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Volumn 73, Issue 7, 2013, Pages 602-612

High mobility group box 1/toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence

Author keywords

Alcoholism; cerebral cortex; cytokines; ethanol; interleukin 1; Toll like receptors

Indexed keywords

HIGH MOBILITY GROUP B1 PROTEIN; INTERLEUKIN 1BETA; MESSENGER RNA; NEUTRALIZING ANTIBODY; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4;

EID: 84875219354     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.09.030     Document Type: Article
Times cited : (235)

References (65)
  • 1
    • 42549161426 scopus 로고    scopus 로고
    • Acute neurodegeneration and the inflammasome: Central processor for danger signals and the inflammatory response?
    • G. Trendelenburg Acute neurodegeneration and the inflammasome: Central processor for danger signals and the inflammatory response? J Cereb Blood Flow Metab 28 2008 867 881
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 867-881
    • Trendelenburg, G.1
  • 3
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: All we need to know about danger
    • M.E. Bianchi DAMPs, PAMPs and alarmins: All we need to know about danger J Leukoc Biol 81 2007 1 5
    • (2007) J Leukoc Biol , vol.81 , pp. 1-5
    • Bianchi, M.E.1
  • 4
    • 79955681780 scopus 로고    scopus 로고
    • IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures
    • A. Vezzani, M. Maroso, S. Balosso, M.A. Sanchez, and T. Bartfai IL-1 receptor/Toll-like receptor signaling in infection, inflammation, stress and neurodegeneration couples hyperexcitability and seizures Brain Behav Immun 25 2011 1281 1289
    • (2011) Brain Behav Immun , vol.25 , pp. 1281-1289
    • Vezzani, A.1    Maroso, M.2    Balosso, S.3    Sanchez, M.A.4    Bartfai, T.5
  • 6
    • 79955729616 scopus 로고    scopus 로고
    • Induction of innate immune genes in brain create the neurobiology of addiction
    • F.T. Crews, J. Zou, and L. Qin Induction of innate immune genes in brain create the neurobiology of addiction Brain Behav Immun 25 suppl 1 2011 S4 S12
    • (2011) Brain Behav Immun , vol.25 , Issue.SUPPL. 1
    • Crews, F.T.1    Zou, J.2    Qin, L.3
  • 7
    • 77955383770 scopus 로고    scopus 로고
    • DAMPening inflammation by modulating TLR signalling
    • A.M. Piccinini, and K.S. Midwood DAMPening inflammation by modulating TLR signalling Mediators Inflamm 2010 2010 672395
    • (2010) Mediators Inflamm , vol.2010 , pp. 672395
    • Piccinini, A.M.1    Midwood, K.S.2
  • 8
    • 43149085744 scopus 로고    scopus 로고
    • Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment
    • L. Qin, J. He, R.N. Hanes, O. Pluzarev, J.S. Hong, and F.T. Crews Increased systemic and brain cytokine production and neuroinflammation by endotoxin following ethanol treatment J Neuroinflammtion 5 2008 10
    • (2008) J Neuroinflammtion , vol.5 , pp. 10
    • Qin, L.1    He, J.2    Hanes, R.N.3    Pluzarev, O.4    Hong, J.S.5    Crews, F.T.6
  • 9
    • 33847759064 scopus 로고    scopus 로고
    • Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration
    • L. Qin, X. Wu, M.L. Block, Y. Liu, G.R. Breese, and J.S. Hong Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration Glia 55 2007 453 462
    • (2007) Glia , vol.55 , pp. 453-462
    • Qin, L.1    Wu, X.2    Block, M.L.3    Liu, Y.4    Breese, G.R.5    Hong, J.S.6
  • 11
