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Volumn 71, Issue 11, 2014, Pages 1437-1444

Emerging therapies for glioblastoma

Author keywords

[No Author keywords available]

Indexed keywords

6 [4 (4 ETHYL 1 PIPERAZINYLMETHYL)PHENYL] 4 (ALPHA METHYLBENZYLAMINO) 7H PYRROLO[2,3 D]PYRIMIDINE; AFATINIB; AXITINIB; BETA CATENIN; BEVACIZUMAB; CABOZANTINIB; CEDIRANIB; CETUXIMAB; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DACOMITINIB; IPILIMUMAB; MANNITOL; N (6,7 DIHYDRO 6 OXO 5H DIBENZ[B,D]AZEPIN 7 YL) 2,2 DIMETHYL N' (2,2,3,3,3 PENTAFLUOROPROPYL)PROPANEDIAMIDE; NANOPARTICLE; NIVOLUMAB; NOTCH RECEPTOR; ONCOLYTIC HERPES VIRUS; ONCOLYTIC VIRUS; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROGRAMMED DEATH 1 LIGAND 1; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAS PROTEIN; RINDOPEPIMUT; SONIC HEDGEHOG PROTEIN; TELOMERASE REVERSE TRANSCRIPTASE; UNINDEXED DRUG; VELEDIMEX; WNT PROTEIN; DACARBAZINE; TEMOZOLOMIDE;

EID: 84919343233     PISSN: 21686149     EISSN: None     Source Type: Journal    
DOI: 10.1001/jamaneurol.2014.1701     Document Type: Article
Times cited : (149)

References (73)
  • 1
    • 84887102623 scopus 로고    scopus 로고
    • Glioblastoma and other malignant gliomas: A clinical review
    • Omuro A, DeAngelis LM. Glioblastoma and other malignant gliomas: a clinical review. JAMA. 2013;310(17):1842-1850.
    • (2013) JAMA , vol.310 , Issue.17 , pp. 1842-1850
    • Omuro, A.1    DeAngelis, L.M.2
  • 2
    • 84886009591 scopus 로고    scopus 로고
    • CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006-2010
    • Ostrom QT, Gittleman H, Farah P, et al. CBTRUS statistical report: primary brain and central nervous system tumors diagnosed in the United States in 2006-2010. Neuro Oncol. 2013;15(suppl 2):ii1-ii56.
    • (2013) Neuro Oncol , vol.15 , pp. ii1-ii56
    • Ostrom, Q.T.1    Gittleman, H.2    Farah, P.3
  • 3
    • 20044366163 scopus 로고    scopus 로고
    • Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma
    • Stupp R, Mason WP, van den Bent MJ, et al; European Organisation for Research and Treatment of Cancer Brain Tumor and Radiotherapy Groups; National Cancer Institute of Canada Clinical Trials Group. Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. N Engl J Med. 2005;352(10):987-996.
    • (2005) N Engl J Med , vol.352 , Issue.10 , pp. 987-996
    • Stupp, R.1    Mason, W.P.2    Van Den Bent, M.J.3
  • 4
    • 84891785971 scopus 로고    scopus 로고
    • Dose-dense temozolomide for newly diagnosed glioblastoma: A randomized phase III clinical trial
    • Gilbert MR, Wang M, Aldape KD, et al. Dose-dense temozolomide for newly diagnosed glioblastoma: a randomized phase III clinical trial. J Clin Oncol. 2013;31(32):4085-4091.
    • (2013) J Clin Oncol , vol.31 , Issue.32 , pp. 4085-4091
    • Gilbert, M.R.1    Wang, M.2    Aldape, K.D.3
  • 5
    • 20044372154 scopus 로고    scopus 로고
    • MGMT gene silencing and benefit from temozolomide in glioblastoma
    • Hegi ME, Diserens AC, Gorlia T, et al. MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med. 2005;352(10):997-1003.
    • (2005) N Engl J Med , vol.352 , Issue.10 , pp. 997-1003
    • Hegi, M.E.1    Diserens, A.C.2    Gorlia, T.3
  • 6
    • 70350461699 scopus 로고    scopus 로고
    • Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma
    • Friedman HS, Prados MD, Wen PY, et al. Bevacizumab alone and in combination with irinotecan in recurrent glioblastoma. J Clin Oncol. 2009;27(28):4733-4740.
