteins. Front. Immunol., 7, 2016, 303.
14. Braga, T.T., Forni, M.F., Correa-Costa, M., Ramos, R.N., Barbuto, J.A., Branco, P., Castoldi, A., Hiyane, M.I., Davanso, M.R., Latz, E., Franklin, B.S., Kowaltowski, A.J., Camara, N.O., Soluble uric acid activates the NLRP3 inflammasome. Sci. Rep., 7, 2017, 39884.
15. Bromet, E., Andrade, L.H., Hwang, I., Sampson, N.A., Alonso, J., de Girolamo, G., de Graaf, R., Demyttenaere, K., Hu, C., Iwata, N., Karam, A.N., Kaur, J., Kostyuchenko, S., Lepine, J.P., Levinson, D., Matschinger, H., Mora, M.E., Browne, M.O., Posada-Villa, J., Viana, M.C., Williams, D.R., Kessler, R.C., Cross-national epidemiology of DSM-IV major depressive episode. BMC Med., 9, 2011, 90.
16. Cai, H.L., Jiang, P., Tan, Q.Y., Dang, R.L., Tang, M.M., Xue, Y., Deng, Y., Zhang, B.K., Fang, P.F., Xu, P., Xiang, D.X., Li, H.D., Yao, J.K., Therapeutic efficacy of atypical antipsychotic drugs by targeting multiple stress-related metabolic pathways. Transl. Psychiatry, 7, 2017, e1130.
17. Calderwood, S.K., Gong, J., Murshid, A., Extracellular HSPs: the complicated roles of extracellular HSPs in immunity. Front. Immunol., 7, 2016, 159.
18. Cao, X., Li, L.P., Wang, Q., Wu, Q., Hu, H.H., Zhang, M., Fang, Y.Y., Zhang, J., Li, S.J., Xiong, W.C., Yan, H.C., Gao, Y.B., Liu, J.H., Li, X.W., Sun, L.R., Zeng, Y.N., Zhu, X.H., Gao, T.M., Astrocyte-derived ATP modulates depressive-like behaviors. Nat. Med. 19 (2013), 773–777.
19. Capuron, L., Gumnick, J.F., Musselman, D.L., Lawson, D.H., Reemsnyder, A., Nemeroff, C.B., Miller, A.H., Neurobehavioral effects of interferon-alpha in cancer patients: phenomenology and paroxetine responsiveness of symptom dimensions. Neuropsychopharmacology 26 (2002), 643–652.
20. Capuron, L., Raison, C.L., Musselman, D.L., Lawson, D.H., Nemeroff, C.B., Miller, A.H., Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy. Am. J. Psychiatry 160 (2003), 1342–1345.
21. Chavan, S.S., Huerta, P.T., Robbiati, S., Valdes-Ferrer, S.I., Ochani, M., Dancho, M., Frankfurt, M., Volpe, B.T., Tracey, K.J., Diamond, B., HMGB1 mediates cognitive impairment in sepsis survivors. Mol. Med. 18 (2012), 930–937.
22. Chen, G.Y., Nunez, G., Sterile inflammation: sensing and reacting to damage. Nat. Rev. Immunol. 10 (2010), 826–837.
23. Cheng, Y., Pardo, M., Armini Rde, S., Martinez, A., Mouhsine, H., Zagury, J.F., Jope, R.S., Beurel, E., Stress-induced neuroinflammation is mediated by GSK3-dependent TLR4 signaling that promotes susceptibility to depression-like behavior. Brain Behav. Immun. 53 (2016), 207–222.
24. Cohen, I.V., Makunts, T., Atayee, R., Abagyan, R., Population scale data reveals the antidepressant effects of ketamine and other therapeutics approved for non-psychiatric indications. Sci Rep, 7, 2017, 1450.
25. Constant, A., Castera, L., Dantzer, R., Couzigou, P., de Ledinghen, V., Demotes-Mainard, J., Henry, C., 2005. Mood alterations during interferon-alfa therapy in patients with chronic hepatits C: evidence for an overlap between manic/hypomanic and depressive symptoms. J. Clin. Psychiatry.
26. Crews, F.T., Qin, L., Sheedy, D., Vetreno, R.P., Zou, J., High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. Biol. Psychiatry 73 (2013), 602–612.
27. Devoto, C., Arcurio, L., Fetta, J., Ley, M., Rodney, T., Kanefsky, R., Gill, J., Inflammation relates to chronic behavioral and neurological symptoms in military with traumatic brain injuries. Cell Transplant, 2016.
28. Dogan, K.H., Unaldi, M., Demirci, S., Evaluation of postmortem cerebrospinal fluid S100B protein and serotonin levels: comparison of suicidal versus nonsuicidal deaths in Konya, Turkey. J. Forensic Sci. 61 (2016), 1285–1291.
29. Donato, R., Cannon, B.R., Sorci, G., Riuzzi, F., Hsu, K., Weber, D.J., Geczy, C.L., Functions of S100 proteins. Curr. Mol. Med. 13 (2013), 24–57.
