메뉴 건너뛰기




Volumn 141, Issue 3, 2014, Pages 347-357

An overview on HMGB1 inhibitors as potential therapeutic agents in HMGB1-related pathologies

Author keywords

DNA based inhibitors; HMGB1; HMGB1 receptors; Peptide protein inhibitors; Small molecule inhibitors

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; CURVED DNA; GABEXATE MESILATE; GLYCYRRHIZIC ACID; HIGH MOBILITY GROUP B1 PROTEIN; HIGH MOBILITY GROUP INHIBITOR; OLIGONUCLEOTIDE; PROTEIN INHIBITOR; UNCLASSIFIED DRUG;

EID: 84892171140     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2013.11.001     Document Type: Review
Times cited : (292)

References (136)
  • 1
    • 0032495658 scopus 로고    scopus 로고
    • Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock
    • E. Abraham, A. Anzueto, G. Gutierrez, S. Tessler, G. San Pedro, and R. Wunderink et al. Double-blind randomised controlled trial of monoclonal antibody to human tumour necrosis factor in treatment of septic shock Lancet 351 1998 929 933
    • (1998) Lancet , vol.351 , pp. 929-933
    • Abraham, E.1    Anzueto, A.2    Gutierrez, G.3    Tessler, S.4    San Pedro, G.5    Wunderink, R.6
  • 3
    • 74849136922 scopus 로고    scopus 로고
    • The role of HMGB1 in the pathogenesis of rheumatic disease
    • U. Andersson, and H.E. Harris The role of HMGB1 in the pathogenesis of rheumatic disease Biochim Biophys Acta 1799 2010 141 148
    • (2010) Biochim Biophys Acta , vol.1799 , pp. 141-148
    • Andersson, U.1    Harris, H.E.2
  • 4
    • 0034698830 scopus 로고    scopus 로고
    • High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes
    • U. Andersson, H. Wang, K. Palmblad, A.C. Aveberger, O. Bloom, and H. Erlandsson-Harris et al. High mobility group 1 protein (HMG-1) stimulates proinflammatory cytokine synthesis in human monocytes J Exp Med 192 2000 565 570
    • (2000) J Exp Med , vol.192 , pp. 565-570
    • Andersson, U.1    Wang, H.2    Palmblad, K.3    Aveberger, A.C.4    Bloom, O.5    Erlandsson-Harris, H.6
  • 5
    • 34247128758 scopus 로고    scopus 로고
    • Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis
    • D.C. Angus, L. Yang, L. Kong, J.A. Kellum, R.L. Delude, and K.J. Tracey et al. Circulating high-mobility group box 1 (HMGB1) concentrations are elevated in both uncomplicated pneumonia and pneumonia with severe sepsis Crit Care Med 35 2007 1061 1067
    • (2007) Crit Care Med , vol.35 , pp. 1061-1067
    • Angus, D.C.1    Yang, L.2    Kong, L.3    Kellum, J.A.4    Delude, R.L.5    Tracey, K.J.6
  • 7
    • 0027496501 scopus 로고
    • Tumor necrosis factor in the pathogenesis of infectious diseases
    • B. Beutler, and G.E. Grau Tumor necrosis factor in the pathogenesis of infectious diseases Crit Care Med 21 1993 S423 S435
    • (1993) Crit Care Med , vol.21
    • Beutler, B.1    Grau, G.E.2
  • 8
    • 0034252817 scopus 로고    scopus 로고
    • Upwardly mobile proteins. The role of HMG proteins in chromatine structure, gene expression and neoplasia
    • M.E. Bianchi, and M. Beltrame Upwardly mobile proteins. The role of HMG proteins in chromatine structure, gene expression and neoplasia EMBO Rep 1 2000 109 119
    • (2000) EMBO Rep , vol.1 , pp. 109-119
    • Bianchi, M.E.1    Beltrame, M.2
  • 9
    • 0024584528 scopus 로고
    • Specific recognition of cruciform DNA by nuclear protein HMG1
    • M.E. Bianchi, M. Beltrame, and G. Pavonessa Specific recognition of cruciform DNA by nuclear protein HMG1 Science 243 1989 1056 1059
    • (1989) Science , vol.243 , pp. 1056-1059
    • Bianchi, M.E.1    Beltrame, M.2    Pavonessa, G.3
  • 11
    • 4243824006 scopus 로고    scopus 로고
    • The DNA chaperone HMGB1 facilitates ACF/CHRAC dependent nucleosome sliding
    • T. Bonaldi, G. Langst, R. Strohner, P.B. Becker, and M.E. Bianchi The DNA chaperone HMGB1 facilitates ACF/CHRAC dependent nucleosome sliding EMBO J 21 2002 6865 6873
    • (2002) EMBO J , vol.21 , pp. 6865-6873
    • Bonaldi, T.1    Langst, G.2    Strohner, R.3    Becker, P.B.4    Bianchi, M.E.5
  • 12
    • 0142137129 scopus 로고    scopus 로고
    • Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion
    • T. Bonaldi, F. Talamo, P. Scaffidi, D. Ferrera, A. Porto, and A. Bachi et al. Monocytic cells hyperacetylate chromatin protein HMGB1 to redirect it towards secretion EMBO J 22 2003 5551 5560
    • (2003) EMBO J , vol.22 , pp. 5551-5560
    • Bonaldi, T.1    Talamo, F.2    Scaffidi, P.3    Ferrera, D.4    Porto, A.5    Bachi, A.6
  • 13
    • 84868204693 scopus 로고    scopus 로고
    • NMR characterization of the C-terminal tail of full-length RAGE in a membrane mimicking environment
    • V. Borsi, L. Cerofolini, M. Fragai, and C. Luchinat NMR characterization of the C-terminal tail of full-length RAGE in a membrane mimicking environment J Biomol NMR 54 2012 285 290
    • (2012) J Biomol NMR , vol.54 , pp. 285-290
    • Borsi, V.1    Cerofolini, L.2    Fragai, M.3    Luchinat, C.4
  • 14
    • 0027718105 scopus 로고
    • Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues
    • J. Brett, A.M. Schmidt, S.D. Yan, Y.S. Zou, E. Weidman, and D. Pinsky et al. Survey of the distribution of a newly characterized receptor for advanced glycation end products in tissues Am J Pathol 143 1993 1699 1712
    • (1993) Am J Pathol , vol.143 , pp. 1699-1712
    • Brett, J.1    Schmidt, A.M.2    Yan, S.D.3    Zou, Y.S.4    Weidman, E.5    Pinsky, D.6
  • 17
    • 0032814140 scopus 로고    scopus 로고
    • Regulation of DNA-dependent activities by the functional motifs of the high mobility group chromosomal proteins
    • M. Bustin Regulation of DNA-dependent activities by the functional motifs of the high mobility group chromosomal proteins Mol Cell Biol 19 1999 5237 5246
    • (1999) Mol Cell Biol , vol.19 , pp. 5237-5246
    • Bustin, M.1
  • 18
    • 0025323711 scopus 로고
    • Structural features of the HMG chromosomal proteins and their genes
    • M. Bustin, D.A. Lehn, and D. Landsman Structural features of the HMG chromosomal proteins and their genes Biochim Biophys Acta 1049 1990 231 243
    • (1990) Biochim Biophys Acta , vol.1049 , pp. 231-243
    • Bustin, M.1    Lehn, D.A.2    Landsman, D.3
  • 19
    • 43449087928 scopus 로고    scopus 로고
    • Neuropeptides rescue mice from lethal sepsis by down-regulating secretion of the late-acting inflammatory mediator high mobility group box 1
    • A. Chorny, and M. Delgado Neuropeptides rescue mice from lethal sepsis by down-regulating secretion of the late-acting inflammatory mediator high mobility group box 1 Am J Pathol 172 2008 1297 1307
    • (2008) Am J Pathol , vol.172 , pp. 1297-1307
    • Chorny, A.1    Delgado, M.2
  • 20
    • 34250171731 scopus 로고    scopus 로고