    • 77951535281 scopus 로고    scopus 로고
    • Induction of innate immune gene expression cascades in brain slice cultures by ethanol: Key role of NF-kappaB and proinflammatory cytokines
    • J. Zou, and F. Crews Induction of innate immune gene expression cascades in brain slice cultures by ethanol: Key role of NF-kappaB and proinflammatory cytokines Alcohol Clin Exp Res 34 2010 777 789
    • (2010) Alcohol Clin Exp Res , vol.34 , pp. 777-789
    • Zou, J.1    Crews, F.2
  • 12
    • 61449176928 scopus 로고    scopus 로고
    • Mechanisms of neurodegeneration and regeneration in alcoholism
    • F.T. Crews, and K. Nixon Mechanisms of neurodegeneration and regeneration in alcoholism Alcohol Alcohol 44 2009 115 127
    • (2009) Alcohol Alcohol , vol.44 , pp. 115-127
    • Crews, F.T.1    Nixon, K.2
  • 13
    • 41349093774 scopus 로고    scopus 로고
    • Increased MCP-1 and microglia in various regions of the human alcoholic brain
    • J. He, and F.T. Crews Increased MCP-1 and microglia in various regions of the human alcoholic brain Exp Neurol 210 2008 349 358
    • (2008) Exp Neurol , vol.210 , pp. 349-358
    • He, J.1    Crews, F.T.2
  • 14
    • 84856722373 scopus 로고    scopus 로고
    • ATP-P2X7 receptor signaling controls basal and TNFalpha-stimulated glial cell proliferation
    • J. Zou, R.P. Vetreno, and F.T. Crews ATP-P2X7 receptor signaling controls basal and TNFalpha-stimulated glial cell proliferation Glia 60 2012 661 673
    • (2012) Glia , vol.60 , pp. 661-673
    • Zou, J.1    Vetreno, R.P.2    Crews, F.T.3
  • 15
    • 84855570853 scopus 로고    scopus 로고
    • NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration
    • L. Qin, and F.T. Crews NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration J Neuroinflammation 9 2012 5
    • (2012) J Neuroinflammation , vol.9 , pp. 5
    • Qin, L.1    Crews, F.T.2
  • 17
    • 79952726676 scopus 로고    scopus 로고
    • Binge alcohol drinking is associated with GABAA alpha2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala
    • J. Liu, A.R. Yang, T. Kelly, A. Puche, C. Esoga, and H.L. June Jr Binge alcohol drinking is associated with GABAA alpha2-regulated Toll-like receptor 4 (TLR4) expression in the central amygdala Proc Natl Acad Sci U S A 108 2011 4465 4470
    • (2011) Proc Natl Acad Sci U S A , vol.108 , pp. 4465-4470
    • Liu, J.1    Yang, A.R.2    Kelly, T.3    Puche, A.4    Esoga, C.5    June, Jr.H.L.6
  • 18
    • 79955717549 scopus 로고    scopus 로고
    • Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment
    • Y. Wu, E.L. Lousberg, L.M. Moldenhauer, J.D. Hayball, S.A. Robertson, and J.K. Coller Attenuation of microglial and IL-1 signaling protects mice from acute alcohol-induced sedation and/or motor impairment Brain Behav Immun 25 suppl 1 2011 S155 S164
    • (2011) Brain Behav Immun , vol.25 , Issue.SUPPL. 1
    • Wu, Y.1    Lousberg, E.L.2    Moldenhauer, L.M.3    Hayball, J.D.4    Robertson, S.A.5    Coller, J.K.6
  • 19
    • 79955713366 scopus 로고    scopus 로고
    • Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice
    • Y.A. Blednov, J.M. Benavidez, C. Geil, S. Perra, H. Morikawa, and R.A. Harris Activation of inflammatory signaling by lipopolysaccharide produces a prolonged increase of voluntary alcohol intake in mice Brain Behav Immun 25 suppl 1 2011 S92 S105
    • (2011) Brain Behav Immun , vol.25 , Issue.SUPPL. 1
