메뉴 건너뛰기




Volumn 16, Issue 5, 2012, Pages

Therapeutic efficacy of CXCR3 blockade in an experimental model of severe sepsis

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CXCR3; CHEMOKINE RECEPTOR CXCR3 ANTIBODY; CILASTATIN PLUS IMIPENEM; CXCL3 CHEMOKINE; IMMUNOGLOBULIN G; INTERLEUKIN 6; NEUTRALIZING ANTIBODY; UNCLASSIFIED DRUG; ANTIIDIOTYPIC ANTIBODY; CXCR3 PROTEIN, MOUSE;

EID: 84866304118     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11642     Document Type: Article
Times cited : (17)

References (33)
  • 1
    • 79951944636 scopus 로고    scopus 로고
    • CXCR3 ligands: redundant, collaborative and antagonistic functions
    • 10.1038/icb.2010.158, 21221121
    • Groom JR, Luster AD. CXCR3 ligands: redundant, collaborative and antagonistic functions. Immunol Cell Biol 2011, 89:207-215. 10.1038/icb.2010.158, 21221121.
    • (2011) Immunol Cell Biol , vol.89 , pp. 207-215
    • Groom, J.R.1    Luster, A.D.2
  • 2
    • 33646561249 scopus 로고    scopus 로고
    • Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11
    • 10.1182/blood-2004-01-0214, 16368892
    • Dagan-Berger M, Feniger-Barish R, Avniel S, Wald H, Galun E, Grabovsky V, Alon R, Nagler A, Ben-Baruch A, Peled A. Role of CXCR3 carboxyl terminus and third intracellular loop in receptor-mediated migration, adhesion and internalization in response to CXCL11. Blood 2006, 107:3821-3831. 10.1182/blood-2004-01-0214, 16368892.
    • (2006) Blood , vol.107 , pp. 3821-3831
    • Dagan-Berger, M.1    Feniger-Barish, R.2    Avniel, S.3    Wald, H.4    Galun, E.5    Grabovsky, V.6    Alon, R.7    Nagler, A.8    Ben-Baruch, A.9    Peled, A.10
  • 3
    • 0032526864 scopus 로고    scopus 로고
    • Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3
    • 10.1084/jem.187.12.2009, 2212354, 9625760
    • Cole KE, Strick CA, Paradis TJ, Ogborne KT, Loetscher M, Gladue RP, Lin W, Boyd JG, Moser B, Wood DE, Sahagan BG, Neote K. Interferon-inducible T cell alpha chemoattractant (I-TAC): a novel non-ELR CXC chemokine with potent activity on activated T cells through selective high affinity binding to CXCR3. J Exp Med 1998, 187:2009-2021. 10.1084/jem.187.12.2009, 2212354, 9625760.
    • (1998) J Exp Med , vol.187 , pp. 2009-2021
    • Cole, K.E.1    Strick, C.A.2    Paradis, T.J.3    Ogborne, K.T.4    Loetscher, M.5    Gladue, R.P.6    Lin, W.7    Boyd, J.G.8    Moser, B.9    Wood, D.E.10    Sahagan, B.G.11    Neote, K.12
  • 4
    • 34447502170 scopus 로고    scopus 로고
    • Antitumor effects of the MIG and IP-10 genes transferred with poly[d,l-2,4-diaminobutyric acid] on murine neuroblastoma
    • 10.1038/sj.cgt.7701059, 17514193
    • Tominaga M, Iwashita Y, Ohta M, Shibata K, Ishio T, Ohmori N, Goto T, Sato S, Kitano S. Antitumor effects of the MIG and IP-10 genes transferred with poly[d,l-2,4-diaminobutyric acid] on murine neuroblastoma. Cancer Gene Ther 2007, 14:696-705. 10.1038/sj.cgt.7701059, 17514193.
