-
1
-
-
0034958947
-
Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care
-
Angus D.C., et al. Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care. Crit. Care Med. 2001, 29:1303-1310.
-
(2001)
Crit. Care Med.
, vol.29
, pp. 1303-1310
-
-
Angus, D.C.1
-
2
-
-
0037451929
-
The epidemiology of sepsis in the United States from 1979 through 2000
-
Martin G.S., et al. The epidemiology of sepsis in the United States from 1979 through 2000. N. Engl. J. Med. 2003, 348:1546-1554.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 1546-1554
-
-
Martin, G.S.1
-
3
-
-
84876665421
-
Benchmarking the incidence and mortality of severe sepsis in the United States
-
Gaieski D.F., et al. Benchmarking the incidence and mortality of severe sepsis in the United States. Crit Care Med. 2013, 41:1167-1174.
-
(2013)
Crit Care Med.
, vol.41
, pp. 1167-1174
-
-
Gaieski, D.F.1
-
4
-
-
84874424895
-
Sepsis definitions: time for change
-
Vincent J.L., et al. Sepsis definitions: time for change. Lancet 2013, 381:774-775.
-
(2013)
Lancet
, vol.381
, pp. 774-775
-
-
Vincent, J.L.1
-
5
-
-
54049130105
-
The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients
-
viii
-
Ward N.S., et al. The compensatory anti-inflammatory response syndrome (CARS) in critically ill patients. Clin. Chest Med. 2008, 29:617-625. viii.
-
(2008)
Clin. Chest Med.
, vol.29
, pp. 617-625
-
-
Ward, N.S.1
-
6
-
-
8244235133
-
P55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group
-
Abraham E., et al. p55 Tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock. A randomized controlled multicenter trial. Ro 45-2081 Study Group. JAMA 1997, 277:1531-1538.
-
(1997)
JAMA
, vol.277
, pp. 1531-1538
-
-
Abraham, E.1
-
7
-
-
84875124740
-
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial
-
Opal S.M., et al. Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial. JAMA 2013, 309:1154-1162.
-
(2013)
JAMA
, vol.309
, pp. 1154-1162
-
-
Opal, S.M.1
-
8
-
-
33746190736
-
Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality
-
Osuchowski M.F., et al. Circulating cytokine/inhibitor profiles reshape the understanding of the SIRS/CARS continuum in sepsis and predict mortality. J. Immunol. 2006, 177:1967-1974.
-
(2006)
J. Immunol.
, vol.177
, pp. 1967-1974
-
-
Osuchowski, M.F.1
-
9
-
-
84888325490
-
Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy
-
Hotchkiss R.S., et al. Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy. Nat. Rev. Immunol. 2013, 13:862-874.
-
(2013)
Nat. Rev. Immunol.
, vol.13
, pp. 862-874
-
-
Hotchkiss, R.S.1
-
10
-
-
0037426726
-
The pathophysiology and treatment of sepsis
-
Hotchkiss R.S., Karl I.E. The pathophysiology and treatment of sepsis. N. Engl. J. Med. 2003, 348:138-150.
-
(2003)
N. Engl. J. Med.
, vol.348
, pp. 138-150
-
-
Hotchkiss, R.S.1
Karl, I.E.2
-
11
-
-
79960653221
-
The late phase of sepsis is characterized by an increased microbiological burden and death rate
-
Otto G.P., et al. The late phase of sepsis is characterized by an increased microbiological burden and death rate. Crit. Care 2011, 15:R183.
-
(2011)
Crit. Care
, vol.15
-
-
Otto, G.P.1
-
12
-
-
0032734726
-
Clinical aspects: from systemic inflammation to 'immunoparalysis'
-
Volk H.D., et al. Clinical aspects: from systemic inflammation to 'immunoparalysis'. Chem. Immunol. 2000, 74:162-177.
-
(2000)
Chem. Immunol.
, vol.74
, pp. 162-177
-
-
Volk, H.D.1
-
13
-
-
84867636107
-
Immunosenescence and challenges of vaccination against influenza in the aging population
-
Reber A.J., et al. Immunosenescence and challenges of vaccination against influenza in the aging population. Aging Dis. 2012, 3:68-90.