30. Dowlati, Y., Herrmann, N., Swardfager, W., Liu, H., Sham, L., Reim, E.K., Lanctot, K.L., A meta-analysis of cytokines in major depression. Biol. Psychiatry 67 (2010), 446–457.
31. Duivis, H.E., de Jonge, P., Penninx, B.W., Na, B.Y., Cohen, B.E., Whooley, M.A., Depressive symptoms, health behaviors, and subsequent inflammation in patients with coronary heart disease: prospective findings from the heart and soul study. Am. J. Psychiatry 168 (2011), 913–920.
32. Duivis, H.E., Kupper, N., Penninx, B.W., Na, B., de Jonge, P., Whooley, M.A., Depressive symptoms and white blood cell count in coronary heart disease patients: prospective findings from the Heart and Soul Study. Psychoneuroendocrinology 38 (2013), 479–487.
33. Ehret, M., Sobieraj, D.M., Prevention of interferon-alpha-associated depression with antidepressant medications in patients with hepatitis C virus: a systematic review and meta-analysis. Int. J. Clin. Pract. 68 (2014), 255–261.
34. Emanuele, E., D'Angelo, A., Tomaino, C., Binetti, G., Ghidoni, R., Politi, P., Bernardi, L., Maletta, R., Bruni, A.C., Geroldi, D., Circulating levels of soluble receptor for advanced glycation end products in Alzheimer disease and vascular dementia. Arch. Neurol. 62 (2005), 1734–1736.
35. Engler, H., Brendt, P., Wischermann, J., Wegner, A., Rohling, R., Schoemberg, T., Meyer, U., Gold, R., Peters, J., Benson, S., Schedlowski, M., Selective increase of cerebrospinal fluid IL-6 during experimental systemic inflammation in humans: association with depressive symptoms. Mol Psychiatry, 2017.
36. Falcone, T., Fazio, V., Lee, C., Simon, B., Franco, K., Marchi, N., Janigro, D., Serum S100B: a potential biomarker for suicidality in adolescents?. PLoS One, 5, 2010, e11089.
37. Falcone, T., Janigro, D., Lovell, R., Simon, B., Brown, C.A., Herrera, M., Myint, A.M., Anand, A., S100B blood levels and childhood trauma in adolescent inpatients. J. Psychiatr. Res. 62 (2015), 14–22.
38. Fang, Y., Xiao, S.F., Zhang, S.Y., Qiu, Q., Wang, T., Li, X., Increased Plasma S100beta Level in Patients with Major Depressive Disorder. CNS Neurosci. Ther. 22 (2016), 248–250.
39. Festoff, B.W., Sajja, R.K., van Dreden, P., Cucullo, L., HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease. J. Neuroinflammation, 13, 2016, 194.
40. Filipovic, D., Zlatkovic, J., Gass, P., Inta, D., The differential effects of acute vs. chronic stress and their combination on hippocampal parvalbumin and inducible heat shock protein 70 expression. Neuroscience 236 (2013), 47–54.
41. Fleshner, M., Campisi, J., Amiri, L., Diamond, D.M., Cat exposure induces both intra- and extracellular Hsp72: the role of adrenal hormones. Psychoneuroendocrinology 29 (2004), 1142–1152.
42. Fleshner, M., Frank, M., Maier, S.F., Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders. Neuropsychopharmacology 42 (2017), 36–45.
43. Frank, M.G., Weber, M.D., Fonken, L.K., Hershman, S.A., Watkins, L.R., Maier, S.F., The redox state of the alarmin HMGB1 is a pivotal factor in neuroinflammatory and microglial priming: A role for the NLRP3 inflammasome. Brain Behav. Immun. 55 (2016), 215–224.
44. Franklin, T.C., Wohleb, E.S., Zhang, Y., Fogaca, M., Hare, B., Duman, R.S., Persistent Increase in Microglial RAGE Contributes to Chronic Stress-Induced Priming of Depressive-like Behavior. Biol. Psychiatry, 2017.
45. Fu, J., Zuo, X., Yin, J., Luo, X., Li, Z., Lin, J., Zhao, B., Ma, G., Li, K., Association of polymorphisms of the receptor for advanced glycation endproducts gene with schizophrenia in a han Chinese population. Biomed. Res. Int., 2017, 2017, 6379639.
46. Gao, J., Teng, J., Liu, H., Han, X., Chen, B., Xie, A., Association of RAGE gene polymorphisms with sporadic Parkinson's disease in Chinese Han population. Neurosci. Lett. 559 (2014), 158–162.
47. Garcia-Bueno, B., Gasso, P., MacDowell, K.S., Callado, L.F., Mas, S., Bernardo, M., Lafuente, A., Meana, J.J., Leza, J.C., Evidence of activation of the Toll-like receptor-4 proinflammatory pathway in patients with schizophrenia. J. Psychiatry Neurosci. 41 (2016), E46–E55.