    • (2007) Cancer Gene Ther , vol.14 , pp. 696-705
    • Tominaga, M.1    Iwashita, Y.2    Ohta, M.3    Shibata, K.4    Ishio, T.5    Ohmori, N.6    Goto, T.7    Sato, S.8    Kitano, S.9
  • 5
    • 80155144555 scopus 로고    scopus 로고
    • CXCL10 and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis
    • 10.1002/art.30573, 3205193, 21811993
    • Laragione T, Brenner M, Sherry B, Gulko PS. CXCL10 and its receptor CXCR3 regulate synovial fibroblast invasion in rheumatoid arthritis. Arthritis Rheum 2011, 63:3274-3283. 10.1002/art.30573, 3205193, 21811993.
    • (2011) Arthritis Rheum , vol.63 , pp. 3274-3283
    • Laragione, T.1    Brenner, M.2    Sherry, B.3    Gulko, P.S.4
  • 6
    • 52149122291 scopus 로고    scopus 로고
    • The role of T helper cell subsets in pathogenesis of systemic lupus erythematosus and their relation to disease activity
    • Al-Saleh J, el-Eissawy S. The role of T helper cell subsets in pathogenesis of systemic lupus erythematosus and their relation to disease activity. Egypt J Immunol 2006, 13:41-48.
    • (2006) Egypt J Immunol , vol.13 , pp. 41-48
    • Al-Saleh, J.1    el-Eissawy, S.2
  • 7
    • 77952884361 scopus 로고    scopus 로고
    • Th1 (CXCL10) and Th2 (CCL2) chemokine expression in patients with immune thrombocytopenia
    • 10.1016/j.humimm.2010.02.010, 20153790
    • Gu D, Chen Z, Zhao H, Du W, Xue F, Ge J, Sui T, Wu H, Liu B, Lu S, Zhang L, Yang R. Th1 (CXCL10) and Th2 (CCL2) chemokine expression in patients with immune thrombocytopenia. Hum Immunol 2010, 71:586-591. 10.1016/j.humimm.2010.02.010, 20153790.
    • (2010) Hum Immunol , vol.71 , pp. 586-591
    • Gu, D.1    Chen, Z.2    Zhao, H.3    Du, W.4    Xue, F.5    Ge, J.6    Sui, T.7    Wu, H.8    Liu, B.9    Lu, S.10    Zhang, L.11    Yang, R.12
  • 9
    • 71349083174 scopus 로고    scopus 로고
    • I-TAC is a dominant chemokine in controlling skin intragraft inflammation via recruiting CXCR3+ cells into the graft
    • 10.1016/j.cellimm.2009.09.004, 19875106
    • Li B, Xu W, Xu L, Jiang Z, Wen Z, Li K, Xiong S. I-TAC is a dominant chemokine in controlling skin intragraft inflammation via recruiting CXCR3+ cells into the graft. Cell Immunol 2010, 260:83-91. 10.1016/j.cellimm.2009.09.004, 19875106.
    • (2010) Cell Immunol , vol.260 , pp. 83-91
    • Li, B.1    Xu, W.2    Xu, L.3    Jiang, Z.4    Wen, Z.5    Li, K.6    Xiong, S.7
  • 10
    • 60349085081 scopus 로고    scopus 로고
    • The chemokine receptors CXCR4 and CXCR3 in cancer
    • 10.1007/s11912-009-0019-1, 19216844
    • Fulton AM. The chemokine receptors CXCR4 and CXCR3 in cancer. Curr Oncol Rep 2009, 11:125-131. 10.1007/s11912-009-0019-1, 19216844.
    • (2009) Curr Oncol Rep , vol.11 , pp. 125-131
    • Fulton, A.M.1
  • 11
    • 33644952574 scopus 로고    scopus 로고
    • Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS
    • 10.1002/eji.200535509, 16479546
    • Stiles LN, Hosking MP, Edwards RA, Strieter RM, Lane TE. Differential roles for CXCR3 in CD4+ and CD8+ T cell trafficking following viral infection of the CNS. Eur J Immunol 2006, 36:613-622. 10.1002/eji.200535509, 16479546.
