Protein targeting and degradation are coupled for elimination of mislocalized proteins

Nature

Volumn 475, Issue 7356, 2011, Pages 394-399

  Hessa, Tara ^a   Sharma, Ajay ^a   Mariappan, Malaiyalam ^a   Eshleman, Heather D ^a,c   Gutierrez, Erik ^a,b   Hegde, Ramanujan S ^a,d  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHAPERONE; CHAPERONE PROTEIN BAG6; MEMBRANE PROTEIN; UBIQUITIN; UNCLASSIFIED DRUG;

CELL ORGANELLE; GENOME; HOMEOSTASIS; MEMBRANE; PROTEIN;

ANIMAL CELL; ARTICLE; CELL TRACKING; CONTROLLED STUDY; CYTOSOL; HYDROPHOBICITY; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN TARGETING; RIBOSOME;

ANIMALS; ARSENITE TRANSPORTING ATPASES; CATTLE; CELL MEMBRANE; CYTOPLASM; ENDOPLASMIC RETICULUM; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MOLECULAR CHAPERONES; MULTIPROTEIN COMPLEXES; NEUROPEPTIDE Y; PRIONS; PROLACTIN; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN FOLDING; PROTEIN PRECURSORS; PROTEIN SORTING SIGNALS; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RIBOSOMES; UBIQUITIN; UBIQUITINATION;

EID: 79960637590     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10181     Document Type: Article

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