48. Grigoleit, J.S., Kullmann, J.S., Wolf, O.T., Hammes, F., Wegner, A., Jablonowski, S., Engler, H., Gizewski, E., Oberbeck, R., Schedlowski, M., Dose-dependent effects of endotoxin on neurobehavioral functions in humans. PLoS One, 6, 2011, e28330.
49. Guzman-Ruiz, R., Ortega, F., Rodriguez, A., Vazquez-Martinez, R., Diaz-Ruiz, A., Garcia-Navarro, S., Giralt, M., Garcia-Rios, A., Cobo-Padilla, D., Tinahones, F.J., Lopez-Miranda, J., Villarroya, F., Fruhbeck, G., Fernandez-Real, J.M., Malagon, M.M., Alarmin high-mobility group B1 (HMGB1) is regulated in human adipocytes in insulin resistance and influences insulin secretion in beta-cells. Int J Obes (Lond) 38 (2014), 1545–1554.
50. Haapakoski, R., Mathieu, J., Ebmeier, K.P., Alenius, H., Kivimaki, M., Cumulative meta-analysis of interleukins 6 and 1beta, tumour necrosis factor alpha and C-reactive protein in patients with major depressive disorder. Brain Behav. Immun. 49 (2015), 206–215.
51. Hammen, C., Stress and depression. Annu. Rev. Clin. Psychol. 1 (2005), 293–319.
52. Hammen, C., Kim, E.Y., Eberhart, N.K., Brennan, P.A., Chronic and acute stress and the prediction of major depression in women. Depress Anxiety 26 (2009), 718–723.
53. Harrison, N.A., Brydon, L., Walker, C., Gray, M.A., Steptoe, A., Critchley, H.D., Inflammation causes mood changes through alterations in subgenual cingulate activity and mesolimbic connectivity. Biol. Psychiatry 66 (2009), 407–414.
54. Harrison, N.A., Brydon, L., Walker, C., Gray, M.A., Steptoe, A., Dolan, R.J., Critchley, H.D., Neural origins of human sickness in interoceptive responses to inflammation. Biol. Psychiatry 66 (2009), 415–422.
55. Harrison, N.A., Cercignani, M., Voon, V., Critchley, H.D., Effects of inflammation on hippocampus and substantia nigra responses to novelty in healthy human participants. Neuropsychopharmacology 40 (2015), 831–838.
56. Harrison, N.A., Cooper, E., Dowell, N.G., Keramida, G., Voon, V., Critchley, H.D., Cercignani, M., Quantitative Magnetization Transfer Imaging as a Biomarker for Effects of Systemic Inflammation on the Brain. Biol. Psychiatry 78 (2015), 49–57.
57. Hashikawa, N., Utaka, Y., Ogawa, T., Tanoue, R., Morita, Y., Yamamoto, S., Yamaguchi, S., Kayano, M., Zamami, Y., Hashikawa-Hobara, N., HSP105 prevents depression-like behavior by increasing hippocampal brain-derived neurotrophic factor levels in mice. Sci Adv, 3, 2017, e1603014.
58. Hayase, T., Yamamoto, Y., Yamamoto, K., Muso, E., Shiota, K., Hayashi, T., Similar effects of cocaine and immobilization stress on the levels of heat-shock proteins and stress-activated protein kinases in the rat hippocampus, and on swimming behaviors: the contribution of dopamine and benzodiazepine receptors. Behav. Pharmacol. 14 (2003), 551–562.
59. Hejjas, K., Szekely, A., Domotor, E., Halmai, Z., Balogh, G., Schilling, B., Sarosi, A., Faludi, G., Sasvari-Szekely, M., Nemoda, Z., Association between depression and the Gln460Arg polymorphism of P2RX7 gene: a dimensional approach. Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (2009), 295–299.
60. Hernanz, A., De la Fuente, M., Navarro, M., Frank, A., Plasma aminothiol compounds, but not serum tumor necrosis factor receptor II and soluble receptor for advanced glycation end products, are related to the cognitive impairment in Alzheimer's disease and mild cognitive impairment patients. Neuroimmunomodulation 14 (2007), 163–167.
61. Hodes, G.E., Pfau, M.L., Leboeuf, M., Golden, S.A., Christoffel, D.J., Bregman, D., Rebusi, N., Heshmati, M., Aleyasin, H., Warren, B.L., Lebonte, B., Horn, S., Lapidus, K.A., Stelzhammer, V., Wong, E.H., Bahn, S., Krishnan, V., Bolanos-Guzman, C.A., Murrough, J.W., Merad, M., Russo, S.J., Individual differences in the peripheral immune system promote resilience versus susceptibility to social stress. Proc. Natl. Acad. Sci. U.S.A. 111 (2014), 16136–16141.
62. Howren, M.B., Lamkin, D.M., Suls, J., Associations of depression with C-reactive protein, IL-1, and IL-6: a meta-analysis. Psychosom. Med. 71 (2009), 171–186.
63. Hung, Y.Y., Huang, K.W., Kang, H.Y., Huang, G.Y., Huang, T.L., Antidepressants normalize elevated Toll-like receptor profile in major depressive disorder. Psychopharmacology 233 (2016), 1707–1714.