    • Blednov, Y.A.1    Benavidez, J.M.2    Geil, C.3    Perra, S.4    Morikawa, H.5    Harris, R.A.6
  • 20
    • 84255187288 scopus 로고    scopus 로고
    • Neuroimmune regulation of alcohol consumption: Behavioral validation of genes obtained from genomic studies
    • Y.A. Blednov, I. Ponomarev, C. Geil, S. Bergeson, G.F. Koob, and R.A. Harris Neuroimmune regulation of alcohol consumption: Behavioral validation of genes obtained from genomic studies Addict Biol 17 2012 108 120
    • (2012) Addict Biol , vol.17 , pp. 108-120
    • Blednov, Y.A.1    Ponomarev, I.2    Geil, C.3    Bergeson, S.4    Koob, G.F.5    Harris, R.A.6
  • 21
    • 0029868268 scopus 로고    scopus 로고
    • Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol
    • E.J. Carson, and S.B. Pruett Development and characterization of a binge drinking model in mice for evaluation of the immunological effects of ethanol Alcohol Clin Exp Res 20 1996 132 138
    • (1996) Alcohol Clin Exp Res , vol.20 , pp. 132-138
    • Carson, E.J.1    Pruett, S.B.2
  • 22
    • 13844270562 scopus 로고    scopus 로고
    • TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: Neuroprotection by NF kappa B inhibition
    • J.Y. Zou, and F.T. Crews TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: Neuroprotection by NF kappa B inhibition Brain Res 1034 2005 11 24
    • (2005) Brain Res , vol.1034 , pp. 11-24
    • Zou, J.Y.1    Crews, F.T.2
  • 23
    • 0347356532 scopus 로고    scopus 로고
    • Alcohol intake and cerebral abnormalities on magnetic resonance imaging in a community-based population of middle-aged adults: The Atherosclerosis Risk in Communities (ARIC) study
    • J. Ding, M.L. Eigenbrodt, T.H. Mosley Jr, R.G. Hutchinson, A.R. Folsom, T.B. Harris, and F.J. Nieto Alcohol intake and cerebral abnormalities on magnetic resonance imaging in a community-based population of middle-aged adults: The Atherosclerosis Risk in Communities (ARIC) study Stroke 35 2004 16 21
    • (2004) Stroke , vol.35 , pp. 16-21
    • Ding, J.1    Eigenbrodt, M.L.2    Mosley, Jr.T.H.3    Hutchinson, R.G.4    Folsom, A.R.5    Harris, T.B.6    Nieto, F.J.7
  • 24
    • 61449209903 scopus 로고    scopus 로고
    • The neuropathology of alcohol-related brain damage
    • C. Harper The neuropathology of alcohol-related brain damage Alcohol Alcohol 44 2009 136 140
    • (2009) Alcohol Alcohol , vol.44 , pp. 136-140
    • Harper, C.1
  • 26
    • 59649119219 scopus 로고    scopus 로고
    • The importance of brain banks for molecular neuropathological research: The New South wales tissue resource centre experience
    • I. Dedova, A. Harding, D. Sheedy, T. Garrick, N. Sundqvist, and C. Hunt The importance of brain banks for molecular neuropathological research: The New South wales tissue resource centre experience Int J Mol Sci 10 2009 366 384
    • (2009) Int J Mol Sci , vol.10 , pp. 366-384
    • Dedova, I.1    Harding, A.2    Sheedy, D.3    Garrick, T.4    Sundqvist, N.5    Hunt, C.6
  • 27
    • 0346463000 scopus 로고    scopus 로고
    • NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
    • L. Qin, Y. Liu, T. Wang, S.J. Wei, M.L. Block, and B. Wilson NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia J Biol Chem 279 2004 1415 1421
    • (2004) J Biol Chem , vol.279 , pp. 1415-1421
    • Qin, L.1    Liu, Y.2    Wang, T.3    Wei, S.J.4    Block, M.L.5    Wilson, B.6
  • 28