-
(2012)
Aging Dis.
, vol.3
, pp. 68-90
-
-
Reber, A.J.1
-
14
-
-
49449085432
-
Predictors of 30-day mortality and hospital costs in patients with ventilator-associated pneumonia attributed to potentially antibiotic-resistant gram-negative bacteria
-
Kollef K.E., et al. Predictors of 30-day mortality and hospital costs in patients with ventilator-associated pneumonia attributed to potentially antibiotic-resistant gram-negative bacteria. Chest 2008, 134:281-287.
-
(2008)
Chest
, vol.134
, pp. 281-287
-
-
Kollef, K.E.1
-
15
-
-
84865301037
-
Virus detection in patients with severe pneumonia: still more questions than answers?
-
Luyt C.E., Kaiser L. Virus detection in patients with severe pneumonia: still more questions than answers?. Am. J. Respir. Crit. Care Med. 2012, 186:301-302.
-
(2012)
Am. J. Respir. Crit. Care Med.
, vol.186
, pp. 301-302
-
-
Luyt, C.E.1
Kaiser, L.2
-
16
-
-
47849130092
-
Cytomegalovirus reactivation in critically ill immunocompetent patients
-
Limaye A.P., et al. Cytomegalovirus reactivation in critically ill immunocompetent patients. JAMA 2008, 300:413-422.
-
(2008)
JAMA
, vol.300
, pp. 413-422
-
-
Limaye, A.P.1
-
17
-
-
0033431682
-
Prevention of lymphocyte cell death in sepsis improves survival in mice
-
Hotchkiss R.S., et al. Prevention of lymphocyte cell death in sepsis improves survival in mice. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:14541-14546.
-
(1999)
Proc. Natl. Acad. Sci. U.S.A.
, vol.96
, pp. 14541-14546
-
-
Hotchkiss, R.S.1
-
18
-
-
0030739250
-
Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice
-
Hotchkiss R.S., et al. Apoptosis in lymphoid and parenchymal cells during sepsis: findings in normal and T- and B-cell-deficient mice. Crit. Care Med. 1997, 25:1298-1307.
-
(1997)
Crit. Care Med.
, vol.25
, pp. 1298-1307
-
-
Hotchkiss, R.S.1
-
19
-
-
17044413706
-
Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways
-
Hotchkiss R.S., et al. Accelerated lymphocyte death in sepsis occurs by both the death receptor and mitochondrial pathways. J. Immunol. 2005, 174:5110-5118.
-
(2005)
J. Immunol.
, vol.174
, pp. 5110-5118
-
-
Hotchkiss, R.S.1
-
20
-
-
0035338993
-
+ T lymphocytes in humans
-
+ T lymphocytes in humans. J. Immunol. 2001, 166:6952-6963.
-
(2001)
J. Immunol.
, vol.166
, pp. 6952-6963
-
-
Hotchkiss, R.S.1
-
21
-
-
0037012470
-
Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis
-
Coopersmith C.M., et al. Inhibition of intestinal epithelial apoptosis and survival in a murine model of pneumonia-induced sepsis. JAMA 2002, 287:1716-1721.
-
(2002)
JAMA
, vol.287
, pp. 1716-1721
-
-
Coopersmith, C.M.1
-
22
-
-
77955009943
-
Deficiency of Bid protein reduces sepsis-induced apoptosis and inflammation, while improving septic survival
-
Chung C.S., et al. Deficiency of Bid protein reduces sepsis-induced apoptosis and inflammation, while improving septic survival. Shock 2010, 34:150-161.
-
(2010)
Shock
, vol.34
, pp. 150-161
-
-
Chung, C.S.1
-
23
-
-
27144512743
-
In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice
-
Wesche-Soldato D.E., et al. In vivo delivery of caspase-8 or Fas siRNA improves the survival of septic mice. Blood 2005, 106:2295-2301.
