메뉴 건너뛰기




Volumn 134, Issue 4, 2011, Pages 361-367

The regulation and role of T follicular helper cells in immunity

Author keywords

Antibody responses; CD4 + T cells; T follicular helper

Indexed keywords

CYTOKINE;

EID: 80355124446     PISSN: 00192805     EISSN: 13652567     Source Type: Journal    
DOI: 10.1111/j.1365-2567.2011.03487.x     Document Type: Review
Times cited : (89)

References (90)
  • 1
    • 0034606359 scopus 로고    scopus 로고
    • Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production
    • Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, Förster R. Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 2000; 192:1545-52.
    • (2000) J Exp Med , vol.192 , pp. 1545-1552
    • Breitfeld, D.1    Ohl, L.2    Kremmer, E.3    Ellwart, J.4    Sallusto, F.5    Lipp, M.6    Förster, R.7
  • 2
    • 0034606348 scopus 로고    scopus 로고
    • CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function
    • Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B. CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 2000; 192:1553-62.
    • (2000) J Exp Med , vol.192 , pp. 1553-1562
    • Schaerli, P.1    Willimann, K.2    Lang, A.B.3    Lipp, M.4    Loetscher, P.5    Moser, B.6
  • 3
    • 0032701695 scopus 로고    scopus 로고
    • In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines
    • Ansel KM, McHeyzer-Williams LJ, Ngo VN, McHeyzer-Williams MG, Cyster JG. In vivo-activated CD4 T cells upregulate CXC chemokine receptor 5 and reprogram their response to lymphoid chemokines. J Exp Med 1999; 190:1123-34.
    • (1999) J Exp Med , vol.190 , pp. 1123-1134
    • Ansel, K.M.1    McHeyzer-Williams, L.J.2    Ngo, V.N.3    McHeyzer-Williams, M.G.4    Cyster, J.G.5
  • 4
    • 24744448228 scopus 로고    scopus 로고
    • Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help
    • Hardtke S, Ohl L, Förster R. Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood 2005; 106:1924-31.
    • (2005) Blood , vol.106 , pp. 1924-1931
    • Hardtke, S.1    Ohl, L.2    Förster, R.3
  • 5
    • 38049144850 scopus 로고    scopus 로고
    • Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation
    • Haynes NM, Allen CDC, Lesley R, Ansel KM, Killeen N, Cyster JG. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation. J Immunol 2007; 179:5099-108.
    • (2007) J Immunol , vol.179 , pp. 5099-5108
    • Haynes, N.M.1    Allen, C.D.C.2    Lesley, R.3    Ansel, K.M.4    Killeen, N.5    Cyster, J.G.6
  • 6
    • 77953747963 scopus 로고    scopus 로고
    • The PD-1 pathway in tolerance and autoimmunity
    • Francisco LM, Sage PT, Sharpe AH. The PD-1 pathway in tolerance and autoimmunity. Immunol Rev 2010; 236:219-42.
    • (2010) Immunol Rev , vol.236 , pp. 219-242
    • Francisco, L.M.1    Sage, P.T.2    Sharpe, A.H.3
  • 9
    • 77955924180 scopus 로고    scopus 로고
    • Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling
    • Deenick EK, Chan A, Ma CS, Gatto D, Schwartzberg PL, Brink R, Tangye SG. Follicular helper T cell differentiation requires continuous antigen presentation that is independent of unique B cell signaling. Immunity 2010; 33:241-53.
    • (2010) Immunity , vol.33 , pp. 241-253
    • Deenick, E.K.1    Chan, A.2    Ma, C.S.3    Gatto, D.4    Schwartzberg, P.L.5    Brink, R.6    Tangye, S.G.7
  • 10
    • 4644325602 scopus 로고    scopus 로고
    • Unique gene expression program of human germinal center T helper cells
    • Kim CH, Lim HW, Kim JR, Rott L, Hillsamer P, Butcher EC. Unique gene expression program of human germinal center T helper cells. Blood 2004; 104:1952-60.
    • (2004) Blood , vol.104 , pp. 1952-1960
    • Kim, C.H.1    Lim, H.W.2    Kim, J.R.3    Rott, L.4    Hillsamer, P.5    Butcher, E.C.6
  • 11
    • 2942755979 scopus 로고    scopus 로고
    • T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells
    • Chtanova T, Tangye SG, Newton R, Frank N, Hodge MR, Rolph MS, Mackay CR. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J Immunol 2004; 173:68-78.