    • 0023913503 scopus 로고
    • Some new, simple and efficient stereological methods and their use in pathological research and diagnosis
    • H.J. Gundersen, T.F. Bendtsen, L. Korbo, N. Marcussen, A. Moller, and K. Nielsen Some new, simple and efficient stereological methods and their use in pathological research and diagnosis APMI 96 1988 379 394
    • (1988) APMI , vol.96 , pp. 379-394
    • Gundersen, H.J.1    Bendtsen, T.F.2    Korbo, L.3    Marcussen, N.4    Moller, A.5    Nielsen, K.6
  • 29
    • 0025327731 scopus 로고
    • Unbiased stereological estimation of the number of neurons in the human hippocampus
    • M.J. West, and H.J. Gundersen Unbiased stereological estimation of the number of neurons in the human hippocampus J Comp Neurol 296 1990 1 22
    • (1990) J Comp Neurol , vol.296 , pp. 1-22
    • West, M.J.1    Gundersen, H.J.2
  • 30
    • 33750312225 scopus 로고    scopus 로고
    • CREB and NF-kappaB transcription factors regulate sensitivity to excitotoxic and oxidative stress induced neuronal cell death
    • J. Zou, and F. Crews CREB and NF-kappaB transcription factors regulate sensitivity to excitotoxic and oxidative stress induced neuronal cell death Cell Mol Neurobiol 26 2006 385 405
    • (2006) Cell Mol Neurobiol , vol.26 , pp. 385-405
    • Zou, J.1    Crews, F.2
  • 31
    • 0032906175 scopus 로고    scopus 로고
    • Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal
    • D.J. Knapp, and F.T. Crews Induction of cyclooxygenase-2 in brain during acute and chronic ethanol treatment and ethanol withdrawal Alcohol Clin Exp Res 23 1999 633 643
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 633-643
    • Knapp, D.J.1    Crews, F.T.2
  • 32
    • 84862255818 scopus 로고    scopus 로고
    • Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration
    • L. Qin, and F.T. Crews Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration J Neuroinflammation 9 2012 130
    • (2012) J Neuroinflammation , vol.9 , pp. 130
    • Qin, L.1    Crews, F.T.2
  • 33
    • 80055009332 scopus 로고    scopus 로고
    • High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and receptor for advanced glycation end products
    • A. Mazarati, M. Maroso, V. Iori, A. Vezzani, and M. Carli High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and receptor for advanced glycation end products Exp Neurol 232 2011 143 148
    • (2011) Exp Neurol , vol.232 , pp. 143-148
    • Mazarati, A.1    Maroso, M.2    Iori, V.3    Vezzani, A.4    Carli, M.5
  • 34
    • 79551627378 scopus 로고    scopus 로고
    • HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling
    • Q.W. Yang, F.L. Lu, Y. Zhou, L. Wang, Q. Zhong, and S. Lin HMBG1 mediates ischemia-reperfusion injury by TRIF-adaptor independent Toll-like receptor 4 signaling J Cereb Blood Flow Metab 31 2011 593 605
    • (2011) J Cereb Blood Flow Metab , vol.31 , pp. 593-605
    • Yang, Q.W.1    Lu, F.L.2    Zhou, Y.3    Wang, L.4    Zhong, Q.5    Lin, S.6
  • 35
    • 77955403878 scopus 로고    scopus 로고
    • A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release
    • H. Yang, H.S. Hreggvidsdottir, K. Palmblad, H. Wang, M. Ochani, and J. Li A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release Proc Natl Acad Sci U S A 107 2010 11942 11947
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 11942-11947
    • Yang, H.1    Hreggvidsdottir, H.S.2    Palmblad, K.3    Wang, H.4    Ochani, M.5    Li, J.6
