-
1
-
-
84929620816
-
CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007–2011
-
Ostrom, Q.T., Gittleman, H., Liao, P., et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2007–2011. Neuro Oncol 16:Suppl 4 (2014), iv1–iv63.
-
(2014)
Neuro Oncol
, vol.16
, pp. iv1-iv63
-
-
Ostrom, Q.T.1
Gittleman, H.2
Liao, P.3
-
2
-
-
20044366163
-
Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
-
Stupp, R., Mason, W.P., van den Bent, M.J., et al. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med 352 (2005), 987–996.
-
(2005)
N Engl J Med
, vol.352
, pp. 987-996
-
-
Stupp, R.1
Mason, W.P.2
van den Bent, M.J.3
-
3
-
-
84867541653
-
A population-based study on the effect of temozolomide in the treatment of glioblastoma multiforme
-
Rønning, P.A., Helseth, E., Meling, T.R., Johannesen, TB., A population-based study on the effect of temozolomide in the treatment of glioblastoma multiforme. Neuro Oncol 14 (2012), 1178–1184.
-
(2012)
Neuro Oncol
, vol.14
, pp. 1178-1184
-
-
Rønning, P.A.1
Helseth, E.2
Meling, T.R.3
Johannesen, T.B.4
-
4
-
-
84950157098
-
Maintenance therapy with tumor-treating fields plus temozolomide vs temozolomide alone for glioblastoma: a randomized clinical trial
-
Stupp, R., Taillibert, S., Kanner, A.A., et al. Maintenance therapy with tumor-treating fields plus temozolomide vs temozolomide alone for glioblastoma: a randomized clinical trial. JAMA 314 (2015), 2535–2543.
-
(2015)
JAMA
, vol.314
, pp. 2535-2543
-
-
Stupp, R.1
Taillibert, S.2
Kanner, A.A.3
-
5
-
-
84904902698
-
EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma
-
Weller, M., van den Bent, M., Hopkins, K., et al. EANO guideline for the diagnosis and treatment of anaplastic gliomas and glioblastoma. Lancet Oncol 15 (2014), e395–e403.
-
(2014)
Lancet Oncol
, vol.15
, pp. e395-e403
-
-
Weller, M.1
van den Bent, M.2
Hopkins, K.3
-
6
-
-
33644820339
-
Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis
-
Phillips, H.S., Kharbanda, S., Chen, R., et al. Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis. Cancer Cell 9 (2006), 157–173.
-
(2006)
Cancer Cell
, vol.9
, pp. 157-173
-
-
Phillips, H.S.1
Kharbanda, S.2
Chen, R.3
-
7
-
-
52949127312
-
An integrated genomic analysis of human glioblastoma multiforme
-
Parsons, D.W., Jones, S., Zhang, X., et al. An integrated genomic analysis of human glioblastoma multiforme. Science 321 (2008), 1807–1812.
-
(2008)
Science
, vol.321
, pp. 1807-1812
-
-
Parsons, D.W.1
Jones, S.2
Zhang, X.3
-
8
-
-
54549108740
-
Comprehensive genomic characterization defines human glioblastoma genes and core pathways
-
Network CGAR, Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature 455 (2008), 1061–1068.
-
(2008)
Nature
, vol.455
, pp. 1061-1068
-
-
Network CGAR1
-
9
-
-
77952108366
-
Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
-
Noushmehr, H., Weisenberger, D.J., Diefes, K., et al. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell 17 (2010), 510–522.
-
(2010)
Cancer Cell
, vol.17
, pp. 510-522
-
-
Noushmehr, H.1
Weisenberger, D.J.2
Diefes, K.3
-
10
-
-
84885074034
-
The somatic genomic landscape of glioblastoma
-
Brennan, C.W., Verhaak, R.G., McKenna, A., et al. The somatic genomic landscape of glioblastoma. Cell 155 (2013), 462–477.
-
(2013)
Cell
, vol.155
, pp. 462-477
-
-
Brennan, C.W.1
Verhaak, R.G.2
McKenna, A.3
-
11
-
-
84884996623
-
The integrated landscape of driver genomic alterations in glioblastoma
-
Frattini, V., Trifonov, V., Chan, J.M., et al. The integrated landscape of driver genomic alterations in glioblastoma. Nat Genet 45 (2013), 1141–1149.
-
(2013)
Nat Genet
, vol.45
, pp. 1141-1149
-
-
Frattini, V.1
Trifonov, V.2
Chan, J.M.3
-
12
-
-
84966687479
-
The 2016 World Health Organization classification of tumors of the central nervous system: a summary
-
Louis, D.N., Perry, A., Reifenberger, G., et al. The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131 (2016), 803–820.
-
(2016)
Acta Neuropathol
, vol.131
, pp. 803-820
-
-
Louis, D.N.1
Perry, A.2
Reifenberger, G.3
-
13
-
-
73649123907
-
Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
-
Verhaak, R.G., Hoadley, K.A., Purdom, E., et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell 17 (2010), 98–110.
-
(2010)
Cancer Cell
, vol.17
, pp. 98-110
-
-
Verhaak, R.G.1
Hoadley, K.A.2
Purdom, E.3
-
14
-
-
84929852263
-
The landscape and therapeutic relevance of cancer-associated transcript fusions
-
Yoshihara, K., Wang, Q., Torres-Garcia, W., et al. The landscape and therapeutic relevance of cancer-associated transcript fusions. Oncogene 34 (2015), 4845–4854.
-
(2015)
Oncogene
, vol.34
, pp. 4845-4854
-
-
Yoshihara, K.1
Wang, Q.2
Torres-Garcia, W.3
-
15
-
-
84955561447
-
Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma
-
Ceccarelli, M., Barthel, F.P., Malta, T.M., et al. Molecular profiling reveals biologically discrete subsets and pathways of progression in diffuse glioma. Cell 164 (2016), 550–563.
-
(2016)
Cell
, vol.164
, pp. 550-563
-
-
Ceccarelli, M.1
Barthel, F.P.2
Malta, T.M.3
-
16
-
-
84873204700
-
Rindopepimut: an evidence-based review of its therapeutic potential in the treatment of EGFRvIII-positive glioblastoma
-
Babu, R., Adamson, DC., Rindopepimut: an evidence-based review of its therapeutic potential in the treatment of EGFRvIII-positive glioblastoma. Core Evid 7 (2012), 93–103.
-
(2012)
Core Evid
, vol.7
, pp. 93-103
-
-
Babu, R.1
Adamson, D.C.2
-
17
-
-
84877632013
-
An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells
-
Rohle, D., Popovici-Muller, J., Palaskas, N., et al. An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science 340 (2013), 626–630.
-
(2013)
Science
, vol.340
, pp. 626-630
-
-
Rohle, D.1
Popovici-Muller, J.2
Palaskas, N.3
-
18
-
-
84911097954
-
Targeted molecular therapies against epidermal growth factor receptor: past experiences and challenges
-
Reardon, D.A., Wen, P.Y., Mellinghoff, IK., Targeted molecular therapies against epidermal growth factor receptor: past experiences and challenges. Neuro Oncol 16:Suppl 8 (2014), viii7–vii13.
-
(2014)
Neuro Oncol
, vol.16
, pp. viii7-vii13
-
-
Reardon, D.A.1
Wen, P.Y.2
Mellinghoff, I.K.3
-
19
-
-
84919343233
-
Emerging therapies for glioblastoma
-
Thomas, A.A., Brennan, C.W., DeAngelis, L.M., Omuro, AM., Emerging therapies for glioblastoma. JAMA Neurol 71 (2014), 1437–1444.
-
(2014)
JAMA Neurol
, vol.71
, pp. 1437-1444
-
-
Thomas, A.A.1
Brennan, C.W.2
DeAngelis, L.M.3
Omuro, A.M.4
-
20
-
-
84893677705
-
Efficacy of erlotinib in patients with relapsed gliobastoma multiforme who expressed EGFRVIII and PTEN determined by immunohistochemistry
-
Gallego, O., Cuatrecasas, M., Benavides, M., et al. Efficacy of erlotinib in patients with relapsed gliobastoma multiforme who expressed EGFRVIII and PTEN determined by immunohistochemistry. J Neurooncol 116 (2014), 413–419.
-
(2014)
J Neurooncol
, vol.116
, pp. 413-419
-
-
Gallego, O.1
Cuatrecasas, M.2
Benavides, M.3
-
21
-
-
84929114925
-
Detection, characterization and inhibition of FGFR-TACC fusions in IDH wild type glioma
-
Di Stefano, A.L., Fucci, A., Frattini, V., et al. Detection, characterization and inhibition of FGFR-TACC fusions in IDH wild type glioma. Clin Cancer Res 21 (2015), 3307–3317.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 3307-3317
-
-
Di Stefano, A.L.1
Fucci, A.2
Frattini, V.3
-
22
-
-
84921415076
-
Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity
-
Meyer, M., Reimand, J., Lan, X., et al. Single cell-derived clonal analysis of human glioblastoma links functional and genomic heterogeneity. Proc Natl Acad Sci USA 112 (2015), 851–856.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 851-856
-
-
Meyer, M.1
Reimand, J.2
Lan, X.3
-
23
-
-
84942252588
-
Toward precision medicine in glioblastoma: the promise and the challenges
-
Prados, M.D., Byron, S.A., Tran, N.L., et al. Toward precision medicine in glioblastoma: the promise and the challenges. Neuro Oncol 17 (2015), 1051–1063.
-
(2015)
Neuro Oncol
, vol.17
, pp. 1051-1063
-
-
Prados, M.D.1
Byron, S.A.2
Tran, N.L.3
-
24
-
-
83455176258
-
Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma
-
Snuderl, M., Fazlollahi, L., Le, L.P., et al. Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Cancer Cell 20 (2011), 810–817.
-
(2011)
Cancer Cell
, vol.20
, pp. 810-817
-
-
Snuderl, M.1
Fazlollahi, L.2
Le, L.P.3
-
25
-
-
84864192438
-
Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1- mutation as common tumor initiating event
-
Lass, U., Nümann, A., von Eckardstein, K., et al. Clonal analysis in recurrent astrocytic, oligoastrocytic and oligodendroglial tumors implicates IDH1- mutation as common tumor initiating event. PLoS One, 7, 2012, e41298.
-
(2012)
PLoS One
, vol.7
, pp. e41298
-
-
Lass, U.1
Nümann, A.2
von Eckardstein, K.3
-
26
-
-
84859376167
-
Receptor tyrosine kinase genes amplified in glioblastoma exhibit a mutual exclusivity in variable proportions reflective of individual tumor heterogeneity
-
Little, S.E., Popov, S., Jury, A., et al. Receptor tyrosine kinase genes amplified in glioblastoma exhibit a mutual exclusivity in variable proportions reflective of individual tumor heterogeneity. Cancer Res 72 (2012), 1614–1620.
-
(2012)
Cancer Res
, vol.72
, pp. 1614-1620
-
-
Little, S.E.1
Popov, S.2
Jury, A.3
-
27
-
-
84874598318
-
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics
-
Sottoriva, A., Spiteri, I., Piccirillo, S.G., et al. Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics. Proc Natl Acad Sci USA 110 (2013), 4009–4014.
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 4009-4014
-
-
Sottoriva, A.1
Spiteri, I.2
Piccirillo, S.G.3
-
28
-
-
84892373020
-
Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma
-
Johnson, B.E., Mazor, T., Hong, C., et al. Mutational analysis reveals the origin and therapy-driven evolution of recurrent glioma. Science 343 (2014), 189–193.
-
(2014)
Science
, vol.343
, pp. 189-193
-
-
Johnson, B.E.1
Mazor, T.2
Hong, C.3
-
29
-
-
84902668801
-
Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma
-
Patel, A.P., Tirosh, I., Trombetta, J.J., et al. Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma. Science 344 (2014), 1396–1401.
-
(2014)
Science
, vol.344
, pp. 1396-1401
-
-
Patel, A.P.1
Tirosh, I.2
Trombetta, J.J.3
-
30
-
-
84905447834
-
EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing
-
Francis, J.M., Zhang, C.Z., Maire, C.L., et al. EGFR variant heterogeneity in glioblastoma resolved through single-nucleus sequencing. Cancer Discov 4 (2014), 956–971.
-
(2014)
Cancer Discov
, vol.4
, pp. 956-971
-
-
Francis, J.M.1
Zhang, C.Z.2
Maire, C.L.3
-
31
-
-
84892775264
-
Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA
-
Nathanson, D.A., Gini, B., Mottahedeh, J., et al. Targeted therapy resistance mediated by dynamic regulation of extrachromosomal mutant EGFR DNA. Science 343 (2014), 72–76.
-
(2014)
Science
, vol.343
, pp. 72-76
-
-
Nathanson, D.A.1
Gini, B.2
Mottahedeh, J.3
-
32
-
-
84923911546
-
Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution
-
Kim, H., Zheng, S., Amini, S.S., et al. Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution. Genome Res 25 (2015), 316–327.
