-
1
-
-
84985031440
-
Molecular basis of APC/C regulation by the spindle assembly checkpoint
-
Alfieri, C., Chang, L., Zhang, Z., Yang, J., Maslen, S., Skehel, M., Barford, D., Molecular basis of APC/C regulation by the spindle assembly checkpoint. Nature 536 (2016), 431–436.
-
(2016)
Nature
, vol.536
, pp. 431-436
-
-
Alfieri, C.1
Chang, L.2
Zhang, Z.3
Yang, J.4
Maslen, S.5
Skehel, M.6
Barford, D.7
-
2
-
-
84976889285
-
In vivo aspects of protein folding and quality control
-
Balchin, D., Hayer-Hartl, M., Hartl, F.U., In vivo aspects of protein folding and quality control. Science, 353, 2016, aac4354.
-
(2016)
Science
, vol.353
, pp. aac4354
-
-
Balchin, D.1
Hayer-Hartl, M.2
Hartl, F.U.3
-
3
-
-
84959360025
-
RAN translation in Huntington Disease
-
Bañez-Coronel, M., Ayhan, F., Tarabochia, A.D., Zu, T., Perez, B.A., Tusi, S.K., Pletnikova, O., Borchelt, D.R., Ross, C.A., Margolis, R.L., et al. RAN translation in Huntington Disease. Neuron 88 (2015), 667–677.
-
(2015)
Neuron
, vol.88
, pp. 667-677
-
-
Bañez-Coronel, M.1
Ayhan, F.2
Tarabochia, A.D.3
Zu, T.4
Perez, B.A.5
Tusi, S.K.6
Pletnikova, O.7
Borchelt, D.R.8
Ross, C.A.9
Margolis, R.L.10
-
4
-
-
84858978818
-
Protein misfolded oligomers: Experimental approaches, mechanism of formation, and structure-toxicity relationships
-
Bemporad, F., Chiti, F., Protein misfolded oligomers: Experimental approaches, mechanism of formation, and structure-toxicity relationships. Chem. Biol. 19 (2012), 315–327.
-
(2012)
Chem. Biol.
, vol.19
, pp. 315-327
-
-
Bemporad, F.1
Chiti, F.2
-
5
-
-
77957169824
-
Role of a ribosome-associated E3 ubiquitin ligase in protein quality control
-
Bengtson, M.H., Joazeiro, C.A., Role of a ribosome-associated E3 ubiquitin ligase in protein quality control. Nature 467 (2010), 470–473.
-
(2010)
Nature
, vol.467
, pp. 470-473
-
-
Bengtson, M.H.1
Joazeiro, C.A.2
-
6
-
-
34547807613
-
Global changes to the ubiquitin system in Huntington's disease
-
Bennett, E.J., Shaler, T.A., Woodman, B., Ryu, K.Y., Zaitseva, T.S., Becker, C.H., Bates, G.P., Schulman, H., Kopito, R.R., Global changes to the ubiquitin system in Huntington's disease. Nature 448 (2007), 704–708.
-
(2007)
Nature
, vol.448
, pp. 704-708
-
-
Bennett, E.J.1
Shaler, T.A.2
Woodman, B.3
Ryu, K.Y.4
Zaitseva, T.S.5
Becker, C.H.6
Bates, G.P.7
Schulman, H.8
Kopito, R.R.9
-
7
-
-
84954207877
-
Ribosome-associated protein quality control
-
Brandman, O., Hegde, R.S., Ribosome-associated protein quality control. Nat. Struct. Mol. Biol. 23 (2016), 7–15.
-
(2016)
Nat. Struct. Mol. Biol.
, vol.23
, pp. 7-15
-
-
Brandman, O.1
Hegde, R.S.2
-
8
-
-
84871523350
-
A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress
-
Brandman, O., Stewart-Ornstein, J., Wong, D., Larson, A., Williams, C.C., Li, G.W., Zhou, S., King, D., Shen, P.S., Weibezahn, J., et al. A ribosome-bound quality control complex triggers degradation of nascent peptides and signals translation stress. Cell 151 (2012), 1042–1054.
-
(2012)
Cell
, vol.151
, pp. 1042-1054
-
-
Brandman, O.1
Stewart-Ornstein, J.2
Wong, D.3
Larson, A.4
Williams, C.C.5
Li, G.W.6
Zhou, S.7
King, D.8
Shen, P.S.9
Weibezahn, J.10
-
9
-
-
84919764653
-
A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease
-
Brehme, M., Voisine, C., Rolland, T., Wachi, S., Soper, J.H., Zhu, Y., Orton, K., Villella, A., Garza, D., Vidal, M., et al. A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease. Cell Rep. 9 (2014), 1135–1150.
-
(2014)
Cell Rep.
, vol.9
, pp. 1135-1150
-
-
Brehme, M.1
Voisine, C.2
Rolland, T.3
Wachi, S.4
Soper, J.H.5
Zhu, Y.6
Orton, K.7
Villella, A.8
Garza, D.9
Vidal, M.10
-
10
-
-
84971517462
-
Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C
-
Brown, N.G., VanderLinden, R., Watson, E.R., Weissmann, F., Ordureau, A., Wu, K.P., Zhang, W., Yu, S., Mercredi, P.Y., Harrison, J.S., et al. Dual RING E3 architectures regulate multiubiquitination and ubiquitin chain elongation by APC/C. Cell 165 (2016), 1440–1453.