    • (2006) Eur J Immunol , vol.36 , pp. 613-622
    • Stiles, L.N.1    Hosking, M.P.2    Edwards, R.A.3    Strieter, R.M.4    Lane, T.E.5
  • 12
    • 79951836784 scopus 로고    scopus 로고
    • A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock
    • 10.4049/jimmunol.1002864, 21257964
    • Thair SA, Walley KR, Nakada TA, McConechy MK, Boyd JH, Wellman H, Russell JA. A single nucleotide polymorphism in NF-κB inducing kinase is associated with mortality in septic shock. J Immunol 2011, 186:2321-2328. 10.4049/jimmunol.1002864, 21257964.
    • (2011) J Immunol , vol.186 , pp. 2321-2328
    • Thair, S.A.1    Walley, K.R.2    Nakada, T.A.3    McConechy, M.K.4    Boyd, J.H.5    Wellman, H.6    Russell, J.A.7
  • 13
    • 78650482176 scopus 로고    scopus 로고
    • A biomarker panel to discriminate between systemic inflammatory response syndrome and sepsis and sepsis severity
    • 10.4103/0974-2700.58666, 2823139, 20165718
    • Punyadeera C, Schneider EM, Schaffer D, Hsu HY, Joos TO, Kriebel F, Weiss M, Verhaegh WF. A biomarker panel to discriminate between systemic inflammatory response syndrome and sepsis and sepsis severity. J Emerg Trauma Shock 2010, 3:26-35. 10.4103/0974-2700.58666, 2823139, 20165718.
    • (2010) J Emerg Trauma Shock , vol.3 , pp. 26-35
    • Punyadeera, C.1    Schneider, E.M.2    Schaffer, D.3    Hsu, H.Y.4    Joos, T.O.5    Kriebel, F.6    Weiss, M.7    Verhaegh, W.F.8
  • 14
    • 79953744140 scopus 로고    scopus 로고
    • Plasma IP-10 as a predictor of serious bacterial infection in infants less than 4 months of age
    • 10.1093/tropej/fmr021, 21447596
    • Chen HL, Hung CH, Tseng HI, Yang RC. Plasma IP-10 as a predictor of serious bacterial infection in infants less than 4 months of age. J Trop Pediatr 2011, 57:145-151. 10.1093/tropej/fmr021, 21447596.
    • (2011) J Trop Pediatr , vol.57 , pp. 145-151
    • Chen, H.L.1    Hung, C.H.2    Tseng, H.I.3    Yang, R.C.4
  • 15
    • 33846941950 scopus 로고    scopus 로고
    • IP-10 is an early diagnostic marker for identification of late-onset bacterial infection in preterm infants
    • 10.1203/01.pdr.0000250207.95723.96, 17211148
    • Ng PC, Li K, Chui KM, Leung TF, Wong RP, Chu WC, Wong E, Fok TF. IP-10 is an early diagnostic marker for identification of late-onset bacterial infection in preterm infants. Pediatr Res 2007, 61:93-98. 10.1203/01.pdr.0000250207.95723.96, 17211148.
    • (2007) Pediatr Res , vol.61 , pp. 93-98
    • Ng, P.C.1    Li, K.2    Chui, K.M.3    Leung, T.F.4    Wong, R.P.5    Chu, W.C.6    Wong, E.7    Fok, T.F.8
  • 16
    • 84856807329 scopus 로고    scopus 로고
    • Regulation of lymphocyte trafficking by CXC chemokine receptor 3 during septic shock
    • 10.1164/rccm.201108-1560OC, 22135342
    • Herzig DS, Driver BR, Fang G, Toliver-Kinsky TE, Shute EN, Sherwood ER. Regulation of lymphocyte trafficking by CXC chemokine receptor 3 during septic shock. Am J Respir Crit Care Med 2012, 185:291-300. 10.1164/rccm.201108-1560OC, 22135342.
