Selective small molecule inhibitor of the Mycobacterium tuberculosis fumarate hydratase reveals an allosteric regulatory site

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 27, 2016, Pages 7503-7508

  Kasbekar, Monica ^a,b   Fischer, Gerhard ^b   Mott, Bryan T ^a   Yasgar, Adam ^a   Hyvönen, Marko ^b   Boshoff, Helena I M ^c   Abell, Chris ^b   Barry, Clifton E ^c   Thomas, Craig J ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

Allosteric regulation; Fumarate hydratase; Mycobacterium tuberculosis; Selective inhibition; Tca cycle

Indexed keywords

FUMARATE HYDRATASE; LYASE INHIBITOR;

ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME STRUCTURE; HIGH THROUGHPUT SCREENING; HUMAN; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; STEADY STATE; X RAY CRYSTALLOGRAPHY; ALLOSTERISM; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; FLUORESCENCE; METABOLISM;

ALLOSTERIC REGULATION; CRYSTALLOGRAPHY, X-RAY; FLUORESCENCE; FUMARATE HYDRATASE; MYCOBACTERIUM TUBERCULOSIS;

EID: 84977273705     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1600630113     Document Type: Article

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