메뉴 건너뛰기




Volumn 14, Issue 11, 2015, Pages 751-758

Hit and lead criteria in drug discovery for infectious diseases of the developing world

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN; INFECTION; NONHUMAN; PRIORITY JOURNAL; REVIEW; ANIMAL; COMMUNICABLE DISEASES; DEVELOPING COUNTRY; DRUG DEVELOPMENT; ECONOMICS; MALARIA; NEGLECTED DISEASES; NON PROFIT ORGANIZATION; TRENDS; TUBERCULOSIS;

EID: 84946483813     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4683     Document Type: Review
Times cited : (465)

References (82)
  • 2
    • 84856289656 scopus 로고    scopus 로고
    • High-Throughput screening: The hits, and leads of drug discovery-An overview
    • Martis, E. A., Radhakrishnan, R., & Badve, R. R. High-Throughput screening: the hits, and leads of drug discovery-An overview. J. Appl. Pharma. Sci. 1, 2-10 (2011
    • (2011) J. Appl. Pharma. Sci , vol.1 , pp. 2-10
    • Martis, E.A.1    Radhakrishnan, R.2    Badve, R.R.3
  • 3
    • 84866739808 scopus 로고    scopus 로고
    • Drug discovery in pharmaceutical industry: Productivity challenges, and trends
    • Khanna, I. Drug discovery in pharmaceutical industry: productivity challenges, and trends. Drug Discov. Today 17, 1088-1102 (2012
    • (2012) Drug Discov. Today , vol.17 , pp. 1088-1102
    • Khanna, I.1
  • 4
    • 33750531864 scopus 로고    scopus 로고
    • Innovative lead discovery strategies for tropical diseases
    • Nwaka, S., & Hudson, A. Innovative lead discovery strategies for tropical diseases. Nat. Rev. Drug Discov. 5, 941-955 (2006
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 941-955
    • Nwaka, S.1    Hudson, A.2
  • 5
    • 70449640250 scopus 로고    scopus 로고
    • Advancing drug innovation for neglected diseases-criteria for lead progression
    • Nwaka, S., et al. Advancing drug innovation for neglected diseases-criteria for lead progression. PLoS Negl Trop. Dis. 3, e440 (2009
    • (2009) PLoS Negl Trop. Dis , vol.3 , pp. e440
    • Nwaka, S.1
  • 7
    • 84875448716 scopus 로고    scopus 로고
    • Phenotypic versus target-based drug discovery for first in class medicines
    • Swinney, D. C. Phenotypic versus target-based drug discovery for first in class medicines. Clin. Pharmacol. Ther. 93, 299-301 (2013
    • (2013) Clin. Pharmacol. Ther , vol.93 , pp. 299-301
    • Swinney, D.C.1
  • 8
    • 84905495729 scopus 로고    scopus 로고
    • The discovery of first in class drugs: Origins, and evolution
    • Eder, J., Sedrani, R., & Wiesmann, C. The discovery of first in class drugs: origins, and evolution. Nat. Rev. Drug Discov. 13, 577-587 (2014
    • (2014) Nat. Rev. Drug Discov , vol.13 , pp. 577-587
    • Eder, J.1    Sedrani, R.2    Wiesmann, C.3
  • 9
    • 33845903833 scopus 로고    scopus 로고
    • Drugs for bad bugs: Confronting the challenges of antibacterial discovery
    • Payne, D. J., Gwynn, M. N., Holmes, D. J., & Pompliano, D. L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6, 29-40 (2007
    • (2007) Nat. Rev. Drug Discov , vol.6 , pp. 29-40
    • Payne, D.J.1    Gwynn, M.N.2    Holmes, D.J.3    Pompliano, D.L.4
  • 10
    • 84903513282 scopus 로고    scopus 로고
    • Fluorine modulates species selectivity in the triazolopyrimidine class of plasmodium falciparum dihydroorotate dehydrogenase inhibitors
    • Deng, X., et al. Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J. Med. Chem. 57, 5381-5394 (2014
    • (2014) J. Med. Chem , vol.57 , pp. 5381-5394
    • Deng, X.1
  • 11
