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Volumn 52, Issue 11, 2017, Pages 1185-1193

Mucosal immune system of the gastrointestinal tract: maintaining balance between the good and the bad

Author keywords

Epithelial barrier; GALT; gut microbiota; immune homeostasis; lamina propria; mucosal immunity; mucosal tolerance

Indexed keywords

ANTIGEN;

EID: 85029681208     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365521.2017.1349173     Document Type: Review
Times cited : (158)

References (91)
  • 2
    • 0038316325 scopus 로고    scopus 로고
    • Anatomical basis of tolerance and immunity to intestinal antigens
    • Mowat AM., Anatomical basis of tolerance and immunity to intestinal antigens. Nat Rev Immunol. 2003;3:331–341.
    • (2003) Nat Rev Immunol , vol.3 , pp. 331-341
    • Mowat, A.M.1
  • 3
    • 48649110421 scopus 로고    scopus 로고
    • Terminology: nomenclature of mucosa-associated lymphoid tissue
    • Brandtzaeg P, Kiyono H, Pabst R, et al. Terminology: nomenclature of mucosa-associated lymphoid tissue. Mucosal Immunol. 2008;1:31–37.
    • (2008) Mucosal Immunol , vol.1 , pp. 31-37
    • Brandtzaeg, P.1    Kiyono, H.2    Pabst, R.3
  • 4
    • 0030900764 scopus 로고    scopus 로고
    • The anatomical basis of intestinal immunity
    • Mowat AM, Viney JL., The anatomical basis of intestinal immunity. Immunol Rev. 1997;156:145–166.
    • (1997) Immunol Rev , vol.156 , pp. 145-166
    • Mowat, A.M.1    Viney, J.L.2
  • 5
    • 84896851032 scopus 로고    scopus 로고
    • Intestinal epithelial cells: regulators of barrier function and immune homeostasis
    • Peterson LW, Artis D., Intestinal epithelial cells: regulators of barrier function and immune homeostasis. Nat Rev Immunol. 2014;14:141–153.
    • (2014) Nat Rev Immunol , vol.14 , pp. 141-153
    • Peterson, L.W.1    Artis, D.2
  • 6
    • 79954915318 scopus 로고    scopus 로고
    • Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis
    • Bevins CL, Salzman NH., Paneth cells, antimicrobial peptides and maintenance of intestinal homeostasis. Nat Rev Microbiol. 2011;9:356–368.
    • (2011) Nat Rev Microbiol , vol.9 , pp. 356-368
    • Bevins, C.L.1    Salzman, N.H.2
  • 7
    • 84866237041 scopus 로고    scopus 로고
    • The gut barrier: new acquisitions and therapeutic approaches
    • Scaldaferri F, Pizzoferrato M, Gerardi V, et al. The gut barrier: new acquisitions and therapeutic approaches. J Clin Gastroenterol. 2012;46:S12–S17.
    • (2012) J Clin Gastroenterol , vol.46 , pp. S12-S17
    • Scaldaferri, F.1    Pizzoferrato, M.2    Gerardi, V.3
  • 8
    • 84922708862 scopus 로고    scopus 로고
    • Intestinal permeability-a new target for disease prevention and therapy
    • Bischoff SC, Barbara G, Buurman W, et al. Intestinal permeability-a new target for disease prevention and therapy. BMC Gastroenterol. 2014;14:189.
    • (2014) BMC Gastroenterol , vol.14 , pp. 189
    • Bischoff, S.C.1    Barbara, G.2    Buurman, W.3
  • 9
    • 67649216750 scopus 로고    scopus 로고
    • Intestinal barrier function: molecular regulation and disease pathogenesis
    • quiz 1–2
    • Groschwitz KR, Hogan SP., Intestinal barrier function: molecular regulation and disease pathogenesis. J Allergy Clin Immunol. 2009;124:3–20. quiz 1–2.
    • (2009) J Allergy Clin Immunol , vol.124 , pp. 3-20
    • Groschwitz, K.R.1    Hogan, S.P.2
  • 10
    • 44449099036 scopus 로고    scopus 로고
    • Tight junctions and the modulation of barrier function in disease
    • Forster C., Tight junctions and the modulation of barrier function in disease. Histochem Cell Biol. 2008;130:55–70.
    • (2008) Histochem Cell Biol , vol.130 , pp. 55-70
    • Forster, C.1
  • 11
    • 0026752739 scopus 로고
    • Structure, function, and regulation of cellular tight junctions
    • Schneeberger EE, Lynch RD., Structure, function, and regulation of cellular tight junctions. Am J Physiol. 1992;262:L647–L661.
