-
2
-
-
84856289656
-
High-Throughput screening: The hits, and leads of drug discovery-An overview
-
Martis, E. A., Radhakrishnan, R., & Badve, R. R. High-Throughput screening: the hits, and leads of drug discovery-An overview. J. Appl. Pharma. Sci. 1, 2-10 (2011
-
(2011)
J. Appl. Pharma. Sci
, vol.1
, pp. 2-10
-
-
Martis, E.A.1
Radhakrishnan, R.2
Badve, R.R.3
-
3
-
-
84866739808
-
Drug discovery in pharmaceutical industry: Productivity challenges, and trends
-
Khanna, I. Drug discovery in pharmaceutical industry: productivity challenges, and trends. Drug Discov. Today 17, 1088-1102 (2012
-
(2012)
Drug Discov. Today
, vol.17
, pp. 1088-1102
-
-
Khanna, I.1
-
4
-
-
33750531864
-
Innovative lead discovery strategies for tropical diseases
-
Nwaka, S., & Hudson, A. Innovative lead discovery strategies for tropical diseases. Nat. Rev. Drug Discov. 5, 941-955 (2006
-
(2006)
Nat. Rev. Drug Discov
, vol.5
, pp. 941-955
-
-
Nwaka, S.1
Hudson, A.2
-
5
-
-
70449640250
-
Advancing drug innovation for neglected diseases-criteria for lead progression
-
Nwaka, S., et al. Advancing drug innovation for neglected diseases-criteria for lead progression. PLoS Negl Trop. Dis. 3, e440 (2009
-
(2009)
PLoS Negl Trop. Dis
, vol.3
, pp. e440
-
-
Nwaka, S.1
-
6
-
-
84878506144
-
Designing the next generation of medicines for malaria control, and eradication
-
Burrows, J. N., Hooft van Huijsduijnen, R., Möhrle, J. J., Oeuvray, C., & Wells, T. N. C. Designing the next generation of medicines for malaria control, and eradication. Malar. J. 12, 187 (2013
-
(2013)
Malar. J.
, vol.12
, pp. 187
-
-
Burrows, J.N.1
Hooft Van Huijsduijnen, R.2
Möhrle, J.J.3
Oeuvray, C.4
Wells, T.N.C.5
-
7
-
-
84875448716
-
Phenotypic versus target-based drug discovery for first in class medicines
-
Swinney, D. C. Phenotypic versus target-based drug discovery for first in class medicines. Clin. Pharmacol. Ther. 93, 299-301 (2013
-
(2013)
Clin. Pharmacol. Ther
, vol.93
, pp. 299-301
-
-
Swinney, D.C.1
-
8
-
-
84905495729
-
The discovery of first in class drugs: Origins, and evolution
-
Eder, J., Sedrani, R., & Wiesmann, C. The discovery of first in class drugs: origins, and evolution. Nat. Rev. Drug Discov. 13, 577-587 (2014
-
(2014)
Nat. Rev. Drug Discov
, vol.13
, pp. 577-587
-
-
Eder, J.1
Sedrani, R.2
Wiesmann, C.3
-
9
-
-
33845903833
-
Drugs for bad bugs: Confronting the challenges of antibacterial discovery
-
Payne, D. J., Gwynn, M. N., Holmes, D. J., & Pompliano, D. L. Drugs for bad bugs: confronting the challenges of antibacterial discovery. Nat. Rev. Drug Discov. 6, 29-40 (2007
-
(2007)
Nat. Rev. Drug Discov
, vol.6
, pp. 29-40
-
-
Payne, D.J.1
Gwynn, M.N.2
Holmes, D.J.3
Pompliano, D.L.4
-
10
-
-
84903513282
-
Fluorine modulates species selectivity in the triazolopyrimidine class of plasmodium falciparum dihydroorotate dehydrogenase inhibitors
-
Deng, X., et al. Fluorine modulates species selectivity in the triazolopyrimidine class of Plasmodium falciparum dihydroorotate dehydrogenase inhibitors. J. Med. Chem. 57, 5381-5394 (2014
-
(2014)
J. Med. Chem
, vol.57
, pp. 5381-5394
-
-
Deng, X.1
-
11
-
-
0036311121
-
Cultivation of plasmodium spp
-
Schuster, F. L. Cultivation of Plasmodium spp. Clin. Microbiol. Rev. 15, 355-364 (2002
-
(2002)
Clin. Microbiol. Rev
, vol.15
, pp. 355-364
-
-
Schuster, F.L.1
-
12
-
-
78650464813
-
Apoptosis stalks plasmodium falciparum maintained in continuous culture condition
-
Mutai, B. K., & Waitumbi, J. N. Apoptosis stalks Plasmodium falciparum maintained in continuous culture condition. Malar J. 9 (Suppl. 3), S6 (2010
-
(2010)
Malar J.