    • The extracellular region of the receptor for advanced glycation end products is composed of two independent structural units
    • B.M. Dattilo, G. Fritz, E. Leclerc, C.W. Kooi, C.W. Heizmann, and W.J. Chazin The extracellular region of the receptor for advanced glycation end products is composed of two independent structural units Biochemistry 46 2007 6957 6970
    • (2007) Biochemistry , vol.46 , pp. 6957-6970
    • Dattilo, B.M.1    Fritz, G.2    Leclerc, E.3    Kooi, C.W.4    Heizmann, C.W.5    Chazin, W.J.6
  • 22
    • 0033529476 scopus 로고    scopus 로고
    • Synthesis and characterization of new 3′-3′ linked oligodeoxyribonucleotides for alternate strand triple helix formation
    • L. De Napoli, G. Di Fabio, A. Messere, D. Montesarchio, D. Musumeci, and G. Piccialli Synthesis and characterization of new 3′-3′ linked oligodeoxyribonucleotides for alternate strand triple helix formation Tetrahedron 55 1999 9899 9914
    • (1999) Tetrahedron , vol.55 , pp. 9899-9914
    • De Napoli, L.1    Di Fabio, G.2    Messere, A.3    Montesarchio, D.4    Musumeci, D.5    Piccialli, G.6
  • 23
    • 0001198677 scopus 로고    scopus 로고
    • Synthesis and triple-helix formation by alternate strand recognition of oligonucleotides containing 3′-3′-phosphodiester bonds
    • L. De Napoli, A. Messere, D. Montesarchio, A. Pepe, G. Piccialli, and M. Varra Synthesis and triple-helix formation by alternate strand recognition of oligonucleotides containing 3′-3′-phosphodiester bonds J Org Chem 62 1997 9024 9030
    • (1997) J Org Chem , vol.62 , pp. 9024-9030
    • De Napoli, L.1    Messere, A.2    Montesarchio, D.3    Pepe, A.4    Piccialli, G.5    Varra, M.6
  • 24
    • 0035911959 scopus 로고    scopus 로고
    • The High Mobility Group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells
    • B. Degryse, T. Bonaldi, P. Scaffidi, S. Müller, M. Resnati, and F. Sancito et al. The High Mobility Group (HMG) boxes of the nuclear protein HMG1 induce chemotaxis and cytoskeleton reorganization in rat smooth muscle cells J Cell Biol 152 2001 1197 2006
    • (2001) J Cell Biol , vol.152 , pp. 1197-2006
    • Degryse, B.1    Bonaldi, T.2    Scaffidi, P.3    Müller, S.4    Resnati, M.5    Sancito, F.6
  • 25
    • 84872287041 scopus 로고    scopus 로고
    • Synthesis, biological evaluation, and molecular modeling of glycyrrhizin derivatives as potent high-mobility group box-1 inhibitors with anti-heart-failure activity in vivo
    • D. Du, J. Yan, J. Ren, H. Lv, Y. Li, and S. Xu et al. Synthesis, biological evaluation, and molecular modeling of glycyrrhizin derivatives as potent high-mobility group box-1 inhibitors with anti-heart-failure activity in vivo J Med Chem 56 2013 97 108
    • (2013) J Med Chem , vol.56 , pp. 97-108
    • Du, D.1    Yan, J.2    Ren, J.3    Lv, H.4    Li, Y.5    Xu, S.6
  • 26
    • 20444426542 scopus 로고    scopus 로고
    • Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products
    • I. Dumitriu, and P. Baruah Release of high mobility group box 1 by dendritic cells controls T cell activation via the receptor for advanced glycation end products J Immunol 174 2005 7506 7515
    • (2005) J Immunol , vol.174 , pp. 7506-7515
    • Dumitriu, I.1    Baruah, P.2
  • 28
    • 0036775236 scopus 로고    scopus 로고
    • The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway
    • S. Gardella, C. Andrei, D. Ferrera, and L. Lotti The nuclear protein HMGB1 is secreted by monocytes via a non-classical, vesicle-mediated secretory pathway EMBO Rep 3 2002 995 1001
    • (2002) EMBO Rep , vol.3 , pp. 995-1001
    • Gardella, S.1    Andrei, C.2    Ferrera, D.3    Lotti, L.4
  • 29
    • 34250620898 scopus 로고    scopus 로고
    • Cholinergic anti-inflammatory pathway activity and High Mobility Group Box-1 (HMGB1) serum levels in patients with rheumatoid arthritis
    • R.S. Goldstein, A. Bruchfeld, L. Yang, A.R. Qureshi, M. Gallowitsch-Puerta, and N.B. Patel et al. Cholinergic anti-inflammatory pathway activity and High Mobility Group Box-1 (HMGB1) serum levels in patients with rheumatoid arthritis Mol Med 13 2007 210 215
    • (2007) Mol Med , vol.13 , pp. 210-215
    • Goldstein, R.S.1    Bruchfeld, A.2    Yang, L.3    Qureshi, A.R.4    Gallowitsch-Puerta, M.5    Patel, N.B.6
  • 30
    • 58149090755 scopus 로고    scopus 로고
    • Protective effect of antagonist of high-mobility group box 1 on lipopolysaccharide-induced acute lung injury in mice
    • Q. Gong, J.-F. Xu, H. Yin, S.-F. Liu, L.-H. Duan, and Z.-L. Bian Protective effect of antagonist of high-mobility group box 1 on lipopolysaccharide-induced acute lung injury in mice Scand J Immunol 69 2009 29 35
    • (2009) Scand J Immunol , vol.69 , pp. 29-35
    • Gong, Q.1    Xu, J.-F.2    Yin, H.3    Liu, S.-F.4    Duan, L.-H.5    Bian, Z.-L.6
  • 31
    • 84855471701 scopus 로고    scopus 로고
    • Glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and HMGB1
    • G. Gong, L.B. Yuan, L. Hu, W. Wu, L. Yin, and J.L. Hou et al. Glycyrrhizin attenuates rat ischemic spinal cord injury by suppressing inflammatory cytokines and HMGB1 Acta Pharmacol Sin 33 2012 11 18
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 11-18
    • Gong, G.1    Yuan, L.B.2    Hu, L.3    Wu, W.4    Yin, L.5    Hou, J.L.6
  • 32
    • 77951673284 scopus 로고    scopus 로고
    • The anti-inflammatory activity of HMGB1 A box is enhanced when fused with C-terminal acidic tail
    • W. Gong, Y. Zheng, F. Chao, Y. Li, Z. Xu, and G. Huang et al. The anti-inflammatory activity of HMGB1 A box is enhanced when fused with C-terminal acidic tail J Biomed Biotechnol 2010 2010 915234
    • (2010) J Biomed Biotechnol , vol.2010 , pp. 915234
    • Gong, W.1    Zheng, Y.2    Chao, F.3    Li, Y.4    Xu, Z.5    Huang, G.6
  • 33
    • 0017366660 scopus 로고
    • The isolation and purification of the high mobility group (HMG) nonhistone chromosomal proteins
    • G. Goodwin, and E. Johns The isolation and purification of the high mobility group (HMG) nonhistone chromosomal proteins Methods Cell Biol 16 1977 257 267
    • (1977) Methods Cell Biol , vol.16 , pp. 257-267
    • Goodwin, G.1    Johns, E.2
  • 34
    • 0015857760 scopus 로고
    • A new group of chromatin-associated proteins with a high content of acidic and basic amino acids
    • G.H. Goodwin, C. Sanders, and E.W. Johns A new group of chromatin-associated proteins with a high content of acidic and basic amino acids Eur J Biochem 38 1973 14 19
    • (1973) Eur J Biochem , vol.38 , pp. 14-19
    • Goodwin, G.H.1    Sanders, C.2    Johns, E.W.3
  • 35
    • 80051771760 scopus 로고    scopus 로고
    • Natural killer cells, dendritic cells, and the alarmin high-mobility group box 1 protein: A dangerous trio in HIV-1 infection?