-
(2005)
Blood
, vol.106
, pp. 2295-2301
-
-
Wesche-Soldato, D.E.1
-
24
-
-
0142093069
-
Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity
-
Chung C.S., et al. Inhibition of Fas/Fas ligand signaling improves septic survival: differential effects on macrophage apoptotic and functional capacity. J. Leukoc. Biol. 2003, 74:344-351.
-
(2003)
J. Leukoc. Biol.
, vol.74
, pp. 344-351
-
-
Chung, C.S.1
-
25
-
-
5944251623
-
Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte
-
Hotchkiss R.S., et al. Caspase inhibitors improve survival in sepsis: a critical role of the lymphocyte. Nat. Immunol. 2000, 1:496-501.
-
(2000)
Nat. Immunol.
, vol.1
, pp. 496-501
-
-
Hotchkiss, R.S.1
-
26
-
-
0036152735
-
Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice
-
Coopersmith C.M., et al. Overexpression of Bcl-2 in the intestinal epithelium improves survival in septic mice. Crit. Care Med. 2002, 30:195-201.
-
(2002)
Crit. Care Med.
, vol.30
, pp. 195-201
-
-
Coopersmith, C.M.1
-
27
-
-
84872059919
-
Decreased T-cell repertoire diversity in sepsis: a preliminary study
-
Venet F., et al. Decreased T-cell repertoire diversity in sepsis: a preliminary study. Crit. Care Med. 2013, 41:111-119.
-
(2013)
Crit. Care Med.
, vol.41
, pp. 111-119
-
-
Venet, F.1
-
28
-
-
84874527862
-
Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130
-
Hutchins N.A., et al. Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130. Am. J. Pathol. 2013, 182:742-754.
-
(2013)
Am. J. Pathol.
, vol.182
, pp. 742-754
-
-
Hutchins, N.A.1
-
29
-
-
79955531733
-
The dual functions of receptor interacting protein 1 in Fas-induced hepatocyte death during sepsis
-
McNeal S.I., et al. The dual functions of receptor interacting protein 1 in Fas-induced hepatocyte death during sepsis. Shock 2011, 35:499-505.
-
(2011)
Shock
, vol.35
, pp. 499-505
-
-
McNeal, S.I.1
-
30
-
-
77951836880
-
Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza
-
23ra19
-
London N.R., et al. Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis and influenza. Sci. Transl. Med. 2010, 2:23ra19.
-
(2010)
Sci. Transl. Med.
, vol.2
-
-
London, N.R.1
-
31
-
-
77951813014
-
Sepsis: calming the cytokine storm
-
Harrison C. Sepsis: calming the cytokine storm. Nat. Rev. Drug Discov. 2010, 9:360-361.
-
(2010)
Nat. Rev. Drug Discov.
, vol.9
, pp. 360-361
-
-
Harrison, C.1
-
32
-
-
66749164669
-
The sepsis seesaw: tilting toward immunosuppression
-
Hotchkiss R.S., et al. The sepsis seesaw: tilting toward immunosuppression. Nat. Med. 2009, 15:496-497.
-
(2009)
Nat. Med.
, vol.15
, pp. 496-497
-
-
Hotchkiss, R.S.1
-
33
-
-
84255194001
-
Immunosuppression in patients who die of sepsis and multiple organ failure
-
Boomer J.S., et al. Immunosuppression in patients who die of sepsis and multiple organ failure. JAMA 2011, 306:2594-2605.
-
(2011)
JAMA
, vol.306
, pp. 2594-2605
-
-
Boomer, J.S.1
-
34
-
-
84874256945
-
Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach
-
Hotchkiss R.S., et al. Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach. Lancet Infect. Dis. 2013, 13:260-268.
-
(2013)
Lancet Infect. Dis.
, vol.13
, pp. 260-268
-
-
Hotchkiss, R.S.1
-
35
-
-
0032770246
-
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction
-
Hotchkiss R.S., et al. Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction. Crit Care Med. 1999, 27:1230-1251.
-
(1999)
Crit Care Med.
, vol.27
, pp. 1230-1251
-
-
Hotchkiss, R.S.1
-
36
-
-
65549084772
-
PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis
-
Huang X., et al. PD-1 expression by macrophages plays a pathologic role in altering microbial clearance and the innate inflammatory response to sepsis. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:6303-6308.