    • (2009) J Clin Oncol , vol.27 , Issue.28 , pp. 4733-4740
    • Friedman, H.S.1    Prados, M.D.2    Wen, P.Y.3
  • 7
    • 59949083263 scopus 로고    scopus 로고
    • Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma
    • Kreisl TN, Kim L, Moore K, et al. Phase II trial of single-agent bevacizumab followed by bevacizumab plus irinotecan at tumor progression in recurrent glioblastoma. J Clin Oncol. 2009;27(5):740-745.
    • (2009) J Clin Oncol , vol.27 , Issue.5 , pp. 740-745
    • Kreisl, T.N.1    Kim, L.2    Moore, K.3
  • 8
    • 84894114159 scopus 로고    scopus 로고
    • A randomized trial of bevacizumab for newly diagnosed glioblastoma
    • Gilbert MR, Dignam JJ, Armstrong TS, et al. A randomized trial of bevacizumab for newly diagnosed glioblastoma. N Engl J Med. 2014;370(8):699-708.
    • (2014) N Engl J Med , vol.370 , Issue.8 , pp. 699-708
    • Gilbert, M.R.1    Dignam, J.J.2    Armstrong, T.S.3
  • 9
    • 84894194756 scopus 로고    scopus 로고
    • Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma
    • Chinot OL, Wick W, Mason W, et al. Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma. N Engl J Med. 2014;370(8):709-722.
    • (2014) N Engl J Med , vol.370 , Issue.8 , pp. 709-722
    • Chinot, O.L.1    Wick, W.2    Mason, W.3
  • 10
    • 84881095932 scopus 로고    scopus 로고
    • Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss
    • Arita H, Narita Y, Fukushima S, et al. Upregulating mutations in the TERT promoter commonly occur in adult malignant gliomas and are strongly associated with total 1p19q loss. Acta Neuropathol. 2013;126(2):267-276.
    • (2013) Acta Neuropathol , vol.126 , Issue.2 , pp. 267-276
    • Arita, H.1    Narita, Y.2    Fukushima, S.3
  • 11
    • 84876067164 scopus 로고    scopus 로고
    • TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal
    • Killela PJ, Reitman ZJ, Jiao Y, et al. TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal. Proc Natl Acad Sci U S A. 2013;110(15):6021-6026.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , Issue.15 , pp. 6021-6026
    • Killela, P.J.1    Reitman, Z.J.2    Jiao, Y.3
  • 13
    • 84892590846 scopus 로고    scopus 로고
    • Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system
    • Koelsche C, Sahm F, Capper D, et al. Distribution of TERT promoter mutations in pediatric and adult tumors of the nervous system. Acta Neuropathol. 2013;126(6):907-915.
    • (2013) Acta Neuropathol , vol.126 , Issue.6 , pp. 907-915
    • Koelsche, C.1    Sahm, F.2    Capper, D.3
  • 14
    • 33747109928 scopus 로고    scopus 로고
    • Telomerase activity and hTERT mRNA expression in glial tumors
    • Boldrini L, Pistolesi S, Gisfredi S, et al. Telomerase activity and hTERT mRNA expression in glial tumors. Int J Oncol. 2006;28(6):1555-1560.
    • (2006) Int J Oncol , vol.28 , Issue.6 , pp. 1555-1560
    • Boldrini, L.1    Pistolesi, S.2    Gisfredi, S.3
  • 16
    • 54549108740 scopus 로고    scopus 로고
    • Comprehensive genomic characterization defines human glioblastoma genes and core pathways
    • Cancer Genome Atlas Research Network. Comprehensive genomic characterization defines human glioblastoma genes and core pathways. Nature. 2008;455(7216):1061-1068.
    • (2008) Nature , vol.455 , Issue.7216 , pp. 1061-1068
    • Cancer Genome Atlas Research Network1
  • 17
    • 73649123907 scopus 로고    scopus 로고
    • Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1
    • Verhaak RG, Hoadley KA, Purdom E, et al; Cancer Genome Atlas Research Network. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer Cell. 2010;17(1):98-110.
