메뉴 건너뛰기




Volumn 38, Issue , 2017, Pages 10-21

Immunobiology of the IL-15/IL-15Rα complex as an antitumor and antiviral agent

Author keywords

Anti viral immunotherapy; Cancer immunotherapy; IL 15 superagonist; IL 15 trans presentation; Memory CD8 T lymphocytes; Natural killer cells

Indexed keywords

ALT 803; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; GAMMA INTERFERON; HYBRID PROTEIN; IMMUNOGLOBULIN G1; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ALPHA; UNCLASSIFIED DRUG;

EID: 85028769651     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2017.08.002     Document Type: Review
Times cited : (106)

References (95)
  • 1
    • 0028179054 scopus 로고
    • Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor
    • Grabstein, K.H., Eisenman, J., Shanebeck, K., Rauch, C., Srinivasan, S., Fung, V., et al. Cloning of a T cell growth factor that interacts with the beta chain of the interleukin-2 receptor. Science 264:5161 (1994), 965–968.
    • (1994) Science , vol.264 , Issue.5161 , pp. 965-968
    • Grabstein, K.H.1    Eisenman, J.2    Shanebeck, K.3    Rauch, C.4    Srinivasan, S.5    Fung, V.6
  • 2
    • 84864983867 scopus 로고    scopus 로고
    • Regulating the immune system via IL-15 transpresentation
    • Castillo, E.F., Schluns, K.S., Regulating the immune system via IL-15 transpresentation. Cytokine 59:3 (2012), 479–490.
    • (2012) Cytokine , vol.59 , Issue.3 , pp. 479-490
    • Castillo, E.F.1    Schluns, K.S.2
  • 3
    • 0036826914 scopus 로고    scopus 로고
    • IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells
    • Dubois, S., Mariner, J., Waldmann, T.A., Tagaya, Y., IL-15Ralpha recycles and presents IL-15 In trans to neighboring cells. Immunity 17:5 (2002), 537–547.
    • (2002) Immunity , vol.17 , Issue.5 , pp. 537-547
    • Dubois, S.1    Mariner, J.2    Waldmann, T.A.3    Tagaya, Y.4
  • 4
    • 84897378109 scopus 로고    scopus 로고
    • The new normal: immunomodulatory agents against sepsis immune suppression
    • Hutchins, N.A., Unsinger, J., Hotchkiss, R.S., Ayala, A., The new normal: immunomodulatory agents against sepsis immune suppression. Trends Mol. Med. 20:4 (2014), 224–233.
    • (2014) Trends Mol. Med. , vol.20 , Issue.4 , pp. 224-233
    • Hutchins, N.A.1    Unsinger, J.2    Hotchkiss, R.S.3    Ayala, A.4
  • 5
    • 0028131273 scopus 로고
    • Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor
    • Carson, W.E., Giri, J.G., Lindemann, M.J., Linett, M.L., Ahdieh, M., Paxton, R., et al. Interleukin (IL) 15 is a novel cytokine that activates human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180:4 (1994), 1395–1403.
    • (1994) J. Exp. Med. , vol.180 , Issue.4 , pp. 1395-1403
    • Carson, W.E.1    Giri, J.G.2    Lindemann, M.J.3    Linett, M.L.4    Ahdieh, M.5    Paxton, R.6
  • 6
    • 79957716455 scopus 로고    scopus 로고
    • Lasek W: Interleukin 15 as a promising candidate for tumor immunotherapy
    • Jakobisiak, M., Golab, J., Lasek W: Interleukin 15 as a promising candidate for tumor immunotherapy. Cytokine Growth Factor Rev. 22:2 (2011), 99–108.
    • (2011) Cytokine Growth Factor Rev. , vol.22 , Issue.2 , pp. 99-108
    • Jakobisiak, M.1    Golab, J.2
  • 7
    • 1642344614 scopus 로고    scopus 로고
    • Monocyte surface-bound IL-15 can function as an activating receptor and participate in reverse signaling
    • Neely, G.G., Epelman, S., Ma, L.L., Colarusso, P., Howlett, C.J., Amankwah, E.K., et al. Monocyte surface-bound IL-15 can function as an activating receptor and participate in reverse signaling. J. Immunol. 172:7 (2004), 4225–4234.
    • (2004) J. Immunol. , vol.172 , Issue.7 , pp. 4225-4234
    • Neely, G.G.1    Epelman, S.2    Ma, L.L.3    Colarusso, P.4    Howlett, C.J.5    Amankwah, E.K.6
  • 8
    • 0035169507 scopus 로고    scopus 로고
    • Caligiuri MA: Interleukin 15: biology and relevance to human disease
    • Fehniger, T.A., Caligiuri MA: Interleukin 15: biology and relevance to human disease. Blood 97:1 (2001), 14–32.
    • (2001) Blood , vol.97 , Issue.1 , pp. 14-32
    • Fehniger, T.A.1
  • 9
    • 33646186619 scopus 로고    scopus 로고
    • Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis
    • Ma, A., Koka, R., Burkett, P., Diverse functions of IL-2, IL-15, and IL-7 in lymphoid homeostasis. Annu. Rev. Immunol. 24 (2006), 657–679.
    • (2006) Annu. Rev. Immunol. , vol.24 , pp. 657-679
    • Ma, A.1    Koka, R.2    Burkett, P.3
  • 10
    • 0035423390 scopus 로고    scopus 로고
    • IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation
    • Mattei, F., Schiavoni, G., Belardelli, F., Tough, D.F., IL-15 is expressed by dendritic cells in response to type I IFN, double-stranded RNA, or lipopolysaccharide and promotes dendritic cell activation. J. Immunol. 167:3 (2001), 1179–1187.
    • (2001) J. Immunol. , vol.167 , Issue.3 , pp. 1179-1187
    • Mattei, F.1    Schiavoni, G.2    Belardelli, F.3    Tough, D.F.4
  • 11
    • 33847083634 scopus 로고    scopus 로고
    • Herpes simplex virus-1 up-regulates IL-15 gene expression in monocytic cells through the activation of protein tyrosine kinase and PKC zeta/lambda signaling pathways
    • Ahmad, R., Ennaciri, J., Cordeiro, P., El Bassam, S., Menezes, J., Herpes simplex virus-1 up-regulates IL-15 gene expression in monocytic cells through the activation of protein tyrosine kinase and PKC zeta/lambda signaling pathways. J. Mol. Biol. 367:1 (2007), 25–35.
    • (2007) J. Mol. Biol. , vol.367 , Issue.1 , pp. 25-35
    • Ahmad, R.1    Ennaciri, J.2    Cordeiro, P.3    El Bassam, S.4    Menezes, J.5
  • 12
    • 34247100277 scopus 로고    scopus 로고
    • Dendritic cells prime natural killer cells by trans-presenting interleukin 15
    • Lucas, M., Schachterle, W., Oberle, K., Aichele, P., Diefenbach, A., Dendritic cells prime natural killer cells by trans-presenting interleukin 15. Immunity 26:4 (2007), 503–517.
