Predicting Solubility/Miscibility in Amorphous Dispersions: It Is Time to Move Beyond Regular Solution Theories

Journal of Pharmaceutical Sciences

Volumn 107, Issue 1, 2018, Pages 24-33

  Anderson, Bradley D ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

amorphous; calorimetry; dispersion; indomethacin interactive mixtures; materials science; phase diagram; physical stability; polymeric drug carrier; polyvinylpyrrolidone; thermodynamics statistical mechanics

Indexed keywords

AMORPHOUS DISPERSION; CONTROLLED STUDY; CRYSTALLIZATION; DISPERSION; FLORY HUGGINS THEORY; HYDROGEN BOND; LIMIT OF QUANTITATION; MEASUREMENT ACCURACY; MEASUREMENT PRECISION; MISCIBILITY; PROPENSITY SCORE; RELIABILITY; REVIEW; SOLUBILITY; THEORY; TREND STUDY; WATER TRANSPORT; CHEMISTRY; DRUG STABILITY; MEDICINAL CHEMISTRY; PROCEDURES;

DRUG; EXCIPIENT; POLYMER;

CHEMISTRY, PHARMACEUTICAL; DRUG STABILITY; EXCIPIENTS; HYDROGEN BONDING; PHARMACEUTICAL PREPARATIONS; POLYMERS; SOLUBILITY;

EID: 85032786444     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1016/j.xphs.2017.09.030     Document Type: Review

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