Estimation of drug-polymer miscibility and solubility in amorphous solid dispersions using experimentally determined interaction parameters

Pharmaceutical Research

Volumn 26, Issue 1, 2009, Pages 139-151

  Marsac, Patrick J ^a,c   Li, Tonglei ^b   Taylor, Lynne S ^c  

^a MERCK RESEARCH LABORATORIES   (United States)

^b University of Kentucky   (United States)

^c PURDUE UNIVERSITY   (United States)

Author keywords

Amorphous; Crystallization; Miscibility; Polymer

Indexed keywords

2 PYRROLIDONE DERIVATIVE; DEXTRAN; DRUG; EUDRAGIT; FELODIPINE; IBUPROFEN; INDOMETACIN; ITRACONAZOLE; KETOCONAZOLE; NIFEDIPINE; POLYMER; POVIDONE; SUCROSE;

ARTICLE; CRYSTALLIZATION; DISPERSION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG MIXTURE; DRUG SOLUBILITY; ENTHALPY; ENTROPY; EXPERIMENTAL MODEL; MISCIBILITY; PRIORITY JOURNAL; THERMODYNAMICS;

CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; HYDROGEN BONDING; MOLECULAR WEIGHT; PHARMACEUTICAL PREPARATIONS; POLYMERS; SOLUBILITY; TEMPERATURE; THERMODYNAMICS;

EID: 57749206650     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9721-1     Document Type: Article

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