Erratum: An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction (Nature Communications (2015) 6 (6072) DOI: 10.1038/ncomms7072);An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction

Nature Communications

Volumn 6, Issue , 2015, Pages

  Zhu, Chen ^a   Sakuishi, Kaori ^a   Xiao, Sheng ^a   Sun, Zhiyi ^b   Zaghouani, Sarah ^a   Gu, Guangxiang ^a   Wang, Chao ^a   Tan, Dewar J ^a   Wu, Chuan ^a   Rangachari, Manu ^a   Pertel, Thomas ^a   Jin, Hyun Tak ^c   Ahmed, Rafi ^c   Anderson, Ana C ^a   Kuchroo, Vijay K ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

^b NEW ENGLAND BIOLABS   (United States)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 27; INTERLEUKIN 3; MEMBRANE PROTEIN; NUCLEAR FACTOR INTERLEUKIN 3 REGULATED TRANSCRIPTION FACTOR; STAT1 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; T CELL IMMUNOGLOBULIN AND MUCIN DOMAIN 3 PROTEIN; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; BASIC LEUCINE ZIPPER TRANSCRIPTION FACTOR; CHROMATIN; HAVCR2 PROTEIN, MOUSE; HEPATITIS A VIRUS CELLULAR RECEPTOR 2; NFIL3 PROTEIN, MOUSE; T BOX TRANSCRIPTION FACTOR; T-BOX TRANSCRIPTION FACTOR TBX21; VIRUS RECEPTOR;

CELL ORGANELLE; DATA SET; GENE EXPRESSION; INHIBITOR; NUMERICAL MODEL; PHENOTYPE; SIGNALING; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CHROMATIN; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; FLOW CYTOMETRY; IMMUNOPATHOLOGY; MOUSE; NONHUMAN; PROMOTER REGION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE DYSFUNCTION; TH0 CELL; TH1 CELL; TUMOR ASSOCIATED LEUKOCYTE; TUMOR GROWTH; TUMOR VOLUME; ANIMAL; C57BL MOUSE; CLONAL ANERGY; DEFICIENCY; GASTROINTESTINAL TRACT; IMMUNOLOGY; INFLAMMATION; METABOLISM; NEOPLASM; PATHOLOGY;

MUS;

ANIMALS; BASIC-LEUCINE ZIPPER TRANSCRIPTION FACTORS; CD4-POSITIVE T-LYMPHOCYTES; CHROMATIN; CLONAL ANERGY; GASTROINTESTINAL TRACT; HEPATITIS A VIRUS CELLULAR RECEPTOR 2; INFLAMMATION; INTERLEUKIN-10; INTERLEUKIN-27; MICE, INBRED C57BL; NEOPLASMS; RECEPTORS, VIRUS; SIGNAL TRANSDUCTION; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; T-BOX DOMAIN PROTEINS;

EID: 84923088133     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms8657     Document Type: Erratum

References (45)