    • M.-L. Gougeon, and M. Bras Natural killer cells, dendritic cells, and the alarmin high-mobility group box 1 protein: A dangerous trio in HIV-1 infection? Curr Opin HIV AIDS 6 2011 364 372
    • (2011) Curr Opin HIV AIDS , vol.6 , pp. 364-372
    • Gougeon, M.-L.1    Bras, M.2
  • 36
    • 84863153618 scopus 로고    scopus 로고
    • Glycyrrhizin attenuates HMGB1-induced hepatocyte apoptosis by inhibiting the p38-dependent mitochondrial pathway
    • G.Y. Gwak, T.G. Moon, D.H. Lee, and B.C. Yoo Glycyrrhizin attenuates HMGB1-induced hepatocyte apoptosis by inhibiting the p38-dependent mitochondrial pathway World J Gastroenterol 18 2012 679 684
    • (2012) World J Gastroenterol , vol.18 , pp. 679-684
    • Gwak, G.Y.1    Moon, T.G.2    Lee, D.H.3    Yoo, B.C.4
  • 37
    • 77149165099 scopus 로고    scopus 로고
    • In vivo and in vitro effects of the anticoagulant, thrombomodulin, on the inflammatory response in rodent models
    • S. Hagiwara, H. Iwasaka, S. Matsumoto, A. Hasegawa, N. Yasuda, and T. Noguchi In vivo and in vitro effects of the anticoagulant, thrombomodulin, on the inflammatory response in rodent models Shock 33 2010 282 288
    • (2010) Shock , vol.33 , pp. 282-288
    • Hagiwara, S.1    Iwasaka, H.2    Matsumoto, S.3    Hasegawa, A.4    Yasuda, N.5    Noguchi, T.6
  • 38
    • 34247890064 scopus 로고    scopus 로고
    • Nafamostat mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury
    • S. Hagiwara, H. Iwasaka, and T. Noguchi Nafamostat mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury J Anesth 21 2007 164 170
    • (2007) J Anesth , vol.21 , pp. 164-170
    • Hagiwara, S.1    Iwasaka, H.2    Noguchi, T.3
  • 39
    • 47649096971 scopus 로고    scopus 로고
    • A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1
    • S. Hagiwara, H. Iwasaka, K. Togo, and T. Noguchi A neutrophil elastase inhibitor, sivelestat, reduces lung injury following endotoxin-induced shock in rats by inhibiting HMGB1 Inflammation 31 2008 227 234
    • (2008) Inflammation , vol.31 , pp. 227-234
    • Hagiwara, S.1    Iwasaka, H.2    Togo, K.3    Noguchi, T.4
  • 40
    • 79952989238 scopus 로고    scopus 로고
    • RAGE: The beneficial and deleterious effects by diverse mechanisms of actions
    • S.H. Han, Y.H. Kim, and I. Mook-Jung RAGE: The beneficial and deleterious effects by diverse mechanisms of actions Mol Cells 31 2011 91 97
    • (2011) Mol Cells , vol.31 , pp. 91-97
    • Han, S.H.1    Kim, Y.H.2    Mook-Jung, I.3
  • 41
    • 0029563931 scopus 로고
    • Structure of the A-domain of HMG1 and its interaction with DNA as studied by heteronuclear three and four dimensional NMR spectroscopy
    • C.H. Hardaman, R.W. Broadhurst, A.R.C. Rain, K.D. Grasser, J.O. Thomas, and E.D. Laue Structure of the A-domain of HMG1 and its interaction with DNA as studied by heteronuclear three and four dimensional NMR spectroscopy Biochemistry 34 1995 16596 16607
    • (1995) Biochemistry , vol.34 , pp. 16596-16607
    • Hardaman, C.H.1    Broadhurst, R.W.2    Rain, A.R.C.3    Grasser, K.D.4    Thomas, J.O.5    Laue, E.D.6
  • 42
    • 78649980480 scopus 로고    scopus 로고
    • Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury
    • S. Hidaka, H. Iwasaka, S. Hagiwara, and T. Noguchi Gabexate mesilate inhibits the expression of HMGB1 in lipopolysaccharide-induced acute lung injury J Surg Res 165 2011 142 150
    • (2011) J Surg Res , vol.165 , pp. 142-150
    • Hidaka, S.1    Iwasaka, H.2    Hagiwara, S.3    Noguchi, T.4
  • 43
    • 0033538569 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but different downstream signaling pathways
    • H.J. Huttunen, C. Fages, and H. Rauvala Receptor for advanced glycation end products (RAGE)-mediated neurite outgrowth and activation of NF-κB require the cytoplasmic domain of the receptor but different downstream signaling pathways J Biol Chem 274 1999 19919 19924
    • (1999) J Biol Chem , vol.274 , pp. 19919-19924
    • Huttunen, H.J.1    Fages, C.2    Rauvala, H.3
  • 44
    • 34447523457 scopus 로고    scopus 로고
    • Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils
    • I. Ito, J. Fukazawa, and M. Yoshida Post-translational methylation of high mobility group box 1 (HMGB1) causes its cytoplasmic localization in neutrophils J Biol Chem 282 2007 16336 16344
    • (2007) J Biol Chem , vol.282 , pp. 16336-16344
    • Ito, I.1    Fukazawa, J.2    Yoshida, M.3
  • 46
    • 84862779194 scopus 로고    scopus 로고
    • Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion
    • S.W. Kim, Y. Jin, J.H. Shin, I.D. Kim, H.K. Lee, and S. Park et al. Glycyrrhizic acid affords robust neuroprotection in the postischemic brain via anti-inflammatory effect by inhibiting HMGB1 phosphorylation and secretion Neurobiol Dis 46 2012 147 156
    • (2012) Neurobiol Dis , vol.46 , pp. 147-156
    • Kim, S.W.1    Jin, Y.2    Shin, J.H.3    Kim, I.D.4    Lee, H.K.5    Park, S.6
  • 47
    • 33745788420 scopus 로고    scopus 로고
    • HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain
    • J.B. Kim, J. Sig Choi, Y.M. Yu, K. Nam, C.S. Piao, and S.W. Kim et al. HMGB1, a novel cytokine-like mediator linking acute neuronal death and delayed neuroinflammation in the postischemic brain J Neurosci 26 2006 6413 6421
    • (2006) J Neurosci , vol.26 , pp. 6413-6421
    • Kim, J.B.1    Sig Choi, J.2    Yu, Y.M.3    Nam, K.4    Piao, C.S.5    Kim, S.W.6
  • 50
    • 0038681182 scopus 로고    scopus 로고
    • Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity
    • R. Kokkola, J. Li, E. Sundberg, A.C. Aveberger, K. Palmblad, and H. Yang et al. Successful treatment of collagen-induced arthritis in mice and rats by targeting extracellular high mobility group box chromosomal protein 1 activity Arthritis Rheum 48 2003 2052 2058
    • (2003) Arthritis Rheum , vol.48 , pp. 2052-2058
    • Kokkola, R.1    Li, J.2    Sundberg, E.3    Aveberger, A.C.4    Palmblad, K.5    Yang, H.6
  • 51
    • 84858273726 scopus 로고    scopus 로고
    • Novel pathways and therapies in experimental diabetic atherosclerosis
    • C. Koulis, J.B. de Haan, and T.J. Allen Novel pathways and therapies in experimental diabetic atherosclerosis Expert Rev Cardiovasc Ther 10 2012 323 335
    • (2012) Expert Rev Cardiovasc Ther , vol.10 , pp. 323-335
    • Koulis, C.1    De Haan, J.B.2    Allen, T.J.3
  • 52
    • 84877063166 scopus 로고    scopus 로고