    • (2004) J Immunol , vol.173 , pp. 68-78
    • Chtanova, T.1    Tangye, S.G.2    Newton, R.3    Frank, N.4    Hodge, M.R.5    Rolph, M.S.6    Mackay, C.R.7
  • 12
    • 41549131849 scopus 로고    scopus 로고
    • T follicular helper (TFH) cells in normal and dysregulated immune responses
    • King C, Tangye SG, Mackay CR. T follicular helper (TFH) cells in normal and dysregulated immune responses. Annu Rev Immunol 2008; 26:741-66.
    • (2008) Annu Rev Immunol , vol.26 , pp. 741-766
    • King, C.1    Tangye, S.G.2    Mackay, C.R.3
  • 13
    • 38049151375 scopus 로고    scopus 로고
    • + T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue
    • + T cells defines terminally differentiated B cell-helping effector T cells in a B cell-rich lymphoid tissue. J Immunol 2007; 179:7448-56.
    • (2007) J Immunol , vol.179 , pp. 7448-7456
    • Lim, H.W.1    Kim, C.H.2
  • 14
    • 34948890535 scopus 로고    scopus 로고
    • Autoimmunity: IL-21: a new player in Th17-cell differentiation
    • Deenick EK, Tangye SG. Autoimmunity: IL-21: a new player in Th17-cell differentiation. Immunol Cell Biol 2007; 85:503-5.
    • (2007) Immunol Cell Biol , vol.85 , pp. 503-505
    • Deenick, E.K.1    Tangye, S.G.2
  • 15
    • 79951672553 scopus 로고    scopus 로고
    • Regulation of T follicular helper cell formation and function by antigen presenting cells
    • Deenick EK, Ma CS, Brink R, Tangye SG. Regulation of T follicular helper cell formation and function by antigen presenting cells. Curr Opin Immunol 2011; 23:111-8.
    • (2011) Curr Opin Immunol , vol.23 , pp. 111-118
    • Deenick, E.K.1    Ma, C.S.2    Brink, R.3    Tangye, S.G.4
  • 16
    • 69249109601 scopus 로고    scopus 로고
    • Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation
    • Johnston RJ, Poholek AC, DiToro D et al. Bcl6 and Blimp-1 are reciprocal and antagonistic regulators of T follicular helper cell differentiation. Science 2009; 325:1006-10.
    • (2009) Science , vol.325 , pp. 1006-1010
    • Johnston, R.J.1    Poholek, A.C.2    DiToro, D.3
  • 18
    • 70049101558 scopus 로고    scopus 로고
    • The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment
    • Yu D, Rao S, Tsai LM et al. The transcriptional repressor Bcl-6 directs T follicular helper cell lineage commitment. Immunity 2009; 31:457-68.
    • (2009) Immunity , vol.31 , pp. 457-468
    • Yu, D.1    Rao, S.2    Tsai, L.M.3
  • 19
    • 33746256850 scopus 로고    scopus 로고
    • Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression
    • Rasheed A-U, Rahn H-P, Sallusto F, Lipp M, Müller G. Follicular B helper T cell activity is confined to CXCR5(hi)ICOS(hi) CD4 T cells and is independent of CD57 expression. Eur J Immunol 2006; 36:1892-903.
    • (2006) Eur J Immunol , vol.36 , pp. 1892-1903
    • Rasheed, A.-U.1    Rahn, H.-P.2    Sallusto, F.3    Lipp, M.4    Müller, G.5
  • 20
    • 77955280012 scopus 로고    scopus 로고
    • Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)
    • Yusuf I, Kageyama R, Monticelli L, Johnston RJ, DiToro D, Hansen K, Barnett B, Crotty S. Germinal center T follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150). J Immunol 2010; 185:190-202.
    • (2010) J Immunol , vol.185 , pp. 190-202
    • Yusuf, I.1    Kageyama, R.2    Monticelli, L.3    Johnston, R.J.4    DiToro, D.5    Hansen, K.6    Barnett, B.7    Crotty, S.8
  • 22
    • 79959343565 scopus 로고    scopus 로고
    • Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity
    • Kitano M, Moriyama S, Ando Y, Hikida M, Mori Y, Kurosaki T, Okada T. Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity. Immunity 2011; 34:961-72.
