SCHEMA-Designed variants of human arginase I and II reveal sequence elements important to stability and catalysis

ACS Synthetic Biology

Volumn 1, Issue 6, 2012, Pages 221-228

  Romero, Philip A ^a   Stone, Everett ^c   Lamb, Candice ^c   Chantranupong, Lynne ^c   Krause, Andreas ^a,b   Miklos, Aleksandr E ^c   Hughes, Randall A ^c   Fechtel, Blake ^c   Ellington, Andrew D ^c   Arnold, Frances H ^a   Georgiou, George ^c  

^a CALIFORNIA INSTITUTE OF TECHNOLOGY   (United States)

^b ETH ZURICH   (Switzerland)

^c UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Active learning; Arginase; Enzyme engineering; Homologous recombination; Protein stability; SCHEMA library design

Indexed keywords

ARGINASE 1; ARGINASE 2; ISOENZYME; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; DNA LIBRARY; ENZYME REPLACEMENT; ENZYME STABILITY; GENE MUTATION; GENE SYNTHESIS; HUMAN; HYDROLYSIS; HYPERARGININEMIA; PRIORITY JOURNAL; SCHEMA LIBRARY;

ALGORITHMS; ARGINASE; CATALYSIS; COMPUTER-AIDED DESIGN; ENZYME STABILITY; HUMANS; MODELS, MOLECULAR; RECOMBINANT FUSION PROTEINS; SYNTHETIC BIOLOGY;

EID: 84868117425     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/sb300014t     Document Type: Article

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