    • Identification and characterization of the direct interaction between methotrexate (MTX) and high-mobility group box 1 (HMGB1) protein
    • Y. Kuroiwa, Y. Takakusagi, T. Kusayanagi, K. Kuramochi, T. Imai, and T. Hirayama et al. Identification and characterization of the direct interaction between methotrexate (MTX) and high-mobility group box 1 (HMGB1) protein PLoS One 8 2013 e63073
    • (2013) PLoS One , vol.8 , pp. 63073
    • Kuroiwa, Y.1    Takakusagi, Y.2    Kusayanagi, T.3    Kuramochi, K.4    Imai, T.5    Hirayama, T.6
  • 53
    • 84860155576 scopus 로고    scopus 로고
    • Inhibitory effects of lycopene on HMGB1-mediated pro-inflammatory responses in both cellular and animal models
    • W. Lee, S.K. Ku, J.W. Bae, and J.S. Bae Inhibitory effects of lycopene on HMGB1-mediated pro-inflammatory responses in both cellular and animal models Food Chem Toxicol 50 2012 1826 1833
    • (2012) Food Chem Toxicol , vol.50 , pp. 1826-1833
    • Lee, W.1    Ku, S.K.2    Bae, J.W.3    Bae, J.S.4
  • 54
    • 42649094198 scopus 로고    scopus 로고
    • A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1
    • W. Li, M. Ashok, J. Li, H. Yang, A.E. Sama, and H. Wang A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1 PLoS One 2 2007 e1153
    • (2007) PLoS One , vol.2 , pp. 1153
    • Li, W.1    Ashok, M.2    Li, J.3    Yang, H.4    Sama, A.E.5    Wang, H.6
  • 55
    • 0038276946 scopus 로고    scopus 로고
    • Structural basis for the proinflammatory cytokine activity of high mobility group box 1
    • J. Li, R. Kokkola, S. Tabibzadeh, R. Yang, M. Oceani, and X. Qiang et al. Structural basis for the proinflammatory cytokine activity of high mobility group box 1 Mol Med 9 2003 37 45
    • (2003) Mol Med , vol.9 , pp. 37-45
    • Li, J.1    Kokkola, R.2    Tabibzadeh, S.3    Yang, R.4    Oceani, M.5    Qiang, X.6
  • 56
    • 33947194239 scopus 로고    scopus 로고
    • A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1
    • W. Li, J. Li, M. Ashok, R. Wu, D. Chen, and L. Yang et al. A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1 J Immunol 178 2007 3856 3864
    • (2007) J Immunol , vol.178 , pp. 3856-3864
    • Li, W.1    Li, J.2    Ashok, M.3    Wu, R.4    Chen, D.5    Yang, L.6
  • 57
    • 84880656352 scopus 로고    scopus 로고
    • Carbenoxolone blocks endotoxin-induced PKR activation and HMGB1 release
    • W. Li, J. Li, A.E. Sama, and H. Wang Carbenoxolone blocks endotoxin-induced PKR activation and HMGB1 release Mol Med 19 2013 203 211
    • (2013) Mol Med , vol.19 , pp. 203-211
    • Li, W.1    Li, J.2    Sama, A.E.3    Wang, H.4
  • 58
    • 84878346810 scopus 로고    scopus 로고
    • HMGB1: The central cytokine for all lymphoid cells
    • G. Li, X. Liang, and M.T. Lotze HMGB1: The central cytokine for all lymphoid cells Front Immunol 4 2013 68
    • (2013) Front Immunol , vol.4 , pp. 68
    • Li, G.1    Liang, X.2    Lotze, M.T.3
  • 59
    • 0032553294 scopus 로고    scopus 로고
    • Sp1-binding elements in the promoter of RAGE are essential for amphoterin-mediated gene expression in cultured neuroblastoma cells
    • J. Li, X. Qu, and A.M. Schmidt Sp1-binding elements in the promoter of RAGE are essential for amphoterin-mediated gene expression in cultured neuroblastoma cells J Biol Chem 273 1998 30870 30878
    • (1998) J Biol Chem , vol.273 , pp. 30870-30878
    • Li, J.1    Qu, X.2    Schmidt, A.M.3
  • 60
    • 33644833800 scopus 로고    scopus 로고
    • Role of HMGB1 in cardiovascular diseases
    • W. Li, A.E. Sama, and H. Wang Role of HMGB1 in cardiovascular diseases Curr Opin Pharmacol 6 2006 130 135
    • (2006) Curr Opin Pharmacol , vol.6 , pp. 130-135
    • Li, W.1    Sama, A.E.2    Wang, H.3
  • 61
    • 0030910830 scopus 로고    scopus 로고
    • Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products
    • J. Li, and A.M. Schmidt Characterization and functional analysis of the promoter of RAGE, the receptor for advanced glycation end products J Biol Chem 272 1997 498 506
    • (1997) J Biol Chem , vol.272 , pp. 498-506
    • Li, J.1    Schmidt, A.M.2
  • 62
    • 84872939937 scopus 로고    scopus 로고
    • Ethyl pyruvate administration suppresses growth and invasion of gallbladder cancer cells via downregulation of HMGB1-RAGE axis
    • M.L. Li, X.F. Wang, Z.J. Tan, P. Dong, J. Gu, and J.H. Lu et al. Ethyl pyruvate administration suppresses growth and invasion of gallbladder cancer cells via downregulation of HMGB1-RAGE axis Int J Immunopathol Pharmacol 25 2012 955 965
    • (2012) Int J Immunopathol Pharmacol , vol.25 , pp. 955-965
    • Li, M.L.1    Wang, X.F.2    Tan, Z.J.3    Dong, P.4    Gu, J.5    Lu, J.H.6
  • 63
    • 77950681441 scopus 로고    scopus 로고
    • Expression of high mobility group box chromosomal protein 1 and its modulating effects on downstream cytokines in systemic lupus erythematosus
    • J. Li, H. Xie, T. Wen, H. Liu, W. Zhu, and X. Chen Expression of high mobility group box chromosomal protein 1 and its modulating effects on downstream cytokines in systemic lupus erythematosus J Rheumatol 37 2010 766 775
    • (2010) J Rheumatol , vol.37 , pp. 766-775
    • Li, J.1    Xie, H.2    Wen, T.3    Liu, H.4    Zhu, W.5    Chen, X.6
  • 64
    • 2942756123 scopus 로고    scopus 로고
    • Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response
    • B. Liliensiek, M.A. Weigand, A. Bierhaus, W. Nicklas, M. Kasper, and S. Hofer et al. Receptor for advanced glycation end products (RAGE) regulates sepsis but not the adaptive immune response J Clin Invest 113 2004 1641 1650
    • (2004) J Clin Invest , vol.113 , pp. 1641-1650
    • Liliensiek, B.1    Weigand, M.A.2    Bierhaus, A.3    Nicklas, W.4    Kasper, M.5    Hofer, S.6
  • 65
    • 84881463486 scopus 로고    scopus 로고
    • Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE(-/-) mice by downregulating the HMGB1-RAGE axis
    • M. Liu, Y. Yu, H. Jiang, L. Zhang, P.P. Zhang, and P. Yu et al. Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE(-/-) mice by downregulating the HMGB1-RAGE axis Acta Pharmacol Sin 34 2013 830 836
    • (2013) Acta Pharmacol Sin , vol.34 , pp. 830-836
    • Liu, M.1    Yu, Y.2    Jiang, H.3    Zhang, L.4    Zhang, P.P.5    Yu, P.6
  • 67
    • 37749005803 scopus 로고    scopus 로고
    • Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection
    • E.C. Lutterloh, S.M. Opal, D.D. Pittman, J.C. Keith Jr., X.Y. Tan, and B.M. Clancy et al. Inhibition of the RAGE products increases survival in experimental models of severe sepsis and systemic infection Crit Care 11 2007 R122