    • (1992) Am J Physiol , vol.262 , pp. L647-L661
    • Schneeberger, E.E.1    Lynch, R.D.2
  • 12
    • 84926189914 scopus 로고    scopus 로고
    • Crosstalk at the mucosal border: importance of the gut microenvironment in IBS
    • 2015
    • Ohman L, Tornblom H, Simren M., Crosstalk at the mucosal border: importance of the gut microenvironment in IBS. Nat Rev Gastroenterol Hepatol. 2015;12:36–49.
    • Nat Rev Gastroenterol Hepatol , vol.12 , pp. 36-49
    • Ohman, L.1    Tornblom, H.2    Simren, M.3
  • 13
    • 77958170401 scopus 로고    scopus 로고
    • Intestinal goblet cells and mucins in health and disease: recent insights and progress
    • Kim YS, Ho SB., Intestinal goblet cells and mucins in health and disease: recent insights and progress. Curr Gastroenterol Rep. 2010;12:319–330.
    • (2010) Curr Gastroenterol Rep , vol.12 , pp. 319-330
    • Kim, Y.S.1    Ho, S.B.2
  • 14
    • 84883319282 scopus 로고    scopus 로고
    • Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches
    • Ermund A, Schutte A, Johansson ME, et al. Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patches. Am J Physiol Gastrointest Liver Physiol. 2013;305:G341–G347.
    • (2013) Am J Physiol Gastrointest Liver Physiol , vol.305 , pp. G341-G347
    • Ermund, A.1    Schutte, A.2    Johansson, M.E.3
  • 15
    • 77954858707 scopus 로고    scopus 로고
    • The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria
    • Hansson GC, Johansson ME., The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteria. Gut Microbes. 2010;1:51–54.
    • (2010) Gut Microbes , vol.1 , pp. 51-54
    • Hansson, G.C.1    Johansson, M.E.2
  • 16
    • 84862862332 scopus 로고    scopus 로고
    • Epithelial antimicrobial defence of the skin and intestine
    • Gallo RL, Hooper LV., Epithelial antimicrobial defence of the skin and intestine. Nat Rev Immunol. 2012;12:503–516.
    • (2012) Nat Rev Immunol , vol.12 , pp. 503-516
    • Gallo, R.L.1    Hooper, L.V.2
  • 17
    • 38649137730 scopus 로고    scopus 로고
    • 4. Gastrointestinal mucosal immunity
    • Wershil BK, Furuta GT., 4. Gastrointestinal mucosal immunity. J Allergy Clin Immunol. 2008;121:S380–S383; quiz S415.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. S380-S383
    • Wershil, B.K.1    Furuta, G.T.2
  • 18
    • 79959664629 scopus 로고    scopus 로고
    • The light and dark sides of intestinal intraepithelial lymphocytes
    • Cheroutre H, Lambolez F, Mucida D., The light and dark sides of intestinal intraepithelial lymphocytes. Nat Rev Immunol. 2011;11:445–456.
    • (2011) Nat Rev Immunol , vol.11 , pp. 445-456
    • Cheroutre, H.1    Lambolez, F.2    Mucida, D.3
  • 19
    • 2542477129 scopus 로고    scopus 로고
    • Starting at the beginning: new perspectives on the biology of mucosal T cells
    • Cheroutre H., Starting at the beginning: new perspectives on the biology of mucosal T cells. Annu Rev Immunol. 2004;22:217–246.
    • (2004) Annu Rev Immunol , vol.22 , pp. 217-246
    • Cheroutre, H.1
  • 20
    • 84921786777 scopus 로고    scopus 로고
    • Regional specialization within the intestinal immune system
    • Mowat AM, Agace WW., Regional specialization within the intestinal immune system. Nat Rev Immunol. 2014;14:667–685.
    • (2014) Nat Rev Immunol , vol.14 , pp. 667-685
    • Mowat, A.M.1    Agace, W.W.2
  • 21
    • 0037013968 scopus 로고    scopus 로고
    • A unique subset of self-specific intraintestinal T cells maintains gut integrity
    • Poussier P, Ning T, Banerjee D, et al. A unique subset of self-specific intraintestinal T cells maintains gut integrity. J Exp Med. 2002;195:1491–1497.
    • (2002) J Exp Med , vol.195 , pp. 1491-1497
    • Poussier, P.1    Ning, T.2    Banerjee, D.3
  • 22
    • 0027944111 scopus 로고
    • Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin
    • Cepek KL, Shaw SK, Parker CM, et al. Adhesion between epithelial cells and T lymphocytes mediated by E-cadherin and the alpha E beta 7 integrin. Nature. 1994;372:190–193.