    • (2011) Immunity , vol.34 , pp. 961-972
    • Kitano, M.1    Moriyama, S.2    Ando, Y.3    Hikida, M.4    Mori, Y.5    Kurosaki, T.6    Okada, T.7
  • 23
    • 79959328032 scopus 로고    scopus 로고
    • ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6
    • Choi YS, Kageyama R, Eto D, Escobar TC, Johnston RJ, Monticelli L, Lao C, Crotty S. ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6. Immunity 2011; 34:932-46.
    • (2011) Immunity , vol.34 , pp. 932-946
    • Choi, Y.S.1    Kageyama, R.2    Eto, D.3    Escobar, T.C.4    Johnston, R.J.5    Monticelli, L.6    Lao, C.7    Crotty, S.8
  • 24
    • 74849138095 scopus 로고    scopus 로고
    • Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus
    • Simpson N, Gatenby PA, Wilson A et al. Expansion of circulating T cells resembling follicular helper T cells is a fixed phenotype that identifies a subset of severe systemic lupus erythematosus. Arthritis Rheum 2010; 62:234-44.
    • (2010) Arthritis Rheum , vol.62 , pp. 234-244
    • Simpson, N.1    Gatenby, P.A.2    Wilson, A.3
  • 25
    • 78751690647 scopus 로고    scopus 로고
    • + T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion
    • + T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion. Immunity 2011; 34:108-21.
    • (2011) Immunity , vol.34 , pp. 108-121
    • Morita, R.1    Schmitt, N.2    Bentebibel, S.-E.3
  • 27
    • 79956196930 scopus 로고    scopus 로고
    • CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses
    • Chevalier N, Jarrossay D, Ho E et al. CXCR5 expressing human central memory CD4 T cells and their relevance for humoral immune responses. J Immunol 2011; 186:5556-68.
    • (2011) J Immunol , vol.186 , pp. 5556-5568
    • Chevalier, N.1    Jarrossay, D.2    Ho, E.3
  • 28
    • 65349119978 scopus 로고    scopus 로고
    • CD28 and CTLA-4 coreceptor expression and signal transduction
    • Rudd CE, Taylor A, Schneider H. CD28 and CTLA-4 coreceptor expression and signal transduction. Immunol Rev 2009; 229:12-26.
    • (2009) Immunol Rev , vol.229 , pp. 12-26
    • Rudd, C.E.1    Taylor, A.2    Schneider, H.3
  • 30
    • 0037454961 scopus 로고    scopus 로고
    • T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation
    • Fillatreau S, Gray D. T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation. J Exp Med 2003; 197:195-206.
    • (2003) J Exp Med , vol.197 , pp. 195-206
    • Fillatreau, S.1    Gray, D.2
  • 31
    • 0032753621 scopus 로고    scopus 로고
    • Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers
    • Walker LS, Gulbranson-Judge A, Flynn S et al. Compromised OX40 function in CD28-deficient mice is linked with failure to develop CXC chemokine receptor 5-positive CD4 cells and germinal centers. J Exp Med 1999; 190:1115-22.
    • (1999) J Exp Med , vol.190 , pp. 1115-1122
    • Walker, L.S.1    Gulbranson-Judge, A.2    Flynn, S.3
  • 32
    • 23444434705 scopus 로고    scopus 로고
    • + follicular B helper T cell maintenance in vivo
    • + follicular B helper T cell maintenance in vivo. J Immunol 2005; 175:2340-8.
    • (2005) J Immunol , vol.175 , pp. 2340-2348
    • Akiba, H.1    Takeda, K.2    Kojima, Y.3
  • 33
    • 0031872028 scopus 로고    scopus 로고
    • CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1
    • Flynn S, Toellner KM, Raykundalia C, Goodall M, Lane P. CD4 T cell cytokine differentiation: the B cell activation molecule, OX40 ligand, instructs CD4 T cells to express interleukin 4 and upregulates expression of the chemokine receptor, Blr-1. J Exp Med 1998; 188:297-304.
