Asmall-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase

Nature Chemical Biology

Volumn 13, Issue 9, 2017, Pages 943-950

  Wellington, Samantha ^a,b,c   Nag, Partha P ^a   Michalska, Karolina ^d,e   Johnston, Stephen E ^a   Jedrzejczak, Robert P ^d,e   Kaushik, Virendar K ^a   Clatworthy, Anne E ^c   Siddiqi, Noman ^f   McCarren, Patrick ^a   Bajrami, Besnik ^a   Maltseva, Natalia I ^d   Combs, Senya ^c   Fisher, Stewart L ^a   Joachimiak, Andrzej ^d,e   Schreiber, Stuart L ^a,g   Hung, Deborah T ^a,b,c  

^a BROAD INSTITUTE OF MIT AND HARVARD   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

^e ARGONNE NATIONAL LABORATORY   (United States)

^f HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^g HARVARD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZETIDINE DERIVATIVE; BRD4592; MOLECULAR LIBRARY; TRYPTOPHAN SYNTHASE; TUBERCULOSTATIC AGENT;

ALLOSTERISM; ANTAGONISTS AND INHIBITORS; BINDING SITE; CHEMISTRY; DRUG DELIVERY SYSTEM; DRUG EFFECTS; ENZYMOLOGY; MOLECULAR LIBRARY; MYCOBACTERIUM TUBERCULOSIS; PHARMACOLOGY; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

ALLOSTERIC REGULATION; ANTITUBERCULAR AGENTS; AZETIDINES; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DRUG DELIVERY SYSTEMS; MYCOBACTERIUM TUBERCULOSIS; SMALL MOLECULE LIBRARIES; TRYPTOPHAN SYNTHASE;

EID: 85027831330     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.2420     Document Type: Article

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