-
(2016)
Cell
, vol.165
, pp. 1440-1453
-
-
Brown, N.G.1
VanderLinden, R.2
Watson, E.R.3
Weissmann, F.4
Ordureau, A.5
Wu, K.P.6
Zhang, W.7
Yu, S.8
Mercredi, P.Y.9
Harrison, J.S.10
-
11
-
-
84933038158
-
Atomic structure of the APC/C and its mechanism of protein ubiquitination
-
Chang, L., Zhang, Z., Yang, J., McLaughlin, S.H., Barford, D., Atomic structure of the APC/C and its mechanism of protein ubiquitination. Nature 522 (2015), 450–454.
-
(2015)
Nature
, vol.522
, pp. 450-454
-
-
Chang, L.1
Zhang, Z.2
Yang, J.3
McLaughlin, S.H.4
Barford, D.5
-
12
-
-
0024514688
-
A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein
-
Chau, V., Tobias, J.W., Bachmair, A., Marriott, D., Ecker, D.J., Gonda, D.K., Varshavsky, A., A multiubiquitin chain is confined to specific lysine in a targeted short-lived protein. Science 243 (1989), 1576–1583.
-
(1989)
Science
, vol.243
, pp. 1576-1583
-
-
Chau, V.1
Tobias, J.W.2
Bachmair, A.3
Marriott, D.4
Ecker, D.J.5
Gonda, D.K.6
Varshavsky, A.7
-
13
-
-
84927619395
-
Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
-
Das, I., Krzyzosiak, A., Schneider, K., Wrabetz, L., D'Antonio, M., Barry, N., Sigurdardottir, A., Bertolotti, A., Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science 348 (2015), 239–242.
-
(2015)
Science
, vol.348
, pp. 239-242
-
-
Das, I.1
Krzyzosiak, A.2
Schneider, K.3
Wrabetz, L.4
D'Antonio, M.5
Barry, N.6
Sigurdardottir, A.7
Bertolotti, A.8
-
15
-
-
33746099650
-
Protein aggregation in crowded environments
-
Ellis, R.J., Minton, A.P., Protein aggregation in crowded environments. Biol. Chem. 387 (2006), 485–497.
-
(2006)
Biol. Chem.
, vol.387
, pp. 485-497
-
-
Ellis, R.J.1
Minton, A.P.2
-
16
-
-
84884345970
-
Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains
-
Emmerich, C.H., Ordureau, A., Strickson, S., Arthur, J.S., Pedrioli, P.G., Komander, D., Cohen, P., Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains. Proc. Natl. Acad. Sci. USA 110 (2013), 15247–15252.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 15247-15252
-
-
Emmerich, C.H.1
Ordureau, A.2
Strickson, S.3
Arthur, J.S.4
Pedrioli, P.G.5
Komander, D.6
Cohen, P.7
-
17
-
-
84965070534
-
Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling
-
Emmerich, C.H., Bakshi, S., Kelsall, I.R., Ortiz-Guerrero, J., Shpiro, N., Cohen, P., Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. Biochem. Biophys. Res. Commun. 474 (2016), 452–461.
-
(2016)
Biochem. Biophys. Res. Commun.
, vol.474
, pp. 452-461
-
-
Emmerich, C.H.1
Bakshi, S.2
Kelsall, I.R.3
Ortiz-Guerrero, J.4
Shpiro, N.5
Cohen, P.6
-
18
-
-
17644396667
-
Degradation-mediated protein quality control in the nucleus
-
Gardner, R.G., Nelson, Z.W., Gottschling, D.E., Degradation-mediated protein quality control in the nucleus. Cell 120 (2005), 803–815.
-
(2005)
Cell
, vol.120
, pp. 803-815
-
-
Gardner, R.G.1
Nelson, Z.W.2
Gottschling, D.E.3
-
19
-
-
84938389137
-
Identification of genetic factors that modify clinical onset of Huntington's disease
-
Genetic Modifiers of Huntington's Disease (GeM-HD) Consortium. Identification of genetic factors that modify clinical onset of Huntington's disease. Cell 162 (2015), 516–526.
-
(2015)
Cell
, vol.162
, pp. 516-526
-
-
-
20
-
-
33644850056
-
Progressive disruption of cellular protein folding in models of polyglutamine diseases
-
Gidalevitz, T., Ben-Zvi, A., Ho, K.H., Brignull, H.R., Morimoto, R.I., Progressive disruption of cellular protein folding in models of polyglutamine diseases. Science 311 (2006), 1471–1474.
-
(2006)
Science
, vol.311
, pp. 1471-1474
-
-
Gidalevitz, T.1
Ben-Zvi, A.2
Ho, K.H.3
Brignull, H.R.4
Morimoto, R.I.5
-
21
-
-
84988336041
-
Proteome complexity and the forces that drive proteome imbalance
-
Harper, J.W., Bennett, E.J., Proteome complexity and the forces that drive proteome imbalance. Nature 537 (2016), 328–338.
-
(2016)
Nature
, vol.537
, pp. 328-338
-
-
Harper, J.W.1
Bennett, E.J.2
-
22
-
-
79960652801
-
Molecular chaperones in protein folding and proteostasis
-
Hartl, F.U., Bracher, A., Hayer-Hartl, M., Molecular chaperones in protein folding and proteostasis. Nature 475 (2011), 324–332.
-
(2011)
Nature
, vol.475
, pp. 324-332
-
-
Hartl, F.U.1
Bracher, A.2
Hayer-Hartl, M.3
-
23
-
-
79960637590
-
Protein targeting and degradation are coupled for elimination of mislocalized proteins
-
Hessa, T., Sharma, A., Mariappan, M., Eshleman, H.D., Gutierrez, E., Hegde, R.S., Protein targeting and degradation are coupled for elimination of mislocalized proteins. Nature 475 (2011), 394–397.