    • 0036311121 scopus 로고    scopus 로고
    • Cultivation of plasmodium spp
    • Schuster, F. L. Cultivation of Plasmodium spp. Clin. Microbiol. Rev. 15, 355-364 (2002
    • (2002) Clin. Microbiol. Rev , vol.15 , pp. 355-364
    • Schuster, F.L.1
  • 12
    • 78650464813 scopus 로고    scopus 로고
    • Apoptosis stalks plasmodium falciparum maintained in continuous culture condition
    • Mutai, B. K., & Waitumbi, J. N. Apoptosis stalks Plasmodium falciparum maintained in continuous culture condition. Malar J. 9 (Suppl. 3), S6 (2010
    • (2010) Malar J. , vol.9 , pp. S6
    • Mutai, B.K.1    Waitumbi, J.N.2
  • 13
    • 84920081179 scopus 로고    scopus 로고
    • Chagas disease drug discovery: Toward a new era
    • Chatelain, E. Chagas disease drug discovery: toward a new era. J. Biomol. Screen 20, 22-35 (2015
    • (2015) J. Biomol. Screen , vol.20 , pp. 22-35
    • Chatelain, E.1
  • 15
    • 40049090584 scopus 로고    scopus 로고
    • A major transition in malaria treatment: The adoption, and deployment of artemisinin-based combination therapies
    • Bosman, A., & Mendis, K. N A major transition in malaria treatment: the adoption, and deployment of artemisinin-based combination therapies. Am. J. Trop. Med. Hyg. 77, 193-197 (2007
    • (2007) Am. J. Trop. Med. Hyg , vol.77 , pp. 193-197
    • Bosman, A.1    Mendis, K.N.2
  • 16
    • 84905225792 scopus 로고    scopus 로고
    • New drugs to treat multidrug-resistant tuberculosis: The case for bedaquiline
    • Leibert, E., Danckers, M., & Rom, W. N. New drugs to treat multidrug-resistant tuberculosis: the case for bedaquiline. Ther. Clin. Risk Manag. 10, 597-602 (2014
    • (2014) Ther. Clin. Risk Manag , vol.10 , pp. 597-602
    • Leibert, E.1    Danckers, M.2    Rom, W.N.3
  • 17
    • 84905712035 scopus 로고    scopus 로고
    • Delamanid: A new armor in combating drug-resistant tuberculosis
    • Xavier, A. S., & Lakshmanan, M. Delamanid: a new armor in combating drug-resistant tuberculosis. J. Pharmacol. Pharmacother. 5, 222-224 (2014
    • (2014) J. Pharmacol. Pharmacother , vol.5 , pp. 222-224
    • Xavier, A.S.1    Lakshmanan, M.2
  • 18
    • 33644867602 scopus 로고    scopus 로고
    • Improving the hit to lead process: Data-driven assessment of drug-like, and lead-like screening hits
    • Wunberg, T., et al. Improving the hit to lead process: data-driven assessment of drug-like, and lead-like screening hits. Drug Discov. Today 11, 175-180 (2006
    • (2006) Drug Discov. Today , vol.11 , pp. 175-180
    • Wunberg, T.1
  • 19
    • 85009155925 scopus 로고    scopus 로고
    • Early drug discovery and development guidelines: For academic researchers collaborators and start up companies
    • Hughes, M., et al. Early drug discovery, and development guidelines: for academic researchers, collaborators, and start up companies. Assay Guidance Manual [online], http://www.ncbi.nlm.nih.gov/books/NBK92015/(2012
    • (2012) Assay Guidance Manual [Online]
    • Hughes, M.1
  • 20
    • 84892372929 scopus 로고    scopus 로고
    • A molecular marker of artemisinin-resistant plasmodium falciparum malaria
    • Ariey, F., et al A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature 505, 50-55 (2014
    • (2014) Nature , vol.505 , pp. 50-55
    • Ariey, F.1
  • 21
    • 84904892931 scopus 로고    scopus 로고
    • Spread of artemisinin resistance in plasmodium falciparum malaria
    • Ashley, E. A., et al. Spread of artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 371, 411-423 (2014