-
(2015)
Genome Res
, vol.25
, pp. 316-327
-
-
Kim, H.1
Zheng, S.2
Amini, S.S.3
-
33
-
-
84942319120
-
Spatiotemporal evolution of the primary glioblastoma genome
-
Kim, J., Lee, I.H., Cho, H.J., et al. Spatiotemporal evolution of the primary glioblastoma genome. Cancer Cell 28 (2015), 318–328.
-
(2015)
Cancer Cell
, vol.28
, pp. 318-328
-
-
Kim, J.1
Lee, I.H.2
Cho, H.J.3
-
34
-
-
84859125350
-
Intratumor heterogeneity: seeing the wood for the trees
-
Yap, T.A., Gerlinger, M., Futreal, P.A., et al. Intratumor heterogeneity: seeing the wood for the trees. Sci Transl Med, 4, 2012, 127ps110.
-
(2012)
Sci Transl Med
, vol.4
, pp. 127ps110
-
-
Yap, T.A.1
Gerlinger, M.2
Futreal, P.A.3
-
35
-
-
84884365015
-
The causes and consequences of genetic heterogeneity in cancer evolution
-
Burrell, R.A., McGranahan, N., Bartek, J., Swanton, C., The causes and consequences of genetic heterogeneity in cancer evolution. Nature 501 (2013), 338–345.
-
(2013)
Nature
, vol.501
, pp. 338-345
-
-
Burrell, R.A.1
McGranahan, N.2
Bartek, J.3
Swanton, C.4
-
36
-
-
84928254065
-
Clonal status of actionable driver events and the timing of mutational processes in cancer evolution
-
McGranahan, N., Favero, F., de Bruin, E.C., et al. Clonal status of actionable driver events and the timing of mutational processes in cancer evolution. Sci Transl Med, 7, 2015, 283ra254.
-
(2015)
Sci Transl Med
, vol.7
, pp. 283ra254
-
-
McGranahan, N.1
Favero, F.2
de Bruin, E.C.3
-
37
-
-
84929084427
-
Adapting the drivers to the road: a new strategy for cancer evolution?
-
Touat, M., Dhermain, F., André, F., Sanson, M., Adapting the drivers to the road: a new strategy for cancer evolution?. Ann Oncol 26 (2015), 827–829.
-
(2015)
Ann Oncol
, vol.26
, pp. 827-829
-
-
Touat, M.1
Dhermain, F.2
André, F.3
Sanson, M.4
-
38
-
-
84976318961
-
Clonal evolution of glioblastoma under therapy
-
Wang, J., Cazzato, E., Ladewig, E., et al. Clonal evolution of glioblastoma under therapy. Nat Genet 48 (2016), 768–776.
-
(2016)
Nat Genet
, vol.48
, pp. 768-776
-
-
Wang, J.1
Cazzato, E.2
Ladewig, E.3
-
39
-
-
35348822482
-
Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies
-
Stommel, J.M., Kimmelman, A.C., Ying, H., et al. Coactivation of receptor tyrosine kinases affects the response of tumor cells to targeted therapies. Science 318 (2007), 287–290.
-
(2007)
Science
, vol.318
, pp. 287-290
-
-
Stommel, J.M.1
Kimmelman, A.C.2
Ying, H.3
-
40
-
-
84857397985
-
Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response
-
Szerlip, N.J., Pedraza, A., Chakravarty, D., et al. Intratumoral heterogeneity of receptor tyrosine kinases EGFR and PDGFRA amplification in glioblastoma defines subpopulations with distinct growth factor response. Proc Natl Acad Sci USA 109 (2012), 3041–3046.
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 3041-3046
-
-
Szerlip, N.J.1
Pedraza, A.2
Chakravarty, D.3
-
41
-
-
84994879687
-
Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate
-
Stevens, M.M., Maire, C.L., Chou, N., et al. Drug sensitivity of single cancer cells is predicted by changes in mass accumulation rate. Nat Biotechnol 34 (2016), 1161–1167.
-
(2016)
Nat Biotechnol
, vol.34
, pp. 1161-1167
-
-
Stevens, M.M.1
Maire, C.L.2
Chou, N.3
-
42
-
-
0028146767
-
A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity
-
Nishikawa, R., Ji, X.D., Harmon, R.C., et al. A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity. Proc Natl Acad Sci USA 91 (1994), 7727–7731.
-
(1994)
Proc Natl Acad Sci USA
, vol.91
, pp. 7727-7731
-
-
Nishikawa, R.1
Ji, X.D.2
Harmon, R.C.3
-
43
-
-
0034163550
-
Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
-
Frederick, L., Wang, X.Y., Eley, G., James, CD., Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res 60 (2000), 1383–1387.
-
(2000)
Cancer Res
, vol.60
, pp. 1383-1387
-
-
Frederick, L.1
Wang, X.Y.2
Eley, G.3
James, C.D.4
-
44
-
-
84911109685
-
Molecular pathologic diagnosis of epidermal growth factor receptor
-
Maire, C.L., Ligon, KL., Molecular pathologic diagnosis of epidermal growth factor receptor. Neuro Oncol 16:Suppl 8 (2014), viii1–viii6.
-
(2014)
Neuro Oncol
, vol.16
, pp. viii1-viii6
-
-
Maire, C.L.1
Ligon, K.L.2
-
45
-
-
84861760527
-
Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors
-
Vivanco, I., Robins, H.I., Rohle, D., et al. Differential sensitivity of glioma- versus lung cancer-specific EGFR mutations to EGFR kinase inhibitors. Cancer Discov 2 (2012), 458–471.
-
(2012)
Cancer Discov
, vol.2
, pp. 458-471
-
-
Vivanco, I.1
Robins, H.I.2
Rohle, D.3
-
46
-
-
84885001496
-
Erlotinib resistance in EGFR-amplified glioblastoma cells is associated with upregulation of EGFRvIII and PI3Kp110δ
-
Schulte, A., Liffers, K., Kathagen, A., et al. Erlotinib resistance in EGFR-amplified glioblastoma cells is associated with upregulation of EGFRvIII and PI3Kp110δ. Neuro Oncol 15 (2013), 1289–1301.
-
(2013)
Neuro Oncol
, vol.15
, pp. 1289-1301
-
-
Schulte, A.1
Liffers, K.2
Kathagen, A.3
-
47
-
-
78149254368
-
Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
-
Sampson, J.H., Heimberger, A.B., Archer, G.E., et al. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol 28 (2010), 4722–4729.
-
(2010)
J Clin Oncol
, vol.28
, pp. 4722-4729
-
-
Sampson, J.H.1
Heimberger, A.B.2
Archer, G.E.3
-
48
-
-
84934981297
-
A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study
-
Schuster, J., Lai, R.K., Recht, L.D., et al. A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study. Neuro Oncol 17 (2015), 854–861.
-
(2015)
Neuro Oncol
, vol.17
, pp. 854-861
-
-
Schuster, J.1
Lai, R.K.2
Recht, L.D.3
-
49
-
-
84966335010
-
IMCT-08ReACT: long-term survival from a randomized phase II study of rindopepimut (CDX-110) plus bevacizumab in relapsed glioblastoma
-
Reardon, D.A., Desjardins, A., Schuster, J., et al. IMCT-08ReACT: long-term survival from a randomized phase II study of rindopepimut (CDX-110) plus bevacizumab in relapsed glioblastoma. Neuro Oncol, 17(Suppl 5), 2015, v109.
-
(2015)
Neuro Oncol
, vol.17
, pp. v109
-
-
Reardon, D.A.1
Desjardins, A.2
Schuster, J.3
-
50
-
-
85019444570
-
ATIM-03. ACT IV: an international, double-blind, phase 3 trial of rindopepimut in newly diagnosed, EGFRvIII-expressing glioblastoma
-
Weller, M., Butowski, N., Tran, D., et al. ATIM-03. ACT IV: an international, double-blind, phase 3 trial of rindopepimut in newly diagnosed, EGFRvIII-expressing glioblastoma. Neuro-Oncology 18:Suppl 6 (2016), vi17–vi18.
-
(2016)
Neuro-Oncology
, vol.18
, pp. vi17-vi18
-
-
Weller, M.1
Butowski, N.2
Tran, D.3
-
51
-
-
84964318484
-
ABT-414, an antibody-drug conjugate targeting a tumor-selective EGFR epitope
-
Phillips, A.C., Boghaert, E.R., Vaidya, K.S., et al. ABT-414, an antibody-drug conjugate targeting a tumor-selective EGFR epitope. Mol Cancer Ther 15 (2016), 661–669.
-
(2016)
Mol Cancer Ther
, vol.15
, pp. 661-669
-
-
Phillips, A.C.1
Boghaert, E.R.2
Vaidya, K.S.3
-
52
-
-
85096679516
-
ACTR-07. Efficacy of a novel antibody-drug conjugate (ADC), ABT-414, as monotherapy in epidermal growth factor receptor (EGFR) amplified (EGFRamp), recurrent glioblastoma (rGBM)
-
van den Bent, M., Gan, H., Lassman, A., et al. ACTR-07. Efficacy of a novel antibody-drug conjugate (ADC), ABT-414, as monotherapy in epidermal growth factor receptor (EGFR) amplified (EGFRamp), recurrent glioblastoma (rGBM). Neuro-Oncology, 18(Suppl 6), 2016, vi2.
-
(2016)
Neuro-Oncology
, vol.18
, pp. vi2
-
-
van den Bent, M.1
Gan, H.2
Lassman, A.3
-
53
-
-
1842500007
-
Phase II trial of gefitinib in recurrent glioblastoma
-
Rich, J.N., Reardon, D.A., Peery, T., et al. Phase II trial of gefitinib in recurrent glioblastoma. J Clin Oncol 22:1 (2004), 133–142.
-
(2004)
J Clin Oncol
, vol.22
, Issue.1
, pp. 133-142
-
-
Rich, J.N.1
Reardon, D.A.2
Peery, T.3
-
54
-
-
34247218483
-
Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO)
-
Franceschi, E., Cavallo, G., Lonardi, S., et al. Gefitinib in patients with progressive high-grade gliomas: a multicentre phase II study by Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO). Br J Cancer 96:7 (2007), 1047–1051.
-
(2007)
Br J Cancer
, vol.96
, Issue.7
, pp. 1047-1051
-
-
Franceschi, E.1
Cavallo, G.2
Lonardi, S.3
-
55
-
-
62449150719
-
Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034
-
van den Bent, M.J., Brandes, A.A., Rampling, R., et al. Randomized phase II trial of erlotinib versus temozolomide or carmustine in recurrent glioblastoma: EORTC brain tumor group study 26034. J Clin Oncol 27 (2009), 1268–1274.
-
(2009)
J Clin Oncol
, vol.27
, pp. 1268-1274
-
-
van den Bent, M.J.1
Brandes, A.A.2
Rampling, R.3
-
56
-
-
69849112085
-
Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma
-
Neyns, B., Sadones, J., Joosens, E., et al. Stratified phase II trial of cetuximab in patients with recurrent high-grade glioma. Ann Oncol 20 (2009), 1596–1603.
-
(2009)
Ann Oncol
, vol.20
, pp. 1596-1603
-
-
Neyns, B.1
Sadones, J.2
Joosens, E.3
-
57
-
-
71349088046
-
A phase I/II trial of GW572016 (lapatinib) in recurrent glioblastoma multiforme: clinical outcomes, pharmacokinetics and molecular correlation
-
Thiessen, B., Stewart, C., Tsao, M., et al. A phase I/II trial of GW572016 (lapatinib) in recurrent glioblastoma multiforme: clinical outcomes, pharmacokinetics and molecular correlation. Cancer Chemother Pharmacol 65 (2010), 353–361.
-
(2010)
Cancer Chemother Pharmacol
, vol.65
, pp. 353-361
-
-
Thiessen, B.1
Stewart, C.2
Tsao, M.3
-
58
-
-
75749122223
-
A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy
-
Raizer, J.J., Abrey, L.E., Lassman, A.B., et al. A phase II trial of erlotinib in patients with recurrent malignant gliomas and nonprogressive glioblastoma multiforme postradiation therapy. Neuro Oncol 12 (2010), 95–103.
-
(2010)
Neuro Oncol
, vol.12
, pp. 95-103
-
-
Raizer, J.J.1
Abrey, L.E.2
Lassman, A.B.3
-
59
-
-
78049306732
-
Safety and efficacy of erlotinib in first-relapse glioblastoma: a phase II open-label study
-
Yung, W.K., Vredenburgh, J.J., Cloughesy, T.F., et al. Safety and efficacy of erlotinib in first-relapse glioblastoma: a phase II open-label study. Neuro Oncol 12 (2010), 1061–1070.
-
(2010)
Neuro Oncol
, vol.12
, pp. 1061-1070
-
-
Yung, W.K.1
Vredenburgh, J.J.2
Cloughesy, T.F.3
-
60
-
-
79955582712
-
Phase II evaluation of gefitinib in patients with newly diagnosed Grade 4 astrocytoma: Mayo/North Central Cancer Treatment Group Study N0074
-
Uhm, J.H., Ballman, K.V., Wu, W., et al. Phase II evaluation of gefitinib in patients with newly diagnosed Grade 4 astrocytoma: Mayo/North Central Cancer Treatment Group Study N0074. Int J Radiat Oncol Biol Phys 80 (2011), 347–353.
