Targeting PTPRK-RSPO3 colon tumours promotes differentiation and loss of stem-cell function

Nature

Volumn 529, Issue 7584, 2016, Pages 97-100

  Storm, Elaine E ^a   Durinck, Steffen ^a   De Sousa E Melo, Felipe ^a   Tremayne, Jarrod ^a   Kljavin, Noelyn ^a   Tan, Christine ^a   Ye, Xiaofen ^a   Chiu, Cecilia ^a   Pham, Thinh ^a   Hongo, Jo Anne ^a   Bainbridge, Travis ^a   Firestein, Ron ^a   Blackwood, Elizabeth ^a   Metcalfe, Ciara ^a   Stawiski, Eric W ^a   Yauch, Robert L ^a   Wu, Yan ^a   De Sauvage, Frederic J ^a  

^a GENENTECH INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE; PROTEIN P53; SMAD4 PROTEIN; ANTIBODY; PTPRK PROTEIN, HUMAN; RECEPTOR LIKE PROTEIN TYROSINE PHOSPHATASE; RSPO3 PROTEIN, HUMAN; THROMBOSPONDIN;

DIFFERENTIATION; GENE EXPRESSION; MEDICAL GEOGRAPHY; TUMOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL DIFFERENTIATION; CELL PROLIFERATION; COLON TUMOR; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION; GENE FUSION; GENE TARGETING; GENOMICS; HOMEOSTASIS; INTESTINAL STEM CELL; LOSS OF FUNCTION MUTATION; MALE; MOUSE; NONHUMAN; ONCOGENE K RAS; PHENOTYPE; PRIORITY JOURNAL; PTPRK GENE; RSPO3 GENE; SECRETORY CELL; STEM CELL; TUMOR ENGRAFTMENT; TUMOR VOLUME; UPREGULATION; WNT SIGNALING PATHWAY; ANIMAL; ANTAGONISTS AND INHIBITORS; CANCER STEM CELL; CELL DIVISION; COLORECTAL NEOPLASMS; CYTOLOGY; DISEASE COURSE; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; HUMAN; IMMUNOLOGY; INTESTINE; METABOLISM; MOLECULARLY TARGETED THERAPY; PATHOLOGY;

ANIMALS; ANTIBODIES; CELL DIFFERENTIATION; CELL DIVISION; COLORECTAL NEOPLASMS; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION; HUMANS; INTESTINES; MALE; MICE; MOLECULAR TARGETED THERAPY; NEOPLASTIC STEM CELLS; RECEPTOR-LIKE PROTEIN TYROSINE PHOSPHATASES, CLASS 2; STEM CELLS; THROMBOSPONDINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84953911698     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature16466     Document Type: Article

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