, vol.9
, pp. S6
-
-
Mutai, B.K.1
Waitumbi, J.N.2
-
13
-
-
84920081179
-
Chagas disease drug discovery: Toward a new era
-
Chatelain, E. Chagas disease drug discovery: toward a new era. J. Biomol. Screen 20, 22-35 (2015
-
(2015)
J. Biomol. Screen
, vol.20
, pp. 22-35
-
-
Chatelain, E.1
-
14
-
-
84930381560
-
Malaria medicines: A glass half full
-
Wells, T. N. C., Hooft van Huijsduijnen, R., & Van Voorhis, W. C. Malaria medicines: a glass half full? Nat. Rev. Drug Discov. 14, 1-18 (2015
-
(2015)
Nat. Rev. Drug Discov
, vol.14
, pp. 1-18
-
-
Wells, T.N.C.1
Hooft Van Huijsduijnen, R.2
Van Voorhis, W.C.3
-
15
-
-
40049090584
-
A major transition in malaria treatment: The adoption, and deployment of artemisinin-based combination therapies
-
Bosman, A., & Mendis, K. N A major transition in malaria treatment: the adoption, and deployment of artemisinin-based combination therapies. Am. J. Trop. Med. Hyg. 77, 193-197 (2007
-
(2007)
Am. J. Trop. Med. Hyg
, vol.77
, pp. 193-197
-
-
Bosman, A.1
Mendis, K.N.2
-
16
-
-
84905225792
-
New drugs to treat multidrug-resistant tuberculosis: The case for bedaquiline
-
Leibert, E., Danckers, M., & Rom, W. N. New drugs to treat multidrug-resistant tuberculosis: the case for bedaquiline. Ther. Clin. Risk Manag. 10, 597-602 (2014
-
(2014)
Ther. Clin. Risk Manag
, vol.10
, pp. 597-602
-
-
Leibert, E.1
Danckers, M.2
Rom, W.N.3
-
17
-
-
84905712035
-
Delamanid: A new armor in combating drug-resistant tuberculosis
-
Xavier, A. S., & Lakshmanan, M. Delamanid: a new armor in combating drug-resistant tuberculosis. J. Pharmacol. Pharmacother. 5, 222-224 (2014
-
(2014)
J. Pharmacol. Pharmacother
, vol.5
, pp. 222-224
-
-
Xavier, A.S.1
Lakshmanan, M.2
-
18
-
-
33644867602
-
Improving the hit to lead process: Data-driven assessment of drug-like, and lead-like screening hits
-
Wunberg, T., et al. Improving the hit to lead process: data-driven assessment of drug-like, and lead-like screening hits. Drug Discov. Today 11, 175-180 (2006
-
(2006)
Drug Discov. Today
, vol.11
, pp. 175-180
-
-
Wunberg, T.1
-
19
-
-
85009155925
-
Early drug discovery and development guidelines: For academic researchers collaborators and start up companies
-
Hughes, M., et al. Early drug discovery, and development guidelines: for academic researchers, collaborators, and start up companies. Assay Guidance Manual [online], http://www.ncbi.nlm.nih.gov/books/NBK92015/(2012
-
(2012)
Assay Guidance Manual [Online]
-
-
Hughes, M.1
-
20
-
-
84892372929
-
A molecular marker of artemisinin-resistant plasmodium falciparum malaria
-
Ariey, F., et al A molecular marker of artemisinin-resistant Plasmodium falciparum malaria. Nature 505, 50-55 (2014
-
(2014)
Nature
, vol.505
, pp. 50-55
-
-
Ariey, F.1
-
21
-
-
84904892931
-
Spread of artemisinin resistance in plasmodium falciparum malaria
-
Ashley, E. A., et al. Spread of artemisinin resistance in Plasmodium falciparum malaria. N. Engl. J. Med. 371, 411-423 (2014
-
(2014)
N. Engl. J. Med
, vol.371
, pp. 411-423
-
-
Ashley, E.A.1
-
22
-
-
84928810196
-
Microbiology: Malaria runs rings round artemisinin
-
Burrows, J. Microbiology: malaria runs rings round artemisinin. Nature 520, 628-630 (2015