    • (1998) J Exp Med , vol.188 , pp. 297-304
    • Flynn, S.1    Toellner, K.M.2    Raykundalia, C.3    Goodall, M.4    Lane, P.5
  • 34
    • 0032923689 scopus 로고    scopus 로고
    • CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles
    • Brocker T, Gulbranson-Judge A, Flynn S, Riedinger M, Raykundalia C, Lane P. CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles. Eur J Immunol 1999; 29:1610-6.
    • (1999) Eur J Immunol , vol.29 , pp. 1610-1616
    • Brocker, T.1    Gulbranson-Judge, A.2    Flynn, S.3    Riedinger, M.4    Raykundalia, C.5    Lane, P.6
  • 35
    • 77956207524 scopus 로고    scopus 로고
    • In vivo regulation of Bcl6 and T follicular helper cell development
    • Poholek AC, Hansen K, Hernandez SG et al. In vivo regulation of Bcl6 and T follicular helper cell development. J Immunol 2010; 185:313-26.
    • (2010) J Immunol , vol.185 , pp. 313-326
    • Poholek, A.C.1    Hansen, K.2    Hernandez, S.G.3
  • 36
  • 37
    • 0037218353 scopus 로고    scopus 로고
    • Established T cell-driven germinal center B cell proliferation is independent of CD28 signaling but is tightly regulated through CTLA-4
    • Walker LSK, Wiggett HE, Gaspal FMC, Raykundalia CR, Goodall MD, Toellner K-M, Lane PJL. Established T cell-driven germinal center B cell proliferation is independent of CD28 signaling but is tightly regulated through CTLA-4. J Immunol 2003; 170:91-8.
    • (2003) J Immunol , vol.170 , pp. 91-98
    • Walker, L.S.K.1    Wiggett, H.E.2    Gaspal, F.M.C.3    Raykundalia, C.R.4    Goodall, M.D.5    Toellner, K.-M.6    Lane, P.J.L.7
  • 38
    • 60149103686 scopus 로고    scopus 로고
    • Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS
    • Linterman MA, Rigby RJ, Wong R et al. Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS. Immunity 2009; 30:228-41.
    • (2009) Immunity , vol.30 , pp. 228-241
    • Linterman, M.A.1    Rigby, R.J.2    Wong, R.3
  • 39
    • 79955534074 scopus 로고    scopus 로고
    • B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus
    • Salek-Ardakani S, Choi YS, Rafii-El-Idrissi Benhnia M et al. B cell-specific expression of B7-2 is required for follicular Th cell function in response to vaccinia virus. J Immunol 2011; 186:5294-303.
    • (2011) J Immunol , vol.186 , pp. 5294-5303
    • Salek-Ardakani, S.1    Choi, Y.S.2    Rafii-El-Idrissi Benhnia, M.3
  • 40
    • 58449124804 scopus 로고    scopus 로고
    • The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells
    • Bauquet AT, Jin H, Paterson AM, Mitsdoerffer M, Ho I-C, Sharpe AH, Kuchroo VK. The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cells. Nat Immunol 2009; 10:167-75.
    • (2009) Nat Immunol , vol.10 , pp. 167-175
    • Bauquet, A.T.1    Jin, H.2    Paterson, A.M.3    Mitsdoerffer, M.4    Ho, I.-C.5    Sharpe, A.H.6    Kuchroo, V.K.7
  • 41
    • 73949090666 scopus 로고    scopus 로고
    • Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase
    • Gigoux M, Shang J, Pak Y, Xu M, Choe J, Mak TW, Suh W-K. Inducible costimulator promotes helper T-cell differentiation through phosphoinositide 3-kinase. Proc Natl Acad Sci USA 2009; 106:20371-6.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 20371-20376
    • Gigoux, M.1    Shang, J.2    Pak, Y.3    Xu, M.4    Choe, J.5    Mak, T.W.6    Suh, W.-K.7
  • 42
    • 46749151286 scopus 로고    scopus 로고
    • Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages
    • Nurieva RI, Chung Y, Hwang D et al. Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages. Immunity 2008; 29:138-49.
    • (2008) Immunity , vol.29 , pp. 138-149
    • Nurieva, R.I.1    Chung, Y.2    Hwang, D.3
  • 43
    • 77958134778 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction
    • Rolf J, Bell SE, Kovesdi D et al. Phosphoinositide 3-kinase activity in T cells regulates the magnitude of the germinal center reaction. J Immunol 2010; 185:4042-52.