    • (2014) N. Engl. J. Med , vol.371 , pp. 411-423
    • Ashley, E.A.1
  • 22
    • 84928810196 scopus 로고    scopus 로고
    • Microbiology: Malaria runs rings round artemisinin
    • Burrows, J. Microbiology: malaria runs rings round artemisinin. Nature 520, 628-630 (2015
    • (2015) Nature , vol.520 , pp. 628-630
    • Burrows, J.1
  • 23
    • 84928814749 scopus 로고    scopus 로고
    • A molecular mechanism of artemisinin resistance in plasmodium falciparum malaria
    • Mbengue, A., et al A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature 520, 683-687 (2015
    • (2015) Nature , vol.520 , pp. 683-687
    • Mbengue, A.1
  • 25
    • 77952704258 scopus 로고    scopus 로고
    • Thousands of chemical starting points for antimalarial lead identification
    • Gamo, F. J., et al. Thousands of chemical starting points for antimalarial lead identification. Nature 465, 305-310 (2010
    • (2010) Nature , vol.465 , pp. 305-310
    • Gamo, F.J.1
  • 26
    • 77952718950 scopus 로고    scopus 로고
    • Chemical genetics of plasmodium falciparum
    • Guiguemde, W. A., et al. Chemical genetics of Plasmodium falciparum. Nature 465, 311-315 (2010
    • (2010) Nature , vol.465 , pp. 311-315
    • Guiguemde, W.A.1
  • 27
    • 48249095940 scopus 로고    scopus 로고
    • In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-Throughput screen
    • Plouffe, D., et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-Throughput screen. Proc. Natl Acad. Sci. USA 105, 9059-9064 (2008
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , pp. 9059-9064
    • Plouffe, D.1
  • 28
    • 83255176722 scopus 로고    scopus 로고
    • Imaging of plasmodium liver stages to drive next-generation antimalarial drug discovery
    • Meister, S., et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science 334, 1372-1377 (2011
    • (2011) Science , vol.334 , pp. 1372-1377
    • Meister, S.1
  • 29
    • 48249090848 scopus 로고    scopus 로고
    • A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes
    • Angulo-Barturen, I., et al A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes. PLoS ONE 3, e2252 (2008
    • (2008) PLoS ONE , vol.3 , pp. e2252
    • Angulo-Barturen, I.1
  • 30
    • 84876002292 scopus 로고    scopus 로고
    • Quinolone 3 diarylethers: A new class of antimalarial drug
    • 177ra37
    • Nilsen, A., et al. Quinolone 3 diarylethers: a new class of antimalarial drug. Sci. Transl. Med. 5, 177ra37 (2013
    • (2013) Sci. Transl. Med , vol.5
    • Nilsen, A.1
  • 31
    • 84924527760 scopus 로고    scopus 로고
    • Drug resistance genomics of the antimalarial drug artemisinin
    • Winzeler, E. A., & Manary, M. J. Drug resistance genomics of the antimalarial drug artemisinin. Genome Biol. 15, 544 (2014
    • (2014) Genome Biol , vol.15 , pp. 544
    • Winzeler, E.A.1    Manary, M.J.2
  • 32
    • 84923120760 scopus 로고    scopus 로고
    • Novel mutations in k13 propeller gene of artemisinin-resistant plasmodium falciparum
    • Isozumi, R., et al. Novel mutations in K13 propeller gene of artemisinin-resistant Plasmodium falciparum. Emerg. Infect. Dis. 21, 490-492 (2015
    • (2015) Emerg. Infect. Dis , vol.21 , pp. 490-492
    • Isozumi, R.1
  • 33
    • 84925354867 scopus 로고    scopus 로고
    • Spread of artemisinin-resistant plasmodium falciparum in myanmar: A cross-sectional survey of the k13 molecular marker
    • Tun, K. M., et al. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker. Lancet Infect. Dis. 15, 415-421 (2015