64. Hung, Y.Y., Kang, H.Y., Huang, K.W., Huang, T.L., Association between toll-like receptors expression and major depressive disorder. Psychiatry Res. 220 (2014), 283–286.
65. Iwata, M., Ota, K.T., Li, X.Y., Sakaue, F., Li, N., Dutheil, S., Banasr, M., Duric, V., Yamanashi, T., Kaneko, K., Rasmussen, K., Glasebrook, A., Koester, A., Song, D., Jones, K.A., Zorn, S., Smagin, G., Duman, R.S., Psychological stress activates the inflammasome via release of adenosine triphosphate and stimulation of the purinergic type 2X7 receptor. Biol. Psychiatry 80 (2016), 12–22.
66. Jo, E.K., Kim, J.K., Shin, D.M., Sasakawa, C., Molecular mechanisms regulating NLRP3 inflammasome activation. Cell. Mol. Immunol. 13 (2016), 148–159.
67. Kappelmann, N., Lewis, G., Dantzer, R., Jones, P.B., Khandaker, G.M., Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions. Mol Psychiatry, 2016.
68. Kendler, K.S., Karkowski, L.M., Prescott, C.A., Stressful life events and major depression: risk period, long-term contextual threat, and diagnostic specificity. J. Nerv. Ment. Dis. 186 (1998), 661–669.
69. Keri, S., Szabo, C., Kelemen, O., Expression of Toll-Like Receptors in peripheral blood mononuclear cells and response to cognitive-behavioral therapy in major depressive disorder. Brain Behav. Immun. 40 (2014), 235–243.
70. Kesebir, S., Suner, O., Yaylaci, E.T., Bayrak, A., Turan, C., Increased uric acid levels in bipolar disorder: is it trait or state?. J. Biol. Regul. Homeost. Agents 27 (2013), 981–988.
71. Kim, Y., Kim, C., Son, S.M., Song, H., Hong, H.S., Han, S.H., Mook-Jung, I., The novel RAGE interactor PRAK is associated with autophagy signaling in Alzheimer's disease pathogenesis. Mol Neurodegener, 11, 2016, 4.
72. Kiraly, D.D., Horn, S.R., Van Dam, N.T., Costi, S., Schwartz, J., Kim-Schulze, S., Patel, M., Hodes, G.E., Russo, S.J., Merad, M., Iosifescu, D.V., Charney, D.S., Murrough, J.W., Altered peripheral immune profiles in treatment-resistant depression: response to ketamine and prediction of treatment outcome. Transl Psychiatry, 7, 2017, e1065.
73. Kongsui, R., Beynon, S.B., Johnson, S.J., Mayhew, J., Kuter, P., Nilsson, M., Walker, F.R., Chronic stress induces prolonged suppression of the P2X7 receptor within multiple regions of the hippocampus: a cumulative threshold spectra analysis. Brain Behav. Immun. 42 (2014), 69–80.
74. Koo, J.W., Duman, R.S., IL-1beta is an essential mediator of the antineurogenic and anhedonic effects of stress. Proc. Natl. Acad. Scil U.S.A. 105 (2008), 751–756.
75. Koo, J.W., Duman, R.S., Evidence for IL-1 receptor blockade as a therapeutic strategy for the treatment of depression. Curr. Opin. Investig. Drugs 10 (2009), 664–671.
76. Koo, J.W., Russo, S.J., Ferguson, D., Nestler, E.J., Duman, R.S., Nuclear factor-kappaB is a critical mediator of stress-impaired neurogenesis and depressive behavior. Proc. Natl. Acad. Sci. U.S.A. 107 (2010), 2669–2674.
77. Kraus, M.R., Schafer, A., Faller, H., Csef, H., Scheurlen, M., 2003. Psychiatric symptos in patients with chronic hepatitis C receiving interferon Alfa-2b therapy, J. Clin. Psychiatry.
78. Kreisel, T., Frank, M.G., Licht, T., Reshef, R., Ben-Menachem-Zidon, O., Baratta, M.V., Maier, S.F., Yirmiya, R., Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis. Mol. Psychiatry 19 (2014), 699–709.
79. Kupper, N., Gidron, Y., Winter, J., Denollet, J., Association between type D personality, depression, and oxidative stress in patients with chronic heart failure. Psychosom. Med. 71 (2009), 973–980.
80. Levine, J., Barak, Y., Chengappa, K.N.R., Rapoport, A., Rebey, M., Barak, V., Cerebrospinal cytokine levels in patients with acute depression. Neuropsychobiology, 1999.
81. Li, X., Wilder-Smith, C.H., Kan, M.E., Lu, J., Cao, Y., Wong, R.K., Combat-training stress in soldiers increases S100B, a marker of increased blood-brain-barrier permeability, and induces immune activation. Neuro Endocrinol. Lett. 35 (2014), 58–63.
82. Lian, Y.J., Gong, H., Wu, T.Y., Su, W.J., Zhang, Y., Yang, Y.Y., Peng, W., Zhang, T., Zhou, J.R., Jiang, C.L., Wang, Y.X., Ds-HMGB1 and fr-HMGB induce depressive behavior through neuroinflammation in contrast to nonoxid-HMGB1. Brain Behav. Immun. 59 (2017), 322–332.