    • (2010) J Immunol , vol.185 , pp. 4042-4052
    • Rolf, J.1    Bell, S.E.2    Kovesdi, D.3
  • 44
    • 79251578633 scopus 로고    scopus 로고
    • The role of SAP and SLAM family molecules in the humoral immune response
    • Ma CS, Deenick EK. The role of SAP and SLAM family molecules in the humoral immune response. Ann NY Acad Sci 2011; 1217:32-44.
    • (2011) Ann NY Acad Sci , vol.1217 , pp. 32-44
    • Ma, C.S.1    Deenick, E.K.2
  • 45
    • 34247892632 scopus 로고    scopus 로고
    • Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules
    • Ma CS, Nichols KE, Tangye SG. Regulation of cellular and humoral immune responses by the SLAM and SAP families of molecules. Annu Rev Immunol 2007; 25:337-79.
    • (2007) Annu Rev Immunol , vol.25 , pp. 337-379
    • Ma, C.S.1    Nichols, K.E.2    Tangye, S.G.3
  • 46
    • 63449096041 scopus 로고    scopus 로고
    • Follicular helper T cells are required for systemic autoimmunity
    • Linterman MA, Rigby RJ, Wong RK et al. Follicular helper T cells are required for systemic autoimmunity. J Exp Med 2009; 206:561-76.
    • (2009) J Exp Med , vol.206 , pp. 561-576
    • Linterman, M.A.1    Rigby, R.J.2    Wong, R.K.3
  • 47
    • 76949091588 scopus 로고    scopus 로고
    • Optimal germinal center responses require a multistage T cell: B cell adhesion process involving integrins, SLAM-associated protein, and CD84
    • Cannons JL, Qi H, Lu KT et al. Optimal germinal center responses require a multistage T cell: B cell adhesion process involving integrins, SLAM-associated protein, and CD84. Immunity 2010; 32:253-65.
    • (2010) Immunity , vol.32 , pp. 253-265
    • Cannons, J.L.1    Qi, H.2    Lu, K.T.3
  • 48
    • 3242749659 scopus 로고    scopus 로고
    • Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4)
    • Romero X, Benítez D, March S, Vilella R, Miralpeix M, Engel P. Differential expression of SAP and EAT-2-binding leukocyte cell-surface molecules CD84, CD150 (SLAM), CD229 (Ly9) and CD244 (2B4). Tissue Antigens 2004; 64:132-44.
    • (2004) Tissue Antigens , vol.64 , pp. 132-144
    • Romero, X.1    Benítez, D.2    March, S.3    Vilella, R.4    Miralpeix, M.5    Engel, P.6
  • 49
    • 33846228857 scopus 로고    scopus 로고
    • SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase
    • McCausland MM, Yusuf I, Tran H, Ono N, Yanagi Y, Crotty S. SAP regulation of follicular helper CD4 T cell development and humoral immunity is independent of SLAM and Fyn kinase. J Immunol 2007; 178:817-28.
    • (2007) J Immunol , vol.178 , pp. 817-828
    • McCausland, M.M.1    Yusuf, I.2    Tran, H.3    Ono, N.4    Yanagi, Y.5    Crotty, S.6
  • 50
    • 8444231176 scopus 로고    scopus 로고
    • Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation
    • Davidson D, Shi X, Zhang S et al. Genetic evidence linking SAP, the X-linked lymphoproliferative gene product, to Src-related kinase FynT in T(H)2 cytokine regulation. Immunity 2004; 21:707-17.
    • (2004) Immunity , vol.21 , pp. 707-717
    • Davidson, D.1    Shi, X.2    Zhang, S.3
  • 51
  • 53
    • 0036498562 scopus 로고    scopus 로고
    • Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha
    • Franchimont D, Galon J, Vacchio MS et al. Positive effects of glucocorticoids on T cell function by up-regulation of IL-7 receptor alpha. J Immunol 2002; 168:2212-8.
    • (2002) J Immunol , vol.168 , pp. 2212-2218
    • Franchimont, D.1    Galon, J.2    Vacchio, M.S.3
  • 54
    • 42149157225 scopus 로고    scopus 로고
    • Antigen controls IL-7R alpha expression levels on CD8 T cells during full activation or tolerance induction
    • Hammerbeck CD, Mescher MF. Antigen controls IL-7R alpha expression levels on CD8 T cells during full activation or tolerance induction. J Immunol 2008; 180:2107-16.