-
(2011)
Int J Radiat Oncol Biol Phys
, vol.80
, pp. 347-353
-
-
Uhm, J.H.1
Ballman, K.V.2
Wu, W.3
-
61
-
-
84865024576
-
Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab
-
Lv, S., Teugels, E., Sadones, J., et al. Correlation of EGFR, IDH1 and PTEN status with the outcome of patients with recurrent glioblastoma treated in a phase II clinical trial with the EGFR-blocking monoclonal antibody cetuximab. Int J Oncol 41 (2012), 1029–1035.
-
(2012)
Int J Oncol
, vol.41
, pp. 1029-1035
-
-
Lv, S.1
Teugels, E.2
Sadones, J.3
-
62
-
-
84987616093
-
Phase I/randomized phase II study of afatinib, an irreversible ErbB family blocker, with or without protracted temozolomide in adults with recurrent glioblastoma
-
Reardon, D.A., Nabors, L.B., Mason, W.P., et al. Phase I/randomized phase II study of afatinib, an irreversible ErbB family blocker, with or without protracted temozolomide in adults with recurrent glioblastoma. Neuro Oncol 17 (2015), 430–439.
-
(2015)
Neuro Oncol
, vol.17
, pp. 430-439
-
-
Reardon, D.A.1
Nabors, L.B.2
Mason, W.P.3
-
63
-
-
78650102866
-
Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma
-
Sathornsumetee, S., Desjardins, A., Vredenburgh, J.J., et al. Phase II trial of bevacizumab and erlotinib in patients with recurrent malignant glioma. Neuro Oncol 12 (2010), 1300–1310.
-
(2010)
Neuro Oncol
, vol.12
, pp. 1300-1310
-
-
Sathornsumetee, S.1
Desjardins, A.2
Vredenburgh, J.J.3
-
64
-
-
77954748580
-
Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: a phase II trial
-
Hasselbalch, B., Lassen, U., Hansen, S., et al. Cetuximab, bevacizumab, and irinotecan for patients with primary glioblastoma and progression after radiation therapy and temozolomide: a phase II trial. Neuro Oncol 12 (2010), 508–516.
-
(2010)
Neuro Oncol
, vol.12
, pp. 508-516
-
-
Hasselbalch, B.1
Lassen, U.2
Hansen, S.3
-
65
-
-
84874038379
-
A phase I/II trial of pazopanib in combination with lapatinib in adult patients with relapsed malignant glioma
-
Reardon, D.A., Groves, M.D., Wen, P.Y., et al. A phase I/II trial of pazopanib in combination with lapatinib in adult patients with relapsed malignant glioma. Clin Cancer Res 19 (2013), 900–908.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 900-908
-
-
Reardon, D.A.1
Groves, M.D.2
Wen, P.Y.3
-
66
-
-
32944478030
-
Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma
-
Reardon, D.A., Quinn, J.A., Vredenburgh, J.J., et al. Phase 1 trial of gefitinib plus sirolimus in adults with recurrent malignant glioma. Clin Cancer Res 12 (2006), 860–868.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 860-868
-
-
Reardon, D.A.1
Quinn, J.A.2
Vredenburgh, J.J.3
-
67
-
-
33746807790
-
Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas
-
Doherty, L., Gigas, D.C., Kesari, S., et al. Pilot study of the combination of EGFR and mTOR inhibitors in recurrent malignant gliomas. Neurology 67 (2006), 156–158.
-
(2006)
Neurology
, vol.67
, pp. 156-158
-
-
Doherty, L.1
Gigas, D.C.2
Kesari, S.3
-
68
-
-
75049084471
-
Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma
-
Reardon, D.A., Desjardins, A., Vredenburgh, J.J., et al. Phase 2 trial of erlotinib plus sirolimus in adults with recurrent glioblastoma. J Neurooncol 96 (2010), 219–230.
-
(2010)
J Neurooncol
, vol.96
, pp. 219-230
-
-
Reardon, D.A.1
Desjardins, A.2
Vredenburgh, J.J.3
-
69
-
-
84896933653
-
Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02
-
Wen, P.Y., Chang, S.M., Lamborn, K.R., et al. Phase I/II study of erlotinib and temsirolimus for patients with recurrent malignant gliomas: North American Brain Tumor Consortium trial 04-02. Neuro Oncol 16 (2014), 567–578.
-
(2014)
Neuro Oncol
, vol.16
, pp. 567-578
-
-
Wen, P.Y.1
Chang, S.M.2
Lamborn, K.R.3
-
70
-
-
59349089499
-
A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM)
-
Kreisl, T.N., Lassman, A.B., Mischel, P.S., et al. A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM). J Neurooncol 92 (2009), 99–105.
-
(2009)
J Neurooncol
, vol.92
, pp. 99-105
-
-
Kreisl, T.N.1
Lassman, A.B.2
Mischel, P.S.3
-
71
-
-
84875740755
-
NABTT 0502: a phase II and pharmacokinetic study of erlotinib and sorafenib for patients with progressive or recurrent glioblastoma multiforme
-
Peereboom, D.M., Ahluwalia, M.S., Ye, X., et al. NABTT 0502: a phase II and pharmacokinetic study of erlotinib and sorafenib for patients with progressive or recurrent glioblastoma multiforme. Neuro Oncol 15 (2013), 490–496.
-
(2013)
Neuro Oncol
, vol.15
, pp. 490-496
-
-
Peereboom, D.M.1
Ahluwalia, M.S.2
Ye, X.3
-
72
-
-
31544474851
-
Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma
-
Prados, M.D., Lamborn, K.R., Chang, S., et al. Phase 1 study of erlotinib HCl alone and combined with temozolomide in patients with stable or recurrent malignant glioma. Neuro Oncol 8 (2006), 67–78.
-
(2006)
Neuro Oncol
, vol.8
, pp. 67-78
-
-
Prados, M.D.1
Lamborn, K.R.2
Chang, S.3
-
73
-
-
41049103648
-
Phase-1 trial of gefitinib and temozolomide in patients with malignant glioma: a North American brain tumor consortium study
-
Prados, M.D., Yung, W.K., Wen, P.Y., et al. Phase-1 trial of gefitinib and temozolomide in patients with malignant glioma: a North American brain tumor consortium study. Cancer Chemother Pharmacol 61 (2008), 1059–1067.
-
(2008)
Cancer Chemother Pharmacol
, vol.61
, pp. 1059-1067
-
-
Prados, M.D.1
Yung, W.K.2
Wen, P.Y.3
-
74
-
-
57149118473
-
Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177
-
Brown, P.D., Krishnan, S., Sarkaria, J.N., et al. Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. J Clin Oncol 26 (2008), 5603–5609.
-
(2008)
J Clin Oncol
, vol.26
, pp. 5603-5609
-
-
Brown, P.D.1
Krishnan, S.2
Sarkaria, J.N.3
-
75
-
-
33745183568
-
Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177
-
Krishnan, S., Brown, P.D., Ballman, K.V., et al. Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177. Int J Radiat Oncol Biol Phys 65 (2006), 1192–1199.
-
(2006)
Int J Radiat Oncol Biol Phys
, vol.65
, pp. 1192-1199
-
-
Krishnan, S.1
Brown, P.D.2
Ballman, K.V.3
-
76
-
-
59149086517
-
Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma
-
Prados, M.D., Chang, S.M., Butowski, N., et al. Phase II study of erlotinib plus temozolomide during and after radiation therapy in patients with newly diagnosed glioblastoma multiforme or gliosarcoma. J Clin Oncol 27 (2009), 579–584.
-
(2009)
J Clin Oncol
, vol.27
, pp. 579-584
-
-
Prados, M.D.1
Chang, S.M.2
Butowski, N.3
-
77
-
-
77953617053
-
Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme
-
Peereboom, D.M., Shepard, D.R., Ahluwalia, M.S., et al. Phase II trial of erlotinib with temozolomide and radiation in patients with newly diagnosed glioblastoma multiforme. J Neurooncol 98 (2010), 93–99.
-
(2010)
J Neurooncol
, vol.98
, pp. 93-99
-
-
Peereboom, D.M.1
Shepard, D.R.2
Ahluwalia, M.S.3
-
78
-
-
84875239034
-
RTOG 0211: a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients
-
Chakravarti, A., Wang, M., Robins, H.I., et al. RTOG 0211: a phase 1/2 study of radiation therapy with concurrent gefitinib for newly diagnosed glioblastoma patients. Int J Radiat Oncol Biol Phys 85 (2013), 1206–1211.
-
(2013)
Int J Radiat Oncol Biol Phys
, vol.85
, pp. 1206-1211
-
-
Chakravarti, A.1
Wang, M.2
Robins, H.I.3
-
79
-
-
84902457349
-
A single-institution phase II trial of radiation, temozolomide, erlotinib, and bevacizumab for initial treatment of glioblastoma
-
Clarke, J.L., Molinaro, A.M., Phillips, J.J., et al. A single-institution phase II trial of radiation, temozolomide, erlotinib, and bevacizumab for initial treatment of glioblastoma. Neuro Oncol 16 (2014), 984–990.
-
(2014)
Neuro Oncol
, vol.16
, pp. 984-990
-
-
Clarke, J.L.1
Molinaro, A.M.2
Phillips, J.J.3
-
80
-
-
84959284470
-
Therapeutic options in recurrent glioblastoma—an update
-
Seystahl, K., Wick, W., Weller, M., Therapeutic options in recurrent glioblastoma—an update. Crit Rev Oncol Hematol 99 (2016), 389–408.
-
(2016)
Crit Rev Oncol Hematol
, vol.99
, pp. 389-408
-
-
Seystahl, K.1
Wick, W.2
Weller, M.3
-
81
-
-
84865805666
-
Transforming fusions of FGFR and TACC genes in human glioblastoma
-
Singh, D., Chan, J.M., Zoppoli, P., et al. Transforming fusions of FGFR and TACC genes in human glioblastoma. Science 337 (2012), 1231–1235.
-
(2012)
Science
, vol.337
, pp. 1231-1235
-
-
Singh, D.1
Chan, J.M.2
Zoppoli, P.3
-
82
-
-
84945186800
-
Phase I dose-escalation study of JNJ-42756493, an oral pan-fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors
-
Tabernero, J., Bahleda, R., Dienstmann, R., et al. Phase I dose-escalation study of JNJ-42756493, an oral pan-fibroblast growth factor receptor inhibitor, in patients with advanced solid tumors. J Clin Oncol 33 (2015), 3401–3408.
-
(2015)
J Clin Oncol
, vol.33
, pp. 3401-3408
-
-
Tabernero, J.1
Bahleda, R.2
Dienstmann, R.3
-
83
-
-
84942163775
-
Targeting FGFR Signaling in Cancer
-
Touat, M., Ileana, E., Postel-Vinay, S., et al. Targeting FGFR Signaling in Cancer. Clin Cancer Res 21 (2015), 2684–2694.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 2684-2694
-
-
Touat, M.1
Ileana, E.2
Postel-Vinay, S.3
-
84
-
-
84936743121
-
Phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627)
-
Lassman, A.B., Pugh, S.L., Gilbert, M.R., et al. Phase 2 trial of dasatinib in target-selected patients with recurrent glioblastoma (RTOG 0627). Neuro Oncol 17 (2015), 992–998.
-
(2015)
Neuro Oncol
, vol.17
, pp. 992-998
-
-
Lassman, A.B.1
Pugh, S.L.2
Gilbert, M.R.3
-
85
-
-
33748376520
-
Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08
-
Wen, P.Y., Yung, W.K., Lamborn, K.R., et al. Phase I/II study of imatinib mesylate for recurrent malignant gliomas: North American Brain Tumor Consortium Study 99-08. Clin Cancer Res 12 (2006), 4899–4907.
-
(2006)
Clin Cancer Res
, vol.12
, pp. 4899-4907
-
-
Wen, P.Y.1
Yung, W.K.2
Lamborn, K.R.3
-
86
-
-
71649102124
-
Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma
-
Reardon, D.A., Dresemann, G., Taillibert, S., et al. Multicentre phase II studies evaluating imatinib plus hydroxyurea in patients with progressive glioblastoma. Br J Cancer 101 (2009), 1995–2004.
-
(2009)
Br J Cancer
, vol.101
, pp. 1995-2004
-
-
Reardon, D.A.1
Dresemann, G.2
Taillibert, S.3
-
87
-
-
70349694368
-
Phase II study of neoadjuvant imatinib in glioblastoma: evaluation of clinical and molecular effects of the treatment
-
Razis, E., Selviaridis, P., Labropoulos, S., et al. Phase II study of neoadjuvant imatinib in glioblastoma: evaluation of clinical and molecular effects of the treatment. Clin Cancer Res 15 (2009), 6258–6266.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6258-6266
-
-
Razis, E.1
Selviaridis, P.2
Labropoulos, S.3
-
88
-
-
75049085049
-
Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide
-
Dresemann, G., Weller, M., Rosenthal, M.A., et al. Imatinib in combination with hydroxyurea versus hydroxyurea alone as oral therapy in patients with progressive pretreated glioblastoma resistant to standard dose temozolomide. J Neurooncol 96 (2010), 393–402.