    • (1994) Nature , vol.372 , pp. 190-193
    • Cepek, K.L.1    Shaw, S.K.2    Parker, C.M.3
  • 23
    • 0037195101 scopus 로고    scopus 로고
    • Protection of the intestinal mucosa by intraepithelial gamma delta T cells
    • Chen Y, Chou K, Fuchs E, et al. Protection of the intestinal mucosa by intraepithelial gamma delta T cells. Proc Natl Acad Sci USA. 2002;99:14338–14343.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 14338-14343
    • Chen, Y.1    Chou, K.2    Fuchs, E.3
  • 24
    • 2542456800 scopus 로고    scopus 로고
    • Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases
    • Tlaskalova-Hogenova H, Stepankova R, Hudcovic T, et al. Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases. Immunol Lett. 2004;93:97–108.
    • (2004) Immunol Lett , vol.93 , pp. 97-108
    • Tlaskalova-Hogenova, H.1    Stepankova, R.2    Hudcovic, T.3
  • 25
    • 1842610056 scopus 로고    scopus 로고
    • Interactions of bacterial pathogens with the host mucosal immune system. Mucosal immune responses
    • Acheson DW, Luccioli S., Interactions of bacterial pathogens with the host mucosal immune system. Mucosal immune responses. Best Pract Res Clin Gastroenterol. 2004;18:387–404.
    • (2004) Best Pract Res Clin Gastroenterol , vol.18 , pp. 387-404
    • Acheson, D.W.1    Luccioli, S.2
  • 26
    • 34249298734 scopus 로고    scopus 로고
    • Control of intestinal homeostasis by regulatory T cells and dendritic cells
    • Coombes JL, Maloy KJ., Control of intestinal homeostasis by regulatory T cells and dendritic cells. Semin Immunol. 2007;19:116–126.
    • (2007) Semin Immunol , vol.19 , pp. 116-126
    • Coombes, J.L.1    Maloy, K.J.2
  • 27
    • 84886076321 scopus 로고    scopus 로고
    • Factors affecting mucosal homeostasis: a fine balance
    • Stephan R., Targan F.S., Karp, LC, (eds), London (UK): Wiley-Blackwell,. In:, editors.,. p
    • Atreya R, Neurath MF., Factors affecting mucosal homeostasis: a fine balance. In: Stephan R, Targan FS, Karp LC, editors. Inflammatory bowel disease: translating basic science into clinical practice. London (UK): Wiley-Blackwell; 2010. p. 52–60.
    • (2010) Inflammatory bowel disease: translating basic science into clinical practice , pp. 52-60
    • Atreya, R.1    Neurath, M.F.2
  • 28
    • 0031864836 scopus 로고    scopus 로고
    • Spontaneous secretion of interferon gamma and interleukin 4 by human intraepithelial and lamina propria gut lymphocytes
    • Carol M, Lambrechts A, Van Gossum A, et al. Spontaneous secretion of interferon gamma and interleukin 4 by human intraepithelial and lamina propria gut lymphocytes. Gut. 1998;42:643–649.
    • (1998) Gut , vol.42 , pp. 643-649
    • Carol, M.1    Lambrechts, A.2    Van Gossum, A.3
  • 29
    • 79956063855 scopus 로고    scopus 로고
    • Peyer's patches: the immune sensors of the intestine
    • Jung C, Hugot JP, Barreau F., Peyer's patches: the immune sensors of the intestine. Int J Inflam. 2010;2010:823710.
    • (2010) Int J Inflam , vol.2010 , pp. 823710
    • Jung, C.1    Hugot, J.P.2    Barreau, F.3
  • 30
    • 84879336857 scopus 로고    scopus 로고
    • Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium
    • Mabbott NA, Donaldson DS, Ohno H, et al. Microfold (M) cells: important immunosurveillance posts in the intestinal epithelium. Mucosal Immunol. 2013;6:666–677.
    • (2013) Mucosal Immunol , vol.6 , pp. 666-677
    • Mabbott, N.A.1    Donaldson, D.S.2    Ohno, H.3
  • 31
    • 0347510684 scopus 로고    scopus 로고
    • The mucosal immune system
    • MacDonald TT., The mucosal immune system. Parasite Immunol. 2003;25:235–246.
    • (2003) Parasite Immunol , vol.25 , pp. 235-246
    • MacDonald, T.T.1
  • 32
    • 23344445169 scopus 로고    scopus 로고
    • Organizing a mucosal defense
    • Newberry RD, Lorenz RG., Organizing a mucosal defense. Immunol Rev. 2005;206:6–21.