-
(2009)
Proc. Natl. Acad. Sci. U.S.A.
, vol.106
, pp. 6303-6308
-
-
Huang, X.1
-
37
-
-
43349107987
-
Regulatory T cell populations in sepsis and trauma
-
Venet F., et al. Regulatory T cell populations in sepsis and trauma. J. Leukoc. Biol. 2008, 83:523-535.
-
(2008)
J. Leukoc. Biol.
, vol.83
, pp. 523-535
-
-
Venet, F.1
-
38
-
-
78650419440
-
Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock
-
Landelle C., et al. Low monocyte human leukocyte antigen-DR is independently associated with nosocomial infections after septic shock. Intensive Care Med. 2010, 36:1859-1866.
-
(2010)
Intensive Care Med.
, vol.36
, pp. 1859-1866
-
-
Landelle, C.1
-
39
-
-
2542461255
-
Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution
-
Buckley R.H. Molecular defects in human severe combined immunodeficiency and approaches to immune reconstitution. Annu. Rev. Immunol. 2004, 22:625-655.
-
(2004)
Annu. Rev. Immunol.
, vol.22
, pp. 625-655
-
-
Buckley, R.H.1
-
40
-
-
0031740732
-
+ severe combined immunodeficiency
-
+ severe combined immunodeficiency. Nat. Genet. 1998, 20:394-397.
-
(1998)
Nat. Genet.
, vol.20
, pp. 394-397
-
-
Puel, A.1
-
41
-
-
84881048554
-
+ thymic emigrants to IL-7 therapy
-
+ thymic emigrants to IL-7 therapy. Blood 2013, 121:4684-4693.
-
(2013)
Blood
, vol.121
, pp. 4684-4693
-
-
Hennion-Tscheltzoff, O.1
-
42
-
-
84861208977
-
+ T cells during the acute phase of SIV infection in Rhesus macaques
-
+ T cells during the acute phase of SIV infection in Rhesus macaques. PLoS Pathog. 2012, 8:e1002636.
-
(2012)
PLoS Pathog.
, vol.8
-
-
Vassena, L.1
-
43
-
-
77953481128
-
+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway
-
+ effector/memory T cells by up-regulating Bcl-2 proteins and activating the JAK/STAT signalling pathway. Immunology 2010, 130:418-426.
-
(2010)
Immunology
, vol.130
, pp. 418-426
-
-
Chetoui, N.1
-
44
-
-
77951648850
-
IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis
-
Unsinger J., et al. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. J. Immunol. 2010, 184:3768-3779.
-
(2010)
J. Immunol.
, vol.184
, pp. 3768-3779
-
-
Unsinger, J.1
-
45
-
-
75149169481
-
Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival
-
Li W.Q., et al. Interleukin-7 regulates Bim proapoptotic activity in peripheral T-cell survival. Mol. Cell. Biol. 2010, 30:590-600.
-
(2010)
Mol. Cell. Biol.
, vol.30
, pp. 590-600
-
-
Li, W.Q.1
-
46
-
-
84868549577
-
IL-7 restores lymphocyte functions in septic patients
-
Venet F., et al. IL-7 restores lymphocyte functions in septic patients. J. Immunol. 2012, 189:5073-5081.
-
(2012)
J. Immunol.
, vol.189
, pp. 5073-5081
-
-
Venet, F.1
-
47
-
-
46949105036
-
Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets
-
Sportes C., et al. Administration of rhIL-7 in humans increases in vivo TCR repertoire diversity by preferential expansion of naive T cell subsets. J. Exp. Med. 2008, 205:1701-1714.
-
(2008)
J. Exp. Med.
, vol.205
, pp. 1701-1714
-
-
Sportes, C.1
-
48
-
-
84860771152
-
Interleukin-7 and immune reconstitution in cancer patients: a new paradigm for dramatically increasing overall survival
-
Morre M., Beq S. Interleukin-7 and immune reconstitution in cancer patients: a new paradigm for dramatically increasing overall survival. Target Oncol. 2012, 7:55-68.