-
(2015)
Nature
, vol.520
, pp. 628-630
-
-
Burrows, J.1
-
23
-
-
84928814749
-
A molecular mechanism of artemisinin resistance in plasmodium falciparum malaria
-
Mbengue, A., et al A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria. Nature 520, 683-687 (2015
-
(2015)
Nature
, vol.520
, pp. 683-687
-
-
Mbengue, A.1
-
25
-
-
77952704258
-
Thousands of chemical starting points for antimalarial lead identification
-
Gamo, F. J., et al. Thousands of chemical starting points for antimalarial lead identification. Nature 465, 305-310 (2010
-
(2010)
Nature
, vol.465
, pp. 305-310
-
-
Gamo, F.J.1
-
26
-
-
77952718950
-
Chemical genetics of plasmodium falciparum
-
Guiguemde, W. A., et al. Chemical genetics of Plasmodium falciparum. Nature 465, 311-315 (2010
-
(2010)
Nature
, vol.465
, pp. 311-315
-
-
Guiguemde, W.A.1
-
27
-
-
48249095940
-
In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-Throughput screen
-
Plouffe, D., et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-Throughput screen. Proc. Natl Acad. Sci. USA 105, 9059-9064 (2008
-
(2008)
Proc. Natl Acad. Sci. USA
, vol.105
, pp. 9059-9064
-
-
Plouffe, D.1
-
28
-
-
83255176722
-
Imaging of plasmodium liver stages to drive next-generation antimalarial drug discovery
-
Meister, S., et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science 334, 1372-1377 (2011
-
(2011)
Science
, vol.334
, pp. 1372-1377
-
-
Meister, S.1
-
29
-
-
48249090848
-
A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes
-
Angulo-Barturen, I., et al A murine model of falciparum-malaria by in vivo selection of competent strains in non-myelodepleted mice engrafted with human erythrocytes. PLoS ONE 3, e2252 (2008
-
(2008)
PLoS ONE
, vol.3
, pp. e2252
-
-
Angulo-Barturen, I.1
-
30
-
-
84876002292
-
Quinolone 3 diarylethers: A new class of antimalarial drug
-
177ra37
-
Nilsen, A., et al. Quinolone 3 diarylethers: a new class of antimalarial drug. Sci. Transl. Med. 5, 177ra37 (2013
-
(2013)
Sci. Transl. Med
, vol.5
-
-
Nilsen, A.1
-
31
-
-
84924527760
-
Drug resistance genomics of the antimalarial drug artemisinin
-
Winzeler, E. A., & Manary, M. J. Drug resistance genomics of the antimalarial drug artemisinin. Genome Biol. 15, 544 (2014
-
(2014)
Genome Biol
, vol.15
, pp. 544
-
-
Winzeler, E.A.1
Manary, M.J.2
-
32
-
-
84923120760
-
Novel mutations in k13 propeller gene of artemisinin-resistant plasmodium falciparum
-
Isozumi, R., et al. Novel mutations in K13 propeller gene of artemisinin-resistant Plasmodium falciparum. Emerg. Infect. Dis. 21, 490-492 (2015
-
(2015)
Emerg. Infect. Dis
, vol.21
, pp. 490-492
-
-
Isozumi, R.1
-
33
-
-
84925354867
-
Spread of artemisinin-resistant plasmodium falciparum in myanmar: A cross-sectional survey of the k13 molecular marker
-
Tun, K. M., et al. Spread of artemisinin-resistant Plasmodium falciparum in Myanmar: a cross-sectional survey of the K13 molecular marker. Lancet Infect. Dis. 15, 415-421 (2015
-
(2015)
Lancet Infect. Dis
, vol.15
, pp. 415-421
-
-
Tun, K.M.1
-
34
-
-
79953322662
-
Towards an in vitro model of plasmodium hypnozoites suitable for drug discovery
-