    • (2005) Immunol Rev , vol.206 , pp. 6-21
    • Newberry, R.D.1    Lorenz, R.G.2
  • 33
    • 33750448647 scopus 로고    scopus 로고
    • Normal structure, function, and histology of lymph nodes
    • Willard-Mack CL., Normal structure, function, and histology of lymph nodes. Toxicol Pathol. 2006;34:409–424.
    • (2006) Toxicol Pathol , vol.34 , pp. 409-424
    • Willard-Mack, C.L.1
  • 34
    • 84864766327 scopus 로고    scopus 로고
    • Lymph node dissection-understanding the immunological function of lymph nodes
    • Buettner M, Bode U. Lymph node dissection-understanding the immunological function of lymph nodes. Clin Exp Immunol. 2012;169:205–212.
    • (2012) Clin Exp Immunol , vol.169 , pp. 205-212
    • Buettner, M.1    Bode, U.2
  • 35
    • 84959453255 scopus 로고    scopus 로고
    • Mucosal immunity to pathogenic intestinal bacteria
    • Perez-Lopez A, Behnsen J, Nuccio SP, et al. Mucosal immunity to pathogenic intestinal bacteria. Nat Rev Immunol. 2016;16:135–148.
    • (2016) Nat Rev Immunol , vol.16 , pp. 135-148
    • Perez-Lopez, A.1    Behnsen, J.2    Nuccio, S.P.3
  • 36
    • 34247642257 scopus 로고    scopus 로고
    • Intestinal M cells: the fallible sentinels?
    • Miller H, Zhang J, Kuolee R, et al. Intestinal M cells: the fallible sentinels? World J Gastroenterol. 2007;13:1477–1486.
    • (2007) World J Gastroenterol , vol.13 , pp. 1477-1486
    • Miller, H.1    Zhang, J.2    Kuolee, R.3
  • 37
    • 3242662009 scopus 로고    scopus 로고
    • Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease
    • Bilsborough J, Viney JL., Gastrointestinal dendritic cells play a role in immunity, tolerance, and disease. Gastroenterology. 2004;127:300–309.
    • (2004) Gastroenterology , vol.127 , pp. 300-309
    • Bilsborough, J.1    Viney, J.L.2
  • 38
    • 12244297799 scopus 로고    scopus 로고
    • CX(3)CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance
    • Niess JH, Brand S, Gu XB, et al. CX(3)CR1-mediated dendritic cell access to the intestinal lumen and bacterial clearance. Science. 2005;307:254–258.
    • (2005) Science , vol.307 , pp. 254-258
    • Niess, J.H.1    Brand, S.2    Gu, X.B.3
  • 39
    • 0032528838 scopus 로고    scopus 로고
    • Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells
    • Hershberg RM, Cho DH, Youakim A, et al. Highly polarized HLA class II antigen processing and presentation by human intestinal epithelial cells. J Clin Invest. 1998;102:792–803.
    • (1998) J Clin Invest , vol.102 , pp. 792-803
    • Hershberg, R.M.1    Cho, D.H.2    Youakim, A.3
  • 40
    • 84855290942 scopus 로고    scopus 로고
    • Prion uptake in the gut: identification of the first uptake and replication sites
    • Kujala P, Raymond CR, Romeijn M, et al. Prion uptake in the gut: identification of the first uptake and replication sites. Plos Pathog. 2011;7:e1002449.
    • (2011) Plos Pathog , vol.7 , pp. e1002449
    • Kujala, P.1    Raymond, C.R.2    Romeijn, M.3
  • 41
    • 84863230541 scopus 로고    scopus 로고
    • Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
    • McDole JR, Wheeler LW, McDonald KG, et al. Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine. Nature. 2012;483:345–349.
    • (2012) Nature , vol.483 , pp. 345-349
    • McDole, J.R.1    Wheeler, L.W.2    McDonald, K.G.3
  • 42
    • 33847183077 scopus 로고    scopus 로고
    • Cooperation of Toll-like receptor signals in innate immune defence
    • Trinchieri G, Sher A., Cooperation of Toll-like receptor signals in innate immune defence. Nat Rev Immunol. 2007;7:179–190.
    • (2007) Nat Rev Immunol , vol.7 , pp. 179-190
    • Trinchieri, G.1    Sher, A.2
  • 43
    • 0042196011 scopus 로고    scopus 로고
    • Toll-like receptor 4-mediated signaling by epithelial surfaces: necessity or threat?