-
(2012)
Target Oncol.
, vol.7
, pp. 55-68
-
-
Morre, M.1
Beq, S.2
-
49
-
-
79955418828
-
Harnessing the biology of IL-7 for therapeutic application
-
Mackall C.L., et al. Harnessing the biology of IL-7 for therapeutic application. Nat. Rev. Immunol. 2011, 11:330-342.
-
(2011)
Nat. Rev. Immunol.
, vol.11
, pp. 330-342
-
-
Mackall, C.L.1
-
50
-
-
33646779561
-
+ T-cell responses when immunizing with multiepitope peptide vaccines
-
+ T-cell responses when immunizing with multiepitope peptide vaccines. J. Immunother. 2006, 29:224-231.
-
(2006)
J. Immunother.
, vol.29
, pp. 224-231
-
-
Rosenberg, S.A.1
-
51
-
-
74549117108
-
Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy
-
Sportes C., et al. Phase I study of recombinant human interleukin-7 administration in subjects with refractory malignancy. Clin. Cancer Res. 2010, 16:727-735.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 727-735
-
-
Sportes, C.1
-
52
-
-
84861195794
-
IL-7 in human health and disease
-
Lundstrom W., et al. IL-7 in human health and disease. Semin. Immunol. 2012, 24:218-224.
-
(2012)
Semin. Immunol.
, vol.24
, pp. 218-224
-
-
Lundstrom, W.1
-
53
-
-
84864125153
-
Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study
-
Levy Y., et al. Effects of recombinant human interleukin 7 on T-cell recovery and thymic output in HIV-infected patients receiving antiretroviral therapy: results of a phase I/IIa randomized, placebo-controlled, multicenter study. Clin. Infect. Dis. 2012, 55:291-300.
-
(2012)
Clin. Infect. Dis.
, vol.55
, pp. 291-300
-
-
Levy, Y.1
-
54
-
-
0036899702
-
Interleukin 15 promotes antigen-independent in vitro expansion and long-term survival of antitumor cytotoxic T lymphocytes
-
Lu J., et al. Interleukin 15 promotes antigen-independent in vitro expansion and long-term survival of antitumor cytotoxic T lymphocytes. Clin. Cancer Res. 2002, 8:3877-3884.
-
(2002)
Clin. Cancer Res.
, vol.8
, pp. 3877-3884
-
-
Lu, J.1
-
55
-
-
84873134031
-
Interleukin-15 in gene therapy of cancer
-
Ochoa M.C., et al. Interleukin-15 in gene therapy of cancer. Curr. Gene Ther. 2013, 13:15-30.
-
(2013)
Curr. Gene Ther.
, vol.13
, pp. 15-30
-
-
Ochoa, M.C.1
-
56
-
-
0037021446
-
Mechanisms involved in interleukin-15-induced suppression of human neutrophil apoptosis: role of the anti-apoptotic Mcl-1 protein and several kinases including Janus kinase-2, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2
-
Pelletier M., et al. Mechanisms involved in interleukin-15-induced suppression of human neutrophil apoptosis: role of the anti-apoptotic Mcl-1 protein and several kinases including Janus kinase-2, p38 mitogen-activated protein kinase and extracellular signal-regulated kinases-1/2. FEBS Lett. 2002, 532:164-170.
-
(2002)
FEBS Lett.
, vol.532
, pp. 164-170
-
-
Pelletier, M.1
-
57
-
-
79955950299
-
Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in Rhesus macaques
-
Waldmann T.A., et al. Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in Rhesus macaques. Blood 2011, 117:4787-4795.
-
(2011)
Blood
, vol.117
, pp. 4787-4795
-
-
Waldmann, T.A.1
-
58
-
-
78650328102
-
Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model
-
Yu P., et al. Simultaneous blockade of multiple immune system inhibitory checkpoints enhances antitumor activity mediated by interleukin-15 in a murine metastatic colon carcinoma model. Clin. Cancer Res. 2010, 16:6019-6028.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 6019-6028
-
-
Yu, P.1
-
59
-
-
76249130335
-
Interleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help
-
Steel J.C., et al. Interleukin-15 and its receptor augment dendritic cell vaccination against the neu oncogene through the induction of antibodies partially independent of CD4 help. Cancer Res. 2010, 70:1072-1081.