Dembele, L., et al. Towards an in vitro model of Plasmodium hypnozoites suitable for drug discovery. PLoS ONE 6, e18162 (2011
-
(2011)
PLoS ONE
, vol.6
, pp. e18162
-
-
Dembele, L.1
-
35
-
-
84858213521
-
The biology of sexual development of plasmodium: The design, and implementation of transmission-blocking strategies
-
Sinden, R. E., Carter, R., Drakeley, C., & Leroy, D. The biology of sexual development of Plasmodium: the design, and implementation of transmission-blocking strategies. Malar J. 11, 70 (2012
-
(2012)
Malar J.
, vol.11
, pp. 70
-
-
Sinden, R.E.1
Carter, R.2
Drakeley, C.3
Leroy, D.4
-
36
-
-
84894198937
-
-
World Health Organization. WHO [online]
-
World Health Organization. Global tuberculosis report 2014. WHO [online], http://www.who.int/tb/Publications/Global-Report/en/(2014
-
(2014)
Global Tuberculosis Report 2014
-
-
-
37
-
-
0031985277
-
Rapid, low-Technology mic determination with clinical mycobacterium tuberculosis isolates by using the microplate alamar blue assay
-
Franzblau, S. G., et al. Rapid, low-Technology MIC determination with clinical Mycobacterium tuberculosis isolates by using the microplate Alamar Blue assay. J. Clin. Microbiol. 36, 362-366 (1998
-
(1998)
J. Clin. Microbiol
, vol.36
, pp. 362-366
-
-
Franzblau, S.G.1
-
38
-
-
34247143197
-
Low-oxygen-recovery assay for high-Throughput screening of compounds against nonreplicating mycobacterium tuberculosis
-
Cho, S. H., et al. Low-oxygen-recovery assay for high-Throughput screening of compounds against nonreplicating Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 51, 1380-1385 (2007
-
(2007)
Antimicrob. Agents Chemother
, vol.51
, pp. 1380-1385
-
-
Cho, S.H.1
-
39
-
-
84864128973
-
A high-Throughput screen to identify inhibitors of atp homeostasis in non-replicating mycobacterium tuberculosis
-
Mak, P. A., et al A high-Throughput screen to identify inhibitors of ATP homeostasis in non-replicating Mycobacterium tuberculosis. ACS Chem. Biol. 7, 1190-1197 (2012
-
(2012)
ACS Chem. Biol
, vol.7
, pp. 1190-1197
-
-
Mak, P.A.1
-
40
-
-
0242651822
-
In vitro model of hypoxically induced nonreplicating persistence of mycobacterium tuberculosis
-
Wayne, L. G. In vitro model of hypoxically induced nonreplicating persistence of Mycobacterium tuberculosis. Methods Mol. Med. 54, 247-269 (2001
-
(2001)
Methods Mol. Med
, vol.54
, pp. 247-269
-
-
Wayne, L.G.1
-
41
-
-
84928178295
-
Comprehensive physicochemical, pharmacokinetic, and activity profiling of anti tb agents
-
Lakshminarayana, S. B., et al. Comprehensive physicochemical, pharmacokinetic, and activity profiling of anti TB agents. J. Antimicrob. Chemother. 70, 857-867 (2015
-
(2015)
J. Antimicrob. Chemother
, vol.70
, pp. 857-867
-
-
Lakshminarayana, S.B.1
-
42
-
-
33846796149
-
Microbial phenotypic heterogeneity, and antibiotic tolerance
-
Dhar, N., & McKinney, J. D. Microbial phenotypic heterogeneity, and antibiotic tolerance. Curr. Opin. Microbiol. 10, 30-38 (2007
-
(2007)
Curr. Opin. Microbiol
, vol.10
, pp. 30-38
-
-
Dhar, N.1
McKinney, J.D.2
-
43
-
-
2442685844
-
The search for new sterilizing anti-Tuberculosis drugs
-