    • (2010) Cancer Cell , vol.17 , Issue.1 , pp. 98-110
    • Verhaak, R.G.1    Hoadley, K.A.2    Purdom, E.3    Cancer Genome Atlas Research Network4
  • 19
    • 84894573670 scopus 로고    scopus 로고
    • Paediatric and adult glioblastoma: Multiform (epi)genomic culprits emerge
    • Sturm D, Bender S, Jones DT, et al. Paediatric and adult glioblastoma: multiform (epi)genomic culprits emerge. Nat Rev Cancer. 2014;14(2):92-107.
    • (2014) Nat Rev Cancer , vol.14 , Issue.2 , pp. 92-107
    • Sturm, D.1    Bender, S.2    Jones, D.T.3
  • 20
    • 83355163405 scopus 로고    scopus 로고
    • Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin
    • Lai A, Kharbanda S, Pope WB, et al. Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. J Clin Oncol. 2011;29(34):4482-4490.
    • (2011) J Clin Oncol , vol.29 , Issue.34 , pp. 4482-4490
    • Lai, A.1    Kharbanda, S.2    Pope, W.B.3
  • 21
    • 84899946668 scopus 로고    scopus 로고
    • Quantitative assessment of intragenic receptor tyrosine kinase deletions in primary glioblastomas: Their prevalence and molecular correlates
    • Kastenhuber ER, Huse JT, Berman SH, et al. Quantitative assessment of intragenic receptor tyrosine kinase deletions in primary glioblastomas: their prevalence and molecular correlates. Acta Neuropathol. 2014;127(5):747-759.
    • (2014) Acta Neuropathol , vol.127 , Issue.5 , pp. 747-759
    • Kastenhuber, E.R.1    Huse, J.T.2    Berman, S.H.3
  • 22
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • Parsons DW, Jones S, Zhang X, et al. An integrated genomic analysis of human glioblastoma multiforme. Science. 2008;321(5897):1807-1812.
    • (2008) Science , vol.321 , Issue.5897 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 23
    • 60849115270 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations in gliomas
    • Yan H, Parsons DW, Jin G, et al. IDH1 and IDH2 mutations in gliomas. N Engl J Med. 2009;360(8):765-773.
    • (2009) N Engl J Med , vol.360 , Issue.8 , pp. 765-773
    • Yan, H.1    Parsons, D.W.2    Jin, G.3
  • 24
    • 77953351926 scopus 로고    scopus 로고
    • All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2
    • Labussière M, Idbaih A, Wang XW, et al. All the 1p19q codeleted gliomas are mutated on IDH1 or IDH2. Neurology. 2010;74(23):1886-1890.
    • (2010) Neurology , vol.74 , Issue.23 , pp. 1886-1890
    • Labussière, M.1    Idbaih, A.2    Wang, X.W.3
  • 25
    • 77952108366 scopus 로고    scopus 로고
    • Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma
    • Noushmehr H, Weisenberger DJ, Diefes K, et al; Cancer Genome Atlas Research Network. Identification of a CpG island methylator phenotype that defines a distinct subgroup of glioma. Cancer Cell. 2010;17(5):510-522.
    • (2010) Cancer Cell , vol.17 , Issue.5 , pp. 510-522
    • Noushmehr, H.1    Weisenberger, D.J.2    Diefes, K.3    Cancer Genome Atlas Research Network4
  • 26
    • 84858796263 scopus 로고    scopus 로고
    • IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
    • Turcan S, Rohle D, Goenka A, et al. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype. Nature. 2012;483(7390):479-483.
    • (2012) Nature , vol.483 , Issue.7390 , pp. 479-483
    • Turcan, S.1    Rohle, D.2    Goenka, A.3
  • 27
    • 0242382624 scopus 로고    scopus 로고
    • Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors: Part 1: Growth factor and Ras signaling pathways
    • Newton HB. Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors: part 1: growth factor and Ras signaling pathways. Expert Rev Anticancer Ther. 2003;3(5):595-614.