-
(2010)
J Neurooncol
, vol.96
, pp. 393-402
-
-
Dresemann, G.1
Weller, M.2
Rosenthal, M.A.3
-
89
-
-
77950461290
-
Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme
-
Holdhoff, M., Supko, J.G., Gallia, G.L., et al. Intratumoral concentrations of imatinib after oral administration in patients with glioblastoma multiforme. J Neurooncol 97 (2010), 241–245.
-
(2010)
J Neurooncol
, vol.97
, pp. 241-245
-
-
Holdhoff, M.1
Supko, J.G.2
Gallia, G.L.3
-
90
-
-
79959971880
-
c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype
-
Li, Y., Li, A., Glas, M., et al. c-Met signaling induces a reprogramming network and supports the glioblastoma stem-like phenotype. Proc Natl Acad Sci USA 108 (2011), 9951–9956.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 9951-9956
-
-
Li, Y.1
Li, A.2
Glas, M.3
-
91
-
-
84877098516
-
Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance
-
Jahangiri, A., De Lay, M., Miller, L.M., et al. Gene expression profile identifies tyrosine kinase c-Met as a targetable mediator of antiangiogenic therapy resistance. Clin Cancer Res 19 (2013), 1773–1783.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1773-1783
-
-
Jahangiri, A.1
De Lay, M.2
Miller, L.M.3
-
92
-
-
84940006011
-
High levels of c-Met is associated with poor prognosis in glioblastoma
-
Petterson, S.A., Dahlrot, R.H., Hermansen, S.K., et al. High levels of c-Met is associated with poor prognosis in glioblastoma. J Neurooncol 122 (2015), 517–527.
-
(2015)
J Neurooncol
, vol.122
, pp. 517-527
-
-
Petterson, S.A.1
Dahlrot, R.H.2
Hermansen, S.K.3
-
93
-
-
84941905211
-
Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma
-
Johnson, J., Ascierto, M.L., Mittal, S., et al. Genomic profiling of a Hepatocyte growth factor-dependent signature for MET-targeted therapy in glioblastoma. J Transl Med, 13, 2015, 306.
-
(2015)
J Transl Med
, vol.13
, pp. 306
-
-
Johnson, J.1
Ascierto, M.L.2
Mittal, S.3
-
94
-
-
79955766450
-
A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma
-
Wen, P.Y., Schiff, D., Cloughesy, T.F., et al. A phase II study evaluating the efficacy and safety of AMG 102 (rilotumumab) in patients with recurrent glioblastoma. Neuro Oncol 13 (2011), 437–446.
-
(2011)
Neuro Oncol
, vol.13
, pp. 437-446
-
-
Wen, P.Y.1
Schiff, D.2
Cloughesy, T.F.3
-
95
-
-
84862908734
-
Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal-epithelial transition inhibitor
-
Chi, A.S., Batchelor, T.T., Kwak, E.L., et al. Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal-epithelial transition inhibitor. J Clin Oncol 30 (2012), e30–e33.
-
(2012)
J Clin Oncol
, vol.30
, pp. e30-e33
-
-
Chi, A.S.1
Batchelor, T.T.2
Kwak, E.L.3
-
96
-
-
85050577857
-
Patterns of response to crizotinib in recurrent glioblastoma according to ALK and MET molecular profile in two patients
-
Le Rhun, E., Chamberlain, M.C., Zairi, F., et al. Patterns of response to crizotinib in recurrent glioblastoma according to ALK and MET molecular profile in two patients. CNS Oncol 4 (2015), 381–386.
-
(2015)
CNS Oncol
, vol.4
, pp. 381-386
-
-
Le Rhun, E.1
Chamberlain, M.C.2
Zairi, F.3
-
97
-
-
85010063077
-
Randomized, double-blind, placebo-controlled, multicenter phase II study of onartuzumab plus bevacizumab versus placebo plus bevacizumab in patients with recurrent glioblastoma: efficacy, safety, and hepatocyte growth factor and O(6)-methylguanine-DNA methyltransferase biomarker analyses
-
Cloughesy, T., Finocchiaro, G., Belda-Iniesta, C., et al. Randomized, double-blind, placebo-controlled, multicenter phase II study of onartuzumab plus bevacizumab versus placebo plus bevacizumab in patients with recurrent glioblastoma: efficacy, safety, and hepatocyte growth factor and O(6)-methylguanine-DNA methyltransferase biomarker analyses. J Clin Oncol 35 (2016), 343–351.
-
(2016)
J Clin Oncol
, vol.35
, pp. 343-351
-
-
Cloughesy, T.1
Finocchiaro, G.2
Belda-Iniesta, C.3
-
98
-
-
23944453425
-
Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study
-
Galanis, E., Buckner, J.C., Maurer, M.J., et al. Phase II trial of temsirolimus (CCI-779) in recurrent glioblastoma multiforme: a North Central Cancer Treatment Group Study. J Clin Oncol 23 (2005), 5294–5304.
-
(2005)
J Clin Oncol
, vol.23
, pp. 5294-5304
-
-
Galanis, E.1
Buckner, J.C.2
Maurer, M.J.3
-
99
-
-
84876766342
-
Phase II study of bevacizumab and temsirolimus combination therapy for recurrent glioblastoma multiforme
-
Lassen, U., Sorensen, M., Gaziel, T.B., et al. Phase II study of bevacizumab and temsirolimus combination therapy for recurrent glioblastoma multiforme. Anticancer Res 33 (2013), 1657–1660.
-
(2013)
Anticancer Res
, vol.33
, pp. 1657-1660
-
-
Lassen, U.1
Sorensen, M.2
Gaziel, T.B.3
-
100
-
-
84940748380
-
A phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057K
-
Ma, D.J., Galanis, E., Anderson, S.K., et al. A phase II trial of everolimus, temozolomide, and radiotherapy in patients with newly diagnosed glioblastoma: NCCTG N057K. Neuro Oncol 17 (2015), 1261–1269.
-
(2015)
Neuro Oncol
, vol.17
, pp. 1261-1269
-
-
Ma, D.J.1
Galanis, E.2
Anderson, S.K.3
-
101
-
-
84940778136
-
Phase II study of PX-866 in recurrent glioblastoma
-
Pitz, M.W., Eisenhauer, E.A., MacNeil, M.V., et al. Phase II study of PX-866 in recurrent glioblastoma. Neuro Oncol 17 (2015), 1270–1274.
-
(2015)
Neuro Oncol
, vol.17
, pp. 1270-1274
-
-
Pitz, M.W.1
Eisenhauer, E.A.2
MacNeil, M.V.3
-
102
-
-
84954357527
-
PI3K inhibitors as new cancer therapeutics: implications for clinical trial design
-
Massacesi, C., Di Tomaso, E., Urban, P., et al. PI3K inhibitors as new cancer therapeutics: implications for clinical trial design. Onco Targets Ther 9 (2016), 203–210.
-
(2016)
Onco Targets Ther
, vol.9
, pp. 203-210
-
-
Massacesi, C.1
Di Tomaso, E.2
Urban, P.3
-
103
-
-
79953184268
-
BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications
-
Dias-Santagata, D., Lam, Q., Vernovsky, K., et al. BRAF V600E mutations are common in pleomorphic xanthoastrocytoma: diagnostic and therapeutic implications. PLoS One, 6, 2011, e17948.
-
(2011)
PLoS One
, vol.6
, pp. e17948
-
-
Dias-Santagata, D.1
Lam, Q.2
Vernovsky, K.3
-
104
-
-
84885059781
-
Salvage therapy with BRAF inhibitors for recurrent pleomorphic xanthoastrocytoma: a retrospective case series
-
Chamberlain, MC., Salvage therapy with BRAF inhibitors for recurrent pleomorphic xanthoastrocytoma: a retrospective case series. J Neurooncol 114 (2013), 237–240.
-
(2013)
J Neurooncol
, vol.114
, pp. 237-240
-
-
Chamberlain, M.C.1
-
105
-
-
84939864059
-
Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations
-
Hyman, D.M., Puzanov, I., Subbiah, V., et al. Vemurafenib in multiple nonmelanoma cancers with BRAF V600 mutations. N Engl J Med 373 (2015), 726–736.
-
(2015)
N Engl J Med
, vol.373
, pp. 726-736
-
-
Hyman, D.M.1
Puzanov, I.2
Subbiah, V.3
-
106
-
-
77955363593
-
Concurrent radiotherapy and temozolomide followed by temozolomide and sorafenib in the first-line treatment of patients with glioblastoma multiforme
-
Hainsworth, J.D., Ervin, T., Friedman, E., et al. Concurrent radiotherapy and temozolomide followed by temozolomide and sorafenib in the first-line treatment of patients with glioblastoma multiforme. Cancer 116 (2010), 3663–3669.
-
(2010)
Cancer
, vol.116
, pp. 3663-3669
-
-
Hainsworth, J.D.1
Ervin, T.2
Friedman, E.3
-
107
-
-
84883474833
-
Phase II study of bevacizumab in combination with sorafenib in recurrent glioblastoma (N0776): a north central cancer treatment group trial
-
Galanis, E., Anderson, S.K., Lafky, J.M., et al. Phase II study of bevacizumab in combination with sorafenib in recurrent glioblastoma (N0776): a north central cancer treatment group trial. Clin Cancer Res 19 (2013), 4816–4823.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 4816-4823
-
-
Galanis, E.1
Anderson, S.K.2
Lafky, J.M.3
-
108
-
-
79751535045
-
Effect of CYP3A-inducing anti-epileptics on sorafenib exposure: results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma
-
Reardon, D.A., Vredenburgh, J.J., Desjardins, A., et al. Effect of CYP3A-inducing anti-epileptics on sorafenib exposure: results of a phase II study of sorafenib plus daily temozolomide in adults with recurrent glioblastoma. J Neurooncol 101 (2011), 57–66.
-
(2011)
J Neurooncol
, vol.101
, pp. 57-66
-
-
Reardon, D.A.1
Vredenburgh, J.J.2
Desjardins, A.3
-
109
-
-
84883261716
-
Sorafenib plus daily low-dose temozolomide for relapsed glioblastoma: a phase II study
-
Zustovich, F., Landi, L., Lombardi, G., et al. Sorafenib plus daily low-dose temozolomide for relapsed glioblastoma: a phase II study. Anticancer Res 33 (2013), 3487–3494.
-
(2013)
Anticancer Res
, vol.33
, pp. 3487-3494
-
-
Zustovich, F.1
Landi, L.2
Lombardi, G.3
-
110
-
-
84869188311
-
Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02
-
Lee, E.Q., Kuhn, J., Lamborn, K.R., et al. Phase I/II study of sorafenib in combination with temsirolimus for recurrent glioblastoma or gliosarcoma: North American Brain Tumor Consortium study 05-02. Neuro Oncol 14 (2012), 1511–1518.
-
(2012)
Neuro Oncol
, vol.14
, pp. 1511-1518
-
-
Lee, E.Q.1
Kuhn, J.2
Lamborn, K.R.3
-
111
-
-
84901595804
-
Phase I study of sorafenib combined with radiation therapy and temozolomide as first-line treatment of high-grade glioma
-
Hottinger, A.F., Aissa, A.B., Espeli, V., et al. Phase I study of sorafenib combined with radiation therapy and temozolomide as first-line treatment of high-grade glioma. Br J Cancer 110 (2014), 2655–2661.
-
(2014)
Br J Cancer
, vol.110
, pp. 2655-2661
-
-
Hottinger, A.F.1
Aissa, A.B.2
Espeli, V.3
-
113
-
-
0026569818
-
Clonal expansion of p53 mutant cells is associated with brain tumour progression
-
Sidransky, D., Mikkelsen, T., Schwechheimer, K., et al. Clonal expansion of p53 mutant cells is associated with brain tumour progression. Nature 355 (1992), 846–847.
-
(1992)
Nature
, vol.355
, pp. 846-847
-
-
Sidransky, D.1
Mikkelsen, T.2
Schwechheimer, K.3
-
114
-
-
0029020027
-
Loss of wild-type p53 bestows a growth advantage on primary cortical astrocytes and facilitates their in vitro transformation
-
Bögler, O., Huang, H.J., Cavenee, WK., Loss of wild-type p53 bestows a growth advantage on primary cortical astrocytes and facilitates their in vitro transformation. Cancer Res 55 (1995), 2746–2751.
-
(1995)
Cancer Res
, vol.55
, pp. 2746-2751
-
-
Bögler, O.1
Huang, H.J.2
Cavenee, W.K.3
-
115
-
-
0027196974
-
Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations
-
Reifenberger, G., Liu, L., Ichimura, K., et al. Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations. Cancer Res 53 (1993), 2736–2739.