    • (2012) Am J Respir Crit Care Med , vol.185 , pp. 291-300
    • Herzig, D.S.1    Driver, B.R.2    Fang, G.3    Toliver-Kinsky, T.E.4    Shute, E.N.5    Sherwood, E.R.6
  • 17
    • 44449143573 scopus 로고    scopus 로고
    • NK but not CD1-restricted NKT cells facilitate systemic inflammation during polymicrobial intra-abdominal sepsis
    • 3413484, 18424757
    • Etogo AO, Nunez J, Lin CY, Toliver-Kinsky TE, Sherwood ER. NK but not CD1-restricted NKT cells facilitate systemic inflammation during polymicrobial intra-abdominal sepsis. J Immunol 2008, 180:6334-6345. 3413484, 18424757.
    • (2008) J Immunol , vol.180 , pp. 6334-6345
    • Etogo, A.O.1    Nunez, J.2    Lin, C.Y.3    Toliver-Kinsky, T.E.4    Sherwood, E.R.5
  • 18
    • 69949133380 scopus 로고    scopus 로고
    • CXCR3, inflammation, and autoimmune diseases
    • 10.1111/j.1749-6632.2009.04813.x, 19758167
    • Lacotte S, Brun S, Muller S, Dumortier H. CXCR3, inflammation, and autoimmune diseases. Ann N Y Acad Sci 2009, 1173:310-317. 10.1111/j.1749-6632.2009.04813.x, 19758167.
    • (2009) Ann N Y Acad Sci , vol.1173 , pp. 310-317
    • Lacotte, S.1    Brun, S.2    Muller, S.3    Dumortier, H.4
  • 19
    • 0036041995 scopus 로고    scopus 로고
    • T-cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking
    • 10.1046/j.1365-2249.2002.01947.x, 1906480, 12197893
    • Kivisakk P, Trebst C, Liu Z, Tucky BH, Sorensen TL, Rudick RA, Mack M, Ransohoff RM. T-cells in the cerebrospinal fluid express a similar repertoire of inflammatory chemokine receptors in the absence or presence of CNS inflammation: implications for CNS trafficking. Clin Exp Immunol 2002, 129:510-518. 10.1046/j.1365-2249.2002.01947.x, 1906480, 12197893.
    • (2002) Clin Exp Immunol , vol.129 , pp. 510-518
    • Kivisakk, P.1    Trebst, C.2    Liu, Z.3    Tucky, B.H.4    Sorensen, T.L.5    Rudick, R.A.6    Mack, M.7    Ransohoff, R.M.8
  • 20
    • 34250800833 scopus 로고    scopus 로고
    • CXCR3 axis: role in inflammatory bowel disease and its therapeutic implication
    • 10.2174/187153007780832109, 17584151
    • Singh UP, Venkataraman C, Singh R, Lillard JW. CXCR3 axis: role in inflammatory bowel disease and its therapeutic implication. Endocr Metab Immune Disord Drug Targets 2007, 7:111-123. 10.2174/187153007780832109, 17584151.
    • (2007) Endocr Metab Immune Disord Drug Targets , vol.7 , pp. 111-123
    • Singh, U.P.1    Venkataraman, C.2    Singh, R.3    Lillard, J.W.4
  • 21
    • 0041326683 scopus 로고    scopus 로고
    • Genetic deletion of chemokine receptor CXCR3 or antibody blockade of its ligand IP-10 modulates posttransplantation graft-site lymphocytic infiltrates and prolongs functional graft survival in pancreatic islet allograft recipients
    • 10.1067/msy.2003.213, 12947308
    • Baker MS, Chen X, Rotramel AR, Nelson JJ, Lu B, Gerard C, Kanwar Y, Kaufman DB. Genetic deletion of chemokine receptor CXCR3 or antibody blockade of its ligand IP-10 modulates posttransplantation graft-site lymphocytic infiltrates and prolongs functional graft survival in pancreatic islet allograft recipients. Surgery 2003, 134:126-133. 10.1067/msy.2003.213, 12947308.