    • (2003) Expert Rev Anticancer Ther , vol.3 , Issue.5 , pp. 595-614
    • Newton, H.B.1
  • 28
    • 1142287357 scopus 로고    scopus 로고
    • Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors: Part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis
    • Newton HB. Molecular neuro-oncology and development of targeted therapeutic strategies for brain tumors: part 2: PI3K/Akt/PTEN, mTOR, SHH/PTCH and angiogenesis. Expert Rev Anticancer Ther. 2004;4(1):105-128.
    • (2004) Expert Rev Anticancer Ther , vol.4 , Issue.1 , pp. 105-128
    • Newton, H.B.1
  • 29
    • 0030936323 scopus 로고    scopus 로고
    • PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
    • Li J, Yen C, Liaw D, et al. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer. Science. 1997;275(5308):1943-1947.
    • (1997) Science , vol.275 , Issue.5308 , pp. 1943-1947
    • Li, J.1    Yen, C.2    Liaw, D.3
  • 30
    • 57349160348 scopus 로고    scopus 로고
    • Exploring multi-targeting strategies for the treatment of gliomas
    • Omuro AM. Exploring multi-targeting strategies for the treatment of gliomas. Curr Opin Investig Drugs. 2008;9(12):1287-1295.
    • (2008) Curr Opin Investig Drugs , vol.9 , Issue.12 , pp. 1287-1295
    • Omuro, A.M.1
  • 31
    • 34447343798 scopus 로고    scopus 로고
    • Lessons learned in the development of targeted therapy for malignant gliomas
    • Omuro AM, Faivre S, Raymond E. Lessons learned in the development of targeted therapy for malignant gliomas. Mol Cancer Ther. 2007;6(7):1909-1919.
    • (2007) Mol Cancer Ther , vol.6 , Issue.7 , pp. 1909-1919
    • Omuro, A.M.1    Faivre, S.2    Raymond, E.3
  • 32
    • 27744606737 scopus 로고    scopus 로고
    • Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors
    • Mellinghoff IK, Wang MY, Vivanco I, et al. Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med. 2005;353(19):2012-2024.
    • (2005) N Engl J Med , vol.353 , Issue.19 , pp. 2012-2024
    • Mellinghoff, I.K.1    Wang, M.Y.2    Vivanco, I.3
  • 33
    • 84969329069 scopus 로고    scopus 로고
    • Treatment with paclitaxel orotate and carboxyamidotriazole orotate in SC-implanted OVCAR-5 human ovarian tumor xenografts
    • Karmali RAMY, Maxuitenko Y, Gorman G. Treatment with paclitaxel orotate and carboxyamidotriazole orotate in SC-implanted OVCAR-5 human ovarian tumor xenografts. J Cancer Ther. 2013;4(4):857-871.
    • (2013) J Cancer Ther , vol.4 , Issue.4 , pp. 857-871
    • Karmali, R.A.M.Y.1    Maxuitenko, Y.2    Gorman, G.3
  • 34
    • 84881475565 scopus 로고    scopus 로고
    • Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme
    • England B, Huang T, Karsy M. Current understanding of the role and targeting of tumor suppressor p53 in glioblastoma multiforme. Tumour Biol. 2013;34(4):2063-2074.
    • (2013) Tumour Biol , vol.34 , Issue.4 , pp. 2063-2074
    • England, B.1    Huang, T.2    Karsy, M.3
  • 35
    • 85047697641 scopus 로고    scopus 로고
    • Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: Biological and clinical results
    • Lang FF, Bruner JM, Fuller GN, et al. Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results. J Clin Oncol. 2003;21(13):2508-2518.
    • (2003) J Clin Oncol , vol.21 , Issue.13 , pp. 2508-2518
    • Lang, F.F.1    Bruner, J.M.2    Fuller, G.N.3
  • 36
    • 79954601408 scopus 로고    scopus 로고
    • Novel targeted therapeutics: Inhibitors of MDM2, ALK and PARP
    • Yuan Y, Liao YM, Hsueh CT, Mirshahidi HR. Novel targeted therapeutics: inhibitors of MDM2, ALK and PARP. J Hematol Oncol. 2011;4:16. doi:10.1186/1756-8722-4-16.