    • (2007) Immunity , vol.26 , Issue.4 , pp. 503-517
    • Lucas, M.1    Schachterle, W.2    Oberle, K.3    Aichele, P.4    Diefenbach, A.5
  • 14
    • 84904725488 scopus 로고    scopus 로고
    • The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells
    • Marcais, A., Cherfils-Vicini, J., Viant, C., Degouve, S., Viel, S., Fenis, A., et al. The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells. Nat. Immunol. 15:8 (2014), 749–757.
    • (2014) Nat. Immunol. , vol.15 , Issue.8 , pp. 749-757
    • Marcais, A.1    Cherfils-Vicini, J.2    Viant, C.3    Degouve, S.4    Viel, S.5    Fenis, A.6
  • 15
    • 84994060661 scopus 로고    scopus 로고
    • IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells
    • Mao, Y., van Hoef, V., Zhang, X., Wennerberg, E., Lorent, J., Witt, K., et al. IL-15 activates mTOR and primes stress-activated gene expression leading to prolonged antitumor capacity of NK cells. Blood 128:11 (2016), 1475–1489.
    • (2016) Blood , vol.128 , Issue.11 , pp. 1475-1489
    • Mao, Y.1    van Hoef, V.2    Zhang, X.3    Wennerberg, E.4    Lorent, J.5    Witt, K.6
  • 16
    • 84935099494 scopus 로고    scopus 로고
    • IL-15-PI3K-AKT-mTOR. a critical pathway in the life journey of natural killer cells
    • Ali, A.K., Nandagopal, N., Lee, S.H., IL-15-PI3K-AKT-mTOR. a critical pathway in the life journey of natural killer cells. Front. Immunol., 6, 2015, 355.
    • (2015) Front. Immunol. , vol.6 , pp. 355
    • Ali, A.K.1    Nandagopal, N.2    Lee, S.H.3
  • 17
    • 33644975335 scopus 로고    scopus 로고
    • Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins
    • Mortier, E., Quemener, A., Vusio, P., Lorenzen, I., Boublik, Y., Grotzinger, J., et al. Soluble interleukin-15 receptor alpha (IL-15R alpha)-sushi as a selective and potent agonist of IL-15 action through IL-15R beta/gamma. Hyperagonist IL-15 x IL-15R alpha fusion proteins. J. Biol. Chem. 281:3 (2006), 1612–1619.
    • (2006) J. Biol. Chem. , vol.281 , Issue.3 , pp. 1612-1619
    • Mortier, E.1    Quemener, A.2    Vusio, P.3    Lorenzen, I.4    Boublik, Y.5    Grotzinger, J.6
  • 18
    • 0025894780 scopus 로고
    • Three-dimensional structure of a complement control protein module in solution
    • Norman, D.G., Barlow, P.N., Baron, M., Day, A.J., Sim, R.B., Campbell, I.D., Three-dimensional structure of a complement control protein module in solution. J. Mol. Biol. 219:4 (1991), 717–725.
    • (1991) J. Mol. Biol. , vol.219 , Issue.4 , pp. 717-725
    • Norman, D.G.1    Barlow, P.N.2    Baron, M.3    Day, A.J.4    Sim, R.B.5    Campbell, I.D.6
  • 19
    • 13344278015 scopus 로고
    • Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes
    • Anderson, D.M., Kumaki, S., Ahdieh, M., Bertles, J., Tometsko, M., Loomis, A., et al. Functional characterization of the human interleukin-15 receptor alpha chain and close linkage of IL15RA and IL2RA genes. J. Biol. Chem. 270:50 (1995), 29862–29869.
    • (1995) J. Biol. Chem. , vol.270 , Issue.50 , pp. 29862-29869
    • Anderson, D.M.1    Kumaki, S.2    Ahdieh, M.3    Bertles, J.4    Tometsko, M.5    Loomis, A.6
  • 20
    • 0033578642 scopus 로고    scopus 로고
    • Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression
    • Dubois, S., Magrangeas, F., Lehours, P., Raher, S., Bernard, J., Boisteau, O., et al. Natural splicing of exon 2 of human interleukin-15 receptor alpha-chain mRNA results in a shortened form with a distinct pattern of expression. J. Biol. Chem. 274:38 (1999), 26978–26984.
    • (1999) J. Biol. Chem. , vol.274 , Issue.38 , pp. 26978-26984
    • Dubois, S.1    Magrangeas, F.2    Lehours, P.3    Raher, S.4    Bernard, J.5    Boisteau, O.6
  • 21
    • 58149382693 scopus 로고    scopus 로고
    • The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation
    • Wu, Z., Xue, H.H., Bernard, J., Zeng, R., Issakov, D., Bollenbacher-Reilley, J., et al. The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation. Blood 112:12 (2008), 4411–4419.
    • (2008) Blood , vol.112 , Issue.12 , pp. 4411-4419
    • Wu, Z.1    Xue, H.H.2    Bernard, J.3    Zeng, R.4    Issakov, D.5    Bollenbacher-Reilley, J.6
  • 22
    • 0034665543 scopus 로고    scopus 로고
    • Selective blockade of IL-15 by soluble IL-15 receptor alpha-chain enhances cardiac allograft survival
    • Smith, X.G., Bolton, E.M., Ruchatz, H., Wei, X., Liew, F.Y., Bradley, J.A., Selective blockade of IL-15 by soluble IL-15 receptor alpha-chain enhances cardiac allograft survival. J. Immunol. 165:6 (2000), 3444–3450.
    • (2000) J. Immunol. , vol.165 , Issue.6 , pp. 3444-3450
    • Smith, X.G.1    Bolton, E.M.2    Ruchatz, H.3    Wei, X.4    Liew, F.Y.5    Bradley, J.A.6
  • 23
    • 0032103993 scopus 로고    scopus 로고
    • Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology
    • Ruchatz, H., Leung, B.P., Wei, X.Q., McInnes, I.B., Liew, F.Y., Soluble IL-15 receptor alpha-chain administration prevents murine collagen-induced arthritis: a role for IL-15 in development of antigen-induced immunopathology. J. Immunol. 160:11 (1998), 5654–5660.
    • (1998) J. Immunol. , vol.160 , Issue.11 , pp. 5654-5660
    • Ruchatz, H.1    Leung, B.P.2    Wei, X.Q.3    McInnes, I.B.4    Liew, F.Y.5
  • 24
    • 3242776039 scopus 로고    scopus 로고
    • Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist
    • Mortier, E., Bernard, J., Plet, A., Jacques, Y., Natural, proteolytic release of a soluble form of human IL-15 receptor alpha-chain that behaves as a specific, high affinity IL-15 antagonist. J. Immunol. 173:3 (2004), 1681–1688.