-
(1993)
Cancer Res
, vol.53
, pp. 2736-2739
-
-
Reifenberger, G.1
Liu, L.2
Ichimura, K.3
-
116
-
-
84923080118
-
p53 as a target for the treatment of cancer
-
Duffy, M.J., Synnott, N.C., McGowan, P.M., et al. p53 as a target for the treatment of cancer. Cancer Treat Rev 40 (2014), 1153–1160.
-
(2014)
Cancer Treat Rev
, vol.40
, pp. 1153-1160
-
-
Duffy, M.J.1
Synnott, N.C.2
McGowan, P.M.3
-
117
-
-
84899051588
-
Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor
-
Costa, B., Bendinelli, S., Gabelloni, P., et al. Human glioblastoma multiforme: p53 reactivation by a novel MDM2 inhibitor. PLoS One, 8, 2013, e72281.
-
(2013)
PLoS One
, vol.8
, pp. e72281
-
-
Costa, B.1
Bendinelli, S.2
Gabelloni, P.3
-
118
-
-
84962295728
-
Preclinical efficacy of the MDM2 inhibitor RG7112 in MDM2-amplified and TP53 wild-type glioblastomas
-
Verreault, M., Schmitt, C., Goldwirt, L., et al. Preclinical efficacy of the MDM2 inhibitor RG7112 in MDM2-amplified and TP53 wild-type glioblastomas. Clin Cancer Res 22 (2016), 1185–1196.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 1185-1196
-
-
Verreault, M.1
Schmitt, C.2
Goldwirt, L.3
-
119
-
-
70449711757
-
Genetic alterations and signaling pathways in the evolution of gliomas
-
Ohgaki, H., Kleihues, P., Genetic alterations and signaling pathways in the evolution of gliomas. Cancer Sci 100 (2009), 2235–2241.
-
(2009)
Cancer Sci
, vol.100
, pp. 2235-2241
-
-
Ohgaki, H.1
Kleihues, P.2
-
120
-
-
77951082119
-
Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts
-
Michaud, K., Solomon, D.A., Oermann, E., et al. Pharmacologic inhibition of cyclin-dependent kinases 4 and 6 arrests the growth of glioblastoma multiforme intracranial xenografts. Cancer Res 70 (2010), 3228–3238.
-
(2010)
Cancer Res
, vol.70
, pp. 3228-3238
-
-
Michaud, K.1
Solomon, D.A.2
Oermann, E.3
-
121
-
-
77954929373
-
Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM
-
Wiedemeyer, W.R., Dunn, I.F., Quayle, S.N., et al. Pattern of retinoblastoma pathway inactivation dictates response to CDK4/6 inhibition in GBM. Proc Natl Acad Sci USA 107 (2010), 11501–11506.
-
(2010)
Proc Natl Acad Sci USA
, vol.107
, pp. 11501-11506
-
-
Wiedemeyer, W.R.1
Dunn, I.F.2
Quayle, S.N.3
-
122
-
-
84862877673
-
p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells
-
Cen, L., Carlson, B.L., Schroeder, M.A., et al. p16-Cdk4-Rb axis controls sensitivity to a cyclin-dependent kinase inhibitor PD0332991 in glioblastoma xenograft cells. Neuro Oncol 14 (2012), 870–881.
-
(2012)
Neuro Oncol
, vol.14
, pp. 870-881
-
-
Cen, L.1
Carlson, B.L.2
Schroeder, M.A.3
-
123
-
-
84884854055
-
PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma
-
Barton, K.L., Misuraca, K., Cordero, F., et al. PD-0332991, a CDK4/6 inhibitor, significantly prolongs survival in a genetically engineered mouse model of brainstem glioma. PLoS One, 8, 2013, e77639.
-
(2013)
PLoS One
, vol.8
, pp. e77639
-
-
Barton, K.L.1
Misuraca, K.2
Cordero, F.3
-
124
-
-
77956517283
-
In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma
-
Mir, S.E., De Witt Hamer, P.C., Krawczyk, P.M., et al. In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma. Cancer Cell 18 (2010), 244–257.
-
(2010)
Cancer Cell
, vol.18
, pp. 244-257
-
-
Mir, S.E.1
De Witt Hamer, P.C.2
Krawczyk, P.M.3
-
125
-
-
79960339454
-
WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe
-
De Witt Hamer, P.C., Mir, S.E., Noske, D., et al. WEE1 kinase targeting combined with DNA-damaging cancer therapy catalyzes mitotic catastrophe. Clin Cancer Res 17 (2011), 4200–4207.
-
(2011)
Clin Cancer Res
, vol.17
, pp. 4200-4207
-
-
De Witt Hamer, P.C.1
Mir, S.E.2
Noske, D.3
-
126
-
-
84952872645
-
Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells
-
Toledo, C.M., Ding, Y., Hoellerbauer, P., et al. Genome-wide CRISPR-Cas9 Screens Reveal Loss of Redundancy between PKMYT1 and WEE1 in Glioblastoma Stem-like Cells. Cell Rep 13 (2015), 2425–2439.
-
(2015)
Cell Rep
, vol.13
, pp. 2425-2439
-
-
Toledo, C.M.1
Ding, Y.2
Hoellerbauer, P.3
-
127
-
-
84904383968
-
Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts
-
Gupta, S.K., Mladek, A.C., Carlson, B.L., et al. Discordant in vitro and in vivo chemopotentiating effects of the PARP inhibitor veliparib in temozolomide-sensitive versus -resistant glioblastoma multiforme xenografts. Clin Cancer Res 20 (2014), 3730–3741.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 3730-3741
-
-
Gupta, S.K.1
Mladek, A.C.2
Carlson, B.L.3
-
128
-
-
84892430577
-
Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells
-
Venere, M., Hamerlik, P., Wu, Q., et al. Therapeutic targeting of constitutive PARP activation compromises stem cell phenotype and survival of glioblastoma-initiating cells. Cell Death Differ 21 (2014), 258–269.
-
(2014)
Cell Death Differ
, vol.21
, pp. 258-269
-
-
Venere, M.1
Hamerlik, P.2
Wu, Q.3
-
129
-
-
85096669973
-
ATCT-27NRG Oncology/RTOG 0929: a randomized phase I/II study of ABT-888IN combination with temozolomide in recurrent temozolomide resistant glioblastoma
-
Robins, H.I., Zhang, P., Gilbert, M., et al. ATCT-27NRG Oncology/RTOG 0929: a randomized phase I/II study of ABT-888IN combination with temozolomide in recurrent temozolomide resistant glioblastoma. Neuro Oncol, 17(Suppl 5), 2015, v7.
-
(2015)
Neuro Oncol
, vol.17
, pp. v7
-
-
Robins, H.I.1
Zhang, P.2
Gilbert, M.3
-
130
-
-
60849115270
-
IDH1 and IDH2 mutations in gliomas
-
Yan, H., Parsons, D.W., Jin, G., et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med 360 (2009), 765–773.
-
(2009)
N Engl J Med
, vol.360
, pp. 765-773
-
-
Yan, H.1
Parsons, D.W.2
Jin, G.3
-
131
-
-
69949114447
-
Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas
-
Hartmann, C., Meyer, J., Balss, J., et al. Type and frequency of IDH1 and IDH2 mutations are related to astrocytic and oligodendroglial differentiation and age: a study of 1,010 diffuse gliomas. Acta Neuropathol 118 (2009), 469–474.
-
(2009)
Acta Neuropathol
, vol.118
, pp. 469-474
-
-
Hartmann, C.1
Meyer, J.2
Balss, J.3
-
132
-
-
85006086265
-
IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives
-
Mondesir, J., Willekens, C., Touat, M., et al. IDH1 and IDH2 mutations as novel therapeutic targets: current perspectives. J Blood Med 7 (2016), 171–180.
-
(2016)
J Blood Med
, vol.7
, pp. 171-180
-
-
Mondesir, J.1
Willekens, C.2
Touat, M.3
-
133
-
-
84858796263
-
IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
-
Turcan, S., Rohle, D., Goenka, A., et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature 483 (2012), 479–483.
-
(2012)
Nature
, vol.483
, pp. 479-483
-
-
Turcan, S.1
Rohle, D.2
Goenka, A.3
-
134
-
-
85043300934
-
ACTR-46. AG120, a first-in-class mutant IDH1 inhibitor in patients with recurrent or progressive IDH1 mutant glioma: results from the phase 1 glioma expansion cohorts
-
Mellinghoff, I.K., Touat, M., Maher, E., et al. ACTR-46. AG120, a first-in-class mutant IDH1 inhibitor in patients with recurrent or progressive IDH1 mutant glioma: results from the phase 1 glioma expansion cohorts. Neuro-Oncology, 18(Suppl 6), 2016, vi12.
-
(2016)
Neuro-Oncology
, vol.18
, pp. vi12
-
-
Mellinghoff, I.K.1
Touat, M.2
Maher, E.3
-
135
-
-
84906557615
-
A vaccine targeting mutant IDH1 induces antitumour immunity
-
Schumacher, T., Bunse, L., Pusch, S., et al. A vaccine targeting mutant IDH1 induces antitumour immunity. Nature 512 (2014), 324–327.
-
(2014)
Nature
, vol.512
, pp. 324-327
-
-
Schumacher, T.1
Bunse, L.2
Pusch, S.3
-
136
-
-
85018199153
-
Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma
-
Pellegatta, S., Valletta, L., Corbetta, C., et al. Effective immuno-targeting of the IDH1 mutation R132H in a murine model of intracranial glioma. Acta Neuropathol Commun, 3, 2015, 4.
-
(2015)
Acta Neuropathol Commun
, vol.3
, pp. 4
-
-
Pellegatta, S.1
Valletta, L.2
Corbetta, C.3
-
137
-
-
82955237437
-
Vorinostat modulates cell cycle regulatory proteins in glioma cells and human glioma slice cultures
-
Xu, J., Sampath, D., Lang, F.F., et al. Vorinostat modulates cell cycle regulatory proteins in glioma cells and human glioma slice cultures. J Neurooncol 105 (2011), 241–251.
-
(2011)
J Neurooncol
, vol.105
, pp. 241-251
-
-
Xu, J.1
Sampath, D.2
Lang, F.F.3
-
138
-
-
84923048337
-
Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe
-
Cornago, M., Garcia-Alberich, C., Blasco-Angulo, N., et al. Histone deacetylase inhibitors promote glioma cell death by G2 checkpoint abrogation leading to mitotic catastrophe. Cell Death Dis, 5, 2014, e1435.
-
(2014)
Cell Death Dis
, vol.5
, pp. e1435
-
-
Cornago, M.1
Garcia-Alberich, C.2
Blasco-Angulo, N.3
-
139
-
-
84930764914
-
Functionally defined therapeutic targets in diffuse intrinsic pontine glioma
-
Grasso, C.S., Tang, Y., Truffaux, N., et al. Functionally defined therapeutic targets in diffuse intrinsic pontine glioma. Nat Med 21 (2015), 555–559.
-
(2015)
Nat Med
, vol.21
, pp. 555-559
-
-
Grasso, C.S.1
Tang, Y.2
Truffaux, N.3
-
140
-
-
65349141942
-
Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study
-
Galanis, E., Jaeckle, K.A., Maurer, M.J., et al. Phase II trial of vorinostat in recurrent glioblastoma multiforme: a north central cancer treatment group study. J Clin Oncol 27 (2009), 2052–2058.
-
(2009)
J Clin Oncol
, vol.27
, pp. 2052-2058
-
-
Galanis, E.1
Jaeckle, K.A.2
Maurer, M.J.3
-
141
-
-
84868561843
-
Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: North American Brain Tumor Consortium Study 04-03
-
Lee, E.Q., Puduvalli, V.K., Reid, J.M., et al. Phase I study of vorinostat in combination with temozolomide in patients with high-grade gliomas: North American Brain Tumor Consortium Study 04-03. Clin Cancer Res 18 (2012), 6032–6039.
-
(2012)
Clin Cancer Res
, vol.18
, pp. 6032-6039
-
-
Lee, E.Q.1
Puduvalli, V.K.2
Reid, J.M.3
-
142
-
-
85044083341
-
Brain Tumor Trials Collaborative Bayesian Adaptive Randomized Phase II trial of bevacizumab plus vorinostat versus bevacizumab alone in adults with recurrent glioblastoma (BTTC-1102). 2015 ASCO Annual Meeting
-
Puduvalli, V.K., Wu, J., Yuan, Y., Armstrong, T.S., et al. Brain Tumor Trials Collaborative Bayesian Adaptive Randomized Phase II trial of bevacizumab plus vorinostat versus bevacizumab alone in adults with recurrent glioblastoma (BTTC-1102). 2015 ASCO Annual Meeting. J Clin Oncol, 33, 2015.
-
(2015)
J Clin Oncol
, vol.33
-
-
Puduvalli, V.K.1
Wu, J.2
Yuan, Y.3
Armstrong, T.S.4
-
143
-
-
84943196028
-
Phase II study of panobinostat in combination with bevacizumab for recurrent glioblastoma and anaplastic glioma
-
Lee, E.Q., Reardon, D.A., Schiff, D., et al. Phase II study of panobinostat in combination with bevacizumab for recurrent glioblastoma and anaplastic glioma. Neuro Oncol 17 (2015), 862–867.