    • (2003) Surgery , vol.134 , pp. 126-133
    • Baker, M.S.1    Chen, X.2    Rotramel, A.R.3    Nelson, J.J.4    Lu, B.5    Gerard, C.6    Kanwar, Y.7    Kaufman, D.B.8
  • 22
    • 48149111878 scopus 로고    scopus 로고
    • Towards small-molecule CXCR3 ligands with clinical potential
    • 10.1002/cmdc.200700365, 18442035
    • Wijtmans M, Verzijl D, Leurs R, de Esch IJ, Smit MJ. Towards small-molecule CXCR3 ligands with clinical potential. ChemMedChem 2008, 3:861-872. 10.1002/cmdc.200700365, 18442035.
    • (2008) ChemMedChem , vol.3 , pp. 861-872
    • Wijtmans, M.1    Verzijl, D.2    Leurs, R.3    de Esch, I.J.4    Smit, M.J.5
  • 25
    • 79957493207 scopus 로고    scopus 로고
    • CXCR3 antagonists: quaternary ammonium salts equipped with biphenyl- and polycycloaliphatic-anchors
    • 10.1016/j.bmc.2011.04.035, 21570852
    • Wijtmans M, Verzijl D, Bergmans S, Lai M, Bosch L, Smit MJ, de Esch IJ, Leurs R. CXCR3 antagonists: quaternary ammonium salts equipped with biphenyl- and polycycloaliphatic-anchors. Bioorg Med Chem 2011, 19:3384-3393. 10.1016/j.bmc.2011.04.035, 21570852.
    • (2011) Bioorg Med Chem , vol.19 , pp. 3384-3393
    • Wijtmans, M.1    Verzijl, D.2    Bergmans, S.3    Lai, M.4    Bosch, L.5    Smit, M.J.6    de Esch, I.J.7    Leurs, R.8
  • 26
    • 0035024450 scopus 로고    scopus 로고
    • Cxcr3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejection
    • 10.1016/S0002-9440(10)64126-0, 1891930, 11337368
    • Agostini C, Calabrese F, Rea F, Facco M, Tosoni A, Loy M, Binotto G, Valente M, Trentin L, Semenzato G. Cxcr3 and its ligand CXCL10 are expressed by inflammatory cells infiltrating lung allografts and mediate chemotaxis of T cells at sites of rejection. Am J Pathol 2001, 158:1703-1711. 10.1016/S0002-9440(10)64126-0, 1891930, 11337368.
    • (2001) Am J Pathol , vol.158 , pp. 1703-1711
    • Agostini, C.1    Calabrese, F.2    Rea, F.3    Facco, M.4    Tosoni, A.5    Loy, M.6    Binotto, G.7    Valente, M.8    Trentin, L.9    Semenzato, G.10
  • 27
    • 3242765880 scopus 로고    scopus 로고
    • Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome
    • Hildebrandt GC, Corrion LA, Olkiewicz KM, Lu B, Lowler K, Duffner UA, Moore BB, Kuziel WA, Liu C, Cooke KR. Blockade of CXCR3 receptor:ligand interactions reduces leukocyte recruitment to the lung and the severity of experimental idiopathic pneumonia syndrome. J Immunol 2004, 173:2050-2059.
    • (2004) J Immunol , vol.173 , pp. 2050-2059
    • Hildebrandt, G.C.1    Corrion, L.A.2    Olkiewicz, K.M.3    Lu, B.4    Lowler, K.5    Duffner, U.A.6    Moore, B.B.7    Kuziel, W.A.8    Liu, C.9    Cooke, K.R.10
  • 28
    • 33751502698 scopus 로고    scopus 로고
    • Expression pattern of chemokine receptors and chemokine release in inflammatory erythroderma and Sezary syndrome
    • 10.1159/000096191, 17135733
    • Fierro MT, Comessatti A, Quaglino P, Ortoncelli M, Osella Abate S, Ponti R, Novelli M, Bernengo MG. Expression pattern of chemokine receptors and chemokine release in inflammatory erythroderma and Sezary syndrome. Dermatology 2006, 213:284-292. 10.1159/000096191, 17135733.