Mitchison, D. A. The search for new sterilizing anti-Tuberculosis drugs. Front. Biosci. 9, 1059-1072 (2004
-
(2004)
Front. Biosci
, vol.9
, pp. 1059-1072
-
-
Mitchison, D.A.1
-
44
-
-
84867334162
-
Comprehensive analysis of methods used for the evaluation of compounds against mycobacterium tuberculosis
-
Franzblau, S. G., et al. Comprehensive analysis of methods used for the evaluation of compounds against Mycobacterium tuberculosis. Tuberculosis (Edinb.) 92, 453-488 (2012
-
(2012)
Tuberculosis (Edinb
, vol.92
, pp. 453-488
-
-
Franzblau, S.G.1
-
45
-
-
84920146502
-
High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against mycobacterium tuberculosis
-
Silva-Miranda, M., et al. High-content screening technology combined with a human granuloma model as a new approach to evaluate the activities of drugs against Mycobacterium tuberculosis. Antimicrob. Agents Chemother. 59, 693-697 (2015
-
(2015)
Antimicrob. Agents Chemother
, vol.59
, pp. 693-697
-
-
Silva-Miranda, M.1
-
46
-
-
84883824094
-
Discovery of q203, a potent clinical candidate for the treatment of tuberculosis
-
Pethe, K., et al. Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis. Nat. Med. 19, 1157-1160 (2013
-
(2013)
Nat. Med
, vol.19
, pp. 1157-1160
-
-
Pethe, K.1
-
47
-
-
69049108875
-
Foamy macrophages, and the progression of the human tuberculosis granuloma
-
Russell, D. G., Cardona, P. J., Kim, M. J., Allain, S., & Altare, F. Foamy macrophages, and the progression of the human tuberculosis granuloma. Nat. Immunol. 10, 943-948 (2009
-
(2009)
Nat. Immunol
, vol.10
, pp. 943-948
-
-
Russell, D.G.1
Cardona, P.J.2
Kim, M.J.3
Allain, S.4
Altare, F.5
-
48
-
-
84856301870
-
Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions
-
Harper, J., et al. Mouse model of necrotic tuberculosis granulomas develops hypoxic lesions. J. Infect. Dis. 205, 595-602 (2012
-
(2012)
J. Infect. Dis
, vol.205
, pp. 595-602
-
-
Harper, J.1
-
49
-
-
84922593368
-
Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature, and improves small molecule delivery
-
Datta, M., et al. Anti-vascular endothelial growth factor treatment normalizes tuberculosis granuloma vasculature, and improves small molecule delivery. Proc. Natl Acad. Sci. USA 112, 1827-1832 (2015
-
(2015)
Proc. Natl Acad. Sci. USA
, vol.112
, pp. 1827-1832
-
-
Datta, M.1
-
50
-
-
84923184472
-
New tricks for old dogs: Countering antibiotic resistance in tuberculosis with host-directed therapeutics
-
Hawn, T. R., Shah, J. A., & Kalman, D. New tricks for old dogs: countering antibiotic resistance in tuberculosis with host-directed therapeutics. Immunol. Rev. 264, 344-362 (2015
-
(2015)
Immunol. Rev
, vol.264
, pp. 344-362
-
-
Hawn, T.R.1
Shah, J.A.2
Kalman, D.3
-
52
-
-
84921033692
-
An update on pharmacotherapy for leishmaniasis
-
Sundar, S., & Chakravarty, J. An update on pharmacotherapy for leishmaniasis. Expert Opin. Pharmacother. 16, 237-252 (2014
-
(2014)
Expert Opin. Pharmacother
, vol.16
, pp. 237-252
-
-
Sundar, S.1
Chakravarty, J.2
-
53
-
-
84900311830
-
Randomized trial of posaconazole, and benznidazole for chronic chagas' disease
-
Molina, I., et al. Randomized trial of posaconazole, and benznidazole for chronic Chagas' disease. N. Engl. J. Med. 370, 1899-1908 (2014