    • (2015) Lancet Infect. Dis , vol.15 , pp. 415-421
    • Tun, K.M.1
  • 34
    • 79953322662 scopus 로고    scopus 로고
    • Towards an in vitro model of plasmodium hypnozoites suitable for drug discovery
    • Dembele, L., et al. Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery. PLoS ONE 6, e18162 (2011
    • (2011) PLoS ONE , vol.6 , pp. e18162
    • Dembele, L.1
  • 35
    • 84858213521 scopus 로고    scopus 로고
    • The biology of sexual development of plasmodium: The design, and implementation of transmission-blocking strategies
    • Sinden, R. E., Carter, R., Drakeley, C., & Leroy, D. The biology of sexual development of Plasmodium: the design, and implementation of transmission-blocking strategies. Malar J. 11, 70 (2012
    • (2012) Malar J. , vol.11 , pp. 70
    • Sinden, R.E.1    Carter, R.2    Drakeley, C.3    Leroy, D.4
  • 36
    • 84894198937 scopus 로고    scopus 로고
    • World Health Organization. WHO [online]
    • World Health Organization. Global tuberculosis report 2014. WHO [online], http://www.who.int/tb/Publications/Global-Report/en/(2014
    • (2014) Global Tuberculosis Report 2014
  • 37
    • 0031985277 scopus 로고    scopus 로고
    • Rapid, low-Technology mic determination with clinical mycobacterium tuberculosis isolates by using the microplate alamar blue assay
    • Franzblau, S. G., et al. Rapid, low-Technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar Blue assay. J. Clin. Microbiol. 36, 362-366 (1998
    • (1998) J. Clin. Microbiol , vol.36 , pp. 362-366
    • Franzblau, S.G.1
  • 38
    • 34247143197 scopus 로고    scopus 로고
    • Low-oxygen-recovery assay for high-Throughput screening of compounds against nonreplicating mycobacterium tuberculosis
    • Cho, S. H., et al. Low-oxygen-recovery assay for high-Throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 51, 1380-1385 (2007
    • (2007) Antimicrob. Agents Chemother , vol.51 , pp. 1380-1385
    • Cho, S.H.1
  • 39
    • 84864128973 scopus 로고    scopus 로고
    • A high-Throughput screen to identify inhibitors of atp homeostasis in non-replicating mycobacterium tuberculosis
    • Mak, P. A., et al A high-Throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis. ACS Chem. Biol. 7, 1190-1197 (2012
    • (2012) ACS Chem. Biol , vol.7 , pp. 1190-1197
    • Mak, P.A.1
  • 40
    • 0242651822 scopus 로고    scopus 로고
    • In vitro model of hypoxically induced nonreplicating persistence of mycobacterium tuberculosis
    • Wayne, L. G. In vitro model of hypoxically induced nonreplicating persistence of Mycobacterium tuberculosis. Methods Mol. Med. 54, 247-269 (2001
    • (2001) Methods Mol. Med , vol.54 , pp. 247-269
    • Wayne, L.G.1
  • 41
    • 84928178295 scopus 로고    scopus 로고
    • Comprehensive physicochemical, pharmacokinetic, and activity profiling of anti tb agents
    • Lakshminarayana, S. B., et al. Comprehensive physicochemical, pharmacokinetic, and activity profiling of anti TB agents. J. Antimicrob. Chemother. 70, 857-867 (2015
    • (2015) J. Antimicrob. Chemother , vol.70 , pp. 857-867
    • Lakshminarayana, S.B.1
  • 42
    • 33846796149 scopus 로고    scopus 로고
    • Microbial phenotypic heterogeneity, and antibiotic tolerance
    • Dhar, N., & McKinney, J. D. Microbial phenotypic heterogeneity, and antibiotic tolerance. Curr. Opin. Microbiol. 10, 30-38 (2007
    • (2007) Curr. Opin. Microbiol , vol.10 , pp. 30-38
    • Dhar, N.1    McKinney, J.D.2
  • 43