-
(2010)
Cancer Res.
, vol.70
, pp. 1072-1081
-
-
Steel, J.C.1
-
60
-
-
77949317183
-
IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis
-
Inoue S., et al. IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J. Immunol. 2010, 184:1401-1409.
-
(2010)
J. Immunol.
, vol.184
, pp. 1401-1409
-
-
Inoue, S.1
-
61
-
-
84872737542
-
Role of IL-15 in sepsis-induced skeletal muscle atrophy and proteolysis
-
Kim H.C., et al. Role of IL-15 in sepsis-induced skeletal muscle atrophy and proteolysis. Tuberc. Respir. Dis. (Seoul.) 2012, 73:312-319.
-
(2012)
Tuberc. Respir. Dis. (Seoul.)
, vol.73
, pp. 312-319
-
-
Kim, H.C.1
-
62
-
-
77955985078
-
Neutrophil paralysis in sepsis
-
Alves-Filho J.C., et al. Neutrophil paralysis in sepsis. Shock 2010, 34(Suppl. 1):15-21.
-
(2010)
Shock
, vol.34
, Issue.SUPPL. 1
, pp. 15-21
-
-
Alves-Filho, J.C.1
-
64
-
-
0033557688
-
Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis
-
Cummings C.J., et al. Expression and function of the chemokine receptors CXCR1 and CXCR2 in sepsis. J. Immunol. 1999, 162:2341-2346.
-
(1999)
J. Immunol.
, vol.162
, pp. 2341-2346
-
-
Cummings, C.J.1
-
65
-
-
0036172413
-
Impairment of polymorphonuclear neutrophil functions precedes nosocomial infections in critically ill patients
-
Stephan F., et al. Impairment of polymorphonuclear neutrophil functions precedes nosocomial infections in critically ill patients. Crit. Care Med. 2002, 30:315-322.
-
(2002)
Crit. Care Med.
, vol.30
, pp. 315-322
-
-
Stephan, F.1
-
66
-
-
70349559403
-
Endotoxin tolerance: new mechanisms, molecules and clinical significance
-
Biswas S.K., Lopez-Collazo E. Endotoxin tolerance: new mechanisms, molecules and clinical significance. Trends Immunol. 2009, 30:475-487.
-
(2009)
Trends Immunol.
, vol.30
, pp. 475-487
-
-
Biswas, S.K.1
Lopez-Collazo, E.2
-
67
-
-
0034141377
-
Decreased response to recall antigens is associated with depressed costimulatory receptor expression in septic critically ill patients
-
Manjuck J., et al. Decreased response to recall antigens is associated with depressed costimulatory receptor expression in septic critically ill patients. J. Lab. Clin. Med. 2000, 135:153-160.
-
(2000)
J. Lab. Clin. Med.
, vol.135
, pp. 153-160
-
-
Manjuck, J.1
-
68
-
-
70349469854
-
Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial
-
Meisel C., et al. Granulocyte-macrophage colony-stimulating factor to reverse sepsis-associated immunosuppression: a double-blind, randomized, placebo-controlled multicenter trial. Am. J. Respir. Crit. Care Med. 2009, 180:640-648.
-
(2009)
Am. J. Respir. Crit. Care Med.
, vol.180
, pp. 640-648
-
-
Meisel, C.1
-
69
-
-
79953819133
-
Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome
-
Hall M.W., et al. Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome. Intensive Care Med. 2011, 37:525-532.
-
(2011)
Intensive Care Med.
, vol.37
, pp. 525-532
-
-
Hall, M.W.1
-
70
-
-
0034596948
-
Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
-
Freeman G.J., et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med. 2000, 192:1027-1034.
-
(2000)
J. Exp. Med.
, vol.192
, pp. 1027-1034
-
-
Freeman, G.J.1
-
71
-
-
84875463042
-
Molecular mechanisms of T cell co-stimulation and co-inhibition
-
Chen L., Flies D.B. Molecular mechanisms of T cell co-stimulation and co-inhibition. Nat. Rev. Immunol. 2013, 13:227-242.