    • (2008) J Immunol , vol.180 , pp. 2107-2116
    • Hammerbeck, C.D.1    Mescher, M.F.2
  • 55
    • 62849126473 scopus 로고    scopus 로고
    • The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding
    • Fazilleau N, McHeyzer-Williams LJ, Rosen H, McHeyzer-Williams MG. The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nat Immunol 2009; 10:375-84.
    • (2009) Nat Immunol , vol.10 , pp. 375-384
    • Fazilleau, N.1    McHeyzer-Williams, L.J.2    Rosen, H.3    McHeyzer-Williams, M.G.4
  • 56
    • 46749115446 scopus 로고    scopus 로고
    • A fundamental role for interleukin-21 in the generation of T follicular helper cells
    • Vogelzang A, McGuire HM, Yu D, Sprent J, Mackay CR, King C. A fundamental role for interleukin-21 in the generation of T follicular helper cells. Immunity 2008; 29:127-37.
    • (2008) Immunity , vol.29 , pp. 127-137
    • Vogelzang, A.1    McGuire, H.M.2    Yu, D.3    Sprent, J.4    Mackay, C.R.5    King, C.6
  • 58
    • 78650646562 scopus 로고    scopus 로고
    • A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection
    • King IL, Mohrs K, Mohrs M. A nonredundant role for IL-21 receptor signaling in plasma cell differentiation and protective type 2 immunity against gastrointestinal helminth infection. J Immunol 2010; 185:6138-45.
    • (2010) J Immunol , vol.185 , pp. 6138-6145
    • King, I.L.1    Mohrs, K.2    Mohrs, M.3
  • 59
    • 77149122105 scopus 로고    scopus 로고
    • IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses
    • Linterman MA, Beaton L, Yu D et al. IL-21 acts directly on B cells to regulate Bcl-6 expression and germinal center responses. J Exp Med 2010; 207:353-63.
    • (2010) J Exp Med , vol.207 , pp. 353-363
    • Linterman, M.A.1    Beaton, L.2    Yu, D.3
  • 60
    • 77149142640 scopus 로고    scopus 로고
    • IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism
    • Zotos D, Coquet JM, Zhang Y et al. IL-21 regulates germinal center B cell differentiation and proliferation through a B cell-intrinsic mechanism. J Exp Med 2010; 207:365-78.
    • (2010) J Exp Med , vol.207 , pp. 365-378
    • Zotos, D.1    Coquet, J.M.2    Zhang, Y.3
  • 61
    • 67649203681 scopus 로고    scopus 로고
    • A vital role for interleukin-21 in the control of a chronic viral infection
    • Yi JS, Du M, Zajac AJ. A vital role for interleukin-21 in the control of a chronic viral infection. Science 2009; 324:1572-6.
    • (2009) Science , vol.324 , pp. 1572-1576
    • Yi, J.S.1    Du, M.2    Zajac, A.J.3
  • 62
    • 79952637807 scopus 로고    scopus 로고
    • IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T Cell (Tfh) differentiation
    • Eto D, Lao C, DiToro D, Barnett B, Escobar TC, Kageyama R, Yusuf I, Crotty S. IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T Cell (Tfh) differentiation. PLoS ONE 2011; 6:e17739.
    • (2011) PLoS ONE , vol.6
    • Eto, D.1    Lao, C.2    DiToro, D.3    Barnett, B.4    Escobar, T.C.5    Kageyama, R.6    Yusuf, I.7    Crotty, S.8
  • 63
    • 63849275584 scopus 로고    scopus 로고
    • Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities
    • Eddahri F, Denanglaire S, Bureau F, Spolski R, Leonard WJ, Leo O, Andris F. Interleukin-6/STAT3 signaling regulates the ability of naive T cells to acquire B-cell help capacities. Blood 2009; 113:2426-33.
    • (2009) Blood , vol.113 , pp. 2426-2433
    • Eddahri, F.1    Denanglaire, S.2    Bureau, F.3    Spolski, R.4    Leonard, W.J.5    Leo, O.6    Andris, F.7
  • 64
    • 78650357814 scopus 로고    scopus 로고
    • IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells
    • Batten M, Ramamoorthi N, Kljavin NM et al. IL-27 supports germinal center function by enhancing IL-21 production and the function of T follicular helper cells. J Exp Med 2010; 207:2895-906.