    • Backhed F, Hornef M., Toll-like receptor 4-mediated signaling by epithelial surfaces: necessity or threat?. Microbes Infect. 2003;5:951–959.
    • (2003) Microbes Infect , vol.5 , pp. 951-959
    • Backhed, F.1    Hornef, M.2
  • 44
    • 8344272836 scopus 로고    scopus 로고
    • Intestinal epithelial defense systems protect against bacterial threats
    • Hurley BP, McCormick BA., Intestinal epithelial defense systems protect against bacterial threats. Curr Gastroenterol Rep. 2004;6:355–361.
    • (2004) Curr Gastroenterol Rep , vol.6 , pp. 355-361
    • Hurley, B.P.1    McCormick, B.A.2
  • 45
    • 3543059967 scopus 로고    scopus 로고
    • Innate immunity of the gut: mucosal defense in health and disease
    • Yuan Q, Walker WA., Innate immunity of the gut: mucosal defense in health and disease. J Pediatr Gastroenterol Nutr. 2004;38:463–473.
    • (2004) J Pediatr Gastroenterol Nutr , vol.38 , pp. 463-473
    • Yuan, Q.1    Walker, W.A.2
  • 46
    • 84856338782 scopus 로고    scopus 로고
    • The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use
    • Perera PY, Lichy JH, Waldmann TA, et al. The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use. Microbes Infect. 2012;14:247–261.
    • (2012) Microbes Infect , vol.14 , pp. 247-261
    • Perera, P.Y.1    Lichy, J.H.2    Waldmann, T.A.3
  • 48
    • 84864971523 scopus 로고    scopus 로고
    • Functions of IL-15 in anti-viral immunity: multiplicity and variety
    • Verbist KC, Klonowski KD., Functions of IL-15 in anti-viral immunity: multiplicity and variety. Cytokine. 2012;59:467–478.
    • (2012) Cytokine , vol.59 , pp. 467-478
    • Verbist, K.C.1    Klonowski, K.D.2
  • 49
    • 41549135632 scopus 로고    scopus 로고
    • The biological functions of T helper 17 cell effector cytokines in inflammation
    • Ouyang W, Kolls JK, Zheng Y., The biological functions of T helper 17 cell effector cytokines in inflammation. Immunity. 2008;28:454–467.
    • (2008) Immunity , vol.28 , pp. 454-467
    • Ouyang, W.1    Kolls, J.K.2    Zheng, Y.3
  • 50
    • 84908148200 scopus 로고    scopus 로고
    • T follicular helper cell differentiation, function, and roles in disease
    • Crotty S., T follicular helper cell differentiation, function, and roles in disease. Immunity. 2014;41:529–542.
    • (2014) Immunity , vol.41 , pp. 529-542
    • Crotty, S.1
  • 51
    • 80355124446 scopus 로고    scopus 로고
    • The regulation and role of T follicular helper cells in immunity
    • Deenick EK, Ma CS., The regulation and role of T follicular helper cells in immunity. Immunology. 2011;134:361–367.
    • (2011) Immunology , vol.134 , pp. 361-367
    • Deenick, E.K.1    Ma, C.S.2
  • 52
    • 84902592657 scopus 로고    scopus 로고
    • IL-15: a central regulator of celiac disease immunopathology
    • Abadie V, Jabri B., IL-15: a central regulator of celiac disease immunopathology. Immunol Rev. 2014;260:221–234.
    • (2014) Immunol Rev , vol.260 , pp. 221-234
    • Abadie, V.1    Jabri, B.2
  • 53
    • 84948712534 scopus 로고    scopus 로고
    • IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction
    • Jabri B, Abadie V., IL-15 functions as a danger signal to regulate tissue-resident T cells and tissue destruction. Nat Rev Immunol. 2015;15:771–783.
    • (2015) Nat Rev Immunol , vol.15 , pp. 771-783
    • Jabri, B.1    Abadie, V.2
  • 54
    • 84856477029 scopus 로고    scopus 로고
    • Induction of gut IgA production through T cell-dependent and T cell-independent pathways
    • Bemark M, Boysen P, Lycke NY., Induction of gut IgA production through T cell-dependent and T cell-independent pathways. Ann NY Acad Sci. 2012;1247:97–116.
    • (2012) Ann NY Acad Sci , vol.1247 , pp. 97-116
    • Bemark, M.1    Boysen, P.2    Lycke, N.Y.3
  • 55
    • 84874218199 scopus 로고    scopus 로고
    • The role of Peyer's patches in synchronizing gut IgA responses
    • Lycke NY, Bemark M., The role of Peyer's patches in synchronizing gut IgA responses. Front Immunol. 2012;3:329.