-
(2011)
Nature
, vol.475
, pp. 394-397
-
-
Hessa, T.1
Sharma, A.2
Mariappan, M.3
Eshleman, H.D.4
Gutierrez, E.5
Hegde, R.S.6
-
24
-
-
84906794886
-
Proteostasis impairment in protein-misfolding and -aggregation diseases
-
Hipp, M.S., Park, S.H., Hartl, F.U., Proteostasis impairment in protein-misfolding and -aggregation diseases. Trends Cell Biol. 24 (2014), 506–514.
-
(2014)
Trends Cell Biol.
, vol.24
, pp. 506-514
-
-
Hipp, M.S.1
Park, S.H.2
Hartl, F.U.3
-
25
-
-
84861783400
-
Ubiquitin-binding proteins: Decoders of ubiquitin-mediated cellular functions
-
Husnjak, K., Dikic, I., Ubiquitin-binding proteins: Decoders of ubiquitin-mediated cellular functions. Annu. Rev. Biochem. 81 (2012), 291–322.
-
(2012)
Annu. Rev. Biochem.
, vol.81
, pp. 291-322
-
-
Husnjak, K.1
Dikic, I.2
-
26
-
-
84937213168
-
The BioPlex Network: A systematic exploration of the human interactome
-
Huttlin, E.L., Ting, L., Bruckner, R.J., Gebreab, F., Gygi, M.P., Szpyt, J., Tam, S., Zarraga, G., Colby, G., Baltier, K., et al. The BioPlex Network: A systematic exploration of the human interactome. Cell 162 (2015), 425–440.
-
(2015)
Cell
, vol.162
, pp. 425-440
-
-
Huttlin, E.L.1
Ting, L.2
Bruckner, R.J.3
Gebreab, F.4
Gygi, M.P.5
Szpyt, J.6
Tam, S.7
Zarraga, G.8
Colby, G.9
Baltier, K.10
-
27
-
-
43049162227
-
Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex
-
Jin, L., Williamson, A., Banerjee, S., Philipp, I., Rape, M., Mechanism of ubiquitin-chain formation by the human anaphase-promoting complex. Cell 133 (2008), 653–665.
-
(2008)
Cell
, vol.133
, pp. 653-665
-
-
Jin, L.1
Williamson, A.2
Banerjee, S.3
Philipp, I.4
Rape, M.5
-
28
-
-
85008439822
-
Initiation of quality control during Poly(A) translation requires site-specific ribosome ubiquitination
-
Juszkiewicz, S., Hegde, R.S., Initiation of quality control during Poly(A) translation requires site-specific ribosome ubiquitination. Mol. Cell 65 (2017), 743–750.
-
(2017)
Mol. Cell
, vol.65
, pp. 743-750
-
-
Juszkiewicz, S.1
Hegde, R.S.2
-
29
-
-
72149107116
-
Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex
-
Kamadurai, H.B., Souphron, J., Scott, D.C., Duda, D.M., Miller, D.J., Stringer, D., Piper, R.C., Schulman, B.A., Insights into ubiquitin transfer cascades from a structure of a UbcH5B approximately ubiquitin-HECT(NEDD4L) complex. Mol. Cell 36 (2009), 1095–1102.
-
(2009)
Mol. Cell
, vol.36
, pp. 1095-1102
-
-
Kamadurai, H.B.1
Souphron, J.2
Scott, D.C.3
Duda, D.M.4
Miller, D.J.5
Stringer, D.6
Piper, R.C.7
Schulman, B.A.8
-
30
-
-
84922319624
-
Ubiquitin chain elongation requires E3-dependent tracking of the emerging conjugate
-
Kelly, A., Wickliffe, K.E., Song, L., Fedrigo, I., Rape, M., Ubiquitin chain elongation requires E3-dependent tracking of the emerging conjugate. Mol. Cell 56 (2014), 232–245.
-
(2014)
Mol. Cell
, vol.56
, pp. 232-245
-
-
Kelly, A.1
Wickliffe, K.E.2
Song, L.3
Fedrigo, I.4
Rape, M.5
-
31
-
-
67649227630
-
Polyubiquitination by HECT E3s and the determinants of chain type specificity
-
Kim, H.C., Huibregtse, J.M., Polyubiquitination by HECT E3s and the determinants of chain type specificity. Mol. Cell. Biol. 29 (2009), 3307–3318.
-
(2009)
Mol. Cell. Biol.
, vol.29
, pp. 3307-3318
-
-
Kim, H.C.1
Huibregtse, J.M.2
-
32
-
-
34547130325
-
Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages
-
Kim, H.T., Kim, K.P., Lledias, F., Kisselev, A.F., Scaglione, K.M., Skowyra, D., Gygi, S.P., Goldberg, A.L., Certain pairs of ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s) synthesize nondegradable forked ubiquitin chains containing all possible isopeptide linkages. J. Biol. Chem. 282 (2007), 17375–17386.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 17375-17386
-
-
Kim, H.T.1
Kim, K.P.2
Lledias, F.3
Kisselev, A.F.4
Scaglione, K.M.5
Skowyra, D.6
Gygi, S.P.7
Goldberg, A.L.8
-
33
-
-
33745742269
-
Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology
-
Kirkpatrick, D.S., Hathaway, N.A., Hanna, J., Elsasser, S., Rush, J., Finley, D., King, R.W., Gygi, S.P., Quantitative analysis of in vitro ubiquitinated cyclin B1 reveals complex chain topology. Nat. Cell Biol. 8 (2006), 700–710.