-
(2013)
Nat. Rev. Immunol.
, vol.13
, pp. 227-242
-
-
Chen, L.1
Flies, D.B.2
-
72
-
-
84886948036
-
B7 family checkpoint regulators in immune regulation and disease
-
Ceeraz S., et al. B7 family checkpoint regulators in immune regulation and disease. Trends Immunol. 2013, 34:556-563.
-
(2013)
Trends Immunol.
, vol.34
, pp. 556-563
-
-
Ceeraz, S.1
-
73
-
-
33748947326
-
PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression
-
Day C.L., et al. PD-1 expression on HIV-specific T cells is associated with T-cell exhaustion and disease progression. Nature 2006, 443:350-354.
-
(2006)
Nature
, vol.443
, pp. 350-354
-
-
Day, C.L.1
-
74
-
-
13444270323
-
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity
-
Hirano F., et al. Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity. Cancer Res. 2005, 65:1089-1096.
-
(2005)
Cancer Res.
, vol.65
, pp. 1089-1096
-
-
Hirano, F.1
-
75
-
-
84862859820
-
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
-
Topalian S.L., et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N. Engl. J. Med. 2012, 366:2443-2454.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 2443-2454
-
-
Topalian, S.L.1
-
76
-
-
84862903106
-
Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
-
Brahmer J.R., et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N. Engl. J. Med. 2012, 366:2455-2465.
-
(2012)
N. Engl. J. Med.
, vol.366
, pp. 2455-2465
-
-
Brahmer, J.R.1
-
77
-
-
33750362179
-
Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways
-
Laudanski K., et al. Cell-specific expression and pathway analyses reveal alterations in trauma-related human T cell and monocyte pathways. Proc. Natl. Acad. Sci. U.S.A. 2006, 103:15564-15569.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, pp. 15564-15569
-
-
Laudanski, K.1
-
78
-
-
77956403940
-
Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis
-
Brahmamdam P., et al. Delayed administration of anti-PD-1 antibody reverses immune dysfunction and improves survival during sepsis. J. Leukoc. Biol. 2010, 88:233-240.
-
(2010)
J. Leukoc. Biol.
, vol.88
, pp. 233-240
-
-
Brahmamdam, P.1
-
79
-
-
78649460067
-
PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction
-
Zhang Y., et al. PD-L1 blockade improves survival in experimental sepsis by inhibiting lymphocyte apoptosis and reversing monocyte dysfunction. Crit. Care 2010, 14:R220.
-
(2010)
Crit. Care
, vol.14
-
-
Zhang, Y.1
-
80
-
-
84893381574
-
Identification of B7-H1 as a novel mediator of the innate immune/pro-inflammatory as well as a possible myeloid prognostic marker in sepsis
-
Huang X., et al. Identification of B7-H1 as a novel mediator of the innate immune/pro-inflammatory as well as a possible myeloid prognostic marker in sepsis. J. Immunol. 2013, 10.4049/jimmunol.1302252.
-
(2013)
J. Immunol.
-
-
Huang, X.1
-
81
-
-
84877262213
-
Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis
-
Chang K.C., et al. Blockade of the negative co-stimulatory molecules PD-1 and CTLA-4 improves survival in primary and secondary fungal sepsis. Crit. Care 2013, 17:R85.
-
(2013)
Crit. Care
, vol.17
-
-
Chang, K.C.1
-
82
-
-
79951947339
-
Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients
-
Zhang Y., et al. Upregulation of programmed death-1 on T cells and programmed death ligand-1 on monocytes in septic shock patients. Crit. Care 2011, 15:R70.
-
(2011)
Crit. Care
, vol.15
-
-
Zhang, Y.1
-
83
-
-
79953121419
-
Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients
-
Guignant C., et al. Programmed death-1 levels correlate with increased mortality, nosocomial infection and immune dysfunctions in septic shock patients. Crit. Care 2011, 15:R99.