83. Lindqvist, D., Janelidze, S., Hagell, P., Erhardt, S., Samuelsson, M., Minthon, L., Hansson, O., Bjorkqvist, M., Traskman-Bendz, L., Brundin, L., Interleukin-6 is elevated in the cerebrospinal fluid of suicide attempters and related to symptom severity. Biol. Psychiatry 66 (2009), 287–292.
84. Liu, Y., Ho, R.C., Mak, A., Interleukin (IL)-6, tumour necrosis factor alpha (TNF-alpha) and soluble interleukin-2 receptors (sIL-2R) are elevated in patients with major depressive disorder: a meta-analysis and meta-regression. J. Affect. Disord. 139 (2012), 230–239.
85. Lucae, S., Salyakina, D., Barden, N., Harvey, M., Gagne, B., Labbe, M., Binder, E.B., Uhr, M., Paez-Pereda, M., Sillaber, I., Ising, M., Bruckl, T., Lieb, R., Holsboer, F., Muller-Myhsok, B., P2RX7, a gene coding for a purinergic ligand-gated ion channel, is associated with major depressive disorder. Hum. Mol. Genet. 15 (2006), 2438–2445.
86. Luo, K.R., Hong, C.J., Liou, Y.J., Hou, S.J., Huang, Y.H., Tsai, S.J., Differential regulation of neurotrophin S100B and BDNF in two rat models of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry 34 (2010), 1433–1439.
87. Margis, R., Zanatto, V.C., Tramontina, F., Vinade, E., Lhullier, F., Portela, L.V., Souza, D.O., Dalmaz, C., Kapczinski, F., Goncalves, C.A., Changes in S100B cerebrospinal fluid levels of rats subjected to predator stress. Brain Res. 1028 (2004), 213–218.
88. Marsh, A.M., Nguyen, A.H., Parker, T.M., Agrawal, D.K., Clinical use of high mobility group box 1 and the receptor for advanced glycation end products in the prognosis and risk stratification of heart failure: a literature review. Can. J. Physiol. Pharmacol. 95 (2017), 253–259.
89. Martinez, J.M., Garakani, A., Yehuda, R., Gorman, J.M., Proinflammatory and “resiliency” proteins in the CSF of patients with major depression. Depress Anxiety 29 (2012), 32–38.
90. Martinon, F., Petrilli, V., Mayor, A., Tardivel, A., Tschopp, J., Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440 (2006), 237–241.
91. Maslanik, T., Mahaffey, L., Tannura, K., Beninson, L., Greenwood, B.N., Fleshner, M., The inflammasome and danger associated molecular patterns (DAMPs) are implicated in cytokine and chemokine responses following stressor exposure. Brain Behav. Immun. 28 (2013), 54–62.
92. McDonald, E.M., Mann, A.H., Thomas, H.C., Interferons as mediators of psychiatric morbidity. Lancet, 1987.
93. McKernan, D.P., Dennison, U., Gaszner, G., Cryan, J.F., Dinan, T.G., Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype. Transl. Psychiatry, 1, 2011, e36.
94. McLaughlin, K.A., Conron, K.J., Koenen, K.C., Gilman, S.E., Childhood adversity, adult stressful life events, and risk of past-year psychiatric disorder: a test of the stress sensitization hypothesis in a population-based sample of adults. Psychol. Med. 40 (2010), 1647–1658.
95. McQuillin, A., Bass, N.J., Choudhury, K., Puri, V., Kosmin, M., Lawrence, J., Curtis, D., Gurling, H.M., Case-control studies show that a non-conservative amino-acid change from a glutamine to arginine in the P2RX7 purinergic receptor protein is associated with both bipolar- and unipolar-affective disorders. Mol. Psychiatry 14 (2009), 614–620.
96. Miyashita, M., Watanabe, T., Ichikawa, T., Toriumi, K., Horiuchi, Y., Kobori, A., Kushima, I., Hashimoto, R., Fukumoto, M., Koike, S., Ujike, H., Arinami, T., Tatebayashi, Y., Kasai, K., Takeda, M., Ozaki, N., Okazaki, Y., Yoshikawa, T., Amano, N., Washizuka, S., Yamamoto, H., Miyata, T., Itokawa, M., Yamamoto, Y., Arai, M., The regulation of soluble receptor for AGEs contributes to carbonyl stress in schizophrenia. Biochem. Biophys. Res. Commun. 479 (2016), 447–452.
97. Mueller, T.I., Leon, A.C., Keller, M.B., Solomon, D.A., Endicott, J., Coryell, W., Warshaw, M., Maser, J.D., Recurrence after recovery from major depressive disorder during 15 years of observational follow-up. Am. J. Psychiatry 156 (1999), 1000–1006.
