Molecular dynamics simulation of amorphous indomethacin-poly(Vinylpyrrolidone) glasses: Solubility and hydrogen bonding interactions

Journal of Pharmaceutical Sciences

Volumn 102, Issue 3, 2013, Pages 876-891

  Xiang, Tian Xiang ^a   Anderson, Bradley D ^a  

^a University of Kentucky   (United States)

Author keywords

Amorphous; Mobility; Molecular dynamics; Physical stability; Poly(vinylpyrrolidone); Polymers; Solid dispersion; Solid state stability; Solubility; Supersaturation

Indexed keywords

INDOMETACIN; POVIDONE;

ARTICLE; CHEMICAL PARAMETERS; COOLING; DISPERSION; DRUG SOLUBILITY; GLASS TRANSITION TEMPERATURE; HYDROGEN BOND; MISCIBILITY; MOLECULAR DYNAMICS; MOLECULAR INTERACTION; MOLECULE; PRECURSOR; SIMULATION; X RAY DIFFRACTION;

EID: 84878144366     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23353     Document Type: Article

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