  • 36
    • 75849151435 scopus 로고    scopus 로고
    • Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll-like receptor-mediated neuronal injury
    • S. Lehnardt Innate immunity and neuroinflammation in the CNS: The role of microglia in Toll-like receptor-mediated neuronal injury Glia 58 2010 253 263
    • (2010) Glia , vol.58 , pp. 253-263
    • Lehnardt, S.1
  • 37
    • 0037477629 scopus 로고    scopus 로고
    • Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway
    • S. Lehnardt, L. Massillon, P. Follett, F.E. Jensen, R. Ratan, and P.A. Rosenberg Activation of innate immunity in the CNS triggers neurodegeneration through a Toll-like receptor 4-dependent pathway Proc Natl Acad Sci U S A 100 2003 8514 8519
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 8514-8519
    • Lehnardt, S.1    Massillon, L.2    Follett, P.3    Jensen, F.E.4    Ratan, R.5    Rosenberg, P.A.6
  • 38
    • 84856739147 scopus 로고    scopus 로고
    • Microglia are required for astroglial Toll-like receptor 4 response and for optimal TLR2 and TLR3 response
    • T.H. Holm, D. Draeby, and T. Owens Microglia are required for astroglial Toll-like receptor 4 response and for optimal TLR2 and TLR3 response Glia 60 2012 630 638
    • (2012) Glia , vol.60 , pp. 630-638
    • Holm, T.H.1    Draeby, D.2    Owens, T.3
  • 39
    • 0036548360 scopus 로고    scopus 로고
    • The toll-like receptor TLR4 is necessary for lipopolysaccharide induced oligodendrocyte injury in the CNS
    • S. Lehnardt, C. Lachance, S. Patrizi, S. Lefebvre, P.L. Follett, and F.E. Jensen The toll-like receptor TLR4 is necessary for lipopolysaccharide induced oligodendrocyte injury in the CNS J Neurosci 22 2002 2478 2486
    • (2002) J Neurosci , vol.22 , pp. 2478-2486
    • Lehnardt, S.1    Lachance, C.2    Patrizi, S.3    Lefebvre, S.4    Follett, P.L.5    Jensen, F.E.6
  • 40
    • 70449732755 scopus 로고    scopus 로고
    • Critical role of TLR4 response in the activation of microglia induced by ethanol
    • S. Fernandez-Lizarbe, M. Pascual, and C. Guerri Critical role of TLR4 response in the activation of microglia induced by ethanol J Immunol 183 2009 4733 4744
    • (2009) J Immunol , vol.183 , pp. 4733-4744
    • Fernandez-Lizarbe, S.1    Pascual, M.2    Guerri, C.3
  • 41
    • 80053028698 scopus 로고    scopus 로고
    • Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: The importance of IL-1beta and high-mobility group box 1
    • M. Maroso, S. Balosso, T. Ravizza, J. Liu, M.E. Bianchi, and A. Vezzani Interleukin-1 type 1 receptor/Toll-like receptor signalling in epilepsy: The importance of IL-1beta and high-mobility group box 1 J Intern Med 270 2011 319 326
    • (2011) J Intern Med , vol.270 , pp. 319-326
    • Maroso, M.1    Balosso, S.2    Ravizza, T.3    Liu, J.4    Bianchi, M.E.5    Vezzani, A.6
  • 42
    • 0036841178 scopus 로고    scopus 로고
    • Broad expression of Toll-like receptors in the human central nervous system
    • M. Bsibsi, R. Ravid, D. Gveric, and J.M. van Noort Broad expression of Toll-like receptors in the human central nervous system J Neuropathol Exp Neurol 61 2002 1013 1021
    • (2002) J Neuropathol Exp Neurol , vol.61 , pp. 1013-1021
    • Bsibsi, M.1    Ravid, R.2    Gveric, D.3    Van Noort, J.M.4
  • 43
    • 34548409654 scopus 로고    scopus 로고