98. Mullington, J., Korth, C., Hermann, D.M., Orth, A., Galanos, C., Holsboer, F., Pollmacher, T., 2000. Dose-dependent effects of endotoxin on human sleep. Am. J. Physiol.-Regul. Integr. Comp. Physiol.
99. Musselman, D.L., Lawson, D.H., Gumnick, J.F., Manatunga, A.K., Penna, S., Goodkin, R.S., Greiner, K., Nemeroff, C.B., Miller, A.H., Paroxetine for the prevention of depression induced by high-dose interferon alfa. N. Engl. J. Med. 344 (2001), 961–966.
100. Musselman, D.L., Miller, A.H., Porter, M.R., Manatunga, A., Gao, F., Penna, S., Pearce, B.D., Landry, J., Glover, S., McDaniel, J.S., Nemeroff, C.B., Higher than normal plasma interleukin-6 concentrations in cancer patients with depression: preliminary findings. Am. J. Psychiatry 158 (2001), 1252–1257.
101. Musumeci, D., Roviello, G.N., Montesarchio, D., An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies. Pharmacol. Ther. 141 (2014), 347–357.
102. Nagy, G., Ronai, Z., Somogyi, A., Sasvari-Szekely, M., Rahman, O.A., Mate, A., Varga, T., Nemoda, Z., P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients. Prog. Neuropsychopharmacol. Biol. Psychiatry 32 (2008), 1884–1888.
103. Nguyen, A.H., Bhavsar, S.B., Riley, E.M., Caponetti, G.C., Agrawal, D.K., Association of high mobility group BOX-1 and receptor for advanced glycation endproducts with clinicopathological features of haematological malignancies: a systematic review. Contemp Oncol (Pozn) 20 (2016), 425–429.
104. Niiranen, A., Laaksonen, R., Iivanainen, M., Mattson, K., Farrkila, M., Cantell, K., Behavioral assessment of patients treated with alpha-interferon. Acta Psychiatr. Scand., 1988.
105. Oktayoglu, P., Tahtasiz, M., Bozkurt, M., Em, S., Ucar, D., Yazmalar, L., Mete, N., Nas, K., Gezer, O., Serum levels of high mobility group box 1 protein and its association with quality of life and psychological and functional status in patients with fibromyalgia. Int. J. Rheum. Dis. 16 (2013), 403–407.
106. Oliveira, J., Busson, M., Etain, B., Jamain, S., Hamdani, N., Boukouaci, W., Amokrane, K., Bennabi, M., Le Guen, E., Dargel, A.A., Houenou, J., Ivanova, R., Bellivier, F., Henry, C., Kahn, J.P., Charron, D., Krishnamoorthy, R., Vervoitte, L., Leboyer, M., Tamouza, R., Polymorphism of Toll-like receptor 4 gene in bipolar disorder. J. Affect. Disord. 152–154 (2014), 395–402.
107. Oliveira, J., Etain, B., Lajnef, M., Hamdani, N., Bennabi, M., Bengoufa, D., Sundaresh, A., Chaabane, A.B., Bellivier, F., Henry, C., Kahn, J.P., Charron, D., Krishnamoorthy, R., Leboyer, M., Tamouza, R., Combined effect of TLR2 gene polymorphism and early life stress on the age at onset of bipolar disorders. PLoS One, 10, 2015, e0119702.
108. Pandey, G.N., Rizavi, H.S., Ren, X., Bhaumik, R., Dwivedi, Y., Toll-like receptors in the depressed and suicide brain. J. Psychiatr. Res. 53 (2014), 62–68.
109. Pasquali, M.A., Harlow, B.L., Soares, C.N., Otto, M.W., Cohen, L.S., Minuzzi, L., Gelain, D.P., Moreira, J.C.F., Frey, B.N., A longitudinal study of neurotrophic, oxidative, and inflammatory markers in first-onset depression in midlife women. Eur. Arch. Psychiatry Clin. Neurosci., 2017.
110. Pearlman, D.M., Brown, J.R., MacKenzie, T.A., Hernandez, F. Jr., Najjar, S., Blood levels of S-100 calcium-binding protein B, high-sensitivity C-reactive protein, and interleukin-6 for changes in depressive symptom severity after coronary artery bypass grafting: prospective cohort nested within a randomized, controlled trial. PLoS One, 9, 2014, e111110.
111. Peng, Y.F., Xiang, Y., Wei, Y.S., The significance of routine biochemical markers in patients with major depressive disorder. Sci Rep, 6, 2016, 34402.
112. Pereira, D.B., Sannes, T., Dodd, S.M., Jensen, S.E., Morgan, L.S., Chan, E.K., Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer. Brain Behav. Immun. 24 (2010), 210–214.
113. Pollmacher, T., Schreiber, W., Gudewill, S., Vedder, H., Fassbender, K., Wiedemann, K., Trachsel, L., Galanos, C., Holsboer, F., 1993. Influence of endotoxin on nocturnal sleep in humans. Am. J. Physiol.-Regul. Integr. Comp. Physiol.
114. Raison, C.L., Capuron, L., Miller, A.H., Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends Immunol. 27 (2006), 24–31.