1. Monney, L. et al. Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415, 536-541 (2002).
2. Zhu, C. et al. The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat. Immunol. 6, 1245-1252 (2005).
3. Jones, R. B. et al. Tim-3 expression defines a novel population of dysfunctional T cells with highly elevated frequencies in progressive HIV-1 infection. J. Exp. Med. 205, 2763-2779 (2008).
4. McMahan, R. H. et al. Tim-3 expression on PD-1+ HCV-specific human CTLs is associated with viral persistence, and its blockade restores hepatocyte-directed in vitro cytotoxicity. J. Clin. Invest. 120, 4546-4557 (2010).
5. Jin, H. T. et al. Cooperation of Tim-3 and PD-1 in CD8 T-cell exhaustion during chronic viral infection. Proc. Natl Acad. Sci. USA 107, 14733-14738 (2010).
6. Sakuishi, K. et al. Targeting Tim-3 and PD-1 pathways to reverse T cell exhaustion and restore anti-tumor immunity. J. Exp. Med. 207, 2187-2194 (2010).
7. Zhou, Q. et al. Coexpression of Tim-3 and PD-1 identifies a CD8+ T-cell exhaustion phenotype in mice with disseminated acute myelogenous leukemia. Blood 117, 4501-4510 (2011).
8. Fourcade, J. et al. Upregulation of Tim-3 and PD-1 expression is associated with tumor antigen-specific CD8+ T cell dysfunction in melanoma patients. J. Exp. Med. 207, 2175-2186 (2010).
9. Barber, D. L. et al. Restoring function in exhausted CD8 T cells during chronic viral infection. Nature 439, 682-687 (2006).
10. Petrovas, C. et al. PD-1 is a regulator of virus-specific CD8+ T cell survival in HIV infection. J. Exp. Med. 203, 2281-2292 (2006).
11. Trautmann, L. et al. Upregulation of PD-1 expression on HIV-specific CD8 + T cells leads to reversible immune dysfunction. Nature Med. 12, 1198-1202 (2006).
12. Day, C. L. et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 443, 350-354 (2006).
13. Zhu, C., Anderson, A. C. & Kuchroo, V. K. TIM-3 and its regulatory role in immune responses. Curr. Top. Microbiol. Immunol. 350, 1-15 (2010).
14. Anderson, A. C. et al. T-bet, a Th1 transcription factor regulates the expression of Tim-3. Eur. J. Immunol. 40, 859-866 (2010).
15. Awasthi, A. et al. A dominant function for interleukin 27 in generating interleukin 10-producing anti-inflammatory T cells. Nat. Immunol. 8, 1380-1389 (2007).
16. Batten, M. et al. Cutting edge: IL-27 is a potent inducer of IL-10 but not FoxP3 in murine T cells. J. Immunol. 180, 2752-2756 (2008).
17. Takeda, A. et al. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J. Immunol. 170, 4886-4890 (2003).
18. Fitzgerald, D. C. et al. Suppression of autoimmune inflammation of the central nervous system by interleukin 10 secreted by interleukin 27-stimulated T cells. Nat. Immunol. 8, 1372-1379 (2007).
19. Kao, C. et al. Transcription factor T-bet represses expression of the inhibitory receptor PD-1 and sustains virus-specific CD8+ T cell responses during chronic infection. Nat. Immunol. 12, 663-671 (2011).
20. Yosef, N. et al. Dynamic regulatory network controlling TH17 cell differentiation. Nature 496, 461-468.
21. Motomura, Y. et al. The transcription factor E4BP4 regulates the production of IL-10 and IL-13 in CD4+ T cells. Nat. Immunol. 12, 450-459 (2011).
22. Afkarian, M. et al. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4 + T cells. Nat. Immunol. 3, 549-557 (2002).
23. Nakayamada, S. et al. Early Th1 cell differentiation is marked by a Tfh cell-like transition. Immunity 35, 919-931 (2011).
24. Brooks, D. G. et al. Interleukin-10 determines viral clearance or persistence in vivo. Nature Med. 12, 1301-1309 (2006).
25. Ejrnaes, M. et al. Resolution of a chronic viral infection after interleukin-10 receptor blockade. J. Exp. Med. 203, 2461-2472 (2006).
26. Klibi, J. et al. Blood diffusion and Th1-suppressive effects of galectin-9-containing exosomes released by Epstein-Barr virus-infected nasopharyngeal carcinoma cells. Blood 113, 1957-1966 (2009).
27. Sehrawat, S., Suryawanshi, A., Hirashima, M. & Rouse, B. T. Role of Tim-3/galectin-9 inhibitory interaction in viral-induced immunopathology: shifting the balance toward regulators. J. Immunol. 182, 3191-3201 (2009).
28. Sanchez-Fueyo, A. et al. Tim-3 inhibits T helper type 1-mediated auto-and alloimmune responses and promotes immunological tolerance. Nat. Immunol. 4, 1093-1101 (2003).
29. Sabatos, C. A. et al. Interaction of Tim-3 and Tim-3 ligand regulates T helper type 1 responses and induction of peripheral tolerance. Nat. Immunol. 4, 1102-1110 (2003).
30. Golden-Mason, L. et al. Negative immune regulator Tim-3 is overexpressed on T cells in hepatitis C virus infection and its blockade rescues dysfunctional CD4 + and CD8 + T cells. J. Virol. 83, 9122-9130 (2009).
31. Yang, Z. Z. et al. IL-12 upregulates TIM-3 expression and induces T cell exhaustion in patients with follicular B cell non-Hodgkin lymphoma. J. Clin. Invest. 122, 1271-1282 (2012).
32. Batten, M. et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat. Immunol. 7, 929-936 (2006).
33. Niedbala, W. et al. Interleukin 27 attenuates collagen-induced arthritis. Ann. Rheum. Dis. 67, 1474-1479 (2008).
34. Sugiyama, N. et al. Amelioration of human lupus-like phenotypes in MRL/lpr mice by overexpression of interleukin 27 receptor alpha (WSX-1). Ann. Rheum. Dis. 67, 1461-1467 (2008).
35. Villarino, A. et al. The IL-27R (WSX-1) is required to suppress T cell hyperactivity during infection. Immunity 19, 645-655 (2003).
36. Hamano, S. et al. WSX-1 is required for resistance to Trypanosoma cruzi infection by regulation of proinflammatory cytokine production. Immunity 19, 657-667 (2003).
37. Diveu, C. et al. IL-27 blocks RORc expression to inhibit lineage commitment of Th17 cells. J. Immunol. 182, 5748-5756 (2009).
38. Lucas, S., Ghilardi, N., Li, J. & de Sauvage, F. J. IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and-independent mechanisms. Proc. Natl Acad. Sci. USA 100, 15047-15052 (2003).
39. Hirahara, K. et al. Interleukin-27 priming of T cells controls IL-17 production in trans via induction of the ligand PD-L1. Immunity 36, 1017-1030 (2012).
40. Morishima, N. et al. Augmentation of effector CD8 + T cell generation with enhanced granzyme B expression by IL-27. J. Immunol. 175, 1686-1693 (2005).
41. Axtell, R. C. et al. T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nature Med. 16, 406-412 (2010).
42. Sun, J., Dodd, H., Moser, E. K., Sharma, R. & Braciale, T. J. CD4 + T cell help and innate-derived IL-27 induce Blimp-1-dependent IL-10 production by antiviral CTLs. Nat. Immunol. 12, 327-334 (2011).
43. Kobayashi, T. et al. NFIL3 is a regulator of IL-12 p40 in macrophages and mucosal immunity. J. Immunol. 186, 4649-4655 (2011).
44. Kashiwada, M., Cassel, S. L., Colgan, J. D. & Rothman, P. B. NFIL3/E4BP4 controls type 2 T helper cell cytokine expression. EMBO J. 30, 2071-2082 (2011).
45. Yoshimura, T. et al. Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4 + T cells partially through STAT3-dependent mechanism. J. Immunol. 177, 5377-5385 (2006).