    • (2012) Front Immunol , vol.3 , pp. 329
    • Lycke, N.Y.1    Bemark, M.2
  • 56
    • 0037270866 scopus 로고    scopus 로고
    • Intestinal IgA synthesis: regulation of front-line body defences
    • Fagarasan S, Honjo T., Intestinal IgA synthesis: regulation of front-line body defences. Nat Rev Immunol. 2003;3:63–72.
    • (2003) Nat Rev Immunol , vol.3 , pp. 63-72
    • Fagarasan, S.1    Honjo, T.2
  • 57
    • 0027237424 scopus 로고
    • Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1
    • Berlin C, Berg EL, Briskin MJ, et al. Alpha 4 beta 7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1. Cell. 1993;74:185–195.
    • (1993) Cell , vol.74 , pp. 185-195
    • Berlin, C.1    Berg, E.L.2    Briskin, M.J.3
  • 58
    • 2442606191 scopus 로고    scopus 로고
    • Lymphocyte trafficking across high endothelial venules: dogmas and enigmas
    • Miyasaka M, Tanaka T., Lymphocyte trafficking across high endothelial venules: dogmas and enigmas. Nat Rev Immunol. 2004;4:360–370.
    • (2004) Nat Rev Immunol , vol.4 , pp. 360-370
    • Miyasaka, M.1    Tanaka, T.2
  • 60
    • 84872977452 scopus 로고    scopus 로고
    • Innate lymphoid cells–a proposal for uniform nomenclature
    • Spits H, Artis D, Colonna M, et al. Innate lymphoid cells–a proposal for uniform nomenclature. Nat Rev Immunol. 2013;13:145–149.
    • (2013) Nat Rev Immunol , vol.13 , pp. 145-149
    • Spits, H.1    Artis, D.2    Colonna, M.3
  • 61
    • 77954411290 scopus 로고    scopus 로고
    • Mucosal T cells in gut homeostasis and inflammation
    • van Wijk F, Cheroutre H., Mucosal T cells in gut homeostasis and inflammation. Expert Rev Clin Immunol. 2010;6:559–566.
    • (2010) Expert Rev Clin Immunol , vol.6 , pp. 559-566
    • van Wijk, F.1    Cheroutre, H.2
  • 62
    • 80054963764 scopus 로고    scopus 로고
    • Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity
    • Johansen FE, Kaetzel CS., Regulation of the polymeric immunoglobulin receptor and IgA transport: new advances in environmental factors that stimulate pIgR expression and its role in mucosal immunity. Mucosal Immunol. 2011;4:598–602.
    • (2011) Mucosal Immunol , vol.4 , pp. 598-602
    • Johansen, F.E.1    Kaetzel, C.S.2
  • 64
    • 80054919389 scopus 로고    scopus 로고
    • Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut
    • Mantis NJ, Rol N, Corthesy B., Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut. Mucosal Immunol. 2011;4:603–611.
    • (2011) Mucosal Immunol , vol.4 , pp. 603-611
    • Mantis, N.J.1    Rol, N.2    Corthesy, B.3
  • 65
    • 84937714861 scopus 로고    scopus 로고
    • Long-lived plasma cells are contained within the CD19(−)CD38(hi)CD138(+) subset in human bone marrow
    • Halliley JL, Tipton CM, Liesveld J, et al. Long-lived plasma cells are contained within the CD19(−)CD38(hi)CD138(+) subset in human bone marrow. Immunity. 2015;43:132–145.
    • (2015) Immunity , vol.43 , pp. 132-145
    • Halliley, J.L.1    Tipton, C.M.2    Liesveld, J.3
  • 66
    • 33749018225 scopus 로고    scopus 로고
    • Competence and competition: the challenge of becoming a long-lived plasma cell
    • Radbruch A, Muehlinghaus G, Luger EO, et al. Competence and competition: the challenge of becoming a long-lived plasma cell. Nat Rev Immunol. 2006;6:741–750.
    • (2006) Nat Rev Immunol , vol.6 , pp. 741-750
    • Radbruch, A.1    Muehlinghaus, G.2    Luger, E.O.3
  • 67
    • 84920662099 scopus 로고    scopus 로고
    • Intestinal mucosal tolerance and impact of gut microbiota to mucosal tolerance
    • Chistiakov DA, Bobryshev YV, Kozarov E, et al. Intestinal mucosal tolerance and impact of gut microbiota to mucosal tolerance. Front Microbiol. 2014;5:781.