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 700-710
-
-
Kirkpatrick, D.S.1
Hathaway, N.A.2
Hanna, J.3
Elsasser, S.4
Rush, J.5
Finley, D.6
King, R.W.7
Gygi, S.P.8
-
34
-
-
0033525589
-
A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly
-
Koegl, M., Hoppe, T., Schlenker, S., Ulrich, H.D., Mayer, T.U., Jentsch, S., A novel ubiquitination factor, E4, is involved in multiubiquitin chain assembly. Cell 96 (1999), 635–644.
-
(1999)
Cell
, vol.96
, pp. 635-644
-
-
Koegl, M.1
Hoppe, T.2
Schlenker, S.3
Ulrich, H.D.4
Mayer, T.U.5
Jentsch, S.6
-
36
-
-
84961288441
-
K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin
-
Kristariyanto, Y.A., Abdul Rehman, S.A., Campbell, D.G., Morrice, N.A., Johnson, C., Toth, R., Kulathu, Y., K29-selective ubiquitin binding domain reveals structural basis of specificity and heterotypic nature of k29 polyubiquitin. Mol. Cell 58 (2015), 83–94.
-
(2015)
Mol. Cell
, vol.58
, pp. 83-94
-
-
Kristariyanto, Y.A.1
Abdul Rehman, S.A.2
Campbell, D.G.3
Morrice, N.A.4
Johnson, C.5
Toth, R.6
Kulathu, Y.7
-
37
-
-
84959086071
-
Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice
-
Langfelder, P., Cantle, J.P., Chatzopoulou, D., Wang, N., Gao, F., Al-Ramahi, I., Lu, X.H., Ramos, E.M., El-Zein, K., Zhao, Y., et al. Integrated genomics and proteomics define huntingtin CAG length-dependent networks in mice. Nat. Neurosci. 19 (2016), 623–633.
-
(2016)
Nat. Neurosci.
, vol.19
, pp. 623-633
-
-
Langfelder, P.1
Cantle, J.P.2
Chatzopoulou, D.3
Wang, N.4
Gao, F.5
Al-Ramahi, I.6
Lu, X.H.7
Ramos, E.M.8
El-Zein, K.9
Zhao, Y.10
-
38
-
-
80052069445
-
RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis
-
Lipkowitz, S., Weissman, A.M., RINGs of good and evil: RING finger ubiquitin ligases at the crossroads of tumour suppression and oncogenesis. Nat. Rev. Cancer 11 (2011), 629–643.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 629-643
-
-
Lipkowitz, S.1
Weissman, A.M.2
-
39
-
-
85011659378
-
Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains
-
Liu, C., Liu, W., Ye, Y., Li, W., Ufd2p synthesizes branched ubiquitin chains to promote the degradation of substrates modified with atypical chains. Nat. Commun., 8, 2017, 14274.
-
(2017)
Nat. Commun.
, vol.8
, pp. 14274
-
-
Liu, C.1
Liu, W.2
Ye, Y.3
Li, W.4
-
40
-
-
77955516435
-
K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody
-
Matsumoto, M.L., Wickliffe, K.E., Dong, K.C., Yu, C., Bosanac, I., Bustos, D., Phu, L., Kirkpatrick, D.S., Hymowitz, S.G., Rape, M., et al. K11-linked polyubiquitination in cell cycle control revealed by a K11 linkage-specific antibody. Mol. Cell 39 (2010), 477–484.
-
(2010)
Mol. Cell
, vol.39
, pp. 477-484
-
-
Matsumoto, M.L.1
Wickliffe, K.E.2
Dong, K.C.3
Yu, C.4
Bosanac, I.5
Bustos, D.6
Phu, L.7
Kirkpatrick, D.S.8
Hymowitz, S.G.9
Rape, M.10
-
41
-
-
84859265771
-
Engineering and structural characterization of a linear polyubiquitin-specific antibody
-
Matsumoto, M.L., Dong, K.C., Yu, C., Phu, L., Gao, X., Hannoush, R.N., Hymowitz, S.G., Kirkpatrick, D.S., Dixit, V.M., Kelley, R.F., Engineering and structural characterization of a linear polyubiquitin-specific antibody. J. Mol. Biol. 418 (2012), 134–144.
-
(2012)
J. Mol. Biol.
, vol.418
, pp. 134-144
-
-
Matsumoto, M.L.1
Dong, K.C.2
Yu, C.3
Phu, L.4
Gao, X.5
Hannoush, R.N.6
Hymowitz, S.G.7
Kirkpatrick, D.S.8
Dixit, V.M.9
Kelley, R.F.10
-
42
-
-
0035142877
-
The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation
-
Meacham, G.C., Patterson, C., Zhang, W., Younger, J.M., Cyr, D.M., The Hsc70 co-chaperone CHIP targets immature CFTR for proteasomal degradation. Nat. Cell Biol. 3 (2001), 100–105.
-
(2001)
Nat. Cell Biol.
, vol.3
, pp. 100-105
-
-
Meacham, G.C.1
Patterson, C.2
Zhang, W.3
Younger, J.M.4
Cyr, D.M.5
-
43
-
-
0031876578
-
An efficient route to human bispecific IgG
-
Merchant, A.M., Zhu, Z., Yuan, J.Q., Goddard, A., Adams, C.W., Presta, L.G., Carter, P., An efficient route to human bispecific IgG. Nat. Biotechnol. 16 (1998), 677–681.
-
(1998)
Nat. Biotechnol.
, vol.16
, pp. 677-681
-
-
Merchant, A.M.1
Zhu, Z.2
Yuan, J.Q.3
Goddard, A.4
Adams, C.W.5
Presta, L.G.6
Carter, P.7
-
44
-
-
84900337781
-
Enhanced protein degradation by branched ubiquitin chains
-
Meyer, H.J., Rape, M., Enhanced protein degradation by branched ubiquitin chains. Cell 157 (2014), 910–921.
