IL-15 Enhances Immune Functions during HIV Infection

Journal of Immunology

Volumn 158, Issue 12, 1997, Pages 5978-5987

  Chehimi, Jihed ^a   Marshall, Jason D ^b   Salvucci, Ombretta ^c   Frank, Ian ^d   Chehimi, Sana ^a   Kawecki, Stephanie ^b   Bacheller, Darlene ^a   Rifat, Salah ^a   Chouaib, Salem ^c  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b WISTAR INSTITUTE   (United States)

^c INSTITUT GUSTAVE ROUSSY   (France)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 15;

ADULT; APOPTOSIS; ARTICLE; BIOSYNTHESIS; CELL CULTURE; CELL DEATH; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; MONOCYTE; MONONUCLEAR CELL; NATURAL KILLER CELL; PHYSIOLOGY;

ADULT; APOPTOSIS; CELL DEATH; CELLS, CULTURED; CYTOKINES; HIV INFECTIONS; HUMANS; INTERLEUKIN-12; INTERLEUKIN-15; KILLER CELLS, NATURAL; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; MONOCYTES;

EID: 0031570451     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (54)

1. Biron, C. A. 1994. Cytokines in the generation of immune responses to, and resolution of, virus infection. Curr. Opin. Immunol. 6:530.
2. Romagnani, S. 1994. Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12:227.
3. Resenberg, Z. F., and A. S. Fauci. 1989. The immunopathogenesis of HIV infection. Adv. Immunol. 47:377.
4. Levy, J. A. 1993. Pathogenesis of human immunodeficiency virus infection. Microbiol. Rev. 57:183.
5. Fauci, A. S. 1993. Multifactorial nature of human immunodeficiency virus disease: implications for therapy. Science 262:1011.
6. + T helper cell depletion occurs. J. Clin. Invest. 82:1908.
7. Shearer, G. M., and M. Clerici. 1991. Early T-helper defects in HIV infection. AIDS 5:245.
8. Burton, J. D., R. N. Bamford, C. Peters, A. J. Grant, Kurys, C. K. Goldman, J. Brennan, E. Roessler, and T. A. Waldmann. 1994. A lymphokine, provisionally designated interleukin T and produced by a human adult T-cell leukemia line, stimulates T-cell proliferation and the induction of lymphokine-aclivated killer cells. Proc. Natl. Acad. Sci. USA 91:4935.
9. Bamford, R. N., A. J. Grant, J. D. Burton, C. Peters, G. Kurys, C. K. Goldman, J. Brennan, E. Roessler, and T. A. Waldmann. 1994. The interleukin (IL) 2 receptor β chain is shared by IL-2 and a cytokine, provisionally designated IL-T, that stimulates T-cell proliferation and the induction of lymphokine-activated killer cells. Proc. Natl. Acad. Sci. USA 91:4940.
10. Grabstein, K. H., J. Eisenman, K. Shanebeck, C. Rauch, S. Srinivasan, V. Fung, C. Beers, J. Richardson, M. A. Schoenborn, M. Ahdieh, L. Johnson, M. R. Alderson, J. D. Watson, D. M. Anderson, and J. G. Giri. 1994. Cloning of a T cell growth factor that interacts with the β chain of the interleukin-2 receptor. Science 264:965.
11. Carson, W. E., J. G. Giri, M. L. Lindemann, M. L. Linen, M. Ahdieh, R. Paxton, D. Anderson, J. Eisenman, K. Grabstein, and M. A. Caligiuri. 1994. Interleukin (IL) 15 is a novel cytokine that activated human natural killer cells via components of the IL-2 receptor. J. Exp. Med. 180:1395.
12. Armitage, R. J., B. M. Macduff, J. Eisenman, R. Paxton, and K. Grabstein. 1995. IL-15 has stimulatory activity for the induction of B cell proliferation and differentiation. J. Immunol. 154:483.
13. Wilkinson, P. C., and F. Y. Liew. 1995. Chemoattraction of human blood T lymphocytes by interleukin-15. J. Exp. Med. 181:1255.
14. Giri, J. G., M. Ahdieh, J. Eisenman, K. Grabstein, S. Kumaki, A. Namen, L. S. Park, D. Cosman, and D. Anderson. 1994. Utilization of the β and γ chains of the IL-2 receptor by the novel cytokine IL-15. EMBO J. 13:2822.
15. Cosman, D., S. Kumaki, M. Ahdieh, J. Eisenman, K. H. Grabstein, R. Paxton, R. DuBose, D. Friend, L. S. Park, D. Anderson, and J. G. Giri. 1995. Interleukin 15 and its receptor. In T Cell Subsets in Infectious and Autoimmune Diseases, Vol. 195. John Wiley and Sons, Inc., Chichester, p. 221.
16. Tagaya, Y., R. N. Bamford, A. P. DeFilippis, and T. A. Waldmann. 1996. IL-15: a pleiotropic cytokine with diverse receptor/signaling pathways whose expression is controlled at multiple levels. Immunity 4:329.
