Engraftment of a galactose receptor footprint onto adeno-associated viral capsids improves transduction efficiency

Journal of Biological Chemistry

Volumn 288, Issue 40, 2013, Pages 28814-28823

  Shen, Shen ^a   Horowitz, Eric D ^a   Troupes, Andrew N ^a   Brown, Sarah M ^a   Pulicherla, Nagesh ^a   Samulski, Richard J ^a   Agbandje McKenna, Mavis ^b   Asokan, Aravind ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL SURFACES; ENGRAFTMENT; GLYCANS; HOST CELLS; SEROTYPES; THERAPEUTIC GENE-TRANSFER; TRANSDUCTION EFFICIENCY; VIRAL CAPSIDS;

CELL MEMBRANES; COMPUTER VIRUSES; GENE TRANSFER; POLYSACCHARIDES;

BACTERIOPHAGES;

CAPSID PROTEIN; GALACTOSE; GALACTOSE RECEPTOR; GLYCAN; GLYCAN RECEPTOR; PARVOVIRUS VECTOR; PROTEOHEPARAN SULFATE; UNCLASSIFIED DRUG;

ADENO ASSOCIATED VIRUS; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOHYDRATE SYNTHESIS; GALACTOSE BINDING FOOTPRINT; GENE EXPRESSION; GENE TRANSFER; GENETIC ENGINEERING AND GENE TECHNOLOGY; GENETIC TRANSDUCTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEROTYPE; SITE DIRECTED MUTAGENESIS; TRANSGENE; VIRAL GENE DELIVERY SYSTEM; VIRUS ATTACHMENT; VIRUS STRAIN; VIRUS TITRATION;

ADENO-ASSOCIATED VIRUS; CARBOHYDRATE; CELL SURFACE RECEPTOR; GENE THERAPY; PROTEIN ENGINEERING; VIRUS ENTRY;

ANIMALS; CAPSID; CHICKENS; CHO CELLS; CRICETINAE; CRICETULUS; DEPENDOVIRUS; FEMALE; GALACTOSE; GENE EXPRESSION; HEPARIN; HEPARITIN SULFATE; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MUSCLE, SKELETAL; PROTEIN BINDING; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS; SEROTYPING; TRANSDUCTION, GENETIC; TRANSGENES;

EID: 84885171074     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.482380     Document Type: Article

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