    • 2442685844 scopus 로고    scopus 로고
    • The search for new sterilizing anti-Tuberculosis drugs
    • Mitchison, D. A. The search for new sterilizing anti-Tuberculosis drugs. Front. Biosci. 9, 1059-1072 (2004
    • (2004) Front. Biosci , vol.9 , pp. 1059-1072
    • Mitchison, D.A.1
  • 44
    • 84867334162 scopus 로고    scopus 로고
    • Comprehensive analysis of methods used for the evaluation of compounds against mycobacterium tuberculosis
    • Franzblau, S. G., et al. Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis. Tuberculosis (Edinb.) 92, 453-488 (2012
    • (2012) Tuberculosis (Edinb , vol.92 , pp. 453-488
    • Franzblau, S.G.1
  • 45
    • 84920146502 scopus 로고    scopus 로고
    • High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against mycobacterium tuberculosis
    • Silva-Miranda, M., et al. High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 59, 693-697 (2015
    • (2015) Antimicrob. Agents Chemother , vol.59 , pp. 693-697
    • Silva-Miranda, M.1
  • 46
    • 84883824094 scopus 로고    scopus 로고
    • Discovery of q203, a potent clinical candidate for the treatment of tuberculosis
    • Pethe, K., et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat. Med. 19, 1157-1160 (2013
    • (2013) Nat. Med , vol.19 , pp. 1157-1160
    • Pethe, K.1
  • 47
    • 69049108875 scopus 로고    scopus 로고
    • Foamy macrophages, and the progression of the human tuberculosis granuloma
    • Russell, D. G., Cardona, P. J., Kim, M. J., Allain, S., & Altare, F. Foamy macrophages, and the progression of the human tuberculosis granuloma. Nat. Immunol. 10, 943-948 (2009
    • (2009) Nat. Immunol , vol.10 , pp. 943-948
    • Russell, D.G.1    Cardona, P.J.2    Kim, M.J.3    Allain, S.4    Altare, F.5
  • 48
    • 84856301870 scopus 로고    scopus 로고
    • Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions
    • Harper, J., et al. Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions. J. Infect. Dis. 205, 595-602 (2012
    • (2012) J. Infect. Dis , vol.205 , pp. 595-602
    • Harper, J.1
  • 49
    • 84922593368 scopus 로고    scopus 로고
    • Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature, and improves small molecule delivery
    • Datta, M., et al. Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature, and improves small molecule delivery. Proc. Natl Acad. Sci. USA 112, 1827-1832 (2015
    • (2015) Proc. Natl Acad. Sci. USA , vol.112 , pp. 1827-1832
    • Datta, M.1
  • 50
    • 84923184472 scopus 로고    scopus 로고
    • New tricks for old dogs: Countering antibiotic resistance in tuberculosis with host-directed therapeutics
    • Hawn, T. R., Shah, J. A., & Kalman, D. New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics. Immunol. Rev. 264, 344-362 (2015
    • (2015) Immunol. Rev , vol.264 , pp. 344-362
    • Hawn, T.R.1    Shah, J.A.2    Kalman, D.3
  • 51
    • 79952326100 scopus 로고    scopus 로고
    • Treatment of visceral leishmaniasis
    • Moore, E. M., & Lockwood, D. N. Treatment of visceral leishmaniasis. J. Glob. Infect. Dis. 2, 151-158 (2010
    • (2010) J. Glob. Infect. Dis , vol.2 , pp. 151-158
    • Moore, E.M.1    Lockwood, D.N.2
  • 52
    • 84921033692 scopus 로고    scopus 로고
    • An update on pharmacotherapy for leishmaniasis
    • Sundar, S., & Chakravarty, J. An update on pharmacotherapy for leishmaniasis. Expert Opin. Pharmacother. 16, 237-252 (2014
    • (2014) Expert Opin. Pharmacother , vol.16 , pp. 237-252
    • Sundar, S.1    Chakravarty, J.2