-
(2014)
Cell
, vol.157
, pp. 910-921
-
-
Meyer, H.J.1
Rape, M.2
-
45
-
-
81355160169
-
Identifying polyglutamine protein species in situ that best predict neurodegeneration
-
Miller, J., Arrasate, M., Brooks, E., Libeu, C.P., Legleiter, J., Hatters, D., Curtis, J., Cheung, K., Krishnan, P., Mitra, S., et al. Identifying polyglutamine protein species in situ that best predict neurodegeneration. Nat. Chem. Biol. 7 (2011), 925–934.
-
(2011)
Nat. Chem. Biol.
, vol.7
, pp. 925-934
-
-
Miller, J.1
Arrasate, M.2
Brooks, E.3
Libeu, C.P.4
Legleiter, J.5
Hatters, D.6
Curtis, J.7
Cheung, K.8
Krishnan, P.9
Mitra, S.10
-
46
-
-
0020120095
-
Cold-sensitive cell-division-cycle mutants of yeast: Isolation, properties, and pseudoreversion studies
-
Moir, D., Stewart, S.E., Osmond, B.C., Botstein, D., Cold-sensitive cell-division-cycle mutants of yeast: Isolation, properties, and pseudoreversion studies. Genetics 100 (1982), 547–563.
-
(1982)
Genetics
, vol.100
, pp. 547-563
-
-
Moir, D.1
Stewart, S.E.2
Osmond, B.C.3
Botstein, D.4
-
47
-
-
49549117842
-
Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies
-
Newton, K., Matsumoto, M.L., Wertz, I.E., Kirkpatrick, D.S., Lill, J.R., Tan, J., Dugger, D., Gordon, N., Sidhu, S.S., Fellouse, F.A., et al. Ubiquitin chain editing revealed by polyubiquitin linkage-specific antibodies. Cell 134 (2008), 668–678.
-
(2008)
Cell
, vol.134
, pp. 668-678
-
-
Newton, K.1
Matsumoto, M.L.2
Wertz, I.E.3
Kirkpatrick, D.S.4
Lill, J.R.5
Tan, J.6
Dugger, D.7
Gordon, N.8
Sidhu, S.S.9
Fellouse, F.A.10
-
48
-
-
84994895357
-
The K48-K63 branched ubiquitin chain regulates NF-κB signaling
-
Ohtake, F., Saeki, Y., Ishido, S., Kanno, J., Tanaka, K., The K48-K63 branched ubiquitin chain regulates NF-κB signaling. Mol. Cell 64 (2016), 251–266.
-
(2016)
Mol. Cell
, vol.64
, pp. 251-266
-
-
Ohtake, F.1
Saeki, Y.2
Ishido, S.3
Kanno, J.4
Tanaka, K.5
-
49
-
-
84865781586
-
Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis
-
Plechanovová, A., Jaffray, E.G., Tatham, M.H., Naismith, J.H., Hay, R.T., Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis. Nature 489 (2012), 115–120.
-
(2012)
Nature
, vol.489
, pp. 115-120
-
-
Plechanovová, A.1
Jaffray, E.G.2
Tatham, M.H.3
Naismith, J.H.4
Hay, R.T.5
-
50
-
-
10344247126
-
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry
-
Rape, M., Kirschner, M.W., Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature 432 (2004), 588–595.
-
(2004)
Nature
, vol.432
, pp. 588-595
-
-
Rape, M.1
Kirschner, M.W.2
-
51
-
-
50149086108
-
Diversity of degradation signals in the ubiquitin-proteasome system
-
Ravid, T., Hochstrasser, M., Diversity of degradation signals in the ubiquitin-proteasome system. Nat. Rev. Mol. Cell Biol. 9 (2008), 679–690.
-
(2008)
Nat. Rev. Mol. Cell Biol.
, vol.9
, pp. 679-690
-
-
Ravid, T.1
Hochstrasser, M.2
-
52
-
-
34247355517
-
Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation
-
Reddy, S.K., Rape, M., Margansky, W.A., Kirschner, M.W., Ubiquitination by the anaphase-promoting complex drives spindle checkpoint inactivation. Nature 446 (2007), 921–925.
-
(2007)
Nature
, vol.446
, pp. 921-925
-
-
Reddy, S.K.1
Rape, M.2
Margansky, W.A.3
Kirschner, M.W.4
-
53
-
-
84904567733
-
Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6
-
Rodrigo-Brenni, M.C., Gutierrez, E., Hegde, R.S., Cytosolic quality control of mislocalized proteins requires RNF126 recruitment to Bag6. Mol. Cell 55 (2014), 227–237.
-
(2014)
Mol. Cell
, vol.55
, pp. 227-237
-
-
Rodrigo-Brenni, M.C.1
Gutierrez, E.2
Hegde, R.S.3
-
54
-
-
67349132223
-
Physiological functions of the HECT family of ubiquitin ligases
-
Rotin, D., Kumar, S., Physiological functions of the HECT family of ubiquitin ligases. Nat. Rev. Mol. Cell Biol. 10 (2009), 398–409.
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 398-409
-
-
Rotin, D.1
Kumar, S.2
-
55
-
-
3543004088
-
Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion
-
Saunders, D.N., Hird, S.L., Withington, S.L., Dunwoodie, S.L., Henderson, M.J., Biben, C., Sutherland, R.L., Ormandy, C.J., Watts, C.K., Edd, the murine hyperplastic disc gene, is essential for yolk sac vascularization and chorioallantoic fusion. Mol. Cell. Biol. 24 (2004), 7225–7234.