    • (2007) Crit Care , vol.11 , pp. 122
    • Lutterloh, E.C.1    Opal, S.M.2    Pittman, D.D.3    Keith, Jr.J.C.4    Tan, X.Y.5    Clancy, B.M.6
  • 68
    • 84880091794 scopus 로고    scopus 로고
    • Assessment of the tolerability profile of an ophthalmic solution of 5% glycyrrhizin and copolymer PEG/PPG on and evaluation of its efficacy in the treatment of moderate to severe blepharitis
    • R. Mencucci, E. Favuzza, and U. Meschini Assessment of the tolerability profile of an ophthalmic solution of 5% glycyrrhizin and copolymer PEG/PPG on and evaluation of its efficacy in the treatment of moderate to severe blepharitis Clin Ophtalmol 7 2013 1403 1410
    • (2013) Clin Ophtalmol , vol.7 , pp. 1403-1410
    • Mencucci, R.1    Favuzza, E.2    Meschini, U.3
  • 69
    • 77249100731 scopus 로고    scopus 로고
    • An alternative strategy to synthesize PNA and DNA magnetic conjugates forming nanoparticle assembly based on PNA/DNA duplexes
    • G. Milano, D. Musumeci, M. Gaglione, and A. Messere An alternative strategy to synthesize PNA and DNA magnetic conjugates forming nanoparticle assembly based on PNA/DNA duplexes Mol BioSyst 6 2010 553 561
    • (2010) Mol BioSyst , vol.6 , pp. 553-561
    • Milano, G.1    Musumeci, D.2    Gaglione, M.3    Messere, A.4
  • 71
    • 34247181253 scopus 로고    scopus 로고
    • Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities
    • L. Mollica, F. De Marchis, A. Spitaleri, C. Dalla Costa, D. Pennacchini, and M. Zamai et al. Glycyrrhizin binds to high-mobility group box 1 protein and inhibits its cytokine activities Chem Biol 14 2007 431 441
    • (2007) Chem Biol , vol.14 , pp. 431-441
    • Mollica, L.1    De Marchis, F.2    Spitaleri, A.3    Dalla Costa, C.4    Pennacchini, D.5    Zamai, M.6
  • 72
    • 0024469223 scopus 로고
    • Tissue specificity of nucleo-cytoplasmic distribution of HMG1 and HMG2 proteins and their probable functions
    • M.I. Mosevitsky, V.A. Novitskaya, M.G. Iogannsen, and M.A. Zabezhinsky Tissue specificity of nucleo-cytoplasmic distribution of HMG1 and HMG2 proteins and their probable functions Eur J Biochem 185 1989 303 310
    • (1989) Eur J Biochem , vol.185 , pp. 303-310
    • Mosevitsky, M.I.1    Novitskaya, V.A.2    Iogannsen, M.G.3    Zabezhinsky, M.A.4
  • 73
    • 0035882102 scopus 로고    scopus 로고
    • New EMBO members' review: The double life of HMGB1 chromatin protein: Architectural factor and extracellular signal
    • S. Müller, P. Scaffidi, B. Degryse, T. Bonaldi, L. Ronfani, and A. Agresti et al. New EMBO members' review: The double life of HMGB1 chromatin protein: Architectural factor and extracellular signal EMBO J 20 2001 4337 4340
    • (2001) EMBO J , vol.20 , pp. 4337-4340
    • Müller, S.1    Scaffidi, P.2    Degryse, B.3    Bonaldi, T.4    Ronfani, L.5    Agresti, A.6
  • 74
    • 79954550870 scopus 로고    scopus 로고
    • DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes
    • D. Musumeci, E.M. Bucci, G.N. Roviello, R. Sapio, M. Valente, and M. Moccia et al. DNA-based strategies for blocking HMGB1 cytokine activity: Design, synthesis and preliminary in vitro/in vivo assays of DNA and DNA-like duplexes Mol BioSyst 7 2011 1742 1752
    • (2011) Mol BioSyst , vol.7 , pp. 1742-1752
    • Musumeci, D.1    Bucci, E.M.2    Roviello, G.N.3    Sapio, R.4    Valente, M.5    Moccia, M.6
  • 75
    • 84867330958 scopus 로고    scopus 로고
    • Polyvalent nucleic acid aptamers and modulation of their activity: A focus on the thrombin binding aptamer
    • D. Musumeci, and D. Montesarchio Polyvalent nucleic acid aptamers and modulation of their activity: A focus on the thrombin binding aptamer Pharmacol Ther 136 2012 202 215
    • (2012) Pharmacol Ther , vol.136 , pp. 202-215
    • Musumeci, D.1    Montesarchio, D.2
  • 76
    • 84858715991 scopus 로고    scopus 로고
    • G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: Synthesis, characterization, and enzymatic stability assays
    • D. Musumeci, G. Oliviero, G.N. Roviello, E.M. Bucci, and G. Piccialli G-quadruplex-forming oligonucleotide conjugated to magnetic nanoparticles: synthesis, characterization, and enzymatic stability assays Bioconjug Chem 23 2012 382 391
    • (2012) Bioconjug Chem , vol.23 , pp. 382-391
    • Musumeci, D.1    Oliviero, G.2    Roviello, G.N.3    Bucci, E.M.4    Piccialli, G.5
  • 77
    • 84881523430 scopus 로고    scopus 로고
    • Hairpin ODN-based ligands as potential inhibitors of HMGB1 cytokine activity
    • D. Musumeci, G.N. Roviello, D. Montesarchio, R. Sapio, M. Valente, and V. Anrò et al. Hairpin ODN-based ligands as potential inhibitors of HMGB1 cytokine activity RSC Adv 3 2013 12176 12184
    • (2013) RSC Adv , vol.3 , pp. 12176-12184
    • Musumeci, D.1    Roviello, G.N.2    Montesarchio, D.3    Sapio, R.4    Valente, M.5    Anrò, V.6
  • 78
    • 67649766887 scopus 로고    scopus 로고
    • Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia
    • M. Nagato, K. Okamoto, Y. Abe, A. Higure, and K. Yamaguchi Recombinant human soluble thrombomodulin decreases the plasma high-mobility group box-1 protein levels, whereas improving the acute liver injury and survival rates in experimental endotoxemia Crit Care Med 37 2009 2181 2186
    • (2009) Crit Care Med , vol.37 , pp. 2181-2186
    • Nagato, M.1    Okamoto, K.2    Abe, Y.3    Higure, A.4    Yamaguchi, K.5
  • 80
    • 80053151867 scopus 로고    scopus 로고
    • Glycyrrhizin prevents liver injury by inhibition of high-mobility group box 1 production by Kupffer cells after ischemia-reperfusion in rats
    • M. Ogiku, H. Kono, M. Hara, M. Tsuchiya, and H. Fujii Glycyrrhizin prevents liver injury by inhibition of high-mobility group box 1 production by Kupffer cells after ischemia-reperfusion in rats J Pharmacol Exp Ther 339 2011 93 98
    • (2011) J Pharmacol Exp Ther , vol.339 , pp. 93-98
    • Ogiku, M.1    Kono, H.2    Hara, M.3    Tsuchiya, M.4    Fujii, H.5
  • 82
    • 2942523093 scopus 로고    scopus 로고
    • Synthesis and characterization of a bunchy oligonucleotide forming a monomolecular parallel quadruplex structure in solution
    • G. Oliviero, N. Borbone, A. Galeone, M. Varra, G. Piccialli, and L. Mayol Synthesis and characterization of a bunchy oligonucleotide forming a monomolecular parallel quadruplex structure in solution Tetrahedron Lett 45 2004 4869 4872
    • (2004) Tetrahedron Lett , vol.45 , pp. 4869-4872