    • (2011) J Hematol Oncol , vol.4 , pp. 16
    • Yuan, Y.1    Liao, Y.M.2    Hsueh, C.T.3    Mirshahidi, H.R.4
  • 38
    • 0026616796 scopus 로고
    • Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase
    • Parker LL, Piwnica-Worms H. Inactivation of the p34cdc2-cyclin B complex by the human WEE1 tyrosine kinase. Science. 1992;257(5078):1955-1957.
    • (1992) Science , vol.257 , Issue.5078 , pp. 1955-1957
    • Parker, L.L.1    Piwnica-Worms, H.2
  • 39
    • 0029048491 scopus 로고
    • Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle
    • Watanabe N, Broome M, Hunter T. Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. EMBO J. 1995;14(9):1878-1891.
    • (1995) EMBO J , vol.14 , Issue.9 , pp. 1878-1891
    • Watanabe, N.1    Broome, M.2    Hunter, T.3
  • 40
    • 67649710471 scopus 로고    scopus 로고
    • Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor
    • Mizuarai S, Yamanaka K, Itadani H, et al. Discovery of gene expression-based pharmacodynamic biomarker for a p53 context-specific anti-tumor drug Wee1 inhibitor. Mol Cancer. 2009;8:34. doi:10.1186/1476-4598-8-34.
    • (2009) Mol Cancer , vol.8 , pp. 34
    • Mizuarai, S.1    Yamanaka, K.2    Itadani, H.3
  • 41
    • 70949083026 scopus 로고    scopus 로고
    • Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents
    • Hirai H, Iwasawa Y, Okada M, et al. Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents. Mol Cancer Ther. 2009;8(11):2992-3000.
    • (2009) Mol Cancer Ther , vol.8 , Issue.11 , pp. 2992-3000
    • Hirai, H.1    Iwasawa, Y.2    Okada, M.3
  • 42
    • 16544392882 scopus 로고    scopus 로고
    • Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis
    • Wang Y, Decker SJ, Sebolt-Leopold J. Knockdown of Chk1, Wee1 and Myt1 by RNA interference abrogates G2 checkpoint and induces apoptosis. Cancer Biol Ther. 2004;3(3):305-313.
    • (2004) Cancer Biol Ther , vol.3 , Issue.3 , pp. 305-313
    • Wang, Y.1    Decker, S.J.2    Sebolt-Leopold, J.3
  • 43
    • 46949107691 scopus 로고    scopus 로고
    • Mechanisms of disease: The role of stem cells in the biology and treatment of gliomas
    • Dietrich J, Imitola J, Kesari S. Mechanisms of disease: the role of stem cells in the biology and treatment of gliomas. Nat Clin Pract Oncol. 2008;5(7):393-404.
    • (2008) Nat Clin Pract Oncol , vol.5 , Issue.7 , pp. 393-404
    • Dietrich, J.1    Imitola, J.2    Kesari, S.3
  • 44
    • 23944445606 scopus 로고    scopus 로고
    • Neural stem cells and the origin of gliomas
    • Sanai N, Alvarez-Buylla A, Berger MS. Neural stem cells and the origin of gliomas. N Engl J Med. 2005;353(8):811-822.
    • (2005) N Engl J Med , vol.353 , Issue.8 , pp. 811-822
    • Sanai, N.1    Alvarez-Buylla, A.2    Berger, M.S.3
  • 45
    • 57849109837 scopus 로고    scopus 로고
    • Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model
    • Alcantara Llaguno S, Chen J, Kwon CH, et al. Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell. 2009;15(1):45-56.
    • (2009) Cancer Cell , vol.15 , Issue.1 , pp. 45-56
    • Alcantara Llaguno, S.1    Chen, J.2    Kwon, C.H.3
  • 47
    • 62549108159 scopus 로고    scopus 로고
    • ABC transporters, drug resistance, and cancer stem cells
    • Dean M. ABC transporters, drug resistance, and cancer stem cells. J Mammary Gland Biol Neoplasia. 2009;14(1):3-9.
    • (2009) J Mammary Gland Biol Neoplasia , vol.14 , Issue.1 , pp. 3-9
    • Dean, M.1
  • 48
    • 77953696850 scopus 로고    scopus 로고
    • Controversies in cancer stem cells: Targeting embryonic signaling pathways
    • Takebe N, Ivy SP. Controversies in cancer stem cells: targeting embryonic signaling pathways. Clin Cancer Res. 2010;16(12):3106-3112.