-
(2004)
Mol. Cell. Biol.
, vol.24
, pp. 7225-7234
-
-
Saunders, D.N.1
Hird, S.L.2
Withington, S.L.3
Dunwoodie, S.L.4
Henderson, M.J.5
Biben, C.6
Sutherland, R.L.7
Ormandy, C.J.8
Watts, C.K.9
-
56
-
-
80051745465
-
Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP
-
Scaglione, K.M., Zavodszky, E., Todi, S.V., Patury, S., Xu, P., Rodríguez-Lebrón, E., Fischer, S., Konen, J., Djarmati, A., Peng, J., et al. Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP. Mol. Cell 43 (2011), 599–612.
-
(2011)
Mol. Cell
, vol.43
, pp. 599-612
-
-
Scaglione, K.M.1
Zavodszky, E.2
Todi, S.V.3
Patury, S.4
Xu, P.5
Rodríguez-Lebrón, E.6
Fischer, S.7
Konen, J.8
Djarmati, A.9
Peng, J.10
-
57
-
-
84929340859
-
EDD, a ubiquitin-protein ligase of the N-end rule pathway, associates with spindle assembly checkpoint components and regulates the mitotic response to nocodazole
-
Scialpi, F., Mellis, D., Ditzel, M., EDD, a ubiquitin-protein ligase of the N-end rule pathway, associates with spindle assembly checkpoint components and regulates the mitotic response to nocodazole. J. Biol. Chem. 290 (2015), 12585–12594.
-
(2015)
J. Biol. Chem.
, vol.290
, pp. 12585-12594
-
-
Scialpi, F.1
Mellis, D.2
Ditzel, M.3
-
58
-
-
70349780560
-
The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries
-
Sha, Z., Brill, L.M., Cabrera, R., Kleifeld, O., Scheliga, J.S., Glickman, M.H., Chang, E.C., Wolf, D.A., The eIF3 interactome reveals the translasome, a supercomplex linking protein synthesis and degradation machineries. Mol. Cell 36 (2009), 141–152.
-
(2009)
Mol. Cell
, vol.36
, pp. 141-152
-
-
Sha, Z.1
Brill, L.M.2
Cabrera, R.3
Kleifeld, O.4
Scheliga, J.S.5
Glickman, M.H.6
Chang, E.C.7
Wolf, D.A.8
-
59
-
-
84924777167
-
Structure and assembly pathway of the ribosome quality control complex
-
Shao, S., Brown, A., Santhanam, B., Hegde, R.S., Structure and assembly pathway of the ribosome quality control complex. Mol. Cell 57 (2015), 433–444.
-
(2015)
Mol. Cell
, vol.57
, pp. 433-444
-
-
Shao, S.1
Brown, A.2
Santhanam, B.3
Hegde, R.S.4
-
60
-
-
84889850198
-
Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibodydependent cellular cytotoxicity
-
Shatz, W., Chung, S., Li, B., Marshall, B., Tejada, M., Phung, W., Sandoval, W., Kelley, R.F., Scheer, J.M., Knobs-into-holes antibody production in mammalian cell lines reveals that asymmetric afucosylation is sufficient for full antibodydependent cellular cytotoxicity. MAbs. 5 (2013), 872–881.
-
(2013)
MAbs.
, vol.5
, pp. 872-881
-
-
Shatz, W.1
Chung, S.2
Li, B.3
Marshall, B.4
Tejada, M.5
Phung, W.6
Sandoval, W.7
Kelley, R.F.8
Scheer, J.M.9
-
61
-
-
84878195272
-
Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway
-
Shemorry, A., Hwang, C.S., Varshavsky, A., Control of protein quality and stoichiometries by N-terminal acetylation and the N-end rule pathway. Mol. Cell 50 (2013), 540–551.
-
(2013)
Mol. Cell
, vol.50
, pp. 540-551
-
-
Shemorry, A.1
Hwang, C.S.2
Varshavsky, A.3
-
62
-
-
84923195900
-
Spatiotemporal regulation of the anaphase-promoting complex in mitosis
-
Sivakumar, S., Gorbsky, G.J., Spatiotemporal regulation of the anaphase-promoting complex in mitosis. Nat. Rev. Mol. Cell Biol. 16 (2015), 82–94.
-
(2015)
Nat. Rev. Mol. Cell Biol.
, vol.16
, pp. 82-94
-
-
Sivakumar, S.1
Gorbsky, G.J.2
-
63
-
-
84878260314
-
Mechanisms and function of substrate recruitment by F-box proteins
-
Skaar, J.R., Pagan, J.K., Pagano, M., Mechanisms and function of substrate recruitment by F-box proteins. Nat. Rev. Mol. Cell Biol. 14 (2013), 369–381.
-
(2013)
Nat. Rev. Mol. Cell Biol.
, vol.14
, pp. 369-381
-
-
Skaar, J.R.1
Pagan, J.K.2
Pagano, M.3
-
64
-
-
0028847989
-
A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
-
Spence, J., Sadis, S., Haas, A.L., Finley, D., A ubiquitin mutant with specific defects in DNA repair and multiubiquitination. Mol. Cell. Biol. 15 (1995), 1265–1273.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 1265-1273
-
-
Spence, J.1
Sadis, S.2
Haas, A.L.3
Finley, D.4
-
65
-
-
85010910635
-
ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation
-
Sundaramoorthy, E., Leonard, M., Mak, R., Liao, J., Fulzele, A., Bennett, E.J., ZNF598 and RACK1 regulate mammalian ribosome-associated quality control function by mediating regulatory 40S ribosomal ubiquitylation. Mol. Cell 65 (2017), 751–760.