    • (2010) J Exp Med , vol.207 , pp. 2895-2906
    • Batten, M.1    Ramamoorthi, N.2    Kljavin, N.M.3
  • 65
    • 68249158536 scopus 로고    scopus 로고
    • Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12
    • Schmitt N, Morita R, Bourdery L, Bentebibel SE, Zurawski SM, Banchereau J, Ueno H. Human dendritic cells induce the differentiation of interleukin-21-producing T follicular helper-like cells through interleukin-12. Immunity 2009; 31:158-69.
    • (2009) Immunity , vol.31 , pp. 158-169
    • Schmitt, N.1    Morita, R.2    Bourdery, L.3    Bentebibel, S.E.4    Zurawski, S.M.5    Banchereau, J.6    Ueno, H.7
  • 67
    • 0026528181 scopus 로고
    • Molecular and biological characterization of a murine ligand for CD40
    • Armitage RJ, Fanslow WC, Strockbine L et al. Molecular and biological characterization of a murine ligand for CD40. Nature 1992; 357:80-2.
    • (1992) Nature , vol.357 , pp. 80-82
    • Armitage, R.J.1    Fanslow, W.C.2    Strockbine, L.3
  • 68
    • 0026772133 scopus 로고
    • A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells
    • Noelle RJ, Roy M, Shepherd DM, Stamenkovic I, Ledbetter JA, Aruffo A. A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells. Proc Natl Acad Sci USA 1992; 89:6550-4.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 6550-6554
    • Noelle, R.J.1    Roy, M.2    Shepherd, D.M.3    Stamenkovic, I.4    Ledbetter, J.A.5    Aruffo, A.6
  • 69
    • 0028486131 scopus 로고
    • Mice deficient for the CD40 ligand
    • Xu J, Foy TM, Laman JD et al. Mice deficient for the CD40 ligand. Immunity 1994; 1:423-31.
    • (1994) Immunity , vol.1 , pp. 423-431
    • Xu, J.1    Foy, T.M.2    Laman, J.D.3
  • 70
    • 0028447437 scopus 로고
    • The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation
    • Kawabe T, Naka T, Yoshida K et al. The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation. Immunity 1994; 1:167-78.
    • (1994) Immunity , vol.1 , pp. 167-178
    • Kawabe, T.1    Naka, T.2    Yoshida, K.3
  • 72
    • 67650744339 scopus 로고    scopus 로고
    • Primary B cell immunodeficiencies: comparisons and contrasts
    • Conley ME, Dobbs AK, Farmer DM et al. Primary B cell immunodeficiencies: comparisons and contrasts. Annu Rev Immunol 2009; 27:199-227.
    • (2009) Annu Rev Immunol , vol.27 , pp. 199-227
    • Conley, M.E.1    Dobbs, A.K.2    Farmer, D.M.3
  • 74
    • 79952114884 scopus 로고    scopus 로고
    • B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis
    • Hamel KM, Cao Y, Wang Y, Rodeghero R, Kobezda T, Chen L, Finnegan A. B7-H1 expression on non-B and non-T cells promotes distinct effects on T- and B-cell responses in autoimmune arthritis. Eur J Immunol 2010; 40:3117-27.
    • (2010) Eur J Immunol , vol.40 , pp. 3117-3127
    • Hamel, K.M.1    Cao, Y.2    Wang, Y.3    Rodeghero, R.4    Kobezda, T.5    Chen, L.6    Finnegan, A.7
  • 75
    • 79956198905 scopus 로고    scopus 로고
    • Blockade of b7-h1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells
    • Hams E, McCarron MJ, Amu S, Yagita H, Azuma M, Chen L, Fallon PG. Blockade of b7-h1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells. J Immunol 2011; 186:5648-55.
    • (2011) J Immunol , vol.186 , pp. 5648-5655
    • Hams, E.1    McCarron, M.J.2    Amu, S.3    Yagita, H.4    Azuma, M.5    Chen, L.6    Fallon, P.G.7
  • 78
    • 0037159687 scopus 로고    scopus 로고
    • A critical role for IL-21 in regulating immunoglobulin production
    • Ozaki K, Spolski R, Feng CG et al. A critical role for IL-21 in regulating immunoglobulin production. Science 2002; 298:1630-4.
