Efficient sampling of SCHEMA chimera families to identify useful sequence elements

Methods in Enzymology

Volumn 523, Issue , 2013, Pages 351-368

  Heinzelman, Pete ^a   Romero, Philip A ^b   Arnold, Frances H ^b  

^a University of Oklahoma   (United States)

^b California Institute of Technology   (United States)

Author keywords

Active learning; Cellulase; Cytochrome P450; Directed evolution library design; Enzyme engineering; Homologous recombination; Protein fitness landscape; Protein stability

Indexed keywords

AMINO ACID; BETA LACTAMASE; CELLULOSE 1,4 BETA CELLOBIOSIDASE; CYTOCHROME P450; GLYCOSIDASE;

AMINO ACID SEQUENCE; ARTICLE; BAYES THEOREM; CHIMERA; CRYSTAL STRUCTURE; ENTROPY; ENZYME ACTIVITY; ENZYME DENATURATION; ESCHERICHIA COLI; GENE SYNTHESIS; HETEROLOGOUS EXPRESSION; INCUBATION TIME; LEARNING ALGORITHM; LINEAR REGRESSION ANALYSIS; NONHUMAN; PARENT; PREDICTION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FAMILY; SACCHAROMYCES CEREVISIAE; THERMOSTABILITY; VALIDATION PROCESS;

EID: 84874032890     PISSN: 00766879     EISSN: 15577988     Source Type: Book Series    
DOI: 10.1016/B978-0-12-394292-0.00016-3     Document Type: Chapter

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