-
(2014)
N. Engl. J. Med
, vol.370
, pp. 1899-1908
-
-
Molina, I.1
-
54
-
-
84879030428
-
Comparison of a high-Throughput high-content intracellular leishmania donovani assay with an axenic amastigote assay
-
De Rycker, M., et al. Comparison of a high-Throughput high-content intracellular Leishmania donovani assay with an axenic amastigote assay. Antimicrob. Agents Chemother. 57, 2913-2922 (2013
-
(2013)
Antimicrob. Agents Chemother
, vol.57
, pp. 2913-2922
-
-
De Rycker, M.1
-
55
-
-
84886540022
-
Selection, and optimization of hits from a high-Throughput phenotypic screen against trypanosoma cruzi
-
Keenan, M., et al. Selection, and optimization of hits from a high-Throughput phenotypic screen against Trypanosoma cruzi. Future Med. Chem. 5, 1733-1752 (2013
-
(2013)
Future Med. Chem
, vol.5
, pp. 1733-1752
-
-
Keenan, M.1
-
56
-
-
84924658062
-
New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: An open resource
-
Pena, I., et al. New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource. Sci. Rep. 5, 8771 (2015
-
(2015)
Sci. Rep
, vol.5
, pp. 8771
-
-
Pena, I.1
-
57
-
-
84891846341
-
Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections
-
Don, R., & Ioset, J. R. Screening strategies to identify new chemical diversity for drug development to treat kinetoplastid infections. Parasitology 141, 140-146 (2014
-
(2014)
Parasitology
, vol.141
, pp. 140-146
-
-
Don, R.1
Ioset, J.R.2
-
58
-
-
0035289779
-
Experimental and computational approaches to estimate solubility, and permeability in drug discovery, and development settings
-
Lipinski, C. A., Lombardo, F., Dominy, B. W., & Feeney, P. J. Experimental, and computational approaches to estimate solubility, and permeability in drug discovery, and development settings. Adv. Drug Deliv. Rev. 46, 3-26 (2001
-
(2001)
Adv. Drug Deliv. Rev
, vol.46
, pp. 3-26
-
-
Lipinski, C.A.1
Lombardo, F.2
Dominy, B.W.3
Feeney, P.J.4
-
59
-
-
84886542459
-
Drug discovery for neglected diseases: Molecular target-based, and phenotypic approaches
-
Gilbert, I. H. Drug discovery for neglected diseases: molecular target-based, and phenotypic approaches. J. Med. Chem. 56, 7719-7726 (2013
-
(2013)
J. Med. Chem
, vol.56
, pp. 7719-7726
-
-
Gilbert, I.H.1
-
60
-
-
84888069951
-
Malaria, and artemisinin derivatives: An updated review
-
Ansari, M. T., et al. Malaria, and artemisinin derivatives: an updated review. Mini Rev. Med. Chem. 13, 1879-1902 (2013
-
(2013)
Mini Rev. Med. Chem
, vol.13
, pp. 1879-1902
-
-
Ansari, M.T.1
-
61
-
-
70349963483
-
Embryotoxicity of the artemisinin antimalarials, and potential consequences for use in women in the first trimester
-
Clark, R. L. Embryotoxicity of the artemisinin antimalarials, and potential consequences for use in women in the first trimester. Reprod. Toxicol. 28, 285-296 (2009
-
(2009)
Reprod. Toxicol
, vol.28
, pp. 285-296
-
-
Clark, R.L.1
-
62
-
-
33645771195
-
Safety of artemisinin antimalarials
-
Toovey, S. Safety of artemisinin antimalarials. Clin. Infect. Dis. 42, 1214-1215 (2006
-
(2006)
Clin. Infect. Dis
, vol.42
, pp. 1214-1215
-
-
Toovey, S.1