    • (2002) Science , vol.298 , pp. 1630-1634
    • Ozaki, K.1    Spolski, R.2    Feng, C.G.3
  • 79
    • 77954500603 scopus 로고    scopus 로고
    • Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner
    • Bessa J, Kopf M, Bachmann MF. Cutting edge: IL-21 and TLR signaling regulate germinal center responses in a B cell-intrinsic manner. J Immunol 2010; 184:4615-9.
    • (2010) J Immunol , vol.184 , pp. 4615-4619
    • Bessa, J.1    Kopf, M.2    Bachmann, M.F.3
  • 80
    • 79251547700 scopus 로고    scopus 로고
    • IL-21 receptor is critical for the development of memory B cell responses
    • Rankin AL, MacLeod H, Keegan S et al. IL-21 receptor is critical for the development of memory B cell responses. J Immunol 2011; 186:667-74.
    • (2011) J Immunol , vol.186 , pp. 667-674
    • Rankin, A.L.1    MacLeod, H.2    Keegan, S.3
  • 81
    • 62849090439 scopus 로고    scopus 로고
    • Cytokine-secreting follicular T cells shape the antibody repertoire
    • Reinhardt RL, Liang H-E, Locksley RM. Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol 2009; 10:385-93.
    • (2009) Nat Immunol , vol.10 , pp. 385-393
    • Reinhardt, R.L.1    Liang, H.-E.2    Locksley, R.M.3
  • 82
    • 65549114338 scopus 로고    scopus 로고
    • + T cells in reactive lymph nodes during helminth infection are T follicular helper cells
    • + T cells in reactive lymph nodes during helminth infection are T follicular helper cells. J Exp Med 2009; 206:1001-7.
    • (2009) J Exp Med , vol.206 , pp. 1001-1007
    • King, I.L.1    Mohrs, M.2
  • 83
    • 38349178776 scopus 로고    scopus 로고
    • Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice
    • Hsu H-C, Yang P, Wang J et al. Interleukin 17-producing T helper cells and interleukin 17 orchestrate autoreactive germinal center development in autoimmune BXD2 mice. Nat Immunol 2008; 9:166-75.
    • (2008) Nat Immunol , vol.9 , pp. 166-175
    • Hsu, H.-C.1    Yang, P.2    Wang, J.3
  • 85
    • 0026445919 scopus 로고
    • Human B lymphocytes: phenotype, proliferation, and differentiation
    • Banchereau J, Rousset F. Human B lymphocytes: phenotype, proliferation, and differentiation. Adv Immunol 1992; 52:125-262.
    • (1992) Adv Immunol , vol.52 , pp. 125-262
    • Banchereau, J.1    Rousset, F.2
  • 86
    • 0027465755 scopus 로고
    • Towards a comprehensive view of immunoglobulin class switching
    • Snapper CM, Mond JJ. Towards a comprehensive view of immunoglobulin class switching. Immunol Today 1993; 14:15-7.
    • (1993) Immunol Today , vol.14 , pp. 15-17
    • Snapper, C.M.1    Mond, J.J.2
  • 87
    • 0030022218 scopus 로고    scopus 로고
    • Antibody class switching
    • Stavnezer J. Antibody class switching. Adv Immunol 1996; 61:79-146.
    • (1996) Adv Immunol , vol.61 , pp. 79-146
    • Stavnezer, J.1
  • 88
    • 0026584291 scopus 로고
    • Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes
    • Rousset F, Garcia E, Defrance T et al. Interleukin 10 is a potent growth and differentiation factor for activated human B lymphocytes. Proc Natl Acad Sci USA 1992; 89:1890-3.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 1890-1893
    • Rousset, F.1    Garcia, E.2    Defrance, T.3
  • 89
    • 77956273246 scopus 로고    scopus 로고
    • Proinflammatory T helper type 17 cells are effective B-cell helpers
    • Mitsdoerffer M, Lee Y, Jäger A et al. Proinflammatory T helper type 17 cells are effective B-cell helpers. Proc Natl Acad Sci USA 2010; 107:14292-7.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 14292-14297
    • Mitsdoerffer, M.1    Lee, Y.2    Jäger, A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.