Degradation-mediated protein quality control in the nucleus

Cell

Volumn 120, Issue 6, 2005, Pages 803-815

  Gardner, Richard G ^a   Nelson, Zara W ^a   Gottschling, Daniel E ^a  

^a USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CYCLE PROTEIN; NUCLEAR PROTEIN; PROTEASOME; UBIQUITIN CONJUGATING ENZYME; UBIQUITIN PROTEIN LIGASE;

ARTICLE; CELL FUNCTION; CELL NUCLEUS; EUKARYOTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUALITY CONTROL; SACCHAROMYCES CEREVISIAE; STRESS; UBIQUITINATION;

EUKARYOTA; SACCHAROMYCES CEREVISIAE;

EID: 17644396667     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cell.2005.01.016     Document Type: Article

References (72)

1. A. Abu-Baker, C. Messaed, J. Laganiere, C. Gaspar, B. Brais, and G.A. Rouleau Involvement of the ubiquitin-proteasome pathway and molecular chaperones in oculopharyngeal muscular dystrophy Hum. Mol. Genet. 12 2003 2609 2623
2. O.M. Aparicio, B.L. Billington, and D.E. Gottschling Modifiers of position effect are shared between telomeric and silent mating-type loci in S. cerevisiae Cell 66 1991 1279 1287
3. I. Arnold, and T. Langer Membrane protein degradation by AAA proteases in mitochondria Biochim. Biophys. Acta 1592 2002 89 96
4. A. Banerjee, R.J. Deshaies, and V. Chau Characterization of a dominant negative mutant of the cell cycle ubiquitin-conjugating enzyme Cdc34 J. Biol. Chem. 270 1995 26209 26215
5. N.W. Bays, R.G. Gardner, L.P. Seelig, C.A. Joazeiro, and R.Y. Hampton Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation Nat. Cell Biol. 3 2001 24 29
6. R. Belotserkovskaya, S. Oh, V.A. Bondarenko, G. Orphanides, V.M. Studitsky, and D. Reinberg FACT facilitates transcription-dependent nucleosome alteration Science 301 2003 1090 1093
7. J. Betting, and W. Seufert A yeast Ubc9 mutant protein with temperature-sensitive in vivo function is subject to conditional proteolysis by a ubiquitin- and proteasome-dependent pathway J. Biol. Chem. 271 1996 25790 25796
8. S. Biggins, F.F. Severin, N. Bhalla, I. Sassoon, A.A. Hyman, and A.W. Murray The conserved protein kinase Ipl1 regulates microtubule binding to kinetochores in budding yeast Genes Dev. 13 1999 532 544
9. M. Blondel, J.M. Galan, Y. Chi, C. Lafourcade, C. Longaretti, R.J. Deshaies, and M. Peter Nuclear-specific degradation of Far1 is controlled by the localization of the F-box protein Cdc4 EMBO J. 19 2000 6085 6097
10. J. Bordallo, R.K. Plemper, A. Finger, and D.H. Wolf Der3p/Hrd1p is required for endoplasmic reticulum-associated degradation of misfolded lumenal and integral membrane proteins Mol. Biol. Cell 9 1998 209 222
11. B. Brais Oculopharyngeal muscular dystrophy: a late-onset polyalanine disease Cytogenet. Genome Res. 100 2003 252 260
12. N.K. Brewster, G.C. Johnston, and R.A. Singer A bipartite yeast SSRP1 analog comprised of Pob3 and Nhp6 proteins modulates transcription Mol. Cell. Biol. 21 2001 3491 3502
13. S.A. Burchett, P. Flanary, C. Aston, L. Jiang, K.H. Young, P. Uetz, S. Fields, and H.G. Dohlman Regulation of stress response signaling by the N-terminal dishevelled/EGL-10/pleckstrin domain of Sst2, a regulator of G protein signaling in Saccharomyces cerevisiae J. Biol. Chem. 277 2002 22156 22167
14. A. Calado, F.M. Tome, B. Brais, G.A. Rouleau, U. Kuhn, E. Wahle, and M. Carmo-Fonseca Nuclear inclusions in oculopharyngeal muscular dystrophy consist of poly(A) binding protein 2 aggregates which sequester poly(A) RNA Hum. Mol. Genet. 9 2000 2321 2328