    • Toll-like receptors in the brain and their potential roles in neuropathology
    • P.J. Crack, and P.J. Bray Toll-like receptors in the brain and their potential roles in neuropathology Immunol Cell Biol 85 2007 476 480
    • (2007) Immunol Cell Biol , vol.85 , pp. 476-480
    • Crack, P.J.1    Bray, P.J.2
  • 45
    • 77950363010 scopus 로고    scopus 로고
    • Mechanisms underlying inflammation in neurodegeneration
    • C.K. Glass, K. Saijo, B. Winner, M.C. Marchetto, and F.H. Gage Mechanisms underlying inflammation in neurodegeneration Cell 140 2010 918 934
    • (2010) Cell , vol.140 , pp. 918-934
    • Glass, C.K.1    Saijo, K.2    Winner, B.3    Marchetto, M.C.4    Gage, F.H.5
  • 46
    • 77950539231 scopus 로고    scopus 로고
    • Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures
    • M. Maroso, S. Balosso, T. Ravizza, J. Liu, E. Aronica, and A.M. Iyer Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures Nat Med 16 2010 413 419
    • (2010) Nat Med , vol.16 , pp. 413-419
    • Maroso, M.1    Balosso, S.2    Ravizza, T.3    Liu, J.4    Aronica, E.5    Iyer, A.M.6
  • 47
    • 78149322599 scopus 로고    scopus 로고
    • Changing face of microglia
    • M.B. Graeber Changing face of microglia Science 330 2010 783 788
    • (2010) Science , vol.330 , pp. 783-788
    • Graeber, M.B.1
  • 48
    • 84868359842 scopus 로고    scopus 로고
    • The persistent release of HMGB1 contributes to tactile hyperalgesia in a rodent model of neuropathic pain
    • P. Feldman, M.R. Due, M.S. Ripsch, R. Khanna, and F.A. White The persistent release of HMGB1 contributes to tactile hyperalgesia in a rodent model of neuropathic pain J Neuroinflammation 9 2012 180
    • (2012) J Neuroinflammation , vol.9 , pp. 180
    • Feldman, P.1    Due, M.R.2    Ripsch, M.S.3    Khanna, R.4    White, F.A.5
  • 49
    • 70349787217 scopus 로고    scopus 로고
    • Ethanol withdrawal and hyperalgesia
    • M.B. Gatch Ethanol withdrawal and hyperalgesia Curr Drug Abuse Rev 2 2009 41 50
    • (2009) Curr Drug Abuse Rev , vol.2 , pp. 41-50
    • Gatch, M.B.1
  • 50
    • 67649439164 scopus 로고    scopus 로고
    • Impulsivity, frontal lobes and risk for addiction
    • F.T. Crews, and C.A. Boettiger Impulsivity, frontal lobes and risk for addiction Pharmacol Biochem Behav 93 2009 237 247
    • (2009) Pharmacol Biochem Behav , vol.93 , pp. 237-247
    • Crews, F.T.1    Boettiger, C.A.2
  • 51
    • 84859164991 scopus 로고    scopus 로고
    • Implications of central immune signaling caused by drugs of abuse: Mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence
    • J.K. Coller, and M.R. Hutchinson Implications of central immune signaling caused by drugs of abuse: Mechanisms, mediators and new therapeutic approaches for prediction and treatment of drug dependence Pharmacol Ther 134 2012 219 245
    • (2012) Pharmacol Ther , vol.134 , pp. 219-245
    • Coller, J.K.1    Hutchinson, M.R.2
  • 52
    • 84255187288 scopus 로고    scopus 로고
    • Neuroimmune regulation of alcohol consumption: Behavioral validation of genes obtained from genomic studies
    • Y.A. Blednov, I. Ponomarev, C. Geil, S. Bergeson, G.F. Koob, and R.A. Harris Neuroimmune regulation of alcohol consumption: behavioral validation of genes obtained from genomic studies Addict Biol 1 2012 108 120
    • (2012) Addict Biol , vol.1 , pp. 108-120
    • Blednov, Y.A.1    Ponomarev, I.2    Geil, C.3    Bergeson, S.4    Koob, G.F.5    Harris, R.A.6