  • 53
    • 84900311830 scopus 로고    scopus 로고
    • Randomized trial of posaconazole, and benznidazole for chronic chagas' disease
    • Molina, I., et al. Randomized trial of posaconazole, and benznidazole for chronic Chagas' disease. N. Engl. J. Med. 370, 1899-1908 (2014
    • (2014) N. Engl. J. Med , vol.370 , pp. 1899-1908
    • Molina, I.1
  • 54
    • 84879030428 scopus 로고    scopus 로고
    • Comparison of a high-Throughput high-content intracellular leishmania donovani assay with an axenic amastigote assay
    • De Rycker, M., et al. Comparison of a high-Throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay. Antimicrob. Agents Chemother. 57, 2913-2922 (2013
    • (2013) Antimicrob. Agents Chemother , vol.57 , pp. 2913-2922
    • De Rycker, M.1
  • 55
    • 84886540022 scopus 로고    scopus 로고
    • Selection, and optimization of hits from a high-Throughput phenotypic screen against trypanosoma cruzi
    • Keenan, M., et al. Selection, and optimization of hits from a high-Throughput phenotypic screen against Trypanosoma cruzi. Future Med. Chem. 5, 1733-1752 (2013
    • (2013) Future Med. Chem , vol.5 , pp. 1733-1752
    • Keenan, M.1
  • 56
    • 84924658062 scopus 로고    scopus 로고
    • New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: An open resource
    • Pena, I., et al. New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource. Sci. Rep. 5, 8771 (2015
    • (2015) Sci. Rep , vol.5 , pp. 8771
    • Pena, I.1
  • 57
    • 84891846341 scopus 로고    scopus 로고
    • Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections
    • Don, R., & Ioset, J. R. Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections. Parasitology 141, 140-146 (2014
    • (2014) Parasitology , vol.141 , pp. 140-146
    • Don, R.1    Ioset, J.R.2
  • 58
    • 0035289779 scopus 로고    scopus 로고
    • Experimental and computational approaches to estimate solubility, and permeability in drug discovery, and development settings
    • Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. Experimental, and computational approaches to estimate solubility, and permeability in drug discovery, and development settings. Adv. Drug Deliv. Rev. 46, 3-26 (2001
    • (2001) Adv. Drug Deliv. Rev , vol.46 , pp. 3-26
    • Lipinski, C.A.1    Lombardo, F.2    Dominy, B.W.3    Feeney, P.J.4
  • 59
    • 84886542459 scopus 로고    scopus 로고
    • Drug discovery for neglected diseases: Molecular target-based, and phenotypic approaches
    • Gilbert, I. H. Drug discovery for neglected diseases: molecular target-based, and phenotypic approaches. J. Med. Chem. 56, 7719-7726 (2013
    • (2013) J. Med. Chem , vol.56 , pp. 7719-7726
    • Gilbert, I.H.1
  • 60
    • 84888069951 scopus 로고    scopus 로고
    • Malaria, and artemisinin derivatives: An updated review
    • Ansari, M. T., et al. Malaria, and artemisinin derivatives: an updated review. Mini Rev. Med. Chem. 13, 1879-1902 (2013
    • (2013) Mini Rev. Med. Chem , vol.13 , pp. 1879-1902
    • Ansari, M.T.1
  • 61
    • 70349963483 scopus 로고    scopus 로고
    • Embryotoxicity of the artemisinin antimalarials, and potential consequences for use in women in the first trimester
    • Clark, R. L. Embryotoxicity of the artemisinin antimalarials, and potential consequences for use in women in the first trimester. Reprod. Toxicol. 28, 285-296 (2009
    • (2009) Reprod. Toxicol , vol.28 , pp. 285-296
    • Clark, R.L.1
  • 62
    • 33645771195 scopus 로고    scopus 로고