-
(2011)
Crit. Care
, vol.15
-
-
Guignant, C.1
-
84
-
-
79959716811
-
Dose-dependent effect of anti-CTLA-4 on survival in sepsis
-
Inoue S., et al. Dose-dependent effect of anti-CTLA-4 on survival in sepsis. Shock 2011, 36:38-44.
-
(2011)
Shock
, vol.36
, pp. 38-44
-
-
Inoue, S.1
-
85
-
-
84865457276
-
BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction
-
Shubin N.J., et al. BTLA expression contributes to septic morbidity and mortality by inducing innate inflammatory cell dysfunction. J. Leukoc. Biol. 2012, 92:593-603.
-
(2012)
J. Leukoc. Biol.
, vol.92
, pp. 593-603
-
-
Shubin, N.J.1
-
86
-
-
84875507855
-
B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells
-
Kobayashi Y., et al. B and T lymphocyte attenuator inhibits LPS-induced endotoxic shock by suppressing Toll-like receptor 4 signaling in innate immune cells. Proc. Natl. Acad. Sci. U.S.A. 2013, 110:5121-5126.
-
(2013)
Proc. Natl. Acad. Sci. U.S.A.
, vol.110
, pp. 5121-5126
-
-
Kobayashi, Y.1
-
87
-
-
84888270655
-
+ T-cells associates with sepsis and subsequent infections in ICU patients
-
+ T-cells associates with sepsis and subsequent infections in ICU patients. Crit. Care 2013, 17:R276.
-
(2013)
Crit. Care
, vol.17
-
-
Shubin, N.J.1
-
88
-
-
84897473053
-
Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency
-
Ayala A., et al. Sepsis-induced potentiation of peritoneal macrophage migration is mitigated by programmed cell death receptor-1 gene deficiency. J. Innate Immun. 2014, 10.1159/000355888.
-
(2014)
J. Innate Immun.
-
-
Ayala, A.1
-
89
-
-
84879104519
-
Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors
-
Duraiswamy J., et al. Dual blockade of PD-1 and CTLA-4 combined with tumor vaccine effectively restores T-cell rejection function in tumors. Cancer Res. 2013, 73:3591-3603.
-
(2013)
Cancer Res.
, vol.73
, pp. 3591-3603
-
-
Duraiswamy, J.1
-
90
-
-
84878625979
-
PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis
-
Zinselmeyer B.H., et al. PD-1 promotes immune exhaustion by inducing antiviral T cell motility paralysis. J. Exp. Med. 2013, 210:757-774.
-
(2013)
J. Exp. Med.
, vol.210
, pp. 757-774
-
-
Zinselmeyer, B.H.1
-
91
-
-
84887006158
-
Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1
-
Hutchins N.A., et al. Kupffer cells potentiate liver sinusoidal endothelial cell injury in sepsis by ligating programmed cell death ligand-1. J. Leukoc. Biol. 2013, 94:963-970.
-
(2013)
J. Leukoc. Biol.
, vol.94
, pp. 963-970
-
-
Hutchins, N.A.1
-
92
-
-
84890059609
-
PD-L1 blockade attenuated sepsis-induced liver injury in a mouse cecal ligation and puncture model
-
Zhu W., et al. PD-L1 blockade attenuated sepsis-induced liver injury in a mouse cecal ligation and puncture model. Mediators Inflamm. 2013, 2013:361501.
-
(2013)
Mediators Inflamm.
, vol.2013
, pp. 361501
-
-
Zhu, W.1
-
93
-
-
0037810670
-
BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1
-
Watanabe N., et al. BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. Nat. Immunol. 2003, 4:670-679.
-
(2003)
Nat. Immunol.
, vol.4
, pp. 670-679
-
-
Watanabe, N.1
-
94
-
-
0035923535
-
PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine
-
Okazaki T., et al. PD-1 immunoreceptor inhibits B cell receptor-mediated signaling by recruiting src homology 2-domain-containing tyrosine phosphatase 2 to phosphotyrosine. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:13866-13871.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 13866-13871
-
-
Okazaki, T.1
|