    • (2010) Clin Cancer Res , vol.16 , Issue.12 , pp. 3106-3112
    • Takebe, N.1    Ivy, S.P.2
  • 49
    • 33747513134 scopus 로고    scopus 로고
    • Notch signalling regulates stem cell numbers in vitro and in vivo
    • Androutsellis-Theotokis A, Leker RR, Soldner F, et al. Notch signalling regulates stem cell numbers in vitro and in vivo. Nature. 2006;442(7104):823-826.
    • (2006) Nature , vol.442 , Issue.7104 , pp. 823-826
    • Androutsellis-Theotokis, A.1    Leker, R.R.2    Soldner, F.3
  • 50
    • 77956623598 scopus 로고    scopus 로고
    • Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate
    • Hovinga KE, Shimizu F, Wang R, et al. Inhibition of notch signaling in glioblastoma targets cancer stem cells via an endothelial cell intermediate. Stem Cells. 2010;28(6):1019-1029.
    • (2010) Stem Cells , vol.28 , Issue.6 , pp. 1019-1029
    • Hovinga, K.E.1    Shimizu, F.2    Wang, R.3
  • 52
    • 33846118474 scopus 로고    scopus 로고
    • Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma
    • Parsa AT, Waldron JS, Panner A, et al. Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nat Med. 2007;13(1):84-88.
    • (2007) Nat Med , vol.13 , Issue.1 , pp. 84-88
    • Parsa, A.T.1    Waldron, J.S.2    Panner, A.3
  • 53
    • 68949085209 scopus 로고    scopus 로고
    • Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors
    • Jacobs JF, Idema AJ, Bol KF, et al. Regulatory T cells and the PD-L1/PD-1 pathway mediate immune suppression in malignant human brain tumors. Neuro Oncol. 2009;11(4):394-402.
    • (2009) Neuro Oncol , vol.11 , Issue.4 , pp. 394-402
    • Jacobs, J.F.1    Idema, A.J.2    Bol, K.F.3
  • 54
    • 77749279776 scopus 로고    scopus 로고
    • PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors
    • Curran MA, Montalvo W, Yagita H, Allison JP. PD-1 and CTLA-4 combination blockade expands infiltrating T cells and reduces regulatory T and myeloid cells within B16 melanoma tumors. Proc Natl Acad Sci U S A. 2010;107(9):4275-4280.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.9 , pp. 4275-4280
    • Curran, M.A.1    Montalvo, W.2    Yagita, H.3    Allison, J.P.4
  • 55
    • 84856753644 scopus 로고    scopus 로고
    • Immunotherapy for the treatment of glioblastoma
    • Thomas AA, Ernstoff MS, Fadul CE. Immunotherapy for the treatment of glioblastoma. Cancer J. 2012;18(1):59-68.
    • (2012) Cancer J , vol.18 , Issue.1 , pp. 59-68
    • Thomas, A.A.1    Ernstoff, M.S.2    Fadul, C.E.3
  • 56
    • 78149254368 scopus 로고    scopus 로고
    • Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma
    • Sampson JH, Heimberger AB, Archer GE, et al. Immunologic escape after prolonged progression-free survival with epidermal growth factor receptor variant III peptide vaccination in patients with newly diagnosed glioblastoma. J Clin Oncol. 2010;28(31):4722-4729.
    • (2010) J Clin Oncol , vol.28 , Issue.31 , pp. 4722-4729
    • Sampson, J.H.1    Heimberger, A.B.2    Archer, G.E.3
  • 57
    • 79955591522 scopus 로고    scopus 로고
    • Immune response in patients with newly diagnosed glioblastoma multiforme treated with intranodal autologous tumor lysate-dendritic cell vaccination after radiation chemotherapy
    • Fadul CE, Fisher JL, Hampton TH, et al. Immune response in patients with newly diagnosed glioblastoma multiforme treated with intranodal autologous tumor lysate-dendritic cell vaccination after radiation chemotherapy. J Immunother. 2011;34(4):382-389.
