HMGB1 and thrombin mediate the blood-brain barrier dysfunction acting as biomarkers of neuroinflammation and progression to neurodegeneration in Alzheimer's disease

Journal of Neuroinflammation

Volumn 13, Issue 1, 2016, Pages

  Festoff, Barry W ^a,b   Sajja, Ravi K ^c   van Dreden, Patrick ^d   Cucullo, Luca ^c  

^a PHLOGISTIX LLC   (United States)

^b UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^c TEXAS TECH UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^d Diagnostica Stago   (France)

Author keywords

Biomarkers; Blood brain barrier; Clinical; DAMPS; HMGB1; Neurodegeneration; Neuroinflammation; Permeability; Thrombin

Indexed keywords

AMYLOID BETA PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; PROTEIN ZO1; THROMBIN; THROMBOMODULIN; ADVANCED GLYCATION END PRODUCT; AMYLOID BETA-PROTEIN (1-42); ANTIBODY; PEPTIDE FRAGMENT;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY ENDOTHELIAL CELL; CELL MEMBRANE PERMEABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE SEVERITY; ENDOTHELIAL DYSFUNCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; IN VITRO STUDY; MALE; MIDDLE AGED; MILD COGNITIVE IMPAIRMENT; NERVOUS SYSTEM INFLAMMATION; PROTEIN BLOOD LEVEL; VERY ELDERLY; BLOOD; CAPILLARY PERMEABILITY; CELL CULTURE; COGNITIVE DEFECT; COMPLICATION; DISEASE COURSE; DRUG EFFECTS; ENCEPHALITIS; ENDOTHELIUM CELL; IMMUNOLOGY; METABOLISM; NERVE DEGENERATION; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY;

AGED; AGED, 80 AND OVER; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANTIBODIES; BLOOD-BRAIN BARRIER; CAPILLARY PERMEABILITY; CELLS, CULTURED; COGNITIVE DYSFUNCTION; DISEASE PROGRESSION; ENCEPHALITIS; ENDOTHELIAL CELLS; FEMALE; GLYCOSYLATION END PRODUCTS, ADVANCED; HMGB1 PROTEIN; HUMANS; MALE; MIDDLE AGED; NERVE DEGENERATION; PEPTIDE FRAGMENTS; THROMBIN;

EID: 84983354553     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/s12974-016-0670-z     Document Type: Article

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