    • (2014) Front Microbiol , vol.5 , pp. 781
    • Chistiakov, D.A.1    Bobryshev, Y.V.2    Kozarov, E.3
  • 68
    • 84859808080 scopus 로고    scopus 로고
    • Oral tolerance to food protein
    • Pabst O, Mowat AM., Oral tolerance to food protein. Mucosal Immunol. 2012;5:232–239.
    • (2012) Mucosal Immunol , vol.5 , pp. 232-239
    • Pabst, O.1    Mowat, A.M.2
  • 69
    • 77954738601 scopus 로고    scopus 로고
    • Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota
    • Round JL, Mazmanian SK., Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota. Proc Natl Acad Sci USA. 2010;107:12204–12209.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 12204-12209
    • Round, J.L.1    Mazmanian, S.K.2
  • 70
    • 43949105866 scopus 로고    scopus 로고
    • Regulatory T cells and immune tolerance
    • Sakaguchi S, Yamaguchi T, Nomura T, et al. Regulatory T cells and immune tolerance. Cell. 2008;133:775–787.
    • (2008) Cell , vol.133 , pp. 775-787
    • Sakaguchi, S.1    Yamaguchi, T.2    Nomura, T.3
  • 71
    • 84959872333 scopus 로고    scopus 로고
    • Role of regulatory T cell in the pathogenesis of inflammatory bowel disease
    • Yamada A, Arakaki R, Saito M, et al. Role of regulatory T cell in the pathogenesis of inflammatory bowel disease. World J Gastroenterol. 2016;22:2195–2205.
    • (2016) World J Gastroenterol , vol.22 , pp. 2195-2205
    • Yamada, A.1    Arakaki, R.2    Saito, M.3
  • 72
    • 71649084107 scopus 로고    scopus 로고
    • T cells, dendritic cells and epithelial cells in intestinal homeostasis
    • Westendorf AM, Fleissner D, Hansen W, et al. T cells, dendritic cells and epithelial cells in intestinal homeostasis. Int J Med Microbiol. 2010;300:11–18.
    • (2010) Int J Med Microbiol , vol.300 , pp. 11-18
    • Westendorf, A.M.1    Fleissner, D.2    Hansen, W.3
  • 73
    • 53849125398 scopus 로고    scopus 로고
    • Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells
    • Tsuji NM, Kosaka A., Oral tolerance: intestinal homeostasis and antigen-specific regulatory T cells. Trends Immunol. 2008;29:532–540.
    • (2008) Trends Immunol , vol.29 , pp. 532-540
    • Tsuji, N.M.1    Kosaka, A.2
  • 74
    • 84936818775 scopus 로고    scopus 로고
    • Effector and suppressor T cells in celiac disease
    • Mazzarella G., Effector and suppressor T cells in celiac disease. World J Gastroenterol. 2015;21:7349–7356.
    • (2015) World J Gastroenterol , vol.21 , pp. 7349-7356
    • Mazzarella, G.1
  • 75
  • 76
    • 84868109200 scopus 로고    scopus 로고
    • Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease
    • e1
    • Desreumaux P, Foussat A, Allez M, et al. Safety and efficacy of antigen-specific regulatory T-cell therapy for patients with refractory Crohn's disease. Gastroenterology. 2012;143:1207–1217. e1–2;
    • (2012) Gastroenterology , vol.143 , pp. 1207-1217
    • Desreumaux, P.1    Foussat, A.2    Allez, M.3
  • 78
    • 0036828289 scopus 로고    scopus 로고
    • Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells
    • Allez M, Brimnes J, Dotan I, et al. Expansion of CD8+ T cells with regulatory function after interaction with intestinal epithelial cells. Gastroenterology. 2002;123:1516–1526.
    • (2002) Gastroenterology , vol.123 , pp. 1516-1526
    • Allez, M.1    Brimnes, J.2    Dotan, I.3
  • 79
    • 17844363998 scopus 로고    scopus 로고
    • Defects in CD8+ regulatory T cells in the lamina propria of patients with inflammatory bowel disease
    • Brimnes J, Allez M, Dotan I, et al. Defects in CD8+ regulatory T cells in the lamina propria of patients with inflammatory bowel disease. J Immunol. 2005;174:5814–5822.
    • (2005) J Immunol , vol.174 , pp. 5814-5822
    • Brimnes, J.1    Allez, M.2    Dotan, I.3
  • 80
    • 78149455416 scopus 로고    scopus 로고
    • Local induction of immunosuppressive CD8+ T cells in the gut-associated lymphoid tissues
    • Fleissner D, Hansen W, Geffers R, et al. Local induction of immunosuppressive CD8+ T cells in the gut-associated lymphoid tissues. PLoS One. 2010;5:e15373.