-
(2015)
Neuro Oncol
, vol.17
, pp. 862-867
-
-
Lee, E.Q.1
Reardon, D.A.2
Schiff, D.3
-
144
-
-
84877097843
-
Inhibition of BET bromodomain targets genetically diverse glioblastoma
-
Cheng, Z., Gong, Y., Ma, Y., et al. Inhibition of BET bromodomain targets genetically diverse glioblastoma. Clin Cancer Res 19 (2013), 1748–1759.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1748-1759
-
-
Cheng, Z.1
Gong, Y.2
Ma, Y.3
-
145
-
-
85050885463
-
Prolonged Ezh2 depletion in glioblastoma causes a robust switch in cell fate resulting in tumor progression
-
S2211–S1247
-
de Vries, N.A., Hulsman, D., Akhtar, W., et al. Prolonged Ezh2 depletion in glioblastoma causes a robust switch in cell fate resulting in tumor progression. Cell Rep, 14, 2015 S2211–S1247.
-
(2015)
Cell Rep
, vol.14
-
-
de Vries, N.A.1
Hulsman, D.2
Akhtar, W.3
-
146
-
-
84936818798
-
The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation
-
Pastori, C., Kapranov, P., Penas, C., et al. The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation. Proc Natl Acad Sci USA 112 (2015), 8326–8331.
-
(2015)
Proc Natl Acad Sci USA
, vol.112
, pp. 8326-8331
-
-
Pastori, C.1
Kapranov, P.2
Penas, C.3
-
147
-
-
84949035547
-
Integrated genomic characterization of IDH1-mutant glioma malignant progression
-
Bai, H., Harmancı, A.S., Erson-Omay, E.Z., et al. Integrated genomic characterization of IDH1-mutant glioma malignant progression. Nat Genet 48 (2016), 59–66.
-
(2016)
Nat Genet
, vol.48
, pp. 59-66
-
-
Bai, H.1
Harmancı, A.S.2
Erson-Omay, E.Z.3
-
148
-
-
70350461699
-
Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
-
Friedman, H.S., Prados, M.D., Wen, P.Y., et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol 27 (2009), 4733–4740.
-
(2009)
J Clin Oncol
, vol.27
, pp. 4733-4740
-
-
Friedman, H.S.1
Prados, M.D.2
Wen, P.Y.3
-
149
-
-
59949083263
-
Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
-
Kreisl, T.N., Kim, L., Moore, K., et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol 27 (2009), 740–745.
-
(2009)
J Clin Oncol
, vol.27
, pp. 740-745
-
-
Kreisl, T.N.1
Kim, L.2
Moore, K.3
-
150
-
-
79960111080
-
Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study
-
de Groot, J.F., Lamborn, K.R., Chang, S.M., et al. Phase II study of aflibercept in recurrent malignant glioma: a North American Brain Tumor Consortium study. J Clin Oncol 29 (2011), 2689–2695.
-
(2011)
J Clin Oncol
, vol.29
, pp. 2689-2695
-
-
de Groot, J.F.1
Lamborn, K.R.2
Chang, S.M.3
-
151
-
-
79959795987
-
Phase II study of sunitinib malate in patients with recurrent high-grade glioma
-
Neyns, B., Sadones, J., Chaskis, C., et al. Phase II study of sunitinib malate in patients with recurrent high-grade glioma. J Neurooncol 103 (2011), 491–501.
-
(2011)
J Neurooncol
, vol.103
, pp. 491-501
-
-
Neyns, B.1
Sadones, J.2
Chaskis, C.3
-
152
-
-
84871816644
-
Continuous daily sunitinib for recurrent glioblastoma
-
Kreisl, T.N., Smith, P., Sul, J., et al. Continuous daily sunitinib for recurrent glioblastoma. J Neurooncol 111 (2013), 41–48.
-
(2013)
J Neurooncol
, vol.111
, pp. 41-48
-
-
Kreisl, T.N.1
Smith, P.2
Sul, J.3
-
153
-
-
84891527003
-
A single-arm phase II Austrian/German multicenter trial on continuous daily sunitinib in primary glioblastoma at first recurrence (SURGE 01-07)
-
Hutterer, M., Nowosielski, M., Haybaeck, J., et al. A single-arm phase II Austrian/German multicenter trial on continuous daily sunitinib in primary glioblastoma at first recurrence (SURGE 01-07). Neuro Oncol 16 (2014), 92–102.
-
(2014)
Neuro Oncol
, vol.16
, pp. 92-102
-
-
Hutterer, M.1
Nowosielski, M.2
Haybaeck, J.3
-
154
-
-
77954720781
-
Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma
-
Batchelor, T.T., Duda, D.G., di Tomaso, E., et al. Phase II study of cediranib, an oral pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, in patients with recurrent glioblastoma. J Clin Oncol 28 (2010), 2817–2823.
-
(2010)
J Clin Oncol
, vol.28
, pp. 2817-2823
-
-
Batchelor, T.T.1
Duda, D.G.2
di Tomaso, E.3
-
155
-
-
84887116872
-
Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma
-
Batchelor, T.T., Mulholland, P., Neyns, B., et al. Phase III randomized trial comparing the efficacy of cediranib as monotherapy, and in combination with lomustine, versus lomustine alone in patients with recurrent glioblastoma. J Clin Oncol 31 (2013), 3212–3218.
-
(2013)
J Clin Oncol
, vol.31
, pp. 3212-3218
-
-
Batchelor, T.T.1
Mulholland, P.2
Neyns, B.3
-
156
-
-
84942912427
-
A multicenter, phase II, randomized, noncomparative clinical trial of radiation and temozolomide with or without vandetanib in newly diagnosed glioblastoma patients
-
Lee, E.Q., Kaley, T.J., Duda, D.G., et al. A multicenter, phase II, randomized, noncomparative clinical trial of radiation and temozolomide with or without vandetanib in newly diagnosed glioblastoma patients. Clin Cancer Res 21 (2015), 3610–3618.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 3610-3618
-
-
Lee, E.Q.1
Kaley, T.J.2
Duda, D.G.3
-
157
-
-
84879300467
-
Phase II open-label study of nintedanib in patients with recurrent glioblastoma multiforme
-
Muhic, A., Poulsen, H.S., Sorensen, M., et al. Phase II open-label study of nintedanib in patients with recurrent glioblastoma multiforme. J Neurooncol 111 (2013), 205–212.
-
(2013)
J Neurooncol
, vol.111
, pp. 205-212
-
-
Muhic, A.1
Poulsen, H.S.2
Sorensen, M.3
-
158
-
-
84908563697
-
Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial
-
Stupp, R., Hegi, M.E., Gorlia, T., et al. Cilengitide combined with standard treatment for patients with newly diagnosed glioblastoma with methylated MGMT promoter (CENTRIC EORTC 26071-22072 study): a multicentre, randomised, open-label, phase 3 trial. Lancet Oncol 15 (2014), 1100–1108.
-
(2014)
Lancet Oncol
, vol.15
, pp. 1100-1108
-
-
Stupp, R.1
Hegi, M.E.2
Gorlia, T.3
-
159
-
-
84928882474
-
Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study
-
Nabors, L.B., Fink, K.L., Mikkelsen, T., et al. Two cilengitide regimens in combination with standard treatment for patients with newly diagnosed glioblastoma and unmethylated MGMT gene promoter: results of the open-label, controlled, randomized phase II CORE study. Neuro Oncol 17 (2015), 708–717.
-
(2015)
Neuro Oncol
, vol.17
, pp. 708-717
-
-
Nabors, L.B.1
Fink, K.L.2
Mikkelsen, T.3
-
160
-
-
77949891455
-
Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma
-
Wick, W., Puduvalli, V.K., Chamberlain, M.C., et al. Phase III study of enzastaurin compared with lomustine in the treatment of recurrent intracranial glioblastoma. J Clin Oncol 28 (2010), 1168–1174.
-
(2010)
J Clin Oncol
, vol.28
, pp. 1168-1174
-
-
Wick, W.1
Puduvalli, V.K.2
Chamberlain, M.C.3
-
161
-
-
84904913239
-
Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial
-
Taal, W., Oosterkamp, H.M., Walenkamp, A.M., et al. Single-agent bevacizumab or lomustine versus a combination of bevacizumab plus lomustine in patients with recurrent glioblastoma (BELOB trial): a randomised controlled phase 2 trial. Lancet Oncol 15 (2014), 943–953.
-
(2014)
Lancet Oncol
, vol.15
, pp. 943-953
-
-
Taal, W.1
Oosterkamp, H.M.2
Walenkamp, A.M.3
-
162
-
-
84894194756
-
Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
-
Chinot, O.L., Wick, W., Mason, W., et al. Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med 370 (2014), 709–722.
-
(2014)
N Engl J Med
, vol.370
, pp. 709-722
-
-
Chinot, O.L.1
Wick, W.2
Mason, W.3
-
163
-
-
84894114159
-
A randomized trial of bevacizumab for newly diagnosed glioblastoma
-
Gilbert, M.R., Dignam, J.J., Armstrong, T.S., et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med 370 (2014), 699–708.
-
(2014)
N Engl J Med
, vol.370
, pp. 699-708
-
-
Gilbert, M.R.1
Dignam, J.J.2
Armstrong, T.S.3
-
164
-
-
85096724746
-
NCCTG N0872 (Alliance): a randomized placebo-controlled phase II trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma (GBM). 2015 ASCO Annual Meeting
-
Galanis, E., Anderson, S.K., Anastasiadis, P., et al. NCCTG N0872 (Alliance): a randomized placebo-controlled phase II trial of bevacizumab plus dasatinib in patients with recurrent glioblastoma (GBM). 2015 ASCO Annual Meeting. J Clin Oncol, 33, 2015.
-
(2015)
J Clin Oncol
, vol.33
-
-
Galanis, E.1
Anderson, S.K.2
Anastasiadis, P.3
-
165
-
-
84959459146
-
Randomized phase II study of axitinib versus physicians best alternative choice of therapy in patients with recurrent glioblastoma
-
Duerinck, J., Du Four, S., Vandervorst, F., et al. Randomized phase II study of axitinib versus physicians best alternative choice of therapy in patients with recurrent glioblastoma. J Neurooncol 128 (2016), 147–155.
-
(2016)
J Neurooncol
, vol.128
, pp. 147-155
-
-
Duerinck, J.1
Du Four, S.2
Vandervorst, F.3
-
166
-
-
84871617507
-
Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end?
-
Tanaka, S., Louis, D.N., Curry, W.T., et al. Diagnostic and therapeutic avenues for glioblastoma: no longer a dead end?. Nat Rev Clin Oncol 10 (2013), 14–26.
-
(2013)
Nat Rev Clin Oncol
, vol.10
, pp. 14-26
-
-
Tanaka, S.1
Louis, D.N.2
Curry, W.T.3
-
167
-
-
84916936049
-
Antiangiogenic therapy for glioblastoma: current status and future prospects
-
Batchelor, T.T., Reardon, D.A., de Groot, J.F., et al. Antiangiogenic therapy for glioblastoma: current status and future prospects. Clin Cancer Res 20 (2014), 5612–5619.
-
(2014)
Clin Cancer Res
, vol.20
, pp. 5612-5619
-
-
Batchelor, T.T.1
Reardon, D.A.2
de Groot, J.F.3
-
168
-
-
84960113608
-
Current status and future directions of anti-angiogenic therapy for gliomas
-
Wick, W., Platten, M., Wick, A., et al. Current status and future directions of anti-angiogenic therapy for gliomas. Neuro Oncol 18 (2016), 315–328.
-
(2016)
Neuro Oncol
, vol.18
, pp. 315-328
-
-
Wick, W.1
Platten, M.2
Wick, A.3
-
169
-
-
84970982109
-
LB-05phase III trial exploring the combination of bevacizumab and lomustine in patients with first recurrence of a glioblastoma: the EORTC 26101 trial
-
Wick, W., Brandes, A., Gorlia, T., et al. LB-05phase III trial exploring the combination of bevacizumab and lomustine in patients with first recurrence of a glioblastoma: the EORTC 26101 trial. Neuro Oncol, 17(Suppl 5), 2015, v1.
-
(2015)
Neuro Oncol
, vol.17
, pp. v1
-
-
Wick, W.1
Brandes, A.2
Gorlia, T.3
-
170
-
-
84941359544
-
Patients with proneural glioblastoma may derive overall survival benefit from the addition of bevacizumab to first-line radiotherapy and temozolomide: retrospective analysis of the AVAglio trial
-
Sandmann, T., Bourgon, R., Garcia, J., et al. Patients with proneural glioblastoma may derive overall survival benefit from the addition of bevacizumab to first-line radiotherapy and temozolomide: retrospective analysis of the AVAglio trial. J Clin Oncol 33 (2015), 2735–2744.
