Visualizing the tunnel in tryptophan synthase with crystallography: Insights into a selective filter for accommodating indole and rejecting water

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1864, Issue 3, 2016, Pages 268-279

  Hilario, Eduardo ^a   Caulkins, Bethany G ^b   Huang, Yu Ming M ^b,c   You, Wanli ^b   Chang, Chia En A ^b   Mueller, Leonard J ^b   Dunn, Michael F ^a   Fan, Li ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

Dewetted channel; Hydrophobic barrier; Hydrophobic nanopore; Substrate channeling; Substrate diffusion; Tryptophan synthase

Indexed keywords

ACRYLIC ACID DERIVATIVE; AMMONIA; INDOLE; PHENYLALANINE; PYRUVIC ACID; TRYPTOPHAN SYNTHASE; INDOLE DERIVATIVE; LIGAND; WATER;

ARTICLE; BETA SHEET; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; HYDROPHOBICITY; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SIMULATION; WATER TRANSPORT; X RAY CRYSTALLOGRAPHY; BINDING SITE; CATALYSIS; CHEMICAL PHENOMENA; CHEMISTRY; ENZYME SPECIFICITY; ENZYMOLOGY; NANOPORE; PROTEIN CONFORMATION; SALMONELLA ENTERICA SEROVAR TYPHIMURIUM;

BINDING SITES; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; INDOLES; LIGANDS; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; NANOPORES; PROTEIN CONFORMATION; SALMONELLA TYPHIMURIUM; SUBSTRATE SPECIFICITY; TRYPTOPHAN SYNTHASE; WATER;

EID: 84953241391     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2015.12.006     Document Type: Article

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