17. Giri, J. G., S. Kumaki, M. Ahdieh, D. J. Friend, A. Loomis, J. Shanebeck, R. DuBose, L. S. Park, D. Cosman, and D. Anderson. 1995. Identification and cloning of a novel IL-15 binding protein that is structurally related to the a chain of the IL-2 receptor. EMBO J. 14:3654.
18. Chehimi, J., S. Starr, I. Frank, M. Rengaraju, S. J. Jackson, C. Llanes, M. Kobayashi, B. Perussia, D. Young, E. Nickbarg, S. F. Wolf, and G. Trinchieri. 1992. Natural killer cell stimulatory factor (NKSF) increases the cytotoxic activity of NK cells from both healthy donors and HIV-infected patients. J. Exp. Med. 175:789.
19. Chehimi, J., N. M. Valiante, A. D'Andrea, M. Rengaraju, Z. Rosado, M. Kobayashi, B. Perussia, S. Wolf, S. E. Starr, and G. Trinchieri. 1993. Enhancing effect of natural killer cell stimulatory factor (NKSF/TL-12) on cell-mediated cytotoxicity against tumor-derived and virus-infected cells. Eur. J. Immunol. 23:1826.
20. Chouaib, S., J. Bertoglio, J. Y. Blay, C. Marchiol-Fournigault, and D. Fradelizi. 1988. Generation of lymphokine-activated killer cells: synergy between tumor necrosis factor and interleukin-2. Proc. Natl. Acad. Sci. USA 85:6875.
21. Chouaib, S., J. Chehimi, L. Bani, N. Genetet, T. Tursz, F. Gay, G. Trinchieri, and F. Mami-Chouaib. 1994. Interleukin 12 induces the differentiation of major histocompatibility complex class I-primed cytotoxic T-lymphocyte precursors into allospecific cytotoxic effectors. Proc. Natl. Acad. Sci. USA 91:12659.
22. Gorczyca, W., J. Gong, and Z. Darzynkiewicz. 1993. Detection of DNA strand breaks in individual apoptotic cells by the in situ terminal desoxynucleotidyl transferase and nick translation assays. Cancer Res. 53:1945.
23. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste-Amezaga, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, R. Chizzonite, S. F. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory factor (NKSF/IL-12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
24. Chehimi, J., S. Starr, I. Frank, A. D'Andrea, X. Ma, R. R. MacGregor, J. Sennelier, and G. Trinchieri. 1994. Impaired interleukin-12 production in human immunodeficiency virus-infected patients. J. Exp. Med. 179:1361.
25. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin-10 inhibits human lymphocyte IFN-γ production by suppressing natural killer cell stimulatory factor/interleukin-12 synthesis in accessory cells. J. Exp. Med. 178:1041.
26. Folks, T. M., J. Justement, A. Kinter, C. A. Dinarello, and A. S. Fauci. 1987. Cytokine-induced expression of HIV-1 in a chronically infected promonocyte cell line. Science 238:800.
27. Folks, T. M., K. A. Clouse, J. Justement, A. Rabson, E. Duh, J. H. Kehrl, and A. S. Fauci. 1989. Tumor necrosis factor a induces expression of human immunodeficiency virus in chronically infected T-cell clone. Proc. Natl. Acad. Sci. USA 86:2365.
28. + T ceils for IFN-γ but have differential effects on priming for IL-4. J. Immunol. 156:2413.
29. Mori, A., M. Suko, O. Kaminuma, S. Inoue, T. Ohmura, Y. Nishizaki, T. Nagahori, Y. Asakura, A. Hoshino, Y. Okumura, G. Sato, K. Ito, and H. Okudaira. 1996. IL-15 promotes cytokine production of human T helper cells. J. Immunol. 156:2400.
30. Radrizzani, M., P. Accornero, A. Amidei, A. Aiello, D. Delia, R. Kurrle, and M. P. Colombo. 1995. IL-12 inhibits apoptosis induced in a human Th1 clone by gp120/CD4 cross-linking and CD3/TCR activation or by IL-2 deprivation. Cell. Immunol. 161:14.
31. Clerici, M., A. Sarin, R. L. Coffman, T. A. Wynn, S. P. Blatt, C. W. Hendrix, S. F. Wolf, G. M. Shearer, and P. A. Henkart. 1995. Type 1/type 2 cytokine modulation of T cell programmed cell death as a model for HIV pathogenesis. Proc. Natl. Acad. Sci. USA 91:11811.
32. + T cells from human immunodeficiency virus-infected persons. J. Exp. Med. 182:1759.
33. van der Pouw Kraan, T. C. T. M., L. C. M. Boeije, R. J. T. Smeenk, J. Wijdenes, and L. A. Aarden. 1995. Prostaglandin-E2 is a potent inhibitor of human interleukin 12 production. J. Exp. Med. 181:775.