    • (2006) Dermatology , vol.213 , pp. 284-292
    • Fierro, M.T.1    Comessatti, A.2    Quaglino, P.3    Ortoncelli, M.4    Osella Abate, S.5    Ponti, R.6    Novelli, M.7    Bernengo, M.G.8
  • 29
    • 20444452354 scopus 로고    scopus 로고
    • Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts
    • 10.1016/j.micinf.2005.02.011, 15893495
    • Kerr AR, Kirkham LA, Kadioglu A, Andrew PW, Garside P, Thompson H, Mitchell TJ. Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts. Microbes Infect 2005, 7:845-852. 10.1016/j.micinf.2005.02.011, 15893495.
    • (2005) Microbes Infect , vol.7 , pp. 845-852
    • Kerr, A.R.1    Kirkham, L.A.2    Kadioglu, A.3    Andrew, P.W.4    Garside, P.5    Thompson, H.6    Mitchell, T.J.7
  • 30
    • 0036674204 scopus 로고    scopus 로고
    • Natural killer cells contribute to the lethality of a murine model of Escherichia coli infection
    • 10.1067/msy.2002.125311, 12219013
    • Badgwell B, Parihar R, Magro C, Dierksheide J, Russo T, Carson WE. Natural killer cells contribute to the lethality of a murine model of Escherichia coli infection. Surgery 2002, 132:205-212. 10.1067/msy.2002.125311, 12219013.
    • (2002) Surgery , vol.132 , pp. 205-212
    • Badgwell, B.1    Parihar, R.2    Magro, C.3    Dierksheide, J.4    Russo, T.5    Carson, W.E.6
  • 31
    • 54049107296 scopus 로고    scopus 로고
    • Depletion of NK cells in a murine polytrauma model is associated with improved outcome and a modulation of the inflammatory response
    • 10.1097/SHK.0b013e31816e2cda, 18391857
    • Barkhausen T, Frerker C, Putz C, Pape HC, Krettek C, van Griensven M. Depletion of NK cells in a murine polytrauma model is associated with improved outcome and a modulation of the inflammatory response. Shock 2008, 30:401-410. 10.1097/SHK.0b013e31816e2cda, 18391857.
    • (2008) Shock , vol.30 , pp. 401-410
    • Barkhausen, T.1    Frerker, C.2    Putz, C.3    Pape, H.C.4    Krettek, C.5    van Griensven, M.6
  • 32
    • 77951723662 scopus 로고    scopus 로고
    • Murine CXCR3+CD27bright NK cells resemble the human CD56bright NK-cell population
    • 10.1002/eji.200940056, 20186880
    • Marquardt N, Wilk E, Pokoyski C, Schmidt RE, Jacobs R. Murine CXCR3+CD27bright NK cells resemble the human CD56bright NK-cell population. Eur J Immunol 2010, 40:1428-1439. 10.1002/eji.200940056, 20186880.
    • (2010) Eur J Immunol , vol.40 , pp. 1428-1439
    • Marquardt, N.1    Wilk, E.2    Pokoyski, C.3    Schmidt, R.E.4    Jacobs, R.5
  • 33
    • 84856104734 scopus 로고    scopus 로고
    • Innate immunity in the vasculature: interactions with pathogenic bacteria
    • 10.1016/j.mib.2011.11.010, 22189442
    • Harding M, Kubes P. Innate immunity in the vasculature: interactions with pathogenic bacteria. Curr Opin Microbiol 2012, 15:85-91. 10.1016/j.mib.2011.11.010, 22189442.
    • (2012) Curr Opin Microbiol , vol.15 , pp. 85-91
    • Harding, M.1    Kubes, P.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.