-
63
-
-
33751197936
-
R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling, and reduces immune complex-mediated inflammation
-
Braselmann, S., et al. R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling, and reduces immune complex-mediated inflammation. J. Pharmacol. Exp. Ther. 319, 998-1008 (2006
-
(2006)
J. Pharmacol. Exp. Ther
, vol.319
, pp. 998-1008
-
-
Braselmann, S.1
-
64
-
-
1442334562
-
Camptothecin and taxol: Historic achievements in natural products research
-
Oberlies, N. H., & Kroll, D. J. Camptothecin, and taxol: historic achievements in natural products research. J. Nat. Prod. 67, 129-135 (2004
-
(2004)
J. Nat. Prod
, vol.67
, pp. 129-135
-
-
Oberlies, N.H.1
Kroll, D.J.2
-
65
-
-
33846569938
-
Targeting mammalian target of rapamycin (mtor) for health, and diseases
-
Tsang, C. K., Qi, H., Liu, L. F., & Zheng, X. F. Targeting mammalian target of rapamycin (mTOR) for health, and diseases. Drug Discov. Today 12, 112-124 (2007
-
(2007)
Drug Discov. Today
, vol.12
, pp. 112-124
-
-
Tsang, C.K.1
Qi, H.2
Liu, L.F.3
Zheng, X.F.4
-
66
-
-
0037188776
-
History of the discovery of cyclosporin, and of its early pharmacological development
-
Borel, J. F. History of the discovery of cyclosporin, and of its early pharmacological development. Wien Klin. Wochenschr. 114, 433-437 (2002
-
(2002)
Wien Klin. Wochenschr
, vol.114
, pp. 433-437
-
-
Borel, J.F.1
-
67
-
-
84887583985
-
The global health innovative technology (ghit) fund: Financing medical innovations for neglected populations
-
Slingsby, B. T., & Kurokawa, K. The Global Health Innovative Technology (GHIT) fund: financing medical innovations for neglected populations. Lancet Glob. Health 1, e184-185 (2013
-
(2013)
Lancet Glob. Health
, vol.1
, pp. e184-185
-
-
Slingsby, B.T.1
Kurokawa, K.2
-
68
-
-
84889562408
-
The ghit fund shows its cards
-
Holmes, D. The GHIT fund shows its cards. Nat. Rev. Drug Discov. 12, 894 (2013
-
(2013)
Nat. Rev. Drug Discov
, vol.12
, pp. 894
-
-
Holmes, D.1
-
69
-
-
79951664903
-
Ivermectin 'wonder drug' from Japan: The human use perspective
-
Crump, A., & Omura, S. Ivermectin, 'wonder drug' from Japan: the human use perspective. Proc. Jpn Acad., Ser. B 87, 13-28 (2011
-
(2011)
Proc. Jpn Acad ser
, vol.B87
, pp. 13-28
-
-
Crump, A.1
Omura, S.2
-
70
-
-
34247215645
-
Advances in drug discovery, and biochemical studies
-
Kita, K., Shiomi, K., & Omura, S. Advances in drug discovery, and biochemical studies. Trends Parasitol. 23, 223-229 (2007
-
(2007)
Trends Parasitol
, vol.23
, pp. 223-229
-
-
Kita, K.1
Shiomi, K.2
Omura, S.3
-
71
-
-
9444230640
-
The life, and times of ivermectin-A success story
-
Omura, S., & Crump, A. The life, and times of ivermectin-A success story. Nat. Rev. Microbiol. 2, 984-989 (2004
-
(2004)
Nat. Rev. Microbiol
, vol.2
, pp. 984-989
-
-
Omura, S.1
Crump, A.2
-
72
-
-
79955408396
-
Fingolimod (fty720): A recently approved multiple sclerosis drug based on a fungal secondary metabolite
-
Strader, C. R., Pearce, C. J., & Oberlies, N. H. Fingolimod (FTY720): a recently approved multiple sclerosis drug based on a fungal secondary metabolite. J. Nat. Prod. 74, 900-907 (2011