34. Chehimi, J., and G. Trinchieri. 1994. Interleukin-12: a bridge between innate resistance and adaptive immunity with a role in infection and acquired immunodeficiency. J. Clin. Immunol. 14:149.
35. Ma, X., J. M. Chow, G. Gri, G. Carra, F. Gerosa, S. F. Wolf, R. Dzialo, and G. Trinchieri. 1995. The interleukin 12 p40 gene promoter is primed by interferon γ in monocytic cells. J. Exp. Med. 183:147.
36. Foli, A., M. W. Saville, M. W. Baseler, and R. Yarchoan. 1995. Effects of the Th1 and Th2 stimulatory cytokines interleukin-12 and interleukin-4 on human immunodeficiency virus replication. Blood 8:2114.
37. Poli, G., and A. S. Fauci. 1992. The role of monocyte/macrophages and cytokines in the pathogenesis of HIV infection. Pathobiology 60:246.
38. Clerici, M., and G. M. Shearer. 1993. A Th1-Th2 switch is a critical step in the etiology of HIV infection. Immunol. Today 14:107.
39. Vicenzi, E., and G. Poli. 1994. Regulation of HIV expression by viral genes and cytokines. J. Leukocyte Biol. 56:328.
40. Emilie, D., R. Fior, M. C. Crevon, M. C. Maillot, F. Boue, and P. Galanaud. 1994. Cytokines from lymphoid organs of HIV-infected patients: production and role in the immune disequilibrium of the disease. Res. Immunol. 145:595.
41. Romagnani, S. 1994. Lymphokine production by human T cells in disease states. Annu. Rev. Immunol. 12:227.
42. Balter, M. 1995. Cytokines move from margins into the spotlight. Science 268: 203.
43. Seder, R. A., K. H. Grabstein, J. A. Berzofsky, and J. F. MacDyer. 1995. Cytokine interaction in HIV-infected individuals: role of IL-2, IL-12 and IL-15 J. Exp. Med. 182:1067.
44. Takanori, K., E. K. Thomas, Y. Yasutomi, and N. L. Levine. 1996. IL-15 stimulates the expansion of AIDS virus-specific CTL. J. Immunol. 157:3681.
45. Flamand, L., I. Stefanescu, and J. Menezes. 1996. Human herpesvirus-6 enhances natural killer cell cytotoxicity via IL-15. J. Clin. Invest. 97:1373.
46. Nishimura, H., K. Hiromatsu, N. Kobayashi, K. H. Grabstein, R. Paxton, K. Sugamura, J. A. Bluestone, and Y. Yoshikai. 1996. IL-15 is a novel growth factor for murine γδ T cells induced by Salmonella infection. J. Immunol. 156: 663.
47. Sirianni, M. C., F. Tagliaferri, and F. Aiuti. 1990. Pathogenesis of the natural killer cell deficiency in AIDS. Immunol. Today 11:81.
48. Sirianni, M. C., I. J. Ansotegui, F. Aiuti, and H. Wigzell. 1995. Natural killer cell stimulatory (NKSF)/IL-12 and cytolytic activities of PBL/NK cells from human immunodeficiency virus type-1 infected patients. Scand. J. Immunol. 40:83.
49. Patki, A. H., M. E. Quinones-Mateu, D. Dorazio, B. Yen-Lieberman, W. H. Boom, E. K. Thomas, and M. M. Lederman. 1996. Activation of antigen-induced lymphocyte proliferation by interleukin-15 without the mitogenic effect of interleukin-2 that may induce human immunodeficiency virus-1 expression. J. Clin. Invest. 98:616.
50. Doherty, T. M., R. A. Seder, and A. Sher. 1996. Induction and regulation of IL-15 expression in murine macrophages. J. Immunol. 156:735.
51. Salvucci, O., F. Mami-Chouaib, J. L. Moreau, J. Theze, J. Chehimi, and S. Chouaib. 1996. Differential regulation of IL-12 and IL-15-induced NK cell activation by IL-4. Eur. J. Immunol. 26:2736.
52. Gazzinelli, R. T., S. Bala, R. Stevens, M. Baseler, L. Wahl, J. Kovacs, and A. Sher. 1995. HIV infection suppresses type 1 lymphokine and IL-12 responses to Toxoplasma gondii but fails to inhibit the synthesis of other parasite induced monokines. J. Immunol. 155:1565.
53. Chougnet, C., T. A. Wynn, M. Clerici, A. L. Landay, H. A. Kessler, J. Rusnak, G. P. Melcher, A. Sher, and G. M. Shearer. 1996. Molecular analysis of decreased IL-12 production in persons infected with human immunodeficiency virus. J. Infect. Dis. 174:46.
54. Harrison, T. S., and S. M. Levitz. 1996. Role of IL-12 in peripheral blood mononuclear cell responses to fungi in persons with and without HIV infection. J. Immunol. 156:4492.