Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer

Cell

Volumn 161, Issue 7, 2015, Pages 1539-1552

  Dow, Lukas E ^a,c   O'Rourke, Kevin P ^a,c   Simon, Janelle ^a   Tschaharganeh, Darjus F ^a   Van Es, Johan H ^b   Clevers, Hans ^b   Lowe, Scott W ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

APC; FAP; polyposis; shRNA; tumor regression; Wnt

Indexed keywords

ALKALINE PHOSPHATASE; APC PROTEIN; CYTOKERATIN 20; DOXYCYCLINE; K RAS PROTEIN; PROTEIN P53; SHORT HAIRPIN RNA; KRAS2 PROTEIN, MOUSE; PROTEIN P21;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER REGRESSION; CARCINOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL RENEWAL; COLON ADENOMA; COLORECTAL CANCER; CONTROLLED STUDY; ENZYME REPRESSION; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE SILENCING; IN VIVO STUDY; INTESTINE CRYPT; INTESTINE FUNCTION; INTESTINE POLYP; INVASIVE CARCINOMA; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; SMALL INTESTINE; TUMOR REGRESSION; WNT SIGNALING PATHWAY; ANIMAL; COLORECTAL TUMOR; DISEASE MODEL; GENETICS; LARGE INTESTINE; METABOLISM; PATHOLOGY; RNA INTERFERENCE; TRANSGENIC MOUSE; TUMOR SUPPRESSOR GENE;

ADENOMATOUS POLYPOSIS COLI PROTEIN; ANIMALS; CELL PROLIFERATION; COLORECTAL NEOPLASMS; DISEASE MODELS, ANIMAL; DOXYCYCLINE; GENES, P53; INTESTINAL POLYPS; INTESTINE, LARGE; INTESTINE, SMALL; MICE; MICE, TRANSGENIC; PROTO-ONCOGENE PROTEINS P21(RAS); RNA INTERFERENCE; WNT SIGNALING PATHWAY;

EID: 84935032984     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.05.033     Document Type: Article

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