15. E. Cameroni, N. Hulo, J. Roosen, J. Winderickx, and C. De Virgilio The novel yeast PAS kinase Rim 15 orchestrates G0-associated antioxidant defense mechanisms Cell Cycle 3 2004 462 468
16. H.C. Causton, B. Ren, S.S. Koh, C.T. Harbison, E. Kanin, E.G. Jennings, T.I. Lee, H.L. True, E.S. Lander, and R.A. Young Remodeling of yeast genome expression in response to environmental changes Mol. Biol. Cell 12 2001 323 337
17. P. Chen, P. Johnson, T. Sommer, S. Jentsch, and M. Hochstrasser Multiple ubiquitin-conjugating enzymes participate in the in vivo degradation of the yeast MAT alpha 2 repressor Cell 74 1993 357 369
18. T.A. Chernova, K.D. Allen, L.M. Wesoloski, J.R. Shanks, Y.O. Chernoff, and K.D. Wilkinson Pleiotropic effects of Ubp6 loss on drug sensitivities and yeast prion are due to depletion of the free ubiquitin pool J. Biol. Chem. 278 2003 52102 52115
19. Z.S. Chughtai, R. Rassadi, N. Matusiewicz, and U. Stochaj Starvation promotes nuclear accumulation of the hsp70 Ssa4p in yeast cells J. Biol. Chem. 276 2001 20261 20266
20. P.J. Cullen, W. Sabbagh Jr., E. Graham, M.M. Irick, E.K. van Olden, C. Neal, J. Delrow, L. Bardwell, and G.F. Sprague Jr. A signaling mucin at the head of the Cdc42- and MAPK-dependent filamentous growth pathway in yeast Genes Dev. 18 2004 1695 1708
21. A. Dasgupta, K.L. Ramsey, J.S. Smith, and D.T. Auble Sir antagonist 1 (San1) is a ubiquitin ligase J. Biol. Chem. 279 2004 26830 26838
22. S.W. Davies, M. Turmaine, B.A. Cozens, M. DiFiglia, A.H. Sharp, C.A. Ross, E. Scherzinger, E.E. Wanker, L. Mangiarini, and G.P. Bates Formation of neuronal intranuclear inclusions underlies the neurological dysfunction in mice transgenic for the HD mutation Cell 90 1997 537 548
23. P.M. Deak, and D.H. Wolf Membrane topology and function of Der3/Hrd1p as a ubiquitin-protein ligase (E3) involved in endoplasmic reticulum degradation J. Biol. Chem. 276 2001 10663 10669
24. J.L. DeRisi, V.R. Iyer, and P.O. Brown Exploring the metabolic and genetic control of gene expression on a genomic scale Science 278 1997 680 686
25. R.J. Deshaies SCF and Cullin/Ring H2-based ubiquitin ligases Annu. Rev. Cell Dev. Biol. 15 1999 435 467
26. D.R. Evans, N.K. Brewster, Q. Xu, A. Rowley, B.A. Altheim, G.C. Johnston, and R.A. Singer The yeast protein complex containing cdc68 and pob3 mediates core-promoter repression through the cdc68 N-terminal domain Genetics 150 1998 1393 1405
27. T.G. Fazzio, C. Kooperberg, J.P. Goldmark, C. Neal, R. Basom, J. Delrow, and T. Tsukiyama Widespread collaboration of Isw2 and Sin3-Rpd3 chromatin remodeling complexes in transcriptional repression Mol. Cell. Biol. 21 2001 6450 6460
28. T. Formosa, P. Eriksson, J. Wittmeyer, J. Ginn, Y. Yu, and D.J. Stillman Spt16-Pob3 and the HMG protein Nhp6 combine to form the nucleosome-binding factor SPN EMBO J. 20 2001 3506 3517
29. R. Friedlander, E. Jarosch, J. Urban, C. Volkwein, and T. Sommer A regulatory link between ER-associated protein degradation and the unfolded-protein response Nat. Cell Biol. 2 2000 379 384
30. R.G. Gardner, and R.Y. Hampton A 'distributed degron' allows regulated entry into the ER degradation pathway EMBO J. 18 1999 5994 6004
31. A.L. Goldberg Protein degradation and protection against misfolded or damaged proteins Nature 426 2003 895 899
32. D.E. Gottschling, O.M. Aparicio, B.L. Billington, and V.A. Zakian Position effect at S. cerevisiae telomeres: Reversible repression of Pol II transcription Cell 63 1990 751 762
33. N. Grandin, and M. Charbonneau Hsp90 levels affect telomere length in yeast Mol. Genet. Genomics 265 2001 126 134