    • (2011) J Immunother , vol.34 , Issue.4 , pp. 382-389
    • Fadul, C.E.1    Fisher, J.L.2    Hampton, T.H.3
  • 58
    • 77958575663 scopus 로고    scopus 로고
    • Harnessing naturally occurring tumor immunity: A clinical vaccine trial in prostate cancer
    • Frank MO, Kaufman J, Tian S, et al. Harnessing naturally occurring tumor immunity: a clinical vaccine trial in prostate cancer. PLoS One. 2010;5(9):e12367. doi:10.1371/journal.pone.0012367.
    • (2010) PLoS One , vol.5 , Issue.9
    • Frank, M.O.1    Kaufman, J.2    Tian, S.3
  • 59
    • 84870985481 scopus 로고    scopus 로고
    • Integration of autologous dendritic cell-based immunotherapy in the standard of care treatment for patients with newly diagnosed glioblastoma: Results of the HGG-2006 phase I/II trial
    • Ardon H, Van Gool SW, Verschuere T, et al. Integration of autologous dendritic cell-based immunotherapy in the standard of care treatment for patients with newly diagnosed glioblastoma: results of the HGG-2006 phase I/II trial. Cancer Immunol Immunother. 2012;61(11):2033-2044.
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.11 , pp. 2033-2044
    • Ardon, H.1    Van Gool, S.W.2    Verschuere, T.3
  • 60
    • 80051693219 scopus 로고    scopus 로고
    • Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide
    • Grossman SA, Ye X, Lesser G, et al; NABTT CNS Consortium. Immunosuppression in patients with high-grade gliomas treated with radiation and temozolomide. Clin Cancer Res. 2011;17(16):5473-5480.
    • (2011) Clin Cancer Res , vol.17 , Issue.16 , pp. 5473-5480
    • Grossman, S.A.1    Ye, X.2    Lesser, G.3
  • 61
    • 68649114787 scopus 로고    scopus 로고
    • Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas
    • Gutin PH, Iwamoto FM, Beal K, et al. Safety and efficacy of bevacizumab with hypofractionated stereotactic irradiation for recurrent malignant gliomas. Int J Radiat Oncol Biol Phys. 2009;75(1):156-163.
    • (2009) Int J Radiat Oncol Biol Phys , vol.75 , Issue.1 , pp. 156-163
    • Gutin, P.H.1    Iwamoto, F.M.2    Beal, K.3
  • 62
    • 84873293197 scopus 로고    scopus 로고
    • Patterns of failure after concurrent bevacizumab and hypofractionated stereotactic radiation therapy for recurrent high-grade glioma
    • Shapiro LQ, Beal K, Goenka A, et al. Patterns of failure after concurrent bevacizumab and hypofractionated stereotactic radiation therapy for recurrent high-grade glioma. Int J Radiat Oncol Biol Phys. 2013;85(3):636-642.
    • (2013) Int J Radiat Oncol Biol Phys , vol.85 , Issue.3 , pp. 636-642
    • Shapiro, L.Q.1    Beal, K.2    Goenka, A.3
  • 63
    • 0025866115 scopus 로고
    • Primary CNS lymphoma treated with osmotic blood-brain barrier disruption: Prolonged survival and preservation of cognitive function
    • Neuwelt EA, Goldman DL, Dahlborg SA, et al. Primary CNS lymphoma treated with osmotic blood-brain barrier disruption: prolonged survival and preservation of cognitive function. J Clin Oncol. 1991;9(9):1580-1590.
    • (1991) J Clin Oncol , vol.9 , Issue.9 , pp. 1580-1590
    • Neuwelt, E.A.1    Goldman, D.L.2    Dahlborg, S.A.3
  • 64
    • 84891016613 scopus 로고    scopus 로고
    • Convection-enhanced delivery and in vivo imaging of polymeric nanoparticles for the treatment of malignant glioma
    • Bernal GM, Lariviere MJ, Mansour N, et al. Convection-enhanced delivery and in vivo imaging of polymeric nanoparticles for the treatment of malignant glioma. Nanomedicine. 2014;10(1):149-157.
    • (2014) Nanomedicine , vol.10 , Issue.1 , pp. 149-157
    • Bernal, G.M.1    Lariviere, M.J.2    Mansour, N.3
  • 66
    • 84893342240 scopus 로고    scopus 로고
    • Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment
    • Xi G, Robinson E, Mania-Farnell B, et al. Convection-enhanced delivery of nanodiamond drug delivery platforms for intracranial tumor treatment. Nanomedicine.2014;10(2):381-391.