    • (2010) PLoS One , vol.5
    • Fleissner, D.1    Hansen, W.2    Geffers, R.3
  • 81
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes JL, Siddiqui KR, Arancibia-Carcamo CV, et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med. 2007;204:1757–1764.
    • (2007) J Exp Med , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3
  • 82
    • 18244387204 scopus 로고    scopus 로고
    • Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells
    • Rimoldi M, Chieppa M, Salucci V, et al. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat Immunol. 2005;6:507–514.
    • (2005) Nat Immunol , vol.6 , pp. 507-514
    • Rimoldi, M.1    Chieppa, M.2    Salucci, V.3
  • 83
    • 33645054315 scopus 로고    scopus 로고
    • Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells
    • Worbs T, Bode U, Yan S, et al. Oral tolerance originates in the intestinal immune system and relies on antigen carriage by dendritic cells. J Exp Med. 2006;203:519–527.
    • (2006) J Exp Med , vol.203 , pp. 519-527
    • Worbs, T.1    Bode, U.2    Yan, S.3
  • 84
    • 84876913132 scopus 로고    scopus 로고
    • Role of the gut microbiota in immunity and inflammatory disease
    • Kamada N, Seo SU, Chen GY, et al. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol. 2013;13:321–335.
    • (2013) Nat Rev Immunol , vol.13 , pp. 321-335
    • Kamada, N.1    Seo, S.U.2    Chen, G.Y.3
  • 85
    • 67349250428 scopus 로고    scopus 로고
    • The gut microbiota shapes intestinal immune responses during health and disease
    • Round JL, Mazmanian SK., The gut microbiota shapes intestinal immune responses during health and disease. Nat Rev Immunol. 2009;9:313–323.
    • (2009) Nat Rev Immunol , vol.9 , pp. 313-323
    • Round, J.L.1    Mazmanian, S.K.2
  • 86
    • 84961616479 scopus 로고    scopus 로고
    • Beneficial microbes: the pharmacy in the gut
    • Linares DM, Ross P, Stanton C., Beneficial microbes: the pharmacy in the gut. Bioengineered. 2016;7:11–20.
    • (2016) Bioengineered , vol.7 , pp. 11-20
    • Linares, D.M.1    Ross, P.2    Stanton, C.3
  • 87
    • 56749146467 scopus 로고    scopus 로고
    • Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
    • Bouskra D, Brezillon C, Berard M, et al. Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis. Nature. 2008;456:507–510.
    • (2008) Nature , vol.456 , pp. 507-510
    • Bouskra, D.1    Brezillon, C.2    Berard, M.3
  • 88
    • 77952311371 scopus 로고    scopus 로고
    • Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis
    • Fagarasan S, Kawamoto S, Kanagawa O, et al. Adaptive immune regulation in the gut: T cell-dependent and T cell-independent IgA synthesis. Annu Rev Immunol. 2010;28:243–273.
    • (2010) Annu Rev Immunol , vol.28 , pp. 243-273
    • Fagarasan, S.1    Kawamoto, S.2    Kanagawa, O.3
  • 89
    • 2942625911 scopus 로고    scopus 로고
    • Interactions between commensal intestinal bacteria and the immune system
    • Macpherson AJ, Harris NL., Interactions between commensal intestinal bacteria and the immune system. Nat Rev Immunol. 2004;4:478–485.
    • (2004) Nat Rev Immunol , vol.4 , pp. 478-485
    • Macpherson, A.J.1    Harris, N.L.2
  • 90
    • 85002587181 scopus 로고    scopus 로고
    • Maintenance of gut homeostasis by the mucosal immune system
    • Okumura R, Takeda K., Maintenance of gut homeostasis by the mucosal immune system. Proc Jpn Acad, Ser B, Phys Biol Sci. 2016;92:423–435.
    • (2016) Proc Jpn Acad, Ser B, Phys Biol Sci , vol.92 , pp. 423-435
    • Okumura, R.1    Takeda, K.2
  • 91
    • 84863380407 scopus 로고    scopus 로고
    • The role of gut microbiota in immune homeostasis and autoimmunity
    • Wu HJ, Wu E., The role of gut microbiota in immune homeostasis and autoimmunity. Gut Microbes. 2012;3:4–14.
    • (2012) Gut Microbes , vol.3 , pp. 4-14
    • Wu, H.J.1    Wu, E.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.