115. Reichenberg, A., Yirmiya, R., Schuld, A., Kraus, T., Haack, M., Morag, A., Pollmacher, T., Cytokine-Associated Emotional and Cognitive Disturbances in Humans. Arch. Gen. Psychiatry, 2001.
116. Renault, P.F., Hoofnagle, J.H., Park, Y., Mullen, K.D., Peters, M., Jones, B., Rustgi, V., Jones, A., 1987. Psychiatric complications of long-term interferon alfa therapy. Arch. Intern. Med. 147.
117. Rong, H., Wang, G., Liu, T., Wang, H., Wan, Q., Weng, S., Chronic mild stress induces fluoxetine-reversible decreases in hippocampal and cerebrospinal fluid levels of the neurotrophic factor S100B and its specific receptor. Int. J. Mol. Sci. 11 (2010), 5310–5322.
118. Rosen, R.L., Levy-Carrick, N., Reibman, J., Xu, N., Shao, Y., Liu, M., Ferri, L., Kazeros, A., Caplan-Shaw, C.E., Pradhan, D.R., Marmor, M., Galatzer-Levy, I.R., Elevated C-reactive protein and posttraumatic stress pathology among survivors of the 9/11 World Trade Center attacks. J. Psychiatr. Res. 89 (2017), 14–21.
119. Rothermundt, M., Arolt, V., Wiesmann, M., Missler, U., Peters, M., Rudolf, S., Kirchner, H., S-100B is increased in melancholic but not in non-melancholic major depression. J. Affect. Disord. 66 (2001), 89–93.
120. Sahin, T.D., Karson, A., Balci, F., Yazir, Y., Bayramgurler, D., Utkan, T., TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression. Behav. Brain Res. 292 (2015), 233–240.
121. Sarandol, A., Sarandol, E., Acikgoz, H.E., Eker, S.S., Akkaya, C., Dirican, M., First-episode psychosis is associated with oxidative stress: Effects of short-term antipsychotic treatment. Psychiatry Clin. Neurosci. 69 (2015), 699–707.
122. Schroeter, M.L., Sacher, J., Steiner, J., Schoenknecht, P., Mueller, K., Serum S100B represents a new biomarker for mood disorders. Curr. Drug Targets 14 (2013), 1237–1248.
123. Shink, E., Harvey, M., Tremblay, M., Gagne, B., Belleau, P., Raymond, C., Labbe, M., Dube, M.P., Lafreniere, R.G., Barden, N., Analysis of microsatellite markers and single nucleotide polymorphisms in candidate genes for susceptibility to bipolar affective disorder in the chromosome 12Q24.31 region. Am J Med Genet B Neuropsychiatr Genet 135B (2005), 50–58.
124. Sulistyowati Soetrisno S., Ardhianto, A., Hadi, S., 2017. The effect of logotherapy on the expressions of cortisol, HSP70, Beck Depression Inventory (BDI), and pain scales in advanced cervical cancer patients Health Care Women Int 38 2017 91 99.
125. Soronen, P., Mantere, O., Melartin, T., Suominen, K., Vuorilehto, M., Rytsala, H., Arvilommi, P., Holma, I., Holma, M., Jylha, P., Valtonen, H.M., Haukka, J., Isometsa, E., Paunio, T., P2RX7 gene is associated consistently with mood disorders and predicts clinical outcome in three clinical cohorts. Am. J. Med. Genet. B Neuropsychiatr. Genet. 156B (2011), 435–447.
126. Stroth, N., Svenningsson, P., S100B interacts with the serotonin 5-HT7 receptor to regulate a depressive-like behavior. Eur. Neuropsychopharmacol. 25 (2015), 2372–2380.
127. Tao, R., Li, H., High serum uric acid level in adolescent depressive patients. J. Affect. Disord. 174 (2015), 464–466.
128. Tsai, M.C., Huang, T.L., Increased activities of both superoxide dismutase and catalase were indicators of acute depressive episodes in patients with major depressive disorder. Psychiatry Res. 235 (2016), 38–42.
129. Uher, T., Bob, P., Cerebrospinal fluid S100B levels reflect symptoms of depression in patients with non-inflammatory neurological disorders. Neurosci. Lett. 529 (2012), 139–143.
130. Valkanova, V., Ebmeier, K.P., Allan, C.L., CRP, IL-6 and depression: a systematic review and meta-analysis of longitudinal studies. J. Affect. Disord. 150 (2013), 736–744.
131. Wang, C.H., Gu, J.Y., Zhang, X.L., Dong, J., Yang, J., Zhang, Y.L., Ning, Q.F., Shan, X.W., Li, Y., Venlafaxine ameliorates the depression-like behaviors and hippocampal S100B expression in a rat depression model. Behav. Brain Funct., 12, 2016, 34.
132. Weber, M.D., Frank, M.G., Tracey, K.J., Watkins, L.R., Maier, S.F., Stress induces the danger-associated molecular pattern HMGB-1 in the hippocampus of male Sprague Dawley rats: a priming stimulus of microglia and the NLRP3 inflammasome. J. Neurosci. 35 (2015), 316–324.