    • Safety of artemisinin antimalarials
    • Toovey, S. Safety of artemisinin antimalarials. Clin. Infect. Dis. 42, 1214-1215 (2006
    • (2006) Clin. Infect. Dis , vol.42 , pp. 1214-1215
    • Toovey, S.1
  • 63
    • 33751197936 scopus 로고    scopus 로고
    • R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling, and reduces immune complex-mediated inflammation
    • Braselmann, S., et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling, and reduces immune complex-mediated inflammation. J. Pharmacol. Exp. Ther. 319, 998-1008 (2006
    • (2006) J. Pharmacol. Exp. Ther , vol.319 , pp. 998-1008
    • Braselmann, S.1
  • 64
    • 1442334562 scopus 로고    scopus 로고
    • Camptothecin and taxol: Historic achievements in natural products research
    • Oberlies, N. H., & Kroll, D. J. Camptothecin, and taxol: historic achievements in natural products research. J. Nat. Prod. 67, 129-135 (2004
    • (2004) J. Nat. Prod , vol.67 , pp. 129-135
    • Oberlies, N.H.1    Kroll, D.J.2
  • 65
    • 33846569938 scopus 로고    scopus 로고
    • Targeting mammalian target of rapamycin (mtor) for health, and diseases
    • Tsang, C. K., Qi, H., Liu, L. F., & Zheng, X. F. Targeting mammalian target of rapamycin (mTOR) for health, and diseases. Drug Discov. Today 12, 112-124 (2007
    • (2007) Drug Discov. Today , vol.12 , pp. 112-124
    • Tsang, C.K.1    Qi, H.2    Liu, L.F.3    Zheng, X.F.4
  • 66
    • 0037188776 scopus 로고    scopus 로고
    • History of the discovery of cyclosporin, and of its early pharmacological development
    • Borel, J. F. History of the discovery of cyclosporin, and of its early pharmacological development. Wien Klin. Wochenschr. 114, 433-437 (2002
    • (2002) Wien Klin. Wochenschr , vol.114 , pp. 433-437
    • Borel, J.F.1
  • 67
    • 84887583985 scopus 로고    scopus 로고
    • The global health innovative technology (ghit) fund: Financing medical innovations for neglected populations
    • Slingsby, B. T., & Kurokawa, K. The Global Health Innovative Technology (GHIT) fund: financing medical innovations for neglected populations. Lancet Glob. Health 1, e184-185 (2013
    • (2013) Lancet Glob. Health , vol.1 , pp. e184-185
    • Slingsby, B.T.1    Kurokawa, K.2
  • 68
    • 84889562408 scopus 로고    scopus 로고
    • The ghit fund shows its cards
    • Holmes, D. The GHIT fund shows its cards. Nat. Rev. Drug Discov. 12, 894 (2013
    • (2013) Nat. Rev. Drug Discov , vol.12 , pp. 894
    • Holmes, D.1
  • 69
    • 79951664903 scopus 로고    scopus 로고
    • Ivermectin 'wonder drug' from Japan: The human use perspective
    • Crump, A., & Omura, S. Ivermectin, 'wonder drug' from Japan: the human use perspective. Proc. Jpn Acad., Ser. B 87, 13-28 (2011
    • (2011) Proc. Jpn Acad ser , vol.B87 , pp. 13-28
    • Crump, A.1    Omura, S.2
  • 70
    • 34247215645 scopus 로고    scopus 로고
    • Advances in drug discovery, and biochemical studies
    • Kita, K., Shiomi, K., & Omura, S. Advances in drug discovery, and biochemical studies. Trends Parasitol. 23, 223-229 (2007
    • (2007) Trends Parasitol , vol.23 , pp. 223-229
    • Kita, K.1    Shiomi, K.2    Omura, S.3
  • 71
    • 9444230640 scopus 로고    scopus 로고
    • The life, and times of ivermectin-A success story
    • Omura, S., & Crump, A. The life, and times of ivermectin-A success story. Nat. Rev. Microbiol. 2, 984-989 (2004
    • (2004) Nat. Rev. Microbiol , vol.2 , pp. 984-989
    • Omura, S.1    Crump, A.2
  • 72