-
(2011)
J. Nat. Prod
, vol.74
, pp. 900-907
-
-
Strader, C.R.1
Pearce, C.J.2
Oberlies, N.H.3
-
73
-
-
77955114517
-
A historical perspective on the discovery of statins
-
Endo, A A historical perspective on the discovery of statins. Proc. Jpn Acad. Ser. B Phys. Biol. Sci. 86, 484-493 (2010
-
(2010)
Proc. Jpn Acad. Ser. B Phys. Biol. Sci
, vol.86
, pp. 484-493
-
-
Endo, A.1
-
74
-
-
0038004785
-
Lovastatin and beyond: The history of the hmg-coa reductase inhibitors
-
Tobert, J. A. Lovastatin, and beyond: the history of the HMG-CoA reductase inhibitors. Nat. Rev. Drug Discov. 2, 517-526 (2003
-
(2003)
Nat. Rev. Drug Discov
, vol.2
, pp. 517-526
-
-
Tobert, J.A.1
-
75
-
-
77950571108
-
New substructure filters for removal of pan assay interference compounds (pains) from screening libraries, and for their exclusion in bioassays
-
Baell, J. B., & Holloway, G. A. New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries, and for their exclusion in bioassays. J. Med. Chem. 53, 2719-2740 (2010
-
(2010)
J. Med. Chem
, vol.53
, pp. 2719-2740
-
-
Baell, J.B.1
Holloway, G.A.2
-
76
-
-
0037061628
-
A common mechanism underlying promiscuous inhibitors from virtual, and high-Throughput screening
-
McGovern, S. L., Caselli, E., Grigorieff, N., & Shoichet, B. K A common mechanism underlying promiscuous inhibitors from virtual, and high-Throughput screening. J. Med. Chem. 45, 1712-1722 (2002
-
(2002)
J. Med. Chem
, vol.45
, pp. 1712-1722
-
-
McGovern, S.L.1
Caselli, E.2
Grigorieff, N.3
Shoichet, B.K.4
-
77
-
-
84908530414
-
Chemistry: Chemical con artists foil drug discovery
-
Baell, J., & Walters, M. A. Chemistry: chemical con artists foil drug discovery. Nature 513, 481-483 (2014
-
(2014)
Nature
, vol.513
, pp. 481-483
-
-
Baell, J.1
Waltersm, A.2
-
78
-
-
80052405122
-
Challenges in antimalarial drug discovery
-
Burrows, J. N., Leroy, D., Lotharius, J., & Waterson, D. Challenges in antimalarial drug discovery. Future Med. Chem. 3, 1401-1412 (2011
-
(2011)
Future Med. Chem
, vol.3
, pp. 1401-1412
-
-
Burrows, J.N.1
Leroy, D.2
Lotharius, J.3
Waterson, D.4
-
79
-
-
84912554796
-
A male, and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs
-
Ruecker, A., et al A male, and female gametocyte functional viability assay to identify biologically relevant malaria transmission-blocking drugs. Antimicrob. Agents Chemother. 58, 7292-7302 (2014
-
(2014)
Antimicrob. Agents Chemother
, vol.58
, pp. 7292-7302
-
-
Ruecker, A.1
-
80
-
-
0032233866
-
Cellular and genetic mechanisms underlying susceptibility of animal models to tuberculosis infection
-
112-117; discussion
-
Orme, I. Cellular, and genetic mechanisms underlying susceptibility of animal models to tuberculosis infection. Novartis Found. Symp. 217, 112-117; discussion 117-119 (1998
-
(1998)
Novartis Found. Symp
, vol.217
, pp. 117-119
-
-
Orme, I.1
-
81
-
-
70049093343
-
Role of herg potassium channel assays in drug development
-
Priest, B. T., Bell, I. M., & Garcia, M. L. Role of hERG potassium channel assays in drug development. Channels (Austin) 2, 87-93 (2008
-
(2008)
Channels (Austin
, vol.2
, pp. 87-93
-
-
Priest, B.T.1
Bell, I.M.2
Garcia, M.L.3
|