133. Wen, S., Cheng, M., Wang, H., Yue, J., Wang, H., Li, G., Zheng, L., Zhong, Z., Peng, F., Serum uric acid levels and the clinical characteristics of depression. Clin. Biochem. 45 (2012), 49–53.
134. Wiener, C., Rassier, G.T., Kaster, M.P., Jansen, K., Pinheiro, R.T., Klamt, F., Magalhaes, P.V., Kapczinski, F., Ghisleni, G., da Silva, R.A., Gender-based differences in oxidative stress parameters do not underlie the differences in mood disorders susceptibility between sexes. Eur. Psychiatry 29 (2014), 58–63.
135. Wilkins, A., Hayes, R., Alonso, P., Baldeh, S., Berry, N., Cham, K., Hughes, A., Jaiteh, K., Oelman, B., Tedder, R., et al. Risk factors for HIV-2 infection in The Gambia. AIDS 5 (1991), 1127–1132.
136. Wohleb, E.S., Fenn, A.M., Pacenta, A.M., Powell, N.D., Sheridan, J.F., Godbout, J.P., Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice. Psychoneuroendocrinology 37 (2012), 1491–1505.
137. Wohleb, E.S., Hanke, M.L., Corona, A.W., Powell, N.D., Stiner, L.M., Bailey, M.T., Nelson, R.J., Godbout, J.P., Sheridan, J.F., beta-Adrenergic receptor antagonism prevents anxiety-like behavior and microglial reactivity induced by repeated social defeat. J. Neurosci. 31 (2011), 6277–6288.
138. Wu, M.K., Huang, T.L., Huang, K.W., Huang, Y.L., Hung, Y.Y., Association between toll-like receptor 4 expression and symptoms of major depressive disorder. Neuropsychiatr. Dis. Treat. 11 (2015), 1853–1857.
139. Wu, T.Y., Liu, L., Zhang, W., Zhang, Y., Liu, Y.Z., Shen, X.L., Gong, H., Yang, Y.Y., Bi, X.Y., Jiang, C.L., Wang, Y.X., High-mobility group box-1 was released actively and involved in LPS induced depressive-like behavior. J. Psychiatr. Res. 64 (2015), 99–106.
140. Xiong, Z., Yang, J., Huang, Y., Zhang, K., Bo, Y., Lu, X., Su, G., Ma, J., Yang, J., Zhao, L., Wu, C., Serum metabonomics study of anti-depressive effect of Xiao-Chai-Hu-Tang on rat model of chronic unpredictable mild stress. J Chromatogr B Analyt Technol Biomed Life Sci 1029–1030 (2016), 28–35.
141. Ye, Y., Wang, G., Wang, H., Wang, X., Brain-derived neurotrophic factor (BDNF) infusion restored astrocytic plasticity in the hippocampus of a rat model of depression. Neurosci. Lett. 503 (2011), 15–19.
142. Yirmiya, R., Endotoxin produces a depressive-like episode in rats. Brain Res. 711 (1996), 163–174.
143. You, Z., Luo, C., Zhang, W., Chen, Y., He, J., Zhao, Q., Zuo, R., Wu, Y., Pro- and anti-inflammatory cytokines expression in rat's brain and spleen exposed to chronic mild stress: involvement in depression. Behav. Brain Res. 225 (2011), 135–141.
144. Yue, N., Huang, H., Zhu, X., Han, Q., Wang, Y., Li, B., Liu, Q., Wu, G., Zhang, Y., Yu, J., Activation of P2X7 receptor and NLRP3 inflammasome assembly in hippocampal glial cells mediates chronic stress-induced depressive-like behaviors. J Neuroinflammation, 14, 2017, 102.
145. Zafir, A., Banu, N., Antioxidant potential of fluoxetine in comparison to Curcuma longa in restraint-stressed rats. Eur. J. Pharmacol. 572 (2007), 23–31.
146. Zhang, J.C., Yao, W., Dong, C., Yang, C., Ren, Q., Ma, M., Hashimoto, K., Blockade of interleukin-6 receptor in the periphery promotes rapid and sustained antidepressant actions: a possible role of gut-microbiota-brain axis. Transl. Psychiatry, 7, 2017, e1138.
147. Zhong, J.M., Wu, S.Y., Bai, J., Guo, Q., Tao, J., Chen, H., Zhao, N.W., Zhao, Z., Fu, H., Antidepressant effect of geranylgeranylacetone in a chronic mild stress model of depression and its possible mechanism. Exp. Ther. Med. 4 (2012), 627–632.
148. Zlatkovic, J., Bernardi, R.E., Filipovic, D., Protective effect of Hsp70i against chronic social isolation stress in the rat hippocampus. J. Neural Transm. (Vienna) 121 (2014), 3–14.
149. Zlatkovic, J., Filipovic, D., Chronic social isolation induces NF-kappaB activation and upregulation of iNOS protein expression in rat prefrontal cortex. Neurochem. Int. 63 (2013), 172–179.