    • (2014) Nanomedicine , vol.10 , Issue.2 , pp. 381-391
    • Xi, G.1    Robinson, E.2    Mania-Farnell, B.3
  • 67
    • 84858407826 scopus 로고    scopus 로고
    • Magnetic nanoparticles: An emerging technology for malignant brain tumor imaging and therapy
    • Wankhede M, Bouras A, Kaluzova M, Hadjipanayis CG. Magnetic nanoparticles: an emerging technology for malignant brain tumor imaging and therapy. Expert Rev Clin Pharmacol. 2012;5(2):173-186.
    • (2012) Expert Rev Clin Pharmacol , vol.5 , Issue.2 , pp. 173-186
    • Wankhede, M.1    Bouras, A.2    Kaluzova, M.3    Hadjipanayis, C.G.4
  • 68
    • 78149461802 scopus 로고    scopus 로고
    • Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: Experimental study in rats
    • Jalali S, Huang Y, Dumont DJ, Hynynen K. Focused ultrasound-mediated bbb disruption is associated with an increase in activation of AKT: experimental study in rats. BMC Neurol. 2010;10:114. doi:10.1186/1471-2377-10-114.
    • (2010) Bmc Neurol , vol.10 , pp. 114
    • Jalali, S.1    Huang, Y.2    Dumont, D.J.3    Hynynen, K.4
  • 69
    • 84878362421 scopus 로고    scopus 로고
    • Opening of the blood-brain barrier with an unfocused ultrasound device in rabbits
    • Beccaria K, Canney M, Goldwirt L, et al. Opening of the blood-brain barrier with an unfocused ultrasound device in rabbits. J Neurosurg. 2013;119(4):887-898.
    • (2013) J Neurosurg , vol.119 , Issue.4 , pp. 887-898
    • Beccaria, K.1    Canney, M.2    Goldwirt, L.3
  • 70
    • 38949156009 scopus 로고    scopus 로고
    • Oncolytic measles virus strains in the treatment of gliomas
    • Allen C, Paraskevakou G, Liu C, et al. Oncolytic measles virus strains in the treatment of gliomas. Expert Opin Biol Ther. 2008;8(2):213-220.
    • (2008) Expert Opin Biol Ther , vol.8 , Issue.2 , pp. 213-220
    • Allen, C.1    Paraskevakou, G.2    Liu, C.3
  • 71
    • 33750611474 scopus 로고    scopus 로고
    • Review: Novel nonviral delivery approaches for interleukin-12 protein and gene systems: Curbing toxicity and enhancing adjuvant activity
    • Salem ML, Gillanders WE, Kadima AN, et al. Review: novel nonviral delivery approaches for interleukin-12 protein and gene systems: curbing toxicity and enhancing adjuvant activity. J Interferon Cytokine Res. 2006;26(9):593-608.
    • (2006) J Interferon Cytokine Res , vol.26 , Issue.9 , pp. 593-608
    • Salem, M.L.1    Gillanders, W.E.2    Kadima, A.N.3
  • 72
    • 84858603856 scopus 로고    scopus 로고
    • Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients usingmagnetic resonance spectroscopy
    • Pope WB, Prins RM, Albert Thomas M, et al. Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients usingmagnetic resonance spectroscopy. J Neurooncol. 2012;107(1):197-205.
    • (2012) J Neurooncol , vol.107 , Issue.1 , pp. 197-205
    • Pope, W.B.1    Prins, R.M.2    Albert Thomas, M.3
  • 73
    • 84875709160 scopus 로고    scopus 로고
    • Phase II trial of continuous low-dose temozolomide for patients with recurrent malignant glioma
    • Omuro A, Chan TA, Abrey LE, et al. Phase II trial of continuous low-dose temozolomide for patients with recurrent malignant glioma. Neuro Oncol. 2013;15(2):242-250.
    • (2013) Neuro Oncol , vol.15 , Issue.2 , pp. 242-250
    • Omuro, A.1    Chan, T.A.2    Abrey, L.E.3


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