    • (2004) J. Immunol. , vol.173 , Issue.3 , pp. 1681-1688
    • Mortier, E.1    Bernard, J.2    Plet, A.3    Jacques, Y.4
  • 25
    • 49549098143 scopus 로고    scopus 로고
    • The exon-3-encoded domain of IL-15ralpha contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15Ralpha
    • Bouchaud, G., Garrigue-Antar, L., Sole, V., Quemener, A., Boublik, Y., Mortier, E., et al. The exon-3-encoded domain of IL-15ralpha contributes to IL-15 high-affinity binding and is crucial for the IL-15 antagonistic effect of soluble IL-15Ralpha. J. Mol. Biol. 382:1 (2008), 1–12.
    • (2008) J. Mol. Biol. , vol.382 , Issue.1 , pp. 1-12
    • Bouchaud, G.1    Garrigue-Antar, L.2    Sole, V.3    Quemener, A.4    Boublik, Y.5    Mortier, E.6
  • 26
    • 84880078963 scopus 로고    scopus 로고
    • Characterization and favorable in vivo properties of heterodimeric soluble IL-15: IL-15Ralpha cytokine compared to IL-15 monomer
    • Chertova, E., Bergamaschi, C., Chertov, O., Sowder, R., Bear, J., Roser, J.D., et al. Characterization and favorable in vivo properties of heterodimeric soluble IL-15: IL-15Ralpha cytokine compared to IL-15 monomer. J. Biol. Chem. 288:25 (2013), 18093–18103.
    • (2013) J. Biol. Chem. , vol.288 , Issue.25 , pp. 18093-18103
    • Chertova, E.1    Bergamaschi, C.2    Chertov, O.3    Sowder, R.4    Bear, J.5    Roser, J.D.6
  • 27
    • 84975709022 scopus 로고    scopus 로고
    • Recombinant human heterodimeric IL-15 complex displays extensive and reproducible N- and O-linked glycosylation
    • Thaysen-Andersen, M., Chertova, E., Bergamaschi, C., Moh, E.S., Chertov, O., Roser, J., et al. Recombinant human heterodimeric IL-15 complex displays extensive and reproducible N- and O-linked glycosylation. Glycoconj. J. 33:3 (2016), 417–433.
    • (2016) Glycoconj. J. , vol.33 , Issue.3 , pp. 417-433
    • Thaysen-Andersen, M.1    Chertova, E.2    Bergamaschi, C.3    Moh, E.S.4    Chertov, O.5    Roser, J.6
  • 28
    • 84922777713 scopus 로고    scopus 로고
    • Hyper-IL-15 suppresses metastatic and autochthonous liver cancers by promoting tumor-specific CD8 T cell responses
    • Cheng, L., Du, X., Wang, Z., Ju, J., Jia, M., Huang, Q., et al. Hyper-IL-15 suppresses metastatic and autochthonous liver cancers by promoting tumor-specific CD8 T cell responses. J. Hepatol., 2014.
    • (2014) J. Hepatol.
    • Cheng, L.1    Du, X.2    Wang, Z.3    Ju, J.4    Jia, M.5    Huang, Q.6
  • 29
    • 84953425816 scopus 로고    scopus 로고
    • IL-15/sIL-15Ralpha gene transfer suppresses Lewis lung cancer growth in the lungs, liver and kidneys
    • Sun, H., Liu, D., IL-15/sIL-15Ralpha gene transfer suppresses Lewis lung cancer growth in the lungs, liver and kidneys. Cancer Gene Ther. 23:2–3 (2016), 54–60.
    • (2016) Cancer Gene Ther. , vol.23 , Issue.2-3 , pp. 54-60
    • Sun, H.1    Liu, D.2
  • 30
    • 60549117539 scopus 로고    scopus 로고
    • IL-15 trans-presentation promotes human NK cell development and differentiation in vivo
    • Huntington, N.D., Legrand, N., Alves, N.L., Jaron, B., Weijer, K., Plet, A., et al. IL-15 trans-presentation promotes human NK cell development and differentiation in vivo. J. Exp. Med. 206:1 (2009), 25–34.
    • (2009) J. Exp. Med. , vol.206 , Issue.1 , pp. 25-34
    • Huntington, N.D.1    Legrand, N.2    Alves, N.L.3    Jaron, B.4    Weijer, K.5    Plet, A.6
  • 31
    • 70349482330 scopus 로고    scopus 로고
    • High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor alpha fusion protein, in metastatic melanoma and colorectal cancer
    • Bessard, A., Sole, V., Bouchaud, G., Quemener, A., Jacques, Y., High antitumor activity of RLI, an interleukin-15 (IL-15)-IL-15 receptor alpha fusion protein, in metastatic melanoma and colorectal cancer. Mol. Cancer Ther. 8:9 (2009), 2736–2745.
    • (2009) Mol. Cancer Ther. , vol.8 , Issue.9 , pp. 2736-2745
    • Bessard, A.1    Sole, V.2    Bouchaud, G.3    Quemener, A.4    Jacques, Y.5
  • 32
    • 84877964989 scopus 로고    scopus 로고
    • Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency
    • Vincent, M., Bessard, A., Cochonneau, D., Teppaz, G., Sole, V., Maillasson, M., et al. Tumor targeting of the IL-15 superagonist RLI by an anti-GD2 antibody strongly enhances its antitumor potency. Int. J. Cancer 133:3 (2013), 757–765.
    • (2013) Int. J. Cancer , vol.133 , Issue.3 , pp. 757-765
    • Vincent, M.1    Bessard, A.2    Cochonneau, D.3    Teppaz, G.4    Sole, V.5    Maillasson, M.6
  • 33
    • 84871947763 scopus 로고    scopus 로고
    • Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein
    • Ochoa, M.C., Fioravanti, J., Rodriguez, I., Hervas-Stubbs, S., Azpilikueta, A., Mazzolini, G., et al. Antitumor immunotherapeutic and toxic properties of an HDL-conjugated chimeric IL-15 fusion protein. Cancer Res. 73:1 (2013), 139–149.
    • (2013) Cancer Res. , vol.73 , Issue.1 , pp. 139-149
    • Ochoa, M.C.1    Fioravanti, J.2    Rodriguez, I.3    Hervas-Stubbs, S.4    Azpilikueta, A.5    Mazzolini, G.6
  • 34
    • 84862565032 scopus 로고    scopus 로고
    • An antibody fusion protein for cancer immunotherapy mimicking IL-15 trans-presentation at the tumor site
    • Kermer, V., Baum, V., Hornig, N., Kontermann, R.E., Muller, D., An antibody fusion protein for cancer immunotherapy mimicking IL-15 trans-presentation at the tumor site. Mol. Cancer Ther. 11:6 (2012), 1279–1288.
    • (2012) Mol. Cancer Ther. , vol.11 , Issue.6 , pp. 1279-1288
    • Kermer, V.1    Baum, V.2    Hornig, N.3    Kontermann, R.E.4    Muller, D.5
  • 36
    • 33750335080 scopus 로고    scopus 로고
    • Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo
    • Stoklasek, T.A., Schluns, K.S., Lefrancois, L., Combined IL-15/IL-15Ralpha immunotherapy maximizes IL-15 activity in vivo. J. Immunol. 177:9 (2006), 6072–6080.
