In Vivo Selection of a Computationally Designed SCHEMA AAV Library Yields a Novel Variant for Infection of Adult Neural Stem Cells in the SVZ

Molecular Therapy

Volumn 26, Issue 1, 2018, Pages 304-319

  Ojala, David S ^a   Sun, Sabrina ^a   Santiago Ortiz, Jorge L ^a   Shapiro, Mikhail G ^b,d   Romero, Philip A ^c   Schaffer, David V ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b University of California at Berkeley   (United States)

^c UNIVERSITY OF WISCONSIN MADISON   (United States)

^d California Institute of Technology   (United States)

Author keywords

adeno associated virus; capsid engineering; CNS; directed evolution; gene therapy; neural stem cell; subventricular zone

Indexed keywords

CRE RECOMBINASE; GALACTOSE; GREEN FLUORESCENT PROTEIN; HEPARAN SULFATE; NEUTRALIZING ANTIBODY; CAPSID PROTEIN;

ADENO ASSOCIATED VIRUS; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHIMERA; CONTROLLED STUDY; IN VIVO STUDY; MOLECULAR LIBRARY; MOUSE; NEURAL STEM CELL; NONHUMAN; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SUBVENTRICULAR ZONE; VIRUS CAPSID; VIRUS RECOMBINATION; ANIMAL; CHEMISTRY; CLASSIFICATION; CYTOLOGY; DEPENDOPARVOVIRUS; GENE LIBRARY; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETIC ENGINEERING; GENETIC TRANSDUCTION; GENETICS; HUMAN; LATERAL BRAIN VENTRICLE; METABOLISM; MOLECULAR MODEL; MUTATION; PROCEDURES; PROTEIN CONFORMATION; THREE DIMENSIONAL IMAGING; ULTRASTRUCTURE; VIRUS GENOME;

ANIMALS; CAPSID PROTEINS; DEPENDOVIRUS; GALACTOSE; GENE LIBRARY; GENE TRANSFER TECHNIQUES; GENETIC ENGINEERING; GENETIC THERAPY; GENETIC VECTORS; GENOME, VIRAL; HEPARITIN SULFATE; HUMANS; IMAGING, THREE-DIMENSIONAL; LATERAL VENTRICLES; MICE; MODELS, MOLECULAR; MUTATION; NEURAL STEM CELLS; PROTEIN CONFORMATION; TRANSDUCTION, GENETIC;

EID: 85030643673     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1016/j.ymthe.2017.09.006     Document Type: Article

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