    • Oliviero, G.1    Borbone, N.2    Galeone, A.3    Varra, M.4    Piccialli, G.5    Mayol, L.6
  • 83
    • 0028429566 scopus 로고
    • The DNA-bending protein HMG-1 enhances progesterone receptor binding to its target DNA sequences
    • S.A. Onate, P. Prendergast, J.P. Wagner, M. Nissen, R. Reeves, and D.E. Pettijhon et al. The DNA-bending protein HMG-1 enhances progesterone receptor binding to its target DNA sequences Mol Cell Biol 14 1994 3375 3391
    • (1994) Mol Cell Biol , vol.14 , pp. 3375-3391
    • Onate, S.A.1    Prendergast, P.2    Wagner, J.P.3    Nissen, M.4    Reeves, R.5    Pettijhon, D.E.6
  • 84
    • 34548070752 scopus 로고    scopus 로고
    • Structural and functional insights into RAGE activation by multimeric S100B
    • T. Ostendorp, E. Leclerc, A. Galichet, M. Koch, N. Demling, and B. Weigle et al. Structural and functional insights into RAGE activation by multimeric S100B EMBO J 26 2007 3868 3878
    • (2007) EMBO J , vol.26 , pp. 3868-3878
    • Ostendorp, T.1    Leclerc, E.2    Galichet, A.3    Koch, M.4    Demling, N.5    Weigle, B.6
  • 86
    • 35349009132 scopus 로고    scopus 로고
    • Cells migrating to sites of tissue damage in response to the danger signal HMGB1 require NF-κB activation
    • R. Palumbo, B.G. Galvez, T. Pusterla, F. De Marchis, G. Cossu, and K.B. Marcu et al. Cells migrating to sites of tissue damage in response to the danger signal HMGB1 require NF-κB activation J Cell Biol 179 2007 33 40
    • (2007) J Cell Biol , vol.179 , pp. 33-40
    • Palumbo, R.1    Galvez, B.G.2    Pusterla, T.3    De Marchis, F.4    Cossu, G.5    Marcu, K.B.6
  • 88
    • 78650341420 scopus 로고    scopus 로고
    • The 1.5 Å crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding
    • H. Park, F.G. Adsit, and J.C. Boyington The 1.5 Å crystal structure of human receptor for advanced glycation endproducts (RAGE) ectodomains reveals unique features determining ligand binding J Biol Chem 285 2010 40762 40770
    • (2010) J Biol Chem , vol.285 , pp. 40762-40770
    • Park, H.1    Adsit, F.G.2    Boyington, J.C.3
  • 89
    • 0032544398 scopus 로고    scopus 로고
    • Preferential binding of high mobility group 1 protein to UV-damaged DNA. Role of the COOH-terminal domain
    • E.A. Pasheva, I.G. Pashev, and A. Favre Preferential binding of high mobility group 1 protein to UV-damaged DNA. Role of the COOH-terminal domain J Biol Chem 273 1998 24730 24736
    • (1998) J Biol Chem , vol.273 , pp. 24730-24736
    • Pasheva, E.A.1    Pashev, I.G.2    Favre, A.3
  • 90
    • 0027216519 scopus 로고
    • The nonspecific DNA-binding and bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures
    • T. Paull, M.J. Hakynson, and R.C. Johnson The nonspecific DNA-binding and bending proteins HMG1 and HMG2 promote the assembly of complex nucleoprotein structures Genes Dev 7 1993 1521 1534
    • (1993) Genes Dev , vol.7 , pp. 1521-1534
    • Paull, T.1    Hakynson, M.J.2    Johnson, R.C.3
  • 91
    • 0026569275 scopus 로고
    • Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin
    • P.M. Pil, and S.J. Lippard Specific binding of chromosomal protein HMG1 to DNA damaged by the anticancer drug cisplatin Science 256 1992 234 237
    • (1992) Science , vol.256 , pp. 234-237
    • Pil, P.M.1    Lippard, S.J.2
  • 92
    • 55549128746 scopus 로고    scopus 로고
    • High-mobility group box protein 1 (HMGB1): An alarmin mediating the pathogenesis of rheumatic disease
    • D.S. Pisetsky, H. Erlandsson-Harris, and U. Andersson High-mobility group box protein 1 (HMGB1): An alarmin mediating the pathogenesis of rheumatic disease Arthritis Res Ther 10 2008 209
    • (2008) Arthritis Res Ther , vol.10 , pp. 209
    • Pisetsky, D.S.1    Erlandsson-Harris, H.2    Andersson, U.3
  • 95
    • 0035036205 scopus 로고    scopus 로고
    • Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein HMGB2
    • L. Ronfani, M. Ferraguti, L. Croci, C.E. Ovitt, H.R. Scholer, and G.G. Consalez et al. Reduced fertility and spermatogenesis defects in mice lacking chromosomal protein HMGB2 Development 128 2001 1265 1273
    • (2001) Development , vol.128 , pp. 1265-1273
    • Ronfani, L.1    Ferraguti, M.2    Croci, L.3    Ovitt, C.E.4    Scholer, H.R.5    Consalez, G.G.6
  • 97
    • 0037062934 scopus 로고    scopus 로고
    • Release of chromatin protein HMGB1 by necrotic cell triggers inflammation
    • P. Scaffidi, T. Misteli, and M.E. Bianchi Release of chromatin protein HMGB1 by necrotic cell triggers inflammation Nature 418 2002 191 195
    • (2002) Nature , vol.418 , pp. 191-195
    • Scaffidi, P.1    Misteli, T.2    Bianchi, M.E.3
  • 98
    • 84858764021 scopus 로고    scopus 로고
    • Monoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models
    • H. Schierbeck, P. Lundbäck, K. Palmblad, L. Klevenvall, H. Erlandsson-Harris, and U. Andersson et al. Monoclonal anti-HMGB1 (high mobility group box chromosomal protein 1) antibody protection in two experimental arthritis models Mol Med 17 2011 1039 1044
    • (2011) Mol Med , vol.17 , pp. 1039-1044
    • Schierbeck, H.1    Lundbäck, P.2    Palmblad, K.3    Klevenvall, L.4    Erlandsson-Harris, H.5    Andersson, U.6
  • 99
    • 84860361435 scopus 로고    scopus 로고
    • HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4
    • M. Schiraldi, A. Rauchi, L.M. Muñoz, E. Livoti, B. Celona, and E. Venereau et al. HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4 J Exp Med 209 2012 551 563
    • (2012) J Exp Med , vol.209 , pp. 551-563
    • Schiraldi, M.1    Rauchi, A.2    Muñoz, L.M.3    Livoti, E.4    Celona, B.5    Venereau, E.6
  • 100
    • 0034795140 scopus 로고    scopus 로고
    • The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses
    • A.M. Schmidt, S.D. Yan, S.F. Yan, and D.M. Stern The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses J Clin Invest 108 2001 949 955
    • (2001) J Clin Invest , vol.108 , pp. 949-955
    • Schmidt, A.M.1    Yan, S.D.2    Yan, S.F.3    Stern, D.M.4
  • 101
    • 20644444013 scopus 로고    scopus 로고
    • NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1
    • C. Semino, G. Angelini, A. Poggi, and A. Rubartelli NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1 Blood 106 2005 609 616
    • (2005) Blood , vol.106 , pp. 609-616
    • Semino, C.1    Angelini, G.2    Poggi, A.3    Rubartelli, A.4
  • 103
    • 64749107607 scopus 로고    scopus 로고
