IL-15 enhances survival and function of HIV-specific CD8+ T cells

Blood

Volumn 101, Issue 3, 2003, Pages 1024-1029

  Mueller, Yvonne M ^a,b   Bojczuk, Paul M ^a,b   Halstead, E Scott ^a,b   Kim, Alfred H J ^a,b   Witek, James ^a,b   Altman, John D ^a,b   Katsikis, Peter D ^a,b  

^a DREXEL UNIVERSITY COLLEGE OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD45 ANTIGEN; CD8 ANTIGEN; DIPEPTIDYL PEPTIDASE IV; FAS ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 15;

ADOLESCENT; ADULT; ANTIVIRAL ACTIVITY; APOPTOSIS; ARTICLE; CELL CULTURE; CELL FUNCTION; CELL SURVIVAL; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOTOXIC T LYMPHOCYTE; CYTOTOXICITY; EFFECTOR CELL; FLOW CYTOMETRY; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; MEMORY CELL; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; T LYMPHOCYTE SUBPOPULATION;

EID: 0037306895     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2002-07-1957     Document Type: Article

References (32)

1. + cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection. J Virol. 1994;68:6103-6110.
2. Ogg GS, Jin X, Bonhoeffer S, et al. Quantitation of HIV-1-specific cytotoxic T lymphocytes and plasma load of viral RNA. Science. 1998;279:2103-2106.
3. Mueller YM, De Rosa SC, Hutton JA, et al. Increased CD95/Fas-induced apoptosis of HIV-specific CD8(+) T cells. Immunity, 2001;15:871-882.
4. Champagne P, Ogg GS, King AS, et al. Skewed maturation of memory HIV-specific CD8 T lymphocytes. Nature. 2001;410:106-110.
5. + T cells in vivo by IL-15. Immunity. 1998;8:591-599.
6. Tanchot C, Lemonnier FA, Perarnau B, Freitas AA, Rocha B. Differential requirements for survival and proliferation of CD8 naive or memory T cells. Science. 1997;276:2057-2062.
7. Kennedy MK, Glaccum M, Brown SN, et al. Reversible defects in natural killer and memory CD8 T cell lineages in interleukin 15-deficient mice. J Exp Med. 2000;191:771-780.
8. Lodolce JP, Boone DL, Chai S, et al. IL-15 receptor maintains lymphoid homeostasis by supporting lymphocyte homing and proliferation. Immunity. 1998;9:669-676.
9. Marks-Konczalik J, Dubois S, Losi JM, et al. IL-2-induced activation-induced cell death is inhibited in IL-15 transgenic mice. Proc Natl Acad Sci U S A. 2000;97:11445-11450.
10. + memory T cells by opposing cytokines. Science. 2000;288:675-678.
11. Schluns KS, Williams K, Ma A, Zheng XX, Lefrancois L. Cutting edge: requirement for IL-15 in the generation of primary and memory antigen-specific CD8 T cells. J Immunol. 2002;168:4827-4831.
12. + T cells following a microbe exposure. J Immunol. 2002;168:1198-1203.
13. Fehniger TA, Suzuki K, Ponnappan A, et al. Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8(+) T cells. J Exp Med. 2001;193:219-232.
14. Ye W, Young JD, Liu CC. Interleukin-15 induces the expression of mRNAs of cytolytic mediators and augments cytotoxic activities in primary murine lymphocytes. Cell Immunol. 1996;174:54-62.
15. + memory T cells. Proc Natl Acad Sci U S A. 2002;99:6192-6197.
16. Seder RA, Grabstein KH, Berzofsky JA, McDyer JF. Cytokine interactions in human immunodeficiency virus-infected individuals: roles of interleukin (IL)-2, IL-12, and IL-15. J Exp Med. 1995;182:1067-1077.
17. Chehimi J, Marshall JD, Salvucci O, et al. IL-15 enhances immune functions during HIV infection. J Immunol. 1997;158:5978-5987.
18. - T cells of human immunodeficiency virus-infected individuals: effects of interleukin-15 and comparison with interleukin-2. Immunology. 1999;97:181-187.
19. Loubeau M, Ahmad A, Toma E, Menezes J. Enhancement of natural killer and antibody-dependent cytolytic activities of the peripheral blood mononuclear cells of HIV-infected patients by recombinant IL-15. J Acquir Immune Defic Syndr Hum Retrovirol. 1997;16:137-145.
20. Kanai T, Thomas EK, Yasutomi Y, Letvin NL. IL-15 stimulates the expansion of AIDS virus-specific CTL. J Immunol. 1996;157:3681-3687.
21. Vella AT, Dow S, Potter TA, Kappler J, Marrack P. Cytokine-induced survival of activated T cells in vitro and in vivo. Proc Natl Acad Sci U S A. 1998;95:3810-3815.
22. Bulfone-Paus S, Ungureanu D, Pohl T, et al. Interleukin-15 protects from lethal apoptosis in vivo. Nat Med. 1997;3:1124-1128.
23. Agostini C, Siviero M, Facco M, et al. Antiapoptotic effects of IL-15 on pulmonary Tc1 cells of patients with human immunodeficiency virus infection. Am J Respir Crit Care Med. 2001;163:484-489.
24. Altman JD, Moss PAH, Goulder PJR, et al. Phenotypic analysis of antigen-specific T lymphocytes. Science. 1996;274:94-96.
25. Katsikis PD, Wunderlich ES, Smith CA, Herzenberg LA. Fas antigen stimulation induces marked apoptosis of T lymphocytes in human immunodeficiency virus-infected individuals. J Exp Med. 1995;181:2029-2036.
26. + CD8 T lymphocytes correlates with reduced viral plasma RNA after primary HIV infection. AIDS. 1999;13:891-899.
27. Qin JZ, Zhang CL, Kamarashev J, et al. Interleukin-7 and interleukin-15 regulate the expression of the bcl-2 and c-myb genes in cutaneous T-cell lymphoma cells. Blood. 2001;98:2778-2783.
28. Wu TS, Lee JM, Lai YG, et al. Reduced expression of Bcl-2 in CD8(+) T cells deficient in the IL-15 receptor alpha-chain. J Immunol. 2002;168:705-712.
29. Prince HE, Lape-Nixon M. CD69 expression reliably predicts the anti-CD3-induced proliferative response of lymphocytes from human immunodeficiency virus type 1-infected patients. Clin Diagn Lab Immunol. 1997;4:217-222.
30. Kanegane H, Tosato G. Activation of naive and memory T cells by intedeukin-15. Blood. 1996;88:230-235.
31. Cooper D, Bansal-Pakala P, Croft M. 4-1BB (CD137) controls the clonal expansion and survival of CD8 T cells in vivo but does not contribute to the development of cytotoxicity. Eur J Immunol. 2002;32:521-529.
32. Kimura K, Nishimura H, Matsuzaki T, et al. Synergistic effect of interleukin-15 and interleukin-12 on antitumor activity in a murine malignant pleurisy model. Cancer Immunol Immunother. 2000;49:71-77.