    • (2006) J. Immunol. , vol.177 , Issue.9 , pp. 6072-6080
    • Stoklasek, T.A.1    Schluns, K.S.2    Lefrancois, L.3
  • 37
    • 84940121794 scopus 로고    scopus 로고
    • IL-15 superagonist-Mediated immunotoxicity: role of NK cells and IFN-gamma
    • Guo, Y., Luan, L., Rabacal, W., Bohannon, J.K., Fensterheim, B.A., Hernandez, A., et al. IL-15 superagonist-Mediated immunotoxicity: role of NK cells and IFN-gamma. J. Immunol. 195:5 (2015), 2353–2364.
    • (2015) J. Immunol. , vol.195 , Issue.5 , pp. 2353-2364
    • Guo, Y.1    Luan, L.2    Rabacal, W.3    Bohannon, J.K.4    Fensterheim, B.A.5    Hernandez, A.6
  • 38
    • 78049415677 scopus 로고    scopus 로고
    • IL-15R alpha-IgG1-Fc enhances IL-2 and IL-15 anti-tumor action through NK and CD8+ T cells proliferation and activation
    • Wu, Z., Xu, Y., IL-15R alpha-IgG1-Fc enhances IL-2 and IL-15 anti-tumor action through NK and CD8+ T cells proliferation and activation. J. Mol. Cell Biol. 2:4 (2010), 217–222.
    • (2010) J. Mol. Cell Biol. , vol.2 , Issue.4 , pp. 217-222
    • Wu, Z.1    Xu, Y.2
  • 39
    • 42149162887 scopus 로고    scopus 로고
    • Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action
    • Dubois, S., Patel, H.J., Zhang, M., Waldmann, T.A., Muller, J.R., Preassociation of IL-15 with IL-15R alpha-IgG1-Fc enhances its activity on proliferation of NK and CD8+/CD44high T cells and its antitumor action. J. Immunol. 180:4 (2008), 2099–2106.
    • (2008) J. Immunol. , vol.180 , Issue.4 , pp. 2099-2106
    • Dubois, S.1    Patel, H.J.2    Zhang, M.3    Waldmann, T.A.4    Muller, J.R.5
  • 40
    • 42349091974 scopus 로고    scopus 로고
    • Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells
    • Epardaud, M., Elpek, K.G., Rubinstein, M.P., Yonekura, A.R., Bellemare-Pelletier, A., Bronson, R., et al. Interleukin-15/interleukin-15R alpha complexes promote destruction of established tumors by reviving tumor-resident CD8+ T cells. Cancer Res. 68:8 (2008), 2972–2983.
    • (2008) Cancer Res. , vol.68 , Issue.8 , pp. 2972-2983
    • Epardaud, M.1    Elpek, K.G.2    Rubinstein, M.P.3    Yonekura, A.R.4    Bellemare-Pelletier, A.5    Bronson, R.6
  • 41
    • 84877865939 scopus 로고    scopus 로고
    • Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor alphaSu/Fc fusion complex in syngeneic murine models of multiple myeloma
    • Xu, W., Jones, M., Liu, B., Zhu, X., Johnson, C.B., Edwards, A.C., et al. Efficacy and mechanism-of-action of a novel superagonist interleukin-15: interleukin-15 receptor alphaSu/Fc fusion complex in syngeneic murine models of multiple myeloma. Cancer Res. 73:10 (2013), 3075–3086.
    • (2013) Cancer Res. , vol.73 , Issue.10 , pp. 3075-3086
    • Xu, W.1    Jones, M.2    Liu, B.3    Zhu, X.4    Johnson, C.B.5    Edwards, A.C.6
  • 42
    • 84892407279 scopus 로고    scopus 로고
    • The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8+ T cells into innate-like effector cells with antitumor activity
    • Wong, H.C., Jeng, E.K., Rhode, P.R., The IL-15-based superagonist ALT-803 promotes the antigen-independent conversion of memory CD8+ T cells into innate-like effector cells with antitumor activity. Oncoimmunology, 2(11), 2013, e26442.
    • (2013) Oncoimmunology , vol.2 , Issue.11 , pp. e26442
    • Wong, H.C.1    Jeng, E.K.2    Rhode, P.R.3
  • 43
    • 84944280347 scopus 로고    scopus 로고
    • Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model
    • Mathios, D., Park, C.K., Marcus, W.D., Alter, S., Rhode, P.R., Jeng, E.K., et al. Therapeutic administration of IL-15 superagonist complex ALT-803 leads to long-term survival and durable antitumor immune response in a murine glioblastoma model. Int. J. Cancer 138:1 (2016), 187–194.
    • (2016) Int. J. Cancer , vol.138 , Issue.1 , pp. 187-194
    • Mathios, D.1    Park, C.K.2    Marcus, W.D.3    Alter, S.4    Rhode, P.R.5    Jeng, E.K.6
  • 44
    • 84959036947 scopus 로고    scopus 로고
    • The IL-15-based ALT-803 complex enhances FcgammaRIIIa-triggered NK cell responses and in vivo clearance of B cell lymphomas
    • Rosario, M., Liu, B., Kong, L., Collins, L.I., Schneider, S.E., Chen, X., et al. The IL-15-based ALT-803 complex enhances FcgammaRIIIa-triggered NK cell responses and in vivo clearance of B cell lymphomas. Clin. Cancer Res. 22:3 (2016), 596–608.
    • (2016) Clin. Cancer Res. , vol.22 , Issue.3 , pp. 596-608
    • Rosario, M.1    Liu, B.2    Kong, L.3    Collins, L.I.4    Schneider, S.E.5    Chen, X.6
  • 45
    • 84994761943 scopus 로고    scopus 로고
    • A novel fusion of ALT-803 (Interleukin (IL)-15 superagonist) with an antibody demonstrates antigen-specific antitumor responses
    • Liu, B., Kong, L., Han, K., Hong, H., Marcus, W.D., Chen, X., et al. A novel fusion of ALT-803 (Interleukin (IL)-15 superagonist) with an antibody demonstrates antigen-specific antitumor responses. J. Biol. Chem. 291:46 (2016), 23869–23881.
    • (2016) J. Biol. Chem. , vol.291 , Issue.46 , pp. 23869-23881
    • Liu, B.1    Kong, L.2    Han, K.3    Hong, H.4    Marcus, W.D.5    Chen, X.6
  • 46
    • 85013456449 scopus 로고    scopus 로고
    • IL-15 super-agonist (ALT-803) enhances natural killer (NK) cell function against ovarian cancer
    • Felices, M., Chu, S., Kodal, B., Bendzick, L., Ryan, C., Lenvik, A.J., et al. IL-15 super-agonist (ALT-803) enhances natural killer (NK) cell function against ovarian cancer. Gynecol. Oncol., 2017.
    • (2017) Gynecol. Oncol.