    • RAGE (receptor for advanced glycation endproducts), RAGE ligands, and their role in cancer and inflammation
    • L.J. Sparvero, D. Asafu-Adjei, R. Kang, D. Tang, N. Amin, and J. Im et al. RAGE (receptor for advanced glycation endproducts), RAGE ligands, and their role in cancer and inflammation J Transl Med 7 2009 17
    • (2009) J Transl Med , vol.7 , pp. 17
    • Sparvero, L.J.1    Asafu-Adjei, D.2    Kang, R.3    Tang, D.4    Amin, N.5    Im, J.6
  • 104
    • 20144380566 scopus 로고    scopus 로고
    • Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock
    • J. Sunden-Cullberg, A. Norrby-Teglund, A. Rouhiainen, H. Rauvala, G. Herman, and K.J. Tracey et al. Persistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock Crit Care Med 33 2005 564 573
    • (2005) Crit Care Med , vol.33 , pp. 564-573
    • Sunden-Cullberg, J.1    Norrby-Teglund, A.2    Rouhiainen, A.3    Rauvala, H.4    Herman, G.5    Tracey, K.J.6
  • 105
    • 84862288751 scopus 로고    scopus 로고
    • Microglial amyloid-β1-40 phagocytosis dysfunction is caused by high-mobility group box protein-1: Implications for the pathological progression of Alzheimer's disease
    • K. Takata, T. Takada, A. Ito, M. Asai, M. Tawa, and Y. Saito et al. Microglial amyloid-β1-40 phagocytosis dysfunction is caused by high-mobility group box protein-1: implications for the pathological progression of Alzheimer's disease Int J Alzheimers Dis 2012 2012 685 739
    • (2012) Int J Alzheimers Dis , vol.2012 , pp. 685-739
    • Takata, K.1    Takada, T.2    Ito, A.3    Asai, M.4    Tawa, M.5    Saito, Y.6
  • 107
    • 71049128963 scopus 로고    scopus 로고
    • Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function
    • D. Tang, R. Kang, W. Xiao, H. Zhang, M.T. Lotze, and H. Wang et al. Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function Am J Respir Cell Mol Biol 41 2009 651 660
    • (2009) Am J Respir Cell Mol Biol , vol.41 , pp. 651-660
    • Tang, D.1    Kang, R.2    Xiao, W.3    Zhang, H.4    Lotze, M.T.5    Wang, H.6
  • 109
    • 84865439684 scopus 로고    scopus 로고
    • Tumor immunity times out: TIM-3 and HMGB1
    • D. Tang, and M.T. Lotze Tumor immunity times out: TIM-3 and HMGB1 Nat Immunol 13 2012 808 810
    • (2012) Nat Immunol , vol.13 , pp. 808-810
    • Tang, D.1    Lotze, M.T.2
  • 110
    • 54549114416 scopus 로고    scopus 로고
    • PACAP inhibit the release and cytokine activity of HMGB1 and improve the survival during lethal endotoxemia
    • Y. Tang, B. Lv, H. Wang, X. Xiao, and X. Zuo PACAP inhibit the release and cytokine activity of HMGB1 and improve the survival during lethal endotoxemia Int Immunopharmacol 8 2008 1646 1651
    • (2008) Int Immunopharmacol , vol.8 , pp. 1646-1651
    • Tang, Y.1    Lv, B.2    Wang, H.3    Xiao, X.4    Zuo, X.5
  • 111
    • 33847775295 scopus 로고    scopus 로고
    • Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1
    • D. Tang, Y. Shi, R. Kang, T. Li, W. Xiao, and H. Wang et al. Hydrogen peroxide stimulates macrophages and monocytes to actively release HMGB1 J Leukoc Biol 81 2007 741 747
    • (2007) J Leukoc Biol , vol.81 , pp. 741-747
    • Tang, D.1    Shi, Y.2    Kang, R.3    Li, T.4    Xiao, W.5    Wang, H.6
  • 112
    • 0034741833 scopus 로고    scopus 로고
    • HMG1 and 2: Architectural DNA-binding proteins
    • J.O. Thomas HMG1 and 2: Architectural DNA-binding proteins Biochem Soc Trans 29 2001 395 401
    • (2001) Biochem Soc Trans , vol.29 , pp. 395-401
    • Thomas, J.O.1
  • 113
    • 84855238144 scopus 로고    scopus 로고
    • High mobility group B1 protein interacts with its receptor RAGE in tumor cells but not in normal tissues
    • J. Todorova, and E. Pasheva High mobility group B1 protein interacts with its receptor RAGE in tumor cells but not in normal tissues Oncol Lett 3 2012 214 218
    • (2012) Oncol Lett , vol.3 , pp. 214-218
    • Todorova, J.1    Pasheva, E.2
  • 114
    • 43049124103 scopus 로고    scopus 로고
    • HMGB1 protein inhibits DNA replication in vitro: A role of the acetylation and the acidic tail
    • D. Topalova, I. Ugrinova, I.G. Pashev, and E.A. Pasceva HMGB1 protein inhibits DNA replication in vitro: A role of the acetylation and the acidic tail Int J Biochem Cell Biol 40 2008 1536 1542
    • (2008) Int J Biochem Cell Biol , vol.40 , pp. 1536-1542
    • Topalova, D.1    Ugrinova, I.2    Pashev, I.G.3    Pasceva, E.A.4
  • 115
    • 67650047868 scopus 로고    scopus 로고
    • Nucleosome binding properties and co-remodeling activities of native and in vivo acetylated HMGB-1 and HMGB-2 proteins
    • I. Ugrinova, I.G. Pashev, and E.A. Pasceva Nucleosome binding properties and co-remodeling activities of native and in vivo acetylated HMGB-1 and HMGB-2 proteins Biochemistry 48 2009 6502 6507
    • (2009) Biochemistry , vol.48 , pp. 6502-6507
    • Ugrinova, I.1    Pashev, I.G.2    Pasceva, E.A.3
  • 116
    • 63049132136 scopus 로고    scopus 로고
    • Native HMGB1 protein inhibits repair of cisplatin-damaged nucleosomes in vitro
    • I. Ugrinova, S. Zlateva, I.G. Pashev, and E.A. Pasceva Native HMGB1 protein inhibits repair of cisplatin-damaged nucleosomes in vitro Int J Biochem Cell Biol 41 2009 1556 1562
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 1556-1562
    • Ugrinova, I.1    Zlateva, S.2    Pashev, I.G.3    Pasceva, E.A.4
  • 117
    • 80052975019 scopus 로고    scopus 로고
    • High-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus
    • V. Urbonaviciute, and R.E. Voll High-mobility group box 1 represents a potential marker of disease activity and novel therapeutic target in systemic lupus erythematosus J Intern Med 270 2011 309 318
    • (2011) J Intern Med , vol.270 , pp. 309-318
    • Urbonaviciute, V.1    Voll, R.E.2
  • 118
    • 84875631644 scopus 로고    scopus 로고
    • HMGB1 and leukocyte migration during trauma and sterile inflammation
    • E. Venereau, M. Schiraldi, M. Uguccioni, and M.E. Bianchi HMGB1 and leukocyte migration during trauma and sterile inflammation Mol Immunol 55 2013 76 82
    • (2013) Mol Immunol , vol.55 , pp. 76-82
    • Venereau, E.1    Schiraldi, M.2    Uguccioni, M.3    Bianchi, M.E.4
  • 119
    • 84879232713 scopus 로고    scopus 로고
    • Dipotassium glycyrrhizate inhibits HMGB1-dependent inflammation and ameliorates colitis in mice
    • R. Vitali, F. Palone, S. Cucchiara, A. Neuroni, L. Cavone, and M. Costanzo et al. Dipotassium glycyrrhizate inhibits HMGB1-dependent inflammation and ameliorates colitis in mice PLoS One 8 2013 e66527