  • 53
    • 41149105977 scopus 로고    scopus 로고
    • Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence
    • H.J. Edenberg, X. Xuei, L.F. Wetherill, L. Bierut, K. Bucholz, and D.M. Dick Association of NFKB1, which encodes a subunit of the transcription factor NF-kappaB, with alcohol dependence Hum Mol Genet 17 2008 963 970
    • (2008) Hum Mol Genet , vol.17 , pp. 963-970
    • Edenberg, H.J.1    Xuei, X.2    Wetherill, L.F.3    Bierut, L.4    Bucholz, K.5    Dick, D.M.6
  • 54
    • 84870152461 scopus 로고    scopus 로고
    • Immune function genes, genetics, and the neurobiology of addiction
    • F. Crews Immune function genes, genetics, and the neurobiology of addiction Alcohol Res Health 34 2011 355 361
    • (2011) Alcohol Res Health , vol.34 , pp. 355-361
    • Crews, F.1
  • 55
    • 79960687433 scopus 로고    scopus 로고
    • Exploring the neuroimmunopharmacology of opioids: An integrative review of mechanisms of central immune signaling and their implications for opioid analgesia
    • M.R. Hutchinson, Y. Shavit, P.M. Grace, K.C. Rice, S.F. Maier, and L.R. Watkins Exploring the neuroimmunopharmacology of opioids: An integrative review of mechanisms of central immune signaling and their implications for opioid analgesia Pharmacol Rev 63 2011 772 810
    • (2011) Pharmacol Rev , vol.63 , pp. 772-810
    • Hutchinson, M.R.1    Shavit, Y.2    Grace, P.M.3    Rice, K.C.4    Maier, S.F.5    Watkins, L.R.6
  • 56
  • 57
    • 84864759986 scopus 로고    scopus 로고
    • Neuroplastic changes in depression: A role for the immune system
    • H. Eyre, and B.T. Baune Neuroplastic changes in depression: A role for the immune system Psychoneuroendocrinology 37 2012 1397 1416
    • (2012) Psychoneuroendocrinology , vol.37 , pp. 1397-1416
    • Eyre, H.1    Baune, B.T.2
  • 58
    • 79953066407 scopus 로고    scopus 로고
    • HMGB1 is a therapeutic target for sterile inflammation and infection
    • U. Andersson, and K.J. Tracey HMGB1 is a therapeutic target for sterile inflammation and infection Annu Rev Immunol 29 2011 139 162
    • (2011) Annu Rev Immunol , vol.29 , pp. 139-162
    • Andersson, U.1    Tracey, K.J.2
  • 59
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • M.L. Block, L. Zecca, and J.S. Hong Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms Nat Rev Neurosci 8 2007 57 69
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 61
    • 78751502344 scopus 로고    scopus 로고
    • HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration
    • H.M. Gao, H. Zhou, F. Zhang, B.C. Wilson, W. Kam, and J.S. Hong HMGB1 acts on microglia Mac1 to mediate chronic neuroinflammation that drives progressive neurodegeneration J Neurosci 31 2011 1081 1092
    • (2011) J Neurosci , vol.31 , pp. 1081-1092
    • Gao, H.M.1    Zhou, H.2    Zhang, F.3    Wilson, B.C.4    Kam, W.5    Hong, J.S.6
  • 62
  • 65
    • 13444254068 scopus 로고    scopus 로고
    • The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
    • R. Spanagel, G. Pendyala, C. Abarca, T. Zghoul, C. Sanchis-Segura, and M.C. Magnone The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption Nat Med 11 2005 35 42
    • (2005) Nat Med , vol.11 , pp. 35-42
    • Spanagel, R.1    Pendyala, G.2    Abarca, C.3    Zghoul, T.4    Sanchis-Segura, C.5    Magnone, M.C.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.