    • Felices, M.1    Chu, S.2    Kodal, B.3    Bendzick, L.4    Ryan, C.5    Lenvik, A.J.6
  • 47
    • 84971667832 scopus 로고    scopus 로고
    • IL-15 superagonist/IL-15RalphaSushi-Fc fusion complex (IL-15SA/IL-15RalphaSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas
    • Kim, P.S., Kwilas, A.R., Xu, W., Alter, S., Jeng, E.K., Wong, H.C., et al. IL-15 superagonist/IL-15RalphaSushi-Fc fusion complex (IL-15SA/IL-15RalphaSu-Fc; ALT-803) markedly enhances specific subpopulations of NK and memory CD8+ T cells, and mediates potent anti-tumor activity against murine breast and colon carcinomas. Oncotarget 7:13 (2016), 16130–16145.
    • (2016) Oncotarget , vol.7 , Issue.13 , pp. 16130-16145
    • Kim, P.S.1    Kwilas, A.R.2    Xu, W.3    Alter, S.4    Jeng, E.K.5    Wong, H.C.6
  • 48
    • 84902438193 scopus 로고    scopus 로고
    • Intravesical ALT-803 and BCG treatment reduces tumor burden in a carcinogen induced bladder cancer rat model; a role for cytokine production and NK cell expansion
    • Gomes-Giacoia, E., Miyake, M., Goodison, S., Sriharan, A., Zhang, G., You, L., et al. Intravesical ALT-803 and BCG treatment reduces tumor burden in a carcinogen induced bladder cancer rat model; a role for cytokine production and NK cell expansion. PLoS One, 9(6), 2014, e96705.
    • (2014) PLoS One , vol.9 , Issue.6 , pp. e96705
    • Gomes-Giacoia, E.1    Miyake, M.2    Goodison, S.3    Sriharan, A.4    Zhang, G.5    You, L.6
  • 49
    • 0036436131 scopus 로고    scopus 로고
    • Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity
    • Eisenman, J., Ahdieh, M., Beers, C., Brasel, K., Kennedy, M.K., Le, T., et al. Interleukin-15 interactions with interleukin-15 receptor complexes: characterization and species specificity. Cytokine 20:3 (2002), 121–129.
    • (2002) Cytokine , vol.20 , Issue.3 , pp. 121-129
    • Eisenman, J.1    Ahdieh, M.2    Beers, C.3    Brasel, K.4    Kennedy, M.K.5    Le, T.6
  • 50
    • 11244255868 scopus 로고    scopus 로고
    • Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance
    • Kobayashi, H., Dubois, S., Sato, N., Sabzevari, H., Sakai, Y., Waldmann, T.A., et al. Role of trans-cellular IL-15 presentation in the activation of NK cell-mediated killing, which leads to enhanced tumor immunosurveillance. Blood 105:2 (2005), 721–727.
    • (2005) Blood , vol.105 , Issue.2 , pp. 721-727
    • Kobayashi, H.1    Dubois, S.2    Sato, N.3    Sabzevari, H.4    Sakai, Y.5    Waldmann, T.A.6
  • 51
    • 58849126980 scopus 로고    scopus 로고
    • Inhibition of tumor growth by NK1. 1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans
    • Rowley, J., Monie, A., Hung, C.F., Wu, T.C., Inhibition of tumor growth by NK1. 1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans. J. Immunol. 181:12 (2008), 8237–8247.
    • (2008) J. Immunol. , vol.181 , Issue.12 , pp. 8237-8247
    • Rowley, J.1    Monie, A.2    Hung, C.F.3    Wu, T.C.4
  • 52
    • 84897571963 scopus 로고    scopus 로고
    • Vaccination with tumor cells expressing IL-15 and IL-15Ralpha inhibits murine breast and prostate cancer
    • Morris, J.C., Ramlogan-Steel, C.A., Yu, P., Black, B.A., Mannan, P., Allison, J.P., et al. Vaccination with tumor cells expressing IL-15 and IL-15Ralpha inhibits murine breast and prostate cancer. Gene Ther. 21:4 (2014), 393–401.
    • (2014) Gene Ther. , vol.21 , Issue.4 , pp. 393-401
    • Morris, J.C.1    Ramlogan-Steel, C.A.2    Yu, P.3    Black, B.A.4    Mannan, P.5    Allison, J.P.6
  • 53
    • 60749101528 scopus 로고    scopus 로고
    • Expression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cis
    • Rowley, J., Monie, A., Hung, C.F., Wu, T.C., Expression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cis. Eur. J. Immunol. 39:2 (2009), 491–506.
    • (2009) Eur. J. Immunol. , vol.39 , Issue.2 , pp. 491-506
    • Rowley, J.1    Monie, A.2    Hung, C.F.3    Wu, T.C.4
  • 54
    • 84999293269 scopus 로고    scopus 로고
    • Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells
    • Hurton, L.V., Singh, H., Najjar, A.M., Switzer, K.C., Mi, T., Maiti, S., et al. Tethered IL-15 augments antitumor activity and promotes a stem-cell memory subset in tumor-specific T cells. Proc. Natl. Acad. Sci. U. S. A. 113:48 (2016), E7788–E7797.
    • (2016) Proc. Natl. Acad. Sci. U. S. A. , vol.113 , Issue.48 , pp. E7788-E7797
    • Hurton, L.V.1    Singh, H.2    Najjar, A.M.3    Switzer, K.C.4    Mi, T.5    Maiti, S.6
  • 55
    • 43549096677 scopus 로고    scopus 로고
    • IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation
    • Mortier, E., Woo, T., Advincula, R., Gozalo, S., Ma, A., IL-15Ralpha chaperones IL-15 to stable dendritic cell membrane complexes that activate NK cells via trans presentation. J. Exp. Med. 205:5 (2008), 1213–1225.
    • (2008) J. Exp. Med. , vol.205 , Issue.5 , pp. 1213-1225
    • Mortier, E.1    Woo, T.2    Advincula, R.3    Gozalo, S.4    Ma, A.5
  • 56
    • 76249130335 scopus 로고    scopus 로고
    • Interleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help
    • Steel, J.C., Ramlogan, C.A., Yu, P., Sakai, Y., Forni, G., Waldmann, T.A., et al. Interleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help. Cancer Res. 70:3 (2010), 1072–1081.
    • (2010) Cancer Res. , vol.70 , Issue.3 , pp. 1072-1081
    • Steel, J.C.1    Ramlogan, C.A.2    Yu, P.3    Sakai, Y.4    Forni, G.5    Waldmann, T.A.6
  • 57
    • 84953432234 scopus 로고    scopus 로고
    • Transpresentation of interleukin-15 by IL-15/IL-15Ralpha mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity
    • Van den Bergh, J., Willemen, Y., Lion, E., Van Acker, H., De Reu, H., Anguille, S., et al. Transpresentation of interleukin-15 by IL-15/IL-15Ralpha mRNA-engineered human dendritic cells boosts antitumoral natural killer cell activity. Oncotarget 6:42 (2015), 44123–44133.