    • (2013) PLoS One , vol.8 , pp. 66527
    • Vitali, R.1    Palone, F.2    Cucchiara, S.3    Neuroni, A.4    Cavone, L.5    Costanzo, M.6
  • 120
    • 55949107346 scopus 로고    scopus 로고
    • The role of high-mobility group box 1 protein in the pathogenesis of autoimmune diseases
    • R.E. Voll, V. Urbonaviciute, B. Furnrohr, M. Herrmann, and J.R. Kalden The role of high-mobility group box 1 protein in the pathogenesis of autoimmune diseases Curr Rheumatol Rep 10 2008 341 342
    • (2008) Curr Rheumatol Rep , vol.10 , pp. 341-342
    • Voll, R.E.1    Urbonaviciute, V.2    Furnrohr, B.3    Herrmann, M.4    Kalden, J.R.5
  • 121
    • 0019335486 scopus 로고
    • The primary structures of non-histone chromosomal proteins HMG1 and 2
    • J.M. Walker, K. Gooderham, J.R. Hastings, E. Mayes, and E.W. Johns The primary structures of non-histone chromosomal proteins HMG1 and 2 FEBS Lett 122 1980 264 270
    • (1980) FEBS Lett , vol.122 , pp. 264-270
    • Walker, J.M.1    Gooderham, K.2    Hastings, J.R.3    Mayes, E.4    Johns, E.W.5
  • 123
    • 1542316768 scopus 로고    scopus 로고
    • Extracellular role of HMGB1 in inflammation and sepsis
    • H. Wang, H. Yang, and K.J. Tracey Extracellular role of HMGB1 in inflammation and sepsis J Intern Med 255 2004 320 331
    • (2004) J Intern Med , vol.255 , pp. 320-331
    • Wang, H.1    Yang, H.2    Tracey, K.J.3
  • 124
    • 34347258088 scopus 로고    scopus 로고
    • The HMGB1 acidic tail regulates HMGB1 DNA binding specificity by a unique mechanism
    • Q. Wang, M. Zeng, W. Wang, and J. Tang The HMGB1 acidic tail regulates HMGB1 DNA binding specificity by a unique mechanism Biochem Biophys Res Commun 360 2007 14 19
    • (2007) Biochem Biophys Res Commun , vol.360 , pp. 14-19
    • Wang, Q.1    Zeng, M.2    Wang, W.3    Tang, J.4
  • 125
    • 76749167941 scopus 로고    scopus 로고
    • Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-kB expression
    • L. Wang, X. Zhang, L. Liu, R. Yang, L. Cui, and M. Li Atorvastatin protects rat brains against permanent focal ischemia and downregulates HMGB1, HMGB1 receptors (RAGE and TLR4), NF-kB expression Neurosci Lett 471 2010 152 156
    • (2010) Neurosci Lett , vol.471 , pp. 152-156
    • Wang, L.1    Zhang, X.2    Liu, L.3    Yang, R.4    Cui, L.5    Li, M.6
  • 126
    • 84874672440 scopus 로고    scopus 로고
    • Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response
    • W. Wang, F. Zhao, Y. Fang, X. Li, L. Shen, and T. Cao et al. Glycyrrhizin protects against porcine endotoxemia through modulation of systemic inflammatory response Crit Care 17 2013 R44
    • (2013) Crit Care , vol.17 , pp. 44
    • Wang, W.1    Zhao, F.2    Fang, Y.3    Li, X.4    Shen, L.5    Cao, T.6
  • 128
    • 84878408642 scopus 로고    scopus 로고
    • The many faces of HMGB1: Molecular structure-functional activity in inflammation, apoptosis, and chemotaxis
    • H. Yang, D.J. Antoine, U. Andersson, and K.J. Tracey The many faces of HMGB1: Molecular structure-functional activity in inflammation, apoptosis, and chemotaxis J Leukoc Biol 93 2013 865 873
    • (2013) J Leukoc Biol , vol.93 , pp. 865-873
    • Yang, H.1    Antoine, D.J.2    Andersson, U.3    Tracey, K.J.4
  • 129
    • 33749019109 scopus 로고    scopus 로고
    • Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock
    • R. Yang, T. Harada, K.P. Mollen, J.M. Prince, R.M. Levy, and J.A. Englert et al. Anti-HMGB1 neutralizing antibody ameliorates gut barrier dysfunction and improves survival after hemorrhagic shock Mol Med 12 2006 105 114
    • (2006) Mol Med , vol.12 , pp. 105-114
    • Yang, R.1    Harada, T.2    Mollen, K.P.3    Prince, J.M.4    Levy, R.M.5    Englert, J.A.6
  • 130
    • 9144241208 scopus 로고    scopus 로고
    • Reversing established sepsis with antagonists of endogenous high-mobility group box 1
    • H. Yang, M. Oceani, J. Li, X. Qiang, M. Tanovic, and H.E. Harris et al. Reversing established sepsis with antagonists of endogenous high-mobility group box 1 Proc Natl Acad Sci U S A 1 2004 296 301
    • (2004) Proc Natl Acad Sci U S A , vol.1 , pp. 296-301
    • Yang, H.1    Oceani, M.2    Li, J.3    Qiang, X.4    Tanovic, M.5    Harris, H.E.6
  • 131
    • 0026770702 scopus 로고
    • Nucleotide sequence of a mouse cDNA encoding the nonhistonne chromosomal high mobility group protein-1 (HMG1)
    • W.V. Yotov, and R. St-Arnaud Nucleotide sequence of a mouse cDNA encoding the nonhistonne chromosomal high mobility group protein-1 (HMG1) Nucleic Acids Res 20 1992 3516
    • (1992) Nucleic Acids Res , vol.20 , pp. 3516
    • Yotov, W.V.1    St-Arnaud, R.2
  • 132
    • 33751584837 scopus 로고    scopus 로고
    • Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion
    • J.H. Youn, and J.S. Shin Nucleocytoplasmic shuttling of HMGB1 is regulated by phosphorylation that redirects it toward secretion J Immunol 177 2006 7889 7897
    • (2006) J Immunol , vol.177 , pp. 7889-7897
    • Youn, J.H.1    Shin, J.S.2
  • 133
    • 84870845880 scopus 로고    scopus 로고
    • Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway
    • C.L. Zhai, M.Q. Zhang, Y. Zhang, H.X. Xu, J.M. Wang, and G.P. An et al. Glycyrrhizin protects rat heart against ischemia-reperfusion injury through blockade of HMGB1-dependent phospho-JNK/Bax pathway Acta Pharmacol Sin 33 2012 1477 1487
    • (2012) Acta Pharmacol Sin , vol.33 , pp. 1477-1487
    • Zhai, C.L.1    Zhang, M.Q.2    Zhang, Y.3    Xu, H.X.4    Wang, J.M.5    An, G.P.6
  • 134
    • 84868503604 scopus 로고    scopus 로고
    • Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake
    • Y. Zhang, W. Li, S. Zhu, A. Jundoria, J. Li, and H. Yang et al. Tanshinone IIA sodium sulfonate facilitates endocytic HMGB1 uptake Biochem Pharmacol 84 2012 1492 1500
    • (2012) Biochem Pharmacol , vol.84 , pp. 1492-1500
    • Zhang, Y.1    Li, W.2    Zhu, S.3    Jundoria, A.4    Li, J.5    Yang, H.6
  • 135
    • 84863245618 scopus 로고    scopus 로고
    • Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo
    • J. Zhang, J.S. Zhu, Z. Zhou, W.X. Chen, and N.W. Chen Inhibitory effects of ethyl pyruvate administration on human gastric cancer growth via regulation of the HMGB1-RAGE and Akt pathways in vitro and in vivo Oncol Rep 27 2012 1511 1519
    • (2012) Oncol Rep , vol.27 , pp. 1511-1519
    • Zhang, J.1    Zhu, J.S.2    Zhou, Z.3    Chen, W.X.4    Chen, N.W.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.