34. C.M. Grant, S. Luikenhuis, A. Beckhouse, M. Soderbergh, and I.W. Dawes Differential regulation of glutaredoxin gene expression in response to stress conditions in the yeast Saccharomyces cerevisiae Biochim. Biophys. Acta 1490 2000 33 42
35. R.Y. Hampton ER-associated degradation in protein quality control and cellular regulation Curr. Opin. Cell Biol. 14 2002 476 482
36. W.K. Huh, J.V. Falvo, L.C. Gerke, A.S. Carroll, R.W. Howson, J.S. Weissman, and E.K. O'Shea Global analysis of protein localization in budding yeast Nature 425 2003 686 691
37. P.K. Jackson, A.G. Eldridge, E. Freed, L. Furstenthal, J.Y. Hsu, B.K. Kaiser, and J.D. Reimann The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases Trends Cell Biol. 10 2000 429 439
38. N.R. Jana, and N. Nukina Recent advances in understanding the pathogenesis of polyglutamine diseases: involvement of molecular chaperones and ubiquitin-proteasome pathway J. Chem. Neuroanat. 26 2003 95 101
39. S.A. Jelinsky, P. Estep, G.M. Church, and L.D. Samson Regulatory networks revealed by transcriptional profiling of damaged Saccharomyces cerevisiae cells: Rpn4 links base excision repair with proteasomes Mol. Cell. Biol. 20 2000 8157 8167
40. C.A. Joazeiro, S.S. Wing, H. Huang, J.D. Leverson, T. Hunter, and Y.C. Liu The tyrosine kinase negative regulator c-Cbl as a RING-type, E2-dependent ubiquitin-protein ligase Science 286 1999 309 312
41. A. Kahana, and D.E. Gottschling DOT4 links silencing and cell growth in Saccharomyces cerevisiae Mol. Cell. Biol. 19 1999 6608 6620
42. C.D. Kaplan, L. Laprade, and F. Winston Transcription elongation factors repress transcription initiation from cryptic sites Science 301 2003 1096 1099
43. R. Kawai, K. Fujita, H. Iwahashi, and Y. Komatsu Direct evidence for the intracellular localization of Hsp104 in Saccharomyces cerevisiae by immunoelectron microscopy Cell Stress Chaperones 4 1999 46 53
44. K.C. Kregel Heat shock proteins: modifying factors in physiological stress responses and acquired thermotolerance J. Appl. Physiol. 92 2002 2177 2186
45. A. Lagorce, N.C. Hauser, D. Labourdette, C. Rodriguez, H. Martin-Yken, J. Arroyo, J.D. Hoheisel, and J. Francois Genome-wide analysis of the response to cell wall mutations in the yeast Saccharomyces cerevisiae J. Biol. Chem. 278 2003 20345 20357
46. Y. Liu, N. Mathias, C.N. Steussy, and M.G. Goebl Intragenic suppression among CDC34 (UBC3) mutations defines a class of ubiquitin-conjugating catalytic domains Mol. Cell. Biol. 15 1995 5635 5644
47. K.L. Lorick, J.P. Jensen, S. Fang, A.M. Ong, S. Hatakeyama, and A.M. Weissman RING fingers mediate ubiquitin-conjugating enzyme (E2)-dependent ubiquitination Proc. Natl. Acad. Sci. USA 96 1999 11364 11369
48. K. Madura, R.J. Dohmen, and A. Varshavsky N-recognin/Ubc2 interactions in the N-end rule pathway J. Biol. Chem. 268 1993 12046 12054
49. H. McDonough, and C. Patterson CHIP: a link between the chaperone and proteasome systems Cell Stress Chaperones 8 2003 303 308
50. D. Moazed, A. Kistler, A. Axelrod, J. Rine, and A.D. Johnson Silent information regulator protein complexes in Saccharomyces cerevisiae: a SIR2/SIR4 complex and evidence for a regulatory domain in SIR4 that inhibits its interaction with SIR3 Proc. Natl. Acad. Sci. USA 94 1997 2186 2191
51. E. Moskvina, C. Schuller, C.T. Maurer, W.H. Mager, and H. Ruis A search in the genome of Saccharomyces cerevisiae for genes regulated via stress response elements Yeast 14 1998 1041 1050
52. F. Palladino, T. Laroche, E. Gilson, A. Axelrod, L. Pillus, and S.M. Gasser SIR3 and SIR4 proteins are required for the positioning and integrity of yeast telomeres Cell 75 1993 543 555
53. D.A. Parsell, A.S. Kowal, M.A. Singer, and S. Lindquist Protein disaggregation mediated by heat-shock protein Hsp104 Nature 372 1994 475 478
54. C. Ptak, C. Gwozd, J.T. Huzil, T.J. Gwozd, G. Garen, and M.J. Ellison Creation of a pluripotent ubiquitin-conjugating enzyme Mol. Cell. Biol. 21 2001 6537 6548
55. H. Qi, and V.A. Zakian The Saccharomyces telomere-binding protein Cdc13p interacts with both the catalytic subunit of DNA polymerase alpha and the telomerase-associated est1 protein Genes Dev. 14 2000 1777 1788
56. J. Rine, and I. Herskowitz Four genes responsible for a position effect on expression from HML and HMR in Saccharomyces cerevisiae Genetics 116 1987 9 22
57. J.M. Rossi, and S. Lindquist The intracellular location of yeast heat-shock protein 26 varies with metabolism J. Cell Biol. 108 1989 425 439
58. A. Rowley, R.A. Singer, and G.C. Johnston CDC68, a yeast gene that affects regulation of cell proliferation and transcription, encodes a protein with a highly acidic carboxyl terminus Mol. Cell. Biol. 11 1991 5718 5726
59. R. Schnell, L. D'Ari, M. Foss, D. Goodman, and J. Rine Genetic and molecular characterization of suppressors of SIR4 mutations in Saccharomyces cerevisiae Genetics 122 1989 29 46
60. U. Schubert, L.C. Antón, J. Gibbs, C.C. Norbury, J.W. Yewdell, and J.R. Bennink Rapid degradation of a large fraction of newly synthesized proteins by proteasomes Nature 404 2000 770 774
61. W. Seufert, and S. Jentsch Ubiquitin-conjugating enzymes UBC4 and UBC5 mediate selective degradation of short-lived and abnormal proteins EMBO J. 9 1990 543 550
62. B.S. Shastry Neurodegenerative disorders of protein aggregation Neurochem. Int. 43 2003 1 7
63. A. Smogorzewska, and T. de Lange Regulation of telomerase by telomeric proteins Annu. Rev. Biochem. 73 2004 177 208
64. P.C. Stirling, V.F. Lundin, and M.R. Leroux Getting a grip on non-native proteins EMBO Rep. 4 2003 565 570
65. K.J. Travers, C.K. Patil, L. Wodicka, D.J. Lockhart, J.S. Weissman, and P. Walter Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation Cell 101 2000 249 258
66. E.S. Trombetta, and A.J. Parodi Quality control and protein folding in the secretory pathway Annu. Rev. Cell Dev. Biol. 19 2003 649 676
67. H.D. Ulrich, and S. Jentsch Two RING finger proteins mediate cooperation between ubiquitin-conjugating enzymes in DNA repair EMBO J. 19 2000 3388 3397
68. S. Waelter, A. Boeddrich, R. Lurz, E. Scherzinger, G. Lueder, H. Lehrach, and E.E. Wanker Accumulation of mutant huntingtin fragments in aggresome-like inclusion bodies as a result of insufficient protein degradation Mol. Biol. Cell 12 2001 1393 1407
69. C. Wojcik, and G.N. DeMartino Intracellular localization of proteasomes Int. J. Biochem. Cell Biol. 35 2003 579 589
70. J.J. Wyrick, F.C. Holstege, E.G. Jennings, H.C. Causton, D. Shore, M. Grunstein, E.S. Lander, and R.A. Young Chromosomal landscape of nucleosome-dependent gene expression and silencing in yeast Nature 402 1999 418 421
71. Q. Xu, G.C. Johnston, and R.A. Singer The Saccharomyces cerevisiae Cdc68 transcription activator is antagonized by San1, a protein implicated in transcriptional silencing Mol. Cell. Biol. 13 1993 7553 7565
72. Q. Xu, R.A. Singer, and G.C. Johnston Sug1 modulates yeast transcription activation by Cdc68 Mol. Cell. Biol. 15 1995 6025 6035