    • (2015) Oncotarget , vol.6 , Issue.42 , pp. 44123-44133
    • Van den Bergh, J.1    Willemen, Y.2    Lion, E.3    Van Acker, H.4    De Reu, H.5    Anguille, S.6
  • 58
    • 84896700711 scopus 로고    scopus 로고
    • Production of bioactive soluble interleukin-15 in complex with interleukin-15 receptor alpha from a conditionally-replicating oncolytic HSV-1
    • Gaston, D.C., Odom, C.I., Li, L., Markert, J.M., Roth, J.C., Cassady, K.A., et al. Production of bioactive soluble interleukin-15 in complex with interleukin-15 receptor alpha from a conditionally-replicating oncolytic HSV-1. PLoS One, 8(11), 2013, e81768.
    • (2013) PLoS One , vol.8 , Issue.11 , pp. e81768
    • Gaston, D.C.1    Odom, C.I.2    Li, L.3    Markert, J.M.4    Roth, J.C.5    Cassady, K.A.6
  • 59
    • 84908045073 scopus 로고    scopus 로고
    • Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity
    • Tosic, V., Thomas, D.L., Kranz, D.M., Liu, J., McFadden, G., Shisler, J.L., et al. Myxoma virus expressing a fusion protein of interleukin-15 (IL15) and IL15 receptor alpha has enhanced antitumor activity. PLoS One, 9(10), 2014, e109801.
    • (2014) PLoS One , vol.9 , Issue.10 , pp. e109801
    • Tosic, V.1    Thomas, D.L.2    Kranz, D.M.3    Liu, J.4    McFadden, G.5    Shisler, J.L.6
  • 60
    • 44449146072 scopus 로고    scopus 로고
    • IL-15 transpresentation augments CD8+ T cell activation and is required for optimal recall responses by central memory CD8+ T cells
    • Kokaji, A.I., Hockley, D.L., Kane, K.P., IL-15 transpresentation augments CD8+ T cell activation and is required for optimal recall responses by central memory CD8+ T cells. J. Immunol. 180:7 (2008), 4391–4401.
    • (2008) J. Immunol. , vol.180 , Issue.7 , pp. 4391-4401
    • Kokaji, A.I.1    Hockley, D.L.2    Kane, K.P.3
  • 61
    • 0033046593 scopus 로고    scopus 로고
    • The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens
    • Waldmann, T.A., Tagaya, Y., The multifaceted regulation of interleukin-15 expression and the role of this cytokine in NK cell differentiation and host response to intracellular pathogens. Annu. Rev. Immunol. 17 (1999), 19–49.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 19-49
    • Waldmann, T.A.1    Tagaya, Y.2
  • 62
    • 0035804056 scopus 로고    scopus 로고
    • Environment, sustainability and health: the learning curve steepens
    • McMichael, A.J., Environment, sustainability and health: the learning curve steepens. Med. J. Aust. 175:11–12 (2001), 569–570.
    • (2001) Med. J. Aust. , vol.175 , Issue.11-12 , pp. 569-570
    • McMichael, A.J.1
  • 63
    • 0037306895 scopus 로고    scopus 로고
    • IL-15 enhances survival and function of HIV-specific CD8+ T cells
    • Mueller, Y.M., Bojczuk, P.M., Halstead, E.S., Kim, A.H., Witek, J., Altman, J.D., et al. IL-15 enhances survival and function of HIV-specific CD8+ T cells. Blood 101:3 (2003), 1024–1029.
    • (2003) Blood , vol.101 , Issue.3 , pp. 1024-1029
    • Mueller, Y.M.1    Bojczuk, P.M.2    Halstead, E.S.3    Kim, A.H.4    Witek, J.5    Altman, J.D.6
  • 64
    • 0030587823 scopus 로고    scopus 로고
    • IL-15 stimulates the expansion of AIDS virus-specific CTL
    • Kanai, T., Thomas, E.K., Yasutomi, Y., Letvin, N.L., IL-15 stimulates the expansion of AIDS virus-specific CTL. J. Immunol. 157:8 (1996), 3681–3687.
    • (1996) J. Immunol. , vol.157 , Issue.8 , pp. 3681-3687
    • Kanai, T.1    Thomas, E.K.2    Yasutomi, Y.3    Letvin, N.L.4
  • 65
    • 27744523526 scopus 로고    scopus 로고
    • NK cells in HIV infection: paradigm for protection or targets for ambush
    • Fauci, A.S., Mavilio, D., Kottilil, S., NK cells in HIV infection: paradigm for protection or targets for ambush. Nat. Rev. Immunol. 5:11 (2005), 835–843.
    • (2005) Nat. Rev. Immunol. , vol.5 , Issue.11 , pp. 835-843
    • Fauci, A.S.1    Mavilio, D.2    Kottilil, S.3
  • 66
    • 33749346275 scopus 로고    scopus 로고
    • Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection
    • Mavilio, D., Lombardo, G., Kinter, A., Fogli, M., La Sala, A., Ortolano, S., et al. Characterization of the defective interaction between a subset of natural killer cells and dendritic cells in HIV-1 infection. J. Exp. Med. 203:10 (2006), 2339–2350.
    • (2006) J. Exp. Med. , vol.203 , Issue.10 , pp. 2339-2350
    • Mavilio, D.1    Lombardo, G.2    Kinter, A.3    Fogli, M.4    La Sala, A.5    Ortolano, S.6
  • 68
    • 0037384061 scopus 로고    scopus 로고
    • Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell function
    • Kottilil, S., Chun, T.W., Moir, S., Liu, S., McLaughlin, M., Hallahan, C.W., et al. Innate immunity in human immunodeficiency virus infection: effect of viremia on natural killer cell function. J. Infect. Dis. 187:7 (2003), 1038–1045.
    • (2003) J. Infect. Dis. , vol.187 , Issue.7 , pp. 1038-1045
    • Kottilil, S.1    Chun, T.W.2    Moir, S.3    Liu, S.4    McLaughlin, M.5    Hallahan, C.W.6
  • 69
    • 84929587181 scopus 로고    scopus 로고
    • In vivo activation of human NK cells by treatment with an interleukin-15 superagonist potently inhibits acute In vivo HIV-1 infection in humanized mice
    • Seay, K., Church, C., Zheng, J.H., Deneroff, K., Ochsenbauer, C., Kappes, J.C., et al. In vivo activation of human NK cells by treatment with an interleukin-15 superagonist potently inhibits acute In vivo HIV-1 infection in humanized mice. J. Virol. 89:12 (2015), 6264–6274.
    • (2015) J. Virol. , vol.89 , Issue.12 , pp. 6264-6274
    • Seay, K.1    Church, C.2    Zheng, J.H.3    Deneroff, K.4    Ochsenbauer, C.5    Kappes, J.C.6
  • 70
    • 63149109249 scopus 로고    scopus 로고
    • Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection
    • Eberly, M.D., Kader, M., Hassan, W., Rogers, K.A., Zhou, J., Mueller, Y.M., et al. Increased IL-15 production is associated with higher susceptibility of memory CD4 T cells to simian immunodeficiency virus during acute infection. J. Immunol. 182:3 (2009), 1439–1448.