-
(2017)
Mol. Cell
, vol.65
, pp. 751-760
-
-
Sundaramoorthy, E.1
Leonard, M.2
Mak, R.3
Liao, J.4
Fulzele, A.5
Bennett, E.J.6
-
66
-
-
84988530002
-
A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins
-
Published online August 23, 2016
-
Sung, M.K., Porras-Yakushi, T.R., Reitsma, J.M., Huber, F.M., Sweredoski, M.J., Hoelz, A., Hess, S., Deshaies, R.J., A conserved quality-control pathway that mediates degradation of unassembled ribosomal proteins. eLife, 2016, 10.7554/eLife.19105 Published online August 23, 2016.
-
(2016)
eLife
-
-
Sung, M.K.1
Porras-Yakushi, T.R.2
Reitsma, J.M.3
Huber, F.M.4
Sweredoski, M.J.5
Hoelz, A.6
Hess, S.7
Deshaies, R.J.8
-
67
-
-
84874610790
-
UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy
-
Tasaki, T., Kim, S.T., Zakrzewska, A., Lee, B.E., Kang, M.J., Yoo, Y.D., Cha-Molstad, H.J., Hwang, J., Soung, N.K., Sung, K.S., et al. UBR box N-recognin-4 (UBR4), an N-recognin of the N-end rule pathway, and its role in yolk sac vascular development and autophagy. Proc. Natl. Acad. Sci. USA 110 (2013), 3800–3805.
-
(2013)
Proc. Natl. Acad. Sci. USA
, vol.110
, pp. 3800-3805
-
-
Tasaki, T.1
Kim, S.T.2
Zakrzewska, A.3
Lee, B.E.4
Kang, M.J.5
Yoo, Y.D.6
Cha-Molstad, H.J.7
Hwang, J.8
Soung, N.K.9
Sung, K.S.10
-
68
-
-
59649103156
-
Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation
-
Tokunaga, F., Sakata, S., Saeki, Y., Satomi, Y., Kirisako, T., Kamei, K., Nakagawa, T., Kato, M., Murata, S., Yamaoka, S., et al. Involvement of linear polyubiquitylation of NEMO in NF-kappaB activation. Nat. Cell Biol. 11 (2009), 123–132.
-
(2009)
Nat. Cell Biol.
, vol.11
, pp. 123-132
-
-
Tokunaga, F.1
Sakata, S.2
Saeki, Y.3
Satomi, Y.4
Kirisako, T.5
Kamei, K.6
Nakagawa, T.7
Kato, M.8
Murata, S.9
Yamaoka, S.10
-
69
-
-
0034703437
-
Detecting and measuring cotranslational protein degradation in vivo
-
Turner, G.C., Varshavsky, A., Detecting and measuring cotranslational protein degradation in vivo. Science 289 (2000), 2117–2120.
-
(2000)
Science
, vol.289
, pp. 2117-2120
-
-
Turner, G.C.1
Varshavsky, A.2
-
70
-
-
84879034688
-
Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome
-
Published online January 22, 2013
-
Verma, R., Oania, R.S., Kolawa, N.J., Deshaies, R.J., Cdc48/p97 promotes degradation of aberrant nascent polypeptides bound to the ribosome. eLife, 2013, 10.7554/eLife.00308 Published online January 22, 2013.
-
(2013)
eLife
-
-
Verma, R.1
Oania, R.S.2
Kolawa, N.J.3
Deshaies, R.J.4
-
71
-
-
0035913278
-
TAK1 is a ubiquitin-dependent kinase of MKK and IKK
-
Wang, C., Deng, L., Hong, M., Akkaraju, G.R., Inoue, J., Chen, Z.J., TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412 (2001), 346–351.
-
(2001)
Nature
, vol.412
, pp. 346-351
-
-
Wang, C.1
Deng, L.2
Hong, M.3
Akkaraju, G.R.4
Inoue, J.5
Chen, Z.J.6
-
72
-
-
84883229070
-
A cotranslational ubiquitination pathway for quality control of misfolded proteins
-
Wang, F., Durfee, L.A., Huibregtse, J.M., A cotranslational ubiquitination pathway for quality control of misfolded proteins. Mol. Cell 50 (2013), 368–378.
-
(2013)
Mol. Cell
, vol.50
, pp. 368-378
-
-
Wang, F.1
Durfee, L.A.2
Huibregtse, J.M.3
-
73
-
-
84930384193
-
Ubiquitination of newly synthesized proteins at the ribosome
-
Wang, F., Canadeo, L.A., Huibregtse, J.M., Ubiquitination of newly synthesized proteins at the ribosome. Biochimie 114 (2015), 127–133.
-
(2015)
Biochimie
, vol.114
, pp. 127-133
-
-
Wang, F.1
Canadeo, L.A.2
Huibregtse, J.M.3
-
74
-
-
84947471999
-
Identification and characterization of essential genes in the human genome
-
Wang, T., Birsoy, K., Hughes, N.W., Krupczak, K.M., Post, Y., Wei, J.J., Lander, E.S., Sabatini, D.M., Identification and characterization of essential genes in the human genome. Science 350 (2015), 1096–1101.
-
(2015)
Science
, vol.350
, pp. 1096-1101
-
-
Wang, T.1
Birsoy, K.2
Hughes, N.W.3
Krupczak, K.M.4
Post, Y.5
Wei, J.J.6
Lander, E.S.7
Sabatini, D.M.8
-
75
-
-
84990925109
-
Common molecular pathways in amyotrophic lateral sclerosis and frontotemporal dementia
-
Weishaupt, J.H., Hyman, T., Dikic, I., Common molecular pathways in amyotrophic lateral sclerosis and frontotemporal dementia. Trends Mol. Med. 22 (2016), 769–783.
-
(2016)
Trends Mol. Med.
, vol.22
, pp. 769-783
-
-
Weishaupt, J.H.1
Hyman, T.2
Dikic, I.3
-
76
-
-
84951176357
-
Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
-
Wertz, I.E., Newton, K., Seshasayee, D., Kusam, S., Lam, C., Zhang, J., Popovych, N., Helgason, E., Schoeffler, A., Jeet, S., et al. Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation. Nature 528 (2015), 370–375.
-
(2015)
Nature
, vol.528
, pp. 370-375
-
-
Wertz, I.E.1
Newton, K.2
Seshasayee, D.3
Kusam, S.4
Lam, C.5
Zhang, J.6
Popovych, N.7
Helgason, E.8
Schoeffler, A.9
Jeet, S.10
-
77
-
-
79952290609
-
The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2
-
Wickliffe, K.E., Lorenz, S., Wemmer, D.E., Kuriyan, J., Rape, M., The mechanism of linkage-specific ubiquitin chain elongation by a single-subunit E2. Cell 144 (2011), 769–781.
-
(2011)
Cell
, vol.144
, pp. 769-781
-
-
Wickliffe, K.E.1
Lorenz, S.2
Wemmer, D.E.3
Kuriyan, J.4
Rape, M.5
-
78
-
-
70849116420
-
Identification of a physiological E2 module for the human anaphase-promoting complex
-
Williamson, A., Wickliffe, K.E., Mellone, B.G., Song, L., Karpen, G.H., Rape, M., Identification of a physiological E2 module for the human anaphase-promoting complex. Proc. Natl. Acad. Sci. USA 106 (2009), 18213–18218.
-
(2009)
Proc. Natl. Acad. Sci. USA
, vol.106
, pp. 18213-18218
-
-
Williamson, A.1
Wickliffe, K.E.2
Mellone, B.G.3
Song, L.4
Karpen, G.H.5
Rape, M.6
-
79
-
-
77955375562
-
Enhancement of DNA uptake in FUT8-deleted CHO cells for transient production of afucosylated antibodies
-
Wong, A.W., Baginski, T.K., Reilly, D.E., Enhancement of DNA uptake in FUT8-deleted CHO cells for transient production of afucosylated antibodies. Biotechnol Bioeng. 106 (2010), 751–763.
-
(2010)
Biotechnol Bioeng.
, vol.106
, pp. 751-763
-
-
Wong, A.W.1
Baginski, T.K.2
Reilly, D.E.3
-
80
-
-
63049125531
-
Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation
-
Xu, P., Duong, D.M., Seyfried, N.T., Cheng, D., Xie, Y., Robert, J., Rush, J., Hochstrasser, M., Finley, D., Peng, J., Quantitative proteomics reveals the function of unconventional ubiquitin chains in proteasomal degradation. Cell 137 (2009), 133–145.
-
(2009)
Cell
, vol.137
, pp. 133-145
-
-
Xu, P.1
Duong, D.M.2
Seyfried, N.T.3
Cheng, D.4
Xie, Y.5
Robert, J.6
Rush, J.7
Hochstrasser, M.8
Finley, D.9
Peng, J.10
-
81
-
-
85013777029
-
The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation
-
Xu, Y., Anderson, D.E., Ye, Y., The HECT domain ubiquitin ligase HUWE1 targets unassembled soluble proteins for degradation. Cell Discov., 2, 2016, 16040.
-
(2016)
Cell Discov.
, vol.2
, pp. 16040
-
-
Xu, Y.1
Anderson, D.E.2
Ye, Y.3
-
82
-
-
84992740859
-
Cryo-EM of mitotic checkpoint complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation
-
Yamaguchi, M., VanderLinden, R., Weissmann, F., Qiao, R., Dube, P., Brown, N.G., Haselbach, D., Zhang, W., Sidhu, S.S., Peters, J.M., et al. Cryo-EM of mitotic checkpoint complex-bound APC/C reveals reciprocal and conformational regulation of ubiquitin ligation. Mol. Cell 63 (2016), 593–607.
-
(2016)
Mol. Cell
, vol.63
, pp. 593-607
-
-
Yamaguchi, M.1
VanderLinden, R.2
Weissmann, F.3
Qiao, R.4
Dube, P.5
Brown, N.G.6
Haselbach, D.7
Zhang, W.8
Sidhu, S.S.9
Peters, J.M.10
-
83
-
-
84971236561
-
The increasing complexity of the ubiquitin code
-
Yau, R., Rape, M., The increasing complexity of the ubiquitin code. Nat. Cell Biol. 18 (2016), 579–586.
-
(2016)
Nat. Cell Biol.
, vol.18
, pp. 579-586
-
-
Yau, R.1
Rape, M.2
-
84
-
-
33746675669
-
Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator
-
Younger, J.M., Chen, L., Ren, H.Y., Rosser, M.F., Turnbull, E.L., Fan, C.Y., Patterson, C., Cyr, D.M., Sequential quality-control checkpoints triage misfolded cystic fibrosis transmembrane conductance regulator. Cell 126 (2006), 571–582.
-
(2006)
Cell
, vol.126
, pp. 571-582
-
-
Younger, J.M.1
Chen, L.2
Ren, H.Y.3
Rosser, M.F.4
Turnbull, E.L.5
Fan, C.Y.6
Patterson, C.7
Cyr, D.M.8
|