-
(2015)
J Clin Oncol
, vol.33
, pp. 2735-2744
-
-
Sandmann, T.1
Bourgon, R.2
Garcia, J.3
-
171
-
-
30444445129
-
How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes
-
Hatterer, E., Davoust, N., Didier-Bazes, M., et al. How to drain without lymphatics? Dendritic cells migrate from the cerebrospinal fluid to the B-cell follicles of cervical lymph nodes. Blood 107 (2006), 806–812.
-
(2006)
Blood
, vol.107
, pp. 806-812
-
-
Hatterer, E.1
Davoust, N.2
Didier-Bazes, M.3
-
172
-
-
84865123660
-
A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β
-
Iliff, J.J., Wang, M., Liao, Y., et al. A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid β. Sci Transl Med, 4, 2012, 147ra111.
-
(2012)
Sci Transl Med
, vol.4
, pp. 147ra111
-
-
Iliff, J.J.1
Wang, M.2
Liao, Y.3
-
173
-
-
84936871460
-
Structural and functional features of central nervous system lymphatic vessels
-
Louveau, A., Smirnov, I., Keyes, T.J., et al. Structural and functional features of central nervous system lymphatic vessels. Nature 523 (2015), 337–341.
-
(2015)
Nature
, vol.523
, pp. 337-341
-
-
Louveau, A.1
Smirnov, I.2
Keyes, T.J.3
-
174
-
-
84942469639
-
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
-
Aspelund, A., Antila, S., Proulx, S.T., et al. A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules. J Exp Med 212 (2015), 991–999.
-
(2015)
J Exp Med
, vol.212
, pp. 991-999
-
-
Aspelund, A.1
Antila, S.2
Proulx, S.T.3
-
175
-
-
84929481480
-
Pembrolizumab for the treatment of non-small-cell lung cancer
-
Garon, E.B., Rizvi, N.A., Hui, R., et al. Pembrolizumab for the treatment of non-small-cell lung cancer. N Engl J Med 372 (2015), 2018–2028.
-
(2015)
N Engl J Med
, vol.372
, pp. 2018-2028
-
-
Garon, E.B.1
Rizvi, N.A.2
Hui, R.3
-
176
-
-
84929481481
-
Pembrolizumab versus Ipilimumab in Advanced Melanoma
-
Robert, C., Schachter, J., Long, G.V., et al. Pembrolizumab versus Ipilimumab in Advanced Melanoma. N Engl J Med 372 (2015), 2521–2532.
-
(2015)
N Engl J Med
, vol.372
, pp. 2521-2532
-
-
Robert, C.1
Schachter, J.2
Long, G.V.3
-
177
-
-
84943241524
-
Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma
-
Berghoff, A.S., Kiesel, B., Widhalm, G., et al. Programmed death ligand 1 expression and tumor-infiltrating lymphocytes in glioblastoma. Neuro Oncol 17 (2015), 1064–1075.
-
(2015)
Neuro Oncol
, vol.17
, pp. 1064-1075
-
-
Berghoff, A.S.1
Kiesel, B.2
Widhalm, G.3
-
178
-
-
84960407098
-
PD-L1 expression and prognostic impact in glioblastoma
-
Nduom, E.K., Wei, J., Yaghi, N.K., et al. PD-L1 expression and prognostic impact in glioblastoma. Neuro Oncol 18 (2016), 195–205.
-
(2016)
Neuro Oncol
, vol.18
, pp. 195-205
-
-
Nduom, E.K.1
Wei, J.2
Yaghi, N.K.3
-
179
-
-
34247502076
-
Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function
-
Fecci, P.E., Ochiai, H., Mitchell, D.A., et al. Systemic CTLA-4 blockade ameliorates glioma-induced changes to the CD4+ T cell compartment without affecting regulatory T-cell function. Clin Cancer Res 13 (2007), 2158–2167.
-
(2007)
Clin Cancer Res
, vol.13
, pp. 2158-2167
-
-
Fecci, P.E.1
Ochiai, H.2
Mitchell, D.A.3
-
180
-
-
84861233216
-
Sequential immunotherapy by vaccination with GM-CSF-expressing glioma cells and CTLA-4 blockade effectively treats established murine intracranial tumors
-
Agarwalla, P., Barnard, Z., Fecci, P., et al. Sequential immunotherapy by vaccination with GM-CSF-expressing glioma cells and CTLA-4 blockade effectively treats established murine intracranial tumors. J Immunother 35 (2012), 385–389.
-
(2012)
J Immunother
, vol.35
, pp. 385-389
-
-
Agarwalla, P.1
Barnard, Z.2
Fecci, P.3
-
181
-
-
84941025149
-
Prospects of immune checkpoint modulators in the treatment of glioblastoma
-
Preusser, M., Lim, M., Hafler, D.A., et al. Prospects of immune checkpoint modulators in the treatment of glioblastoma. Nat Rev Neurol 11 (2015), 504–514.
-
(2015)
Nat Rev Neurol
, vol.11
, pp. 504-514
-
-
Preusser, M.1
Lim, M.2
Hafler, D.A.3
-
182
-
-
84962032646
-
Glioblastoma eradication following immune checkpoint blockade in an orthotopic, immunocompetent model
-
Reardon, D.A., Gokhale, P.C., Klein, S.R., et al. Glioblastoma eradication following immune checkpoint blockade in an orthotopic, immunocompetent model. Cancer Immunol Res 4 (2016), 124–135.
-
(2016)
Cancer Immunol Res
, vol.4
, pp. 124-135
-
-
Reardon, D.A.1
Gokhale, P.C.2
Klein, S.R.3
-
183
-
-
85007574463
-
Safety and activity of nivolumab (nivo) monotherapy and nivo in combination with ipilimumab (ipi) in recurrent glioblastoma (GBM): updated results from checkmate-143. 2016 ASCO Annual Meeting
-
Reardon, D.A., Sampson, J.H., Sahebjam, S., et al. Safety and activity of nivolumab (nivo) monotherapy and nivo in combination with ipilimumab (ipi) in recurrent glioblastoma (GBM): updated results from checkmate-143. 2016 ASCO Annual Meeting. J Clin Oncol, 34, 2016.
-
(2016)
J Clin Oncol
, vol.34
-
-
Reardon, D.A.1
Sampson, J.H.2
Sahebjam, S.3
-
184
-
-
85019119369
-
ATIM-35. Results of the phase IB KEYNOTE-028 multi-cohort trial of pembrolizumab monotherapy in patients with recurrent PD-L1-positive glioblastoma multiforme (GBM)
-
Reardon, D.A., Kim, T.-M., Frenel, J.-S., et al. ATIM-35. Results of the phase IB KEYNOTE-028 multi-cohort trial of pembrolizumab monotherapy in patients with recurrent PD-L1-positive glioblastoma multiforme (GBM). Neuro-Oncology 18:Suppl 6 (2016), vi25–vi26.
-
(2016)
Neuro-Oncology
, vol.18
, pp. vi25-vi26
-
-
Reardon, D.A.1
Kim, T.-M.2
Frenel, J.-S.3
-
185
-
-
85020613620
-
ATIM-04. Phase 2 study to evaluate the clinical efficacy and safety of MEDI4736 (durvalumab [DUR]) in patients with glioblastoma (GBM): results for cohort B (DUR monotherapy), bevacizumab (BEV) naïve patients with recurrent GBM
-
Reardon, D., Kaley, T., Dietrich, J., et al. ATIM-04. Phase 2 study to evaluate the clinical efficacy and safety of MEDI4736 (durvalumab [DUR]) in patients with glioblastoma (GBM): results for cohort B (DUR monotherapy), bevacizumab (BEV) naïve patients with recurrent GBM. Neuro-Oncology, 18(Suppl 6), 2016, vi18.
-
(2016)
Neuro-Oncology
, vol.18
, pp. vi18
-
-
Reardon, D.1
Kaley, T.2
Dietrich, J.3
-
186
-
-
85024490818
-
ATIM-16. Nivolumab combined with radiotherapy with or without temozolomide in patients with newly diagnosed glioblastoma: results from phase 1 safety cohorts in checkmate 143
-
Omuro, A., Vlahovic, G., Baehring, J., et al. ATIM-16. Nivolumab combined with radiotherapy with or without temozolomide in patients with newly diagnosed glioblastoma: results from phase 1 safety cohorts in checkmate 143. Neuro-Oncology, 18(Suppl 6), 2016, vi21.
-
(2016)
Neuro-Oncology
, vol.18
, pp. vi21
-
-
Omuro, A.1
Vlahovic, G.2
Baehring, J.3
-
187
-
-
84918828514
-
Genetic basis for clinical response to CTLA-4 blockade in melanoma
-
Snyder, A., Makarov, V., Merghoub, T., et al. Genetic basis for clinical response to CTLA-4 blockade in melanoma. N Engl J Med 371 (2014), 2189–2199.
-
(2014)
N Engl J Med
, vol.371
, pp. 2189-2199
-
-
Snyder, A.1
Makarov, V.2
Merghoub, T.3
-
188
-
-
84943516465
-
Genomic correlates of response to CTLA-4 blockade in metastatic melanoma
-
Van Allen, E.M., Miao, D., Schilling, B., et al. Genomic correlates of response to CTLA-4 blockade in metastatic melanoma. Science 350 (2015), 207–211.
-
(2015)
Science
, vol.350
, pp. 207-211
-
-
Van Allen, E.M.1
Miao, D.2
Schilling, B.3
-
189
-
-
84928761118
-
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer
-
Rizvi, N.A., Hellmann, M.D., Snyder, A., et al. Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer. Science 348 (2015), 124–128.
-
(2015)
Science
, vol.348
, pp. 124-128
-
-
Rizvi, N.A.1
Hellmann, M.D.2
Snyder, A.3
-
190
-
-
84932628341
-
PD-1 blockade in tumors with mismatch-repair deficiency
-
Le, D.T., Uram, J.N., Wang, H., et al. PD-1 blockade in tumors with mismatch-repair deficiency. N Engl J Med 372 (2015), 2509–2520.
-
(2015)
N Engl J Med
, vol.372
, pp. 2509-2520
-
-
Le, D.T.1
Uram, J.N.2
Wang, H.3
-
191
-
-
84976467739
-
Immune checkpoint inhibition for hypermutant glioblastoma multiforme resulting from germline biallelic mismatch repair deficiency
-
Bouffet, E., Larouche, V., Campbell, B.B., et al. Immune checkpoint inhibition for hypermutant glioblastoma multiforme resulting from germline biallelic mismatch repair deficiency. J Clin Oncol 34 (2016), 2206–2211.
-
(2016)
J Clin Oncol
, vol.34
, pp. 2206-2211
-
-
Bouffet, E.1
Larouche, V.2
Campbell, B.B.3
-
192
-
-
84870985481
-
Integration of autologous dendritic cell-based immunotherapy in the standard of care treatment for patients with newly diagnosed glioblastoma: results of the HGG-2006 phase I/II trial
-
Ardon, H., Van Gool, S.W., Verschuere, T., et al. Integration of autologous dendritic cell-based immunotherapy in the standard of care treatment for patients with newly diagnosed glioblastoma: results of the HGG-2006 phase I/II trial. Cancer Immunol Immunother 61 (2012), 2033–2044.
-
(2012)
Cancer Immunol Immunother
, vol.61
, pp. 2033-2044
-
-
Ardon, H.1
Van Gool, S.W.2
Verschuere, T.3
-
193
-
-
84872498982
-
Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma
-
Phuphanich, S., Wheeler, C.J., Rudnick, J.D., et al. Phase I trial of a multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma. Cancer Immunol Immunother 62 (2013), 125–135.
-
(2013)
Cancer Immunol Immunother
, vol.62
, pp. 125-135
-
-
Phuphanich, S.1
Wheeler, C.J.2
Rudnick, J.D.3
-
194
-
-
84893073441
-
Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trial
-
Bloch, O., Crane, C.A., Fuks, Y., et al. Heat-shock protein peptide complex-96 vaccination for recurrent glioblastoma: a phase II, single-arm trial. Neuro Oncol 16 (2014), 274–279.
-
(2014)
Neuro Oncol
, vol.16
, pp. 274-279
-
-
Bloch, O.1
Crane, C.A.2
Fuks, Y.3
-
195
-
-
85050579231
-
Dendritic cell immunotherapy for solid tumors: evaluation of the DCVax® platform in the treatment of glioblastoma multiforme
-
Hdeib, A., Sloan, AE., Dendritic cell immunotherapy for solid tumors: evaluation of the DCVax® platform in the treatment of glioblastoma multiforme. CNS Oncol 4 (2015), 63–69.
-
(2015)
CNS Oncol
, vol.4
, pp. 63-69
-
-
Hdeib, A.1
Sloan, A.E.2
-
196
-
-
85046070401
-
ATIM-25. Ten-year follow up with long term remission in patients with newly diagnosed glioblastoma (GBM) treated with ICT-107 vaccine (phase I)
-
Phuphanich, S., Wheeler, C., Rudnick, J., et al. ATIM-25. Ten-year follow up with long term remission in patients with newly diagnosed glioblastoma (GBM) treated with ICT-107 vaccine (phase I). Neuro-Oncology, 18(Suppl 6), 2016, vi23.