    • (2009) J. Immunol. , vol.182 , Issue.3 , pp. 1439-1448
    • Eberly, M.D.1    Kader, M.2    Hassan, W.3    Rogers, K.A.4    Zhou, J.5    Mueller, Y.M.6
  • 71
    • 40449100795 scopus 로고    scopus 로고
    • IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses
    • Mueller, Y.M., Do, D.H., Altork, S.R., Artlett, C.M., Gracely, E.J., Katsetos, C.D., et al. IL-15 treatment during acute simian immunodeficiency virus (SIV) infection increases viral set point and accelerates disease progression despite the induction of stronger SIV-specific CD8+ T cell responses. J. Immunol. 180:1 (2008), 350–360.
    • (2008) J. Immunol. , vol.180 , Issue.1 , pp. 350-360
    • Mueller, Y.M.1    Do, D.H.2    Altork, S.R.3    Artlett, C.M.4    Gracely, E.J.5    Katsetos, C.D.6
  • 72
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid, O., Robert, C., Daud, A., Hodi, F.S., Hwu, W.J., Kefford, R., et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N. Engl. J. Med. 369:2 (2013), 134–144.
    • (2013) N. Engl. J. Med. , vol.369 , Issue.2 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3    Hodi, F.S.4    Hwu, W.J.5    Kefford, R.6
  • 73
    • 67349182592 scopus 로고    scopus 로고
    • Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments: clinical and immunological evidence from three patient cases
    • Di Giacomo, A.M., Danielli, R., Guidoboni, M., Calabro, L., Carlucci, D., Miracco, C., et al. Therapeutic efficacy of ipilimumab, an anti-CTLA-4 monoclonal antibody, in patients with metastatic melanoma unresponsive to prior systemic treatments: clinical and immunological evidence from three patient cases. Cancer Immunol. Immunother.: CII 58:8 (2009), 1297–1306.
    • (2009) Cancer Immunol. Immunother.: CII , vol.58 , Issue.8 , pp. 1297-1306
    • Di Giacomo, A.M.1    Danielli, R.2    Guidoboni, M.3    Calabro, L.4    Carlucci, D.5    Miracco, C.6
  • 74
    • 84920577302 scopus 로고    scopus 로고
    • Redistribution, hyperproliferation, activation of natural killer cells and CD8T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer
    • Conlon, K.C., Lugli, E., Welles, H.C., Rosenberg, S.A., Fojo, A.T., Morris, J.C., et al. Redistribution, hyperproliferation, activation of natural killer cells and CD8T cells, and cytokine production during first-in-human clinical trial of recombinant human interleukin-15 in patients with cancer. J. Clin. Oncol., 2014.
    • (2014) J. Clin. Oncol.
    • Conlon, K.C.1    Lugli, E.2    Welles, H.C.3    Rosenberg, S.A.4    Fojo, A.T.5    Morris, J.C.6
  • 75
    • 0035862325 scopus 로고    scopus 로고
    • Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells
    • Fehniger, T.A., Suzuki, K., Ponnappan, A., VanDeusen, J.B., Cooper, M.A., Florea, S.M., et al. Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells. J. Exp. Med. 193:2 (2001), 219–231.
    • (2001) J. Exp. Med. , vol.193 , Issue.2 , pp. 219-231
    • Fehniger, T.A.1    Suzuki, K.2    Ponnappan, A.3    VanDeusen, J.B.4    Cooper, M.A.5    Florea, S.M.6
  • 76
    • 84869006006 scopus 로고    scopus 로고
    • Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation
    • Mishra, A., Liu, S., Sams, G.H., Curphey, D.P., Santhanam, R., Rush, L.J., et al. Aberrant overexpression of IL-15 initiates large granular lymphocyte leukemia through chromosomal instability and DNA hypermethylation. Cancer Cell 22:5 (2012), 645–655.
    • (2012) Cancer Cell , vol.22 , Issue.5 , pp. 645-655
    • Mishra, A.1    Liu, S.2    Sams, G.H.3    Curphey, D.P.4    Santhanam, R.5    Rush, L.J.6
  • 77
    • 85009760467 scopus 로고    scopus 로고
    • IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM)
    • Wege, A.K., Weber, F., Kroemer, A., Ortmann, O., Nimmerjahn, F., Brockhoff, G., IL-15 enhances the anti-tumor activity of trastuzumab against breast cancer cells but causes fatal side effects in humanized tumor mice (HTM). Oncotarget 8:2 (2017), 2731–2744.
    • (2017) Oncotarget , vol.8 , Issue.2 , pp. 2731-2744
    • Wege, A.K.1    Weber, F.2    Kroemer, A.3    Ortmann, O.4    Nimmerjahn, F.5    Brockhoff, G.6
  • 78
    • 79955950299 scopus 로고    scopus 로고
    • Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques
    • Waldmann, T.A., Lugli, E., Roederer, M., Perera, L.P., Smedley, J.V., Macallister, R.P., et al. Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques. Blood 117:18 (2011), 4787–4795.
    • (2011) Blood , vol.117 , Issue.18 , pp. 4787-4795
    • Waldmann, T.A.1    Lugli, E.2    Roederer, M.3    Perera, L.P.4    Smedley, J.V.5    Macallister, R.P.6
  • 79
    • 77951945662 scopus 로고    scopus 로고
    • Treatment of hepatocellular carcinoma with adeno-associated virus encoding interleukin-15 superagonist
    • Chang, C.M., Lo, C.H., Shih, Y.M., Chen, Y., Wu, P.Y., Tsuneyama, K., et al. Treatment of hepatocellular carcinoma with adeno-associated virus encoding interleukin-15 superagonist. Hum. Gene Ther. 21:5 (2010), 611–621.
    • (2010) Hum. Gene Ther. , vol.21 , Issue.5 , pp. 611-621
    • Chang, C.M.1    Lo, C.H.2    Shih, Y.M.3    Chen, Y.4    Wu, P.Y.5    Tsuneyama, K.6
  • 80
  • 81
    • 0034176003 scopus 로고    scopus 로고
    • IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production
    • Liu, Z., Geboes, K., Colpaert, S., D'Haens, G.R., Rutgeerts, P., Ceuppens, J.L., IL-15 is highly expressed in inflammatory bowel disease and regulates local T cell-dependent cytokine production. J. Immunol. 164:7 (2000), 3608–3615.
    • (2000) J. Immunol. , vol.164 , Issue.7 , pp. 3608-3615
    • Liu, Z.1    Geboes, K.2    Colpaert, S.3    D'Haens, G.R.4    Rutgeerts, P.5    Ceuppens, J.L.6
  • 82
    • 30944440017 scopus 로고    scopus 로고
    • IL-15 is elevated in serum and cerebrospinal fluid of patients with multiple sclerosis
    • Rentzos, M., Cambouri, C., Rombos, A., Nikolaou, C., Anagnostouli, M., Tsoutsou, A., et al. IL-15 is elevated in serum and cerebrospinal fluid of patients with multiple sclerosis. J. Neurol. Sci. 241:1–2 (2006), 25–29.
