Structure-Based Design and Synthesis of Apramycin-Paromomycin Analogues: Importance of the Configuration at the 6′-Position and Differences between the 6′-Amino and Hydroxy Series

Journal of the American Chemical Society

Volumn 139, Issue 41, 2017, Pages 14611-14619

  Mandhapati, Appi Reddy ^a   Yang, Guanyu ^a   Kato, Takayuki ^a   Shcherbakov, Dimitri ^b   Hobbie, Sven N ^b   Vasella, Andrea ^c   Böttger, Erik C ^b   Crich, David ^a  

^a WAYNE STATE UNIVERSITY   (United States)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c ETH ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIA; BINDING ENERGY; CHAINS; MACROMOLECULES; METHANOL;

AMINOGLYCOSIDE ANTIBIOTICS; ANTI-BACTERIAL ACTIVITY; CELL-FREE TRANSLATIONS; EQUATORIAL HYDROXYL GROUPS; GRAM-POSITIVE BACTERIUM; RECOMBINANT BACTERIA; SPECIFIC RESISTANCES; STRUCTURE-BASED DESIGNS;

ANTIBIOTICS;

6' DEOXYAPRAMYCIN; 6' DESHYDROMETHYL PAROMOMYCIN; 6' EPIAPRAMYCIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; APRAMYCIN; APROSAMINE; GENTAMICIN; HYDROXYL GROUP; KANAMYCIN A; NEOMYCIN; PAROMOMYCIN; TOBRAMYCIN; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; NEBRAMYCIN;

ACINETOBACTER BAUMANNII; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIUM; CONTROLLED STUDY; DECARBOXYLATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTRON TRANSPORT; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; FREEZE DRYING; HYDROGENOLYSIS; KLEBSIELLA PNEUMONIAE; MITOCHONDRIAL RIBOSOME; NONHUMAN; PHOTOCATALYSIS; PSEUDOMONAS; RIBOSOME; RNA TRANSLATION; STAPHYLOCOCCUS AUREUS; ANALOGS AND DERIVATIVES; CHEMISTRY; METABOLISM; SYNTHESIS;

ANTI-BACTERIAL AGENTS; NEBRAMYCIN; NEOMYCIN; PAROMOMYCIN; RIBOSOMES;

EID: 85031716627     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/jacs.7b07754     Document Type: Article

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