A fast and reliable empirical approach for estimating solubility of crystalline drugs in polymers for hot melt extrusion formulations

Journal of Pharmaceutical Sciences

Volumn 103, Issue 9, 2014, Pages 2847-2858

  Kyeremateng, Samuel O ^a   Pudlas, Marieke ^a   Woehrle, Gerd H ^a  

^a ABBVIE INC   (United States)

Author keywords

copovidone; differential scanning calorimetry (DSC); drug polymer interactions; FTIR imaging; hot melt extrusion; phase separation; physical stability; solid dispersion; solubility; Soluplus

Indexed keywords

COPOVIDONE; IBUPROFEN; INDOMETACIN; ITRACONAZOLE; NAPROXEN; NIFEDIPINE; PARACETAMOL; POLYMER; POLYVINYL ACETATE; POVIDONE; POVIDONE DERIVATIVE; SOLUPLUS; SULFADIMIDINE; SULFAMERAZINE; SULFATHIAZOLE; UNCLASSIFIED DRUG; DRUG; GLASS; MACROGOL DERIVATIVE; POLYVINYL CAPROLACTAM-POLYVINYL ACETATE-POLYETHYLENE GLYCOL GRAFT COPOLYMER; POLYVINYL DERIVATIVE;

AMORPHOUS SOLID DISPERSION; ARTICLE; CONTROLLED STUDY; CURVE FITTING; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; GLASS TRANSITION TEMPERATURE; HOT MELT EXTRUSION; INFRARED SPECTROSCOPY; MATHEMATICAL MODEL; MICROSCOPY; PREDICTION; SOLID; CHEMISTRY; CRYSTALLIZATION; HEAT; MEDICINAL CHEMISTRY; PROCEDURES; SOLUBILITY; TRANSITION TEMPERATURE;

CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CRYSTALLIZATION; DRUG STABILITY; GLASS; HOT TEMPERATURE; IBUPROFEN; NAPROXEN; PHARMACEUTICAL PREPARATIONS; POLYETHYLENE GLYCOLS; POLYMERS; POLYVINYLS; SOLUBILITY; TRANSITION TEMPERATURE;

EID: 84906327570     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.23941     Document Type: Article

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