The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling

Molecular Cell

Volumn 64, Issue 2, 2016, Pages 251-266

  Ohtake, Fumiaki ^a,b   Saeki, Yasushi ^a   Ishido, Satoshi ^c   Kanno, Jun ^b   Tanaka, Keiji ^a  

^a TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^b NATIONAL INSTITUTE OF HEALTH SCIENCES   (Japan)

^c HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

AQUA; CYLD; HUWE1; inflammation; Lys48; Lys63; NF B; proteomics; TRAF6

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; LYSINE; POLYUBIQUITIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UBIQUITIN PROTEIN LIGASE E3; CYLD PROTEIN, HUMAN; HUWE1 PROTEIN, HUMAN; IL1B PROTEIN, HUMAN; PROTEIN BINDING; RECOMBINANT PROTEIN; SIGNAL TRANSDUCING ADAPTOR PROTEIN; TAB2 PROTEIN, HUMAN; TIFAB PROTEIN, HUMAN; TUMOR SUPPRESSOR PROTEIN; UBIQUITIN; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; IN VITRO STUDY; IN VIVO STUDY; INFLAMMATION; MOLECULAR RECOGNITION; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; TUMOR GROWTH; UBIQUITINATION; ALPHA HELIX; AMINO ACID SEQUENCE; BETA SHEET; BINDING SITE; CHEMISTRY; CYTOLOGY; DRUG EFFECTS; ENZYME SPECIFICITY; GENETICS; HUMAN; METABOLISM; MOLECULAR MODEL; OSTEOBLAST; PROTEIN DOMAIN; SEQUENCE ALIGNMENT; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; BINDING SITES; CELL LINE, TUMOR; GENE EXPRESSION; HUMANS; INTERLEUKIN-1BETA; LYSINE; MODELS, MOLECULAR; NF-KAPPA B; OSTEOBLASTS; POLYUBIQUITIN; PROTEIN BINDING; PROTEIN CONFORMATION, ALPHA-HELICAL; PROTEIN CONFORMATION, BETA-STRAND; PROTEIN INTERACTION DOMAINS AND MOTIFS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TNF RECEPTOR-ASSOCIATED FACTOR 6; TUMOR SUPPRESSOR PROTEINS; UBIQUITIN; UBIQUITIN-PROTEIN LIGASES; UBIQUITINATION;

EID: 84994895357     PISSN: 10972765     EISSN: 10974164     Source Type: Journal    
DOI: 10.1016/j.molcel.2016.09.014     Document Type: Article

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