Construction of drug-polymer thermodynamic phase diagrams using flory-huggins interaction theory: Identifying the relevance of temperature and drug weight fraction to phase separation within solid dispersions

Molecular Pharmaceutics

Volumn 10, Issue 1, 2013, Pages 236-248

  Tian, Yiwei ^a   Booth, Jonathan ^b   Meehan, Elizabeth ^b   Jones, David S ^a   Li, Shu ^a   Andrews, Gavin P ^a  

^a QUEEN'S UNIVERSITY BELFAST   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

drug polymer thermodynamic phase diagrams; Flory Huggins interaction theory; high speed differential scanning calorimetry; HPMCAS HF felodipine; Soluplus felodipine

Indexed keywords

FELODIPINE; HYDROXYPROPYLMETHYLCELLULOSE ACETATE SUCCINATE; MACROGOL; POLYMER; POLYVINYL CAPROLACTAM POLYVINYL ACETATE POLYETHYLENE GLYCOL; UNCLASSIFIED DRUG;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DRUG SOLUBILITY; DRUG STRUCTURE; FLORY HUGGINS INTERACTION THEORY; LOW TEMPERATURE; MELTING POINT; PHASE SEPARATION; PRIORITY JOURNAL; SOLID; TEMPERATURE MEASUREMENT; THEORY; THERMODYNAMICS;

CALORIMETRY, DIFFERENTIAL SCANNING; CRYSTALLIZATION; DRUG STABILITY; ENTROPY; FELODIPINE; METHYLCELLULOSE; POLYETHYLENE GLYCOLS; POLYMERS; POLYVINYLS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TEMPERATURE; THERMODYNAMICS;

EID: 84872164745     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300386v     Document Type: Article

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