    • 79955408396 scopus 로고    scopus 로고
    • Fingolimod (fty720): A recently approved multiple sclerosis drug based on a fungal secondary metabolite
    • Strader, C. R., Pearce, C. J., & Oberlies, N. H. Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite. J. Nat. Prod. 74, 900-907 (2011
    • (2011) J. Nat. Prod , vol.74 , pp. 900-907
    • Strader, C.R.1    Pearce, C.J.2    Oberlies, N.H.3
  • 73
    • 77955114517 scopus 로고    scopus 로고
    • A historical perspective on the discovery of statins
    • Endo, A A historical perspective on the discovery of statins. Proc. Jpn Acad. Ser. B Phys. Biol. Sci. 86, 484-493 (2010
    • (2010) Proc. Jpn Acad. Ser. B Phys. Biol. Sci , vol.86 , pp. 484-493
    • Endo, A.1
  • 74
    • 0038004785 scopus 로고    scopus 로고
    • Lovastatin and beyond: The history of the hmg-coa reductase inhibitors
    • Tobert, J. A. Lovastatin, and beyond: the history of the HMG-CoA reductase inhibitors. Nat. Rev. Drug Discov. 2, 517-526 (2003
    • (2003) Nat. Rev. Drug Discov , vol.2 , pp. 517-526
    • Tobert, J.A.1
  • 75
    • 77950571108 scopus 로고    scopus 로고
    • New substructure filters for removal of pan assay interference compounds (pains) from screening libraries, and for their exclusion in bioassays
    • Baell, J. B., & Holloway, G. A. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries, and for their exclusion in bioassays. J. Med. Chem. 53, 2719-2740 (2010
    • (2010) J. Med. Chem , vol.53 , pp. 2719-2740
    • Baell, J.B.1    Holloway, G.A.2
  • 76
    • 0037061628 scopus 로고    scopus 로고
    • A common mechanism underlying promiscuous inhibitors from virtual, and high-Throughput screening
    • McGovern, S. L., Caselli, E., Grigorieff, N., & Shoichet, B. K A common mechanism underlying promiscuous inhibitors from virtual, and high-Throughput screening. J. Med. Chem. 45, 1712-1722 (2002
    • (2002) J. Med. Chem , vol.45 , pp. 1712-1722
    • McGovern, S.L.1    Caselli, E.2    Grigorieff, N.3    Shoichet, B.K.4
  • 77
    • 84908530414 scopus 로고    scopus 로고
    • Chemistry: Chemical con artists foil drug discovery
    • Baell, J., & Walters, M. A. Chemistry: chemical con artists foil drug discovery. Nature 513, 481-483 (2014
    • (2014) Nature , vol.513 , pp. 481-483
    • Baell, J.1    Waltersm, A.2
  • 79
    • 84912554796 scopus 로고    scopus 로고
    • A male, and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs
    • Ruecker, A., et al A male, and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs. Antimicrob. Agents Chemother. 58, 7292-7302 (2014
    • (2014) Antimicrob. Agents Chemother , vol.58 , pp. 7292-7302
    • Ruecker, A.1
  • 80
    • 0032233866 scopus 로고    scopus 로고
    • Cellular and genetic mechanisms underlying susceptibility of animal models to tuberculosis infection
    • 112-117; discussion
    • Orme, I. Cellular, and genetic mechanisms underlying susceptibility of animal models to tuberculosis infection. Novartis Found. Symp. 217, 112-117; discussion 117-119 (1998
    • (1998) Novartis Found. Symp , vol.217 , pp. 117-119
    • Orme, I.1
  • 81
    • 70049093343 scopus 로고    scopus 로고
    • Role of herg potassium channel assays in drug development
    • Priest, B. T., Bell, I. M., & Garcia, M. L. Role of hERG potassium channel assays in drug development. Channels (Austin) 2, 87-93 (2008
    • (2008) Channels (Austin , vol.2 , pp. 87-93
    • Priest, B.T.1    Bell, I.M.2    Garcia, M.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.