-
(2016)
Neuro-Oncology
, vol.18
, pp. vi23
-
-
Phuphanich, S.1
Wheeler, C.2
Rudnick, J.3
-
197
-
-
85045839550
-
ATIM-11. Phase 2 trial of SL-701, a novel immunotherapy comprised of synthetic short peptides against GBM targets IL-13Rα2, EphA2, and survivin, in adults with second-line recurrent GBM: interim results
-
Reardon, D., Peereboom, D., Nabors, B., et al. ATIM-11. Phase 2 trial of SL-701, a novel immunotherapy comprised of synthetic short peptides against GBM targets IL-13Rα2, EphA2, and survivin, in adults with second-line recurrent GBM: interim results. Neuro-Oncology, 18(Suppl 6), 2016, vi20.
-
(2016)
Neuro-Oncology
, vol.18
, pp. vi20
-
-
Reardon, D.1
Peereboom, D.2
Nabors, B.3
-
198
-
-
84923078274
-
Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma
-
Johnson, L.A., Scholler, J., Ohkuri, T., et al. Rational development and characterization of humanized anti-EGFR variant III chimeric antigen receptor T cells for glioblastoma. Sci Transl Med, 7, 2015, 275ra222.
-
(2015)
Sci Transl Med
, vol.7
, pp. 275ra222
-
-
Johnson, L.A.1
Scholler, J.2
Ohkuri, T.3
-
199
-
-
85007332348
-
IMCT-15PILOT study of T cells redirected to EGFRvIII with a chimeric antigen receptor in patients with EGFRvIII+ glioblastoma
-
O'Rourke, D., Desai, A., Morrissette, J., et al. IMCT-15PILOT study of T cells redirected to EGFRvIII with a chimeric antigen receptor in patients with EGFRvIII+ glioblastoma. Neuro-Oncology 17:Suppl 5 (2015), v110–v111.
-
(2015)
Neuro-Oncology
, vol.17
, pp. v110-v111
-
-
O'Rourke, D.1
Desai, A.2
Morrissette, J.3
-
200
-
-
85096671431
-
Multi-omics analysis of primary glioblastoma cell lines shows recapitulation of pivotal molecular features of parental tumors
-
Rosenberg, S., Verreault, M., Schmitt, C., et al. Multi-omics analysis of primary glioblastoma cell lines shows recapitulation of pivotal molecular features of parental tumors. Neuro Oncol, 2016, now160.
-
(2016)
Neuro Oncol
, pp. now160
-
-
Rosenberg, S.1
Verreault, M.2
Schmitt, C.3
-
201
-
-
27744606737
-
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
-
Mellinghoff, I.K., Wang, M.Y., Vivanco, I., et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med 353 (2005), 2012–2024.
-
(2005)
N Engl J Med
, vol.353
, pp. 2012-2024
-
-
Mellinghoff, I.K.1
Wang, M.Y.2
Vivanco, I.3
-
202
-
-
21444450373
-
Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib
-
Haas-Kogan, D.A., Prados, M.D., Tihan, T., et al. Epidermal growth factor receptor, protein kinase B/Akt, and glioma response to erlotinib. J Natl Cancer Inst 97 (2005), 880–887.
-
(2005)
J Natl Cancer Inst
, vol.97
, pp. 880-887
-
-
Haas-Kogan, D.A.1
Prados, M.D.2
Tihan, T.3
-
203
-
-
84942255080
-
Emerging circulating biomarkers in glioblastoma: promises and challenges
-
Touat, M., Duran-Peña, A., Alentorn, A., et al. Emerging circulating biomarkers in glioblastoma: promises and challenges. Expert Rev Mol Diagn 15 (2015), 1311–1323.
-
(2015)
Expert Rev Mol Diagn
, vol.15
, pp. 1311-1323
-
-
Touat, M.1
Duran-Peña, A.2
Alentorn, A.3
-
204
-
-
84977499654
-
Evaluating cancer of the central nervous system through next-generation sequencing of cerebrospinal fluid
-
Pentsova, E.I., Shah, R.H., Tang, J., et al. Evaluating cancer of the central nervous system through next-generation sequencing of cerebrospinal fluid. J Clin Oncol 34 (2016), 2404–2415.
-
(2016)
J Clin Oncol
, vol.34
, pp. 2404-2415
-
-
Pentsova, E.I.1
Shah, R.H.2
Tang, J.3
-
205
-
-
84943194890
-
Development of resistance to EGFR-targeted therapy in malignant glioma can occur through EGFR-dependent and -independent mechanisms
-
Klingler, S., Guo, B., Yao, J., et al. Development of resistance to EGFR-targeted therapy in malignant glioma can occur through EGFR-dependent and -independent mechanisms. Cancer Res 75 (2015), 2109–2119.
-
(2015)
Cancer Res
, vol.75
, pp. 2109-2119
-
-
Klingler, S.1
Guo, B.2
Yao, J.3
-
206
-
-
79958757490
-
Pathway analysis of glioblastoma tissue after preoperative treatment with the EGFR tyrosine kinase inhibitor gefitinib–a phase II trial
-
Hegi, M.E., Diserens, A.C., Bady, P., et al. Pathway analysis of glioblastoma tissue after preoperative treatment with the EGFR tyrosine kinase inhibitor gefitinib–a phase II trial. Mol Cancer Ther 10 (2011), 1102–1112.
-
(2011)
Mol Cancer Ther
, vol.10
, pp. 1102-1112
-
-
Hegi, M.E.1
Diserens, A.C.2
Bady, P.3
-
207
-
-
84963614599
-
High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines
-
Yu, C., Mannan, A.M., Yvone, G.M., et al. High-throughput identification of genotype-specific cancer vulnerabilities in mixtures of barcoded tumor cell lines. Nat Biotechnol 34 (2016), 419–423.
-
(2016)
Nat Biotechnol
, vol.34
, pp. 419-423
-
-
Yu, C.1
Mannan, A.M.2
Yvone, G.M.3
-
208
-
-
84965036990
-
Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies
-
Xiu, J., Piccioni, D., Juarez, T., et al. Multi-platform molecular profiling of a large cohort of glioblastomas reveals potential therapeutic strategies. Oncotarget 7 (2016), 21556–21569.
-
(2016)
Oncotarget
, vol.7
, pp. 21556-21569
-
-
Xiu, J.1
Piccioni, D.2
Juarez, T.3
-
209
-
-
84960433266
-
Strategies to improve delivery of anticancer drugs across the blood–brain barrier to treat glioblastoma
-
Oberoi, R.K., Parrish, K.E., Sio, T.T., et al. Strategies to improve delivery of anticancer drugs across the blood–brain barrier to treat glioblastoma. Neuro Oncol 18 (2016), 27–36.
-
(2016)
Neuro Oncol
, vol.18
, pp. 27-36
-
-
Oberoi, R.K.1
Parrish, K.E.2
Sio, T.T.3
-
210
-
-
27744506881
-
Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01
-
Lassman, A.B., Rossi, M.R., Raizer, J.J., et al. Molecular study of malignant gliomas treated with epidermal growth factor receptor inhibitors: tissue analysis from North American Brain Tumor Consortium Trials 01-03 and 00-01. Clin Cancer Res 11 (2005), 7841–7850.
-
(2005)
Clin Cancer Res
, vol.11
, pp. 7841-7850
-
-
Lassman, A.B.1
Rossi, M.R.2
Raizer, J.J.3
-
211
-
-
84858055260
-
Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP
-
de Vries, N.A., Buckle, T., Zhao, J., et al. Restricted brain penetration of the tyrosine kinase inhibitor erlotinib due to the drug transporters P-gp and BCRP. Invest New Drugs 30 (2012), 443–449.
-
(2012)
Invest New Drugs
, vol.30
, pp. 443-449
-
-
de Vries, N.A.1
Buckle, T.2
Zhao, J.3
-
212
-
-
84991711203
-
Blood–brain barrier, cytotoxic chemotherapies and glioblastoma
-
Dréan, A., Goldwirt, L., Verreault, M., et al. Blood–brain barrier, cytotoxic chemotherapies and glioblastoma. Expert Rev Neurother 16 (2016), 1285–1300.
-
(2016)
Expert Rev Neurother
, vol.16
, pp. 1285-1300
-
-
Dréan, A.1
Goldwirt, L.2
Verreault, M.3
-
213
-
-
84975090470
-
Clinical trial of blood–brain barrier disruption by pulsed ultrasound
-
Carpentier, A., Canney, M., Vignot, A., et al. Clinical trial of blood–brain barrier disruption by pulsed ultrasound. Sci Transl Med, 8, 2016, 343re342.
-
(2016)
Sci Transl Med
, vol.8
, pp. 343re342
-
-
Carpentier, A.1
Canney, M.2
Vignot, A.3
-
214
-
-
84928498231
-
Prioritizing targets for precision cancer medicine
-
Andre, F., Mardis, E., Salm, M., et al. Prioritizing targets for precision cancer medicine. Ann Oncol 25 (2014), 2295–2303.
-
(2014)
Ann Oncol
, vol.25
, pp. 2295-2303
-
-
Andre, F.1
Mardis, E.2
Salm, M.3
-
215
-
-
3042757984
-
Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance
-
Aldape, K.D., Ballman, K., Furth, A., et al. Immunohistochemical detection of EGFRvIII in high malignancy grade astrocytomas and evaluation of prognostic significance. J Neuropathol Exp Neurol 63 (2004), 700–707.
-
(2004)
J Neuropathol Exp Neurol
, vol.63
, pp. 700-707
-
-
Aldape, K.D.1
Ballman, K.2
Furth, A.3
-
216
-
-
70449518400
-
Monoclonal antibody specific for IDH1 R132H mutation
-
Capper, D., Zentgraf, H., Balss, J., et al. Monoclonal antibody specific for IDH1 R132H mutation. Acta Neuropathol 118 (2009), 599–601.
-
(2009)
Acta Neuropathol
, vol.118
, pp. 599-601
-
-
Capper, D.1
Zentgraf, H.2
Balss, J.3
-
217
-
-
71549122009
-
Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors
-
Capper, D., Weissert, S., Balss, J., et al. Characterization of R132H mutation-specific IDH1 antibody binding in brain tumors. Brain Pathol 20 (2010), 245–254.
-
(2010)
Brain Pathol
, vol.20
, pp. 245-254
-
-
Capper, D.1
Weissert, S.2
Balss, J.3
-
218
-
-
79959580390
-
Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody
-
Capper, D., Preusser, M., Habel, A., et al. Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol 122 (2011), 11–19.
-
(2011)
Acta Neuropathol
, vol.122
, pp. 11-19
-
-
Capper, D.1
Preusser, M.2
Habel, A.3
-
219
-
-
57649138665
-
Utility of chromogenic in situ hybridization (CISH) for detection of EGFR amplification in glioblastoma: comparison with fluorescence in situ hybridization (FISH)
-
Fischer, I., de la Cruz, C., Rivera, A.L., Aldape, K., Utility of chromogenic in situ hybridization (CISH) for detection of EGFR amplification in glioblastoma: comparison with fluorescence in situ hybridization (FISH). Diagn Mol Pathol 17 (2008), 227–230.
-
(2008)
Diagn Mol Pathol
, vol.17
, pp. 227-230
-
-
Fischer, I.1
de la Cruz, C.2
Rivera, A.L.3
Aldape, K.4
-
220
-
-
84960108414
-
Targeted next-generation sequencing panel (GlioSeq) provides comprehensive genetic profiling of central nervous system tumors
-
Nikiforova, M.N., Wald, A.I., Melan, M.A., et al. Targeted next-generation sequencing panel (GlioSeq) provides comprehensive genetic profiling of central nervous system tumors. Neuro Oncol 18 (2016), 379–387.
-
(2016)
Neuro Oncol
, vol.18
, pp. 379-387
-
-
Nikiforova, M.N.1
Wald, A.I.2
Melan, M.A.3
-
221
-
-
84927606243
-
Lung master protocol (Lung-MAP)-a biomarker-driven protocol for accelerating development of therapies for squamous cell lung cancer: SWOG S1400
-
Herbst, R.S., Gandara, D.R., Hirsch, F.R., et al. Lung master protocol (Lung-MAP)-a biomarker-driven protocol for accelerating development of therapies for squamous cell lung cancer: SWOG S1400. Clin Cancer Res 21 (2015), 1514–1524.
-
(2015)
Clin Cancer Res
, vol.21
, pp. 1514-1524
-
-
Herbst, R.S.1
Gandara, D.R.2
Hirsch, F.R.3
-
222
-
-
84940931907
-
Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma
-
Ramkissoon, S.H., Bi, W.L., Schumacher, S.E., et al. Clinical implementation of integrated whole-genome copy number and mutation profiling for glioblastoma. Neuro Oncol 17 (2015), 1344–1355.
-
(2015)
Neuro Oncol
, vol.17
, pp. 1344-1355
-
-
Ramkissoon, S.H.1
Bi, W.L.2
Schumacher, S.E.3
|