    • (2006) J. Neurol. Sci. , vol.241 , Issue.1-2 , pp. 25-29
    • Rentzos, M.1    Cambouri, C.2    Rombos, A.3    Nikolaou, C.4    Anagnostouli, M.5    Tsoutsou, A.6
  • 83
    • 85014707915 scopus 로고    scopus 로고
    • IL-15 enables septic shock by maintaining NK cell integrity and function
    • Guo, Y., Luan, L., Patil, N.K., Wang, J., Bohannon, J.K., Rabacal, W., et al. IL-15 enables septic shock by maintaining NK cell integrity and function. J. Immunol. 198:3 (2017), 1320–1333.
    • (2017) J. Immunol. , vol.198 , Issue.3 , pp. 1320-1333
    • Guo, Y.1    Luan, L.2    Patil, N.K.3    Wang, J.4    Bohannon, J.K.5    Rabacal, W.6
  • 85
    • 84959238664 scopus 로고    scopus 로고
    • IL-15 superagonist expands mCD8+ T, NK and NKT cells after burn injury but fails to improve outcome during burn wound infection
    • Patil, N.K., Luan, L., Bohannon, J.K., Guo, Y., Hernandez, A., Fensterheim, B., et al. IL-15 superagonist expands mCD8+ T, NK and NKT cells after burn injury but fails to improve outcome during burn wound infection. PLoS One., 11(2), 2016, e0148452.
    • (2016) PLoS One. , vol.11 , Issue.2 , pp. e0148452
    • Patil, N.K.1    Luan, L.2    Bohannon, J.K.3    Guo, Y.4    Hernandez, A.5    Fensterheim, B.6
  • 86
    • 84866597448 scopus 로고    scopus 로고
    • STAT1-deficient mice are resistant to cecal ligation and puncture-induced septic shock
    • Herzig, D., Fang, G., Toliver-Kinsky, T.E., Guo, Y., Bohannon, J., Sherwood, E.R., STAT1-deficient mice are resistant to cecal ligation and puncture-induced septic shock. Shock 38:4 (2012), 395–402.
    • (2012) Shock , vol.38 , Issue.4 , pp. 395-402
    • Herzig, D.1    Fang, G.2    Toliver-Kinsky, T.E.3    Guo, Y.4    Bohannon, J.5    Sherwood, E.R.6
  • 87
    • 84870812398 scopus 로고    scopus 로고
    • The role of natural killer cells in the pathogenesis of sepsis: the ongoing enigma
    • Bohannon, J., Guo, Y., Sherwood, E.R., The role of natural killer cells in the pathogenesis of sepsis: the ongoing enigma. Crit. Care, 16(6), 2012, 185.
    • (2012) Crit. Care , vol.16 , Issue.6 , pp. 185
    • Bohannon, J.1    Guo, Y.2    Sherwood, E.R.3
  • 88
    • 84866304118 scopus 로고    scopus 로고
    • Therapeutic efficacy of CXCR3 blockade in an experimental model of severe sepsis
    • Herzig, D.S., Guo, Y., Fang, G., Toliver-Kinsky, T.E., Sherwood, E.R., Therapeutic efficacy of CXCR3 blockade in an experimental model of severe sepsis. Crit. Care, 16(5), 2012, R168.
    • (2012) Crit. Care , vol.16 , Issue.5 , pp. R168
    • Herzig, D.S.1    Guo, Y.2    Fang, G.3    Toliver-Kinsky, T.E.4    Sherwood, E.R.5
  • 89
    • 33745146498 scopus 로고    scopus 로고
    • The epidemiology of sepsis in patients with malignancy
    • Danai, P.A., Moss, M., Mannino, D.M., Martin, G.S., The epidemiology of sepsis in patients with malignancy. Chest 129:6 (2006), 1432–1440.
    • (2006) Chest , vol.129 , Issue.6 , pp. 1432-1440
    • Danai, P.A.1    Moss, M.2    Mannino, D.M.3    Martin, G.S.4
  • 90
    • 19444388216 scopus 로고    scopus 로고
    • Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care
    • Williams, M.D., Braun, L.A., Cooper, L.M., Johnston, J., Weiss, R.V., Qualy, R.L., et al. Hospitalized cancer patients with severe sepsis: analysis of incidence, mortality, and associated costs of care. Crit. Care 8:5 (2004), R291–R298.
    • (2004) Crit. Care , vol.8 , Issue.5 , pp. R291-R298
    • Williams, M.D.1    Braun, L.A.2    Cooper, L.M.3    Johnston, J.4    Weiss, R.V.5    Qualy, R.L.6
  • 91
    • 78650737758 scopus 로고    scopus 로고
    • Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes
    • Elpek, K.G., Rubinstein, M.P., Bellemare-Pelletier, A., Goldrath, A.W., Turley, S.J., Mature natural killer cells with phenotypic and functional alterations accumulate upon sustained stimulation with IL-15/IL-15Ralpha complexes. Proc. Natl. Acad. Sci. U. S. A. 107:50 (2010), 21647–21652.
    • (2010) Proc. Natl. Acad. Sci. U. S. A. , vol.107 , Issue.50 , pp. 21647-21652
    • Elpek, K.G.1    Rubinstein, M.P.2    Bellemare-Pelletier, A.3    Goldrath, A.W.4    Turley, S.J.5
  • 92
    • 41149132993 scopus 로고    scopus 로고
    • Twelve immunotherapy drugs that could cure cancers
    • Cheever, M.A., Twelve immunotherapy drugs that could cure cancers. Immunol. Rev. 222 (2008), 357–368.
    • (2008) Immunol. Rev. , vol.222 , pp. 357-368
    • Cheever, M.A.1
  • 93
    • 67049114093 scopus 로고    scopus 로고
    • Maturation of mouse NK cells is a 4-stage developmental program
    • Chiossone, L., Chaix, J., Fuseri, N., Roth, C., Vivier, E., Walzer, T., Maturation of mouse NK cells is a 4-stage developmental program. Blood 113:22 (2009), 5488–5496.
    • (2009) Blood , vol.113 , Issue.22 , pp. 5488-5496
    • Chiossone, L.1    Chaix, J.2    Fuseri, N.3    Roth, C.4    Vivier, E.5    Walzer, T.6
  • 94
    • 84899673110 scopus 로고    scopus 로고
    • T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy
    • Melero, I., Rouzaut, A., Motz, G.T., Coukos, G., T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy. Cancer Discov. 4:5 (2014), 522–526.
    • (2014) Cancer Discov. , vol.4 , Issue.5 , pp. 522-526
    • Melero, I.1    Rouzaut, A.2    Motz, G.T.3    Coukos, G.4
  • 95
    • 84858760109 scopus 로고    scopus 로고
    • Combining immunotherapy and targeted therapies in cancer treatment
    • Vanneman, M., Dranoff, G., Combining immunotherapy and targeted therapies in cancer treatment. Nat. Rev. Cancer 12:4 (2012), 237–251.
    • (2012) Nat. Rev. Cancer , vol.12 , Issue.4 , pp. 237-251
    • Vanneman, M.1    Dranoff, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.