A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

Nature Neuroscience

Volumn 13, Issue 1, 2010, Pages 133-140

  Madisen, Linda ^a   Zwingman, Theresa A ^a   Sunkin, Susan M ^a   Oh, Seung Wook ^a   Zariwala, Hatim A ^a   Gu, Hong ^a   Ng, Lydia L ^a   Palmiter, Richard D ^b   Hawrylycz, Michael J ^a   Jones, Allan R ^a   Lein, Ed S ^a   Zeng, Hongkui ^a  

^a ALLEN INSTITUTE FOR BRAIN SCIENCE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRE RECOMBINASE; BACTERIAL PROTEIN; INTEGRASE; PHOTOPROTEIN; TAMOXIFEN; VIRUS PROTEIN; YELLOW FLUORESCENT PROTEIN, BACTERIA;

ANIMAL CELL; ARTICLE; BRAIN CORTEX; BRAIN MAPPING; BRAIN REGION; CELL POPULATION; CELL TYPE; CONTROLLED STUDY; DENDRITE; FLUORESCENCE; GENE EXPRESSION PROFILING; GENETIC MANIPULATION; IN SITU HYBRIDIZATION; IN VIVO STUDY; MOUSE; NERVE PROJECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; BRAIN; C57BL MOUSE; CONFOCAL MICROSCOPY; CYTOLOGY; GENE TRANSFER; GENETIC RECOMBINATION; GENETICS; METABOLISM; NERVE CELL; PHYSIOLOGY; PROMOTER REGION; REGULATORY SEQUENCE; TISSUE DISTRIBUTION; TRANSGENIC MOUSE;

ANIMALS; BACTERIAL PROTEINS; BRAIN; DENDRITES; GENE TRANSFER TECHNIQUES; INTEGRASES; LUMINESCENT PROTEINS; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MICROSCOPY, CONFOCAL; NEURONS; PROMOTER REGIONS, GENETIC; RECOMBINATION, GENETIC; REGULATORY SEQUENCES, NUCLEIC ACID; TAMOXIFEN; TISSUE DISTRIBUTION; VIRAL PROTEINS;

EID: 73949140059     PISSN: 10976256     EISSN: None     Source Type: Journal    
DOI: 10.1038/nn.2467     Document Type: Article

References (46)

1. Feng, G. et al. Imaging neuronal subsets in transgenic mice expressing multiple spectral variants of GFP. Neuron 28, 41-51 (2000).
2. Sugino, K. et al. Molecular taxonomy of major neuronal classes in the adult mouse forebrain. Nat. Neurosci. 9, 99-107 (2006).
3. Zong, H., Espinosa, J.S., Su, H.H., Muzumdar, M.D. & Luo, L. Mosaic analysis with double markers in mice. Cell 121, 479-492 (2005).
4. Balthasar, N. et al. Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron 42, 983-991 (2004).
5. Kellendonk, C. et al. Transient and selective overexpression of dopamine D2 receptors in the striatum causes persistent abnormalities in prefrontal cortex functioning. Neuron 49, 603-615 (2006).
6. McHugh, T.J. et al. Dentate gyrus NMDA receptors mediate rapid pattern separation in the hippocampal network. Science 317, 94-99 (2007).
7. Karpova, A.Y., Tervo, D.G., Gray, N.W. & Svoboda, K. Rapid and reversible chemical inactivation of synaptic transmission in genetically targeted neurons. Neuron 48, 727-735 (2005).
8. Luquet, S., Perez, F.A., Hnasko, T.S. & Palmiter, R.D. NPY/AgRP neurons are essential for feeding in adult mice but can be ablated in neonates. Science 310, 683-685 (2005).
9. Nakashiba, T., Young, J.Z., McHugh, T.J., Buhl, D.L. & Tonegawa, S. Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning. Science 319, 1260-1264 (2008).
10. Barth, A.L. Visualizing circuits and systems using transgenic reporters of neural activity. Curr. Opin. Neurobiol. 17, 567-571 (2007).
11. Luo, L., Callaway, E.M. & Svoboda, K. Genetic dissection of neural circuits. Neuron 57, 634-660 (2008).
12. Xu, X., Roby, K.D. & Callaway, E.M. Mouse cortical inhibitory neuron type that coexpresses somatostatin and calretinin. J. Comp. Neurol. 499, 144-160 (2006).
13. Holtmaat, A., Wilbrecht, L., Knott, G.W., Welker, E. & Svoboda, K. Experience-dependent and cell-type-specifc spine growth in the neocortex. Nature 441, 979-983 (2006). (Pubitemid 43980351)
14. Livet, J. et al. Transgenic strategies for combinatorial expression of fuorescent proteins in the nervous system. Nature 450, 56-62 (2007).
15. Boyden, E.S., Zhang, F., Bamberg, E., Nagel, G. & Deisseroth, K. Millisecond-timescale, genetically targeted optical control of neural activity. Nat. Neurosci. 8, 1263-1268 (2005).
16. Arenkiel, B.R. et al. In vivo light-induced activation of neural circuitry in transgenic mice expressing channelrhodopsin-2. Neuron 54, 205-218 (2007).
17. Soriano, P. Generalized lacZ expression with the ROSA26 Cre reporter strain. Nat. Genet. 21, 70-71 (1999).
18. Srinivas, S. et al. Cre reporter strains produced by targeted insertion of EYFP and ECFP into the ROSA26 locus. BMC Dev. Biol. 1, 4 (2001).
19. Novak, A., Guo, C., Yang, W., Nagy, A. & Lobe, C.G. Z/EG, a double reporter mouse line that expresses enhanced green fuorescent protein upon Cre-mediated excision. Genesis 28, 147-155 (2000).
20. Muzumdar, M.D., Tasic, B., Miyamichi, K., Li, L. & Luo, L. A global double-fuorescent Cre reporter mouse. Genesis 45, 593-605 (2007).
21. Shaner, N.C., Patterson, G.H. & Davidson, M.W. Advances in fuorescent protein technology. J. Cell Sci. 120, 4247-4260 (2007).
22. Zufferey, R., Donello, J.E., Trono, D. & Hope, T.J. Woodchuck hepatitis virus posttranscriptional regulatory element enhances expression of transgenes delivered by retroviral vectors. J. Virol. 73, 2886-2892 (1999).
23. Raymond, C.S. & Soriano, P. High-effciency FLP and PhiC31 site-specifc recombination in mammalian cells. PLoS ONE 2, e162 (2007).
24. Lein, E.S. et al. Genome-wide atlas of gene expression in the adult mouse brain. Nature 445, 168-176 (2007).
25. Zhuang, X., Masson, J., Gingrich, J.A., Rayport, S. & Hen, R. Targeted gene expression in dopamine and serotonin neurons of the mouse brain. J. Neurosci. Methods 143, 27-32 (2005).
26. Lewis, P.M., Gritli-Linde, A., Smeyne, R., Kottmann, A. & McMahon, A.P. Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev. Biol. 270, 393-410 (2004).
27. Gong, S. et al. Targeting Cre recombinase to specifc neuron populations with bacterial artifcial chromosome constructs. J. Neurosci. 27, 9817-9823 (2007).
28. Dong, H.W. The Allen Reference Atlas: A Digital Color Brain Atlas of the C57BL/6J Male Mouse (Wiley, Hoboken, New Jersey, USA, 2008).
29. Ng, L. et al. Neuroinformatics for genome-wide 3D gene expression mapping in the mouse brain. IEEE/ACM Trans. Comput. Biol. Bioinform. 4, 382-393 (2007).
30. Lau, C. et al. Exploration and visualization of gene expression with neuroanatomy in the adult mouse brain. BMC Bioinformatics 9, 153 (2008).
31. Coulter, C.L., Happe, H.K. & Murrin, L.C. Postnatal development of the dopamine transporter: a quantitative autoradiographic study. Brain Res. Dev. Brain Res. 92, 172-181 (1996).
32. Furuta, Y., Lagutin, O., Hogan, B.L. & Oliver, G.C. Retina-and ventral forebrain-specifc Cre recombinase activity in transgenic mice. Genesis 26, 130-132 (2000).
33. Szymczak, A.L. et al. Correction of multi-gene defciency in vivo using a single 'self-cleaving' 2A peptide-based retroviral vector. Nat. Biotechnol. 22, 589-594 (2004).
34. Hippenmeyer, S. et al. A developmental switch in the response of DRG neurons to ETS transcription factor signaling. PLoS Biol. 3, e159 (2005).
35. Atasoy, D., Aponte, Y., Su, H.H. & Sternson, S.M.A. FLEX switch targets Channelrhodopsin-2 to multiple cell types for imaging and long-range circuit mapping. J. Neurosci. 28, 7025-7030 (2008).
36. Kuhlman, S.J. & Huang, Z.J. High-resolution labeling and functional manipulation of specifc neuron types in mouse brain by Cre-activated viral gene expression. PLoS ONE 3, e2005 (2008).
37. Rotolo, T., Smallwood, P.M., Williams, J. & Nathans, J. Genetically-directed, cell type-specifc sparse labeling for the analysis of neuronal morphology. PLoS ONE 3, e4099 (2008).
38. Tsien, J.Z. et al. Subregion-and cell type-restricted gene knockout in mouse brain. Cell 87, 1317-1326 (1996).
39. Heusner, C.L., Beutler, L.R., Houser, C.R. & Palmiter, R.D. Deletion of GAD67 in dopamine receptor-1 expressing cells causes specifc motor defcits. Genesis 46, 357-367 (2008).
40. Gorski, J.A. et al. Cortical excitatory neurons and glia, but not GABAergic neurons, are produced in the Emx1-expressing lineage. J. Neurosci. 22, 6309-6314 (2002).
41. Zhuo, L. et al. hGFAP-cre transgenic mice for manipulation of glial and neuronal function in vivo. Genesis 31, 85-94 (2001).
42. George, S.H. et al. Developmental and adult phenotyping directly from mutant embryonic stem cells. Proc. Natl. Acad. Sci. USA 104, 4455-4460 (2007).
43. Zhang, Y., Buchholz, F., Muyrers, J.P. & Stewart, A.F. A new logic for DNA engineering using recombination in Escherichia coli. Nat. Genet. 20, 123-128 (1998).
44. Thompson, C.L. et al. Genomic anatomy of the hippocampus. Neuron 60, 1010-1021 (2008).
45. Tsai, P.S. et al. Principle, design and construction of a two photon laser-scanning microscope for in vitro and in vivo brain imaging. in In Vivo Optical Imaging of Brain Function (ed. Frostig, R.D.) 113-172 (CRC, Boca Raton, Florida, USA, 2002).
46. Garaschuk, O., Milos, R.I. & Konnerth, A. Targeted bulk-loading of fuorescent indicators for two-photon brain imaging